1-20 of 31
Jan H. Beumer
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles

Abstract 3019: Non-linear absorption pharmacokinetics (PK) of the ATR inhibitor AZD6738 in mice

Brian F. Kiesel, Jianxia Guo, Christopher J. Bakkenist, Jan H. Beumer
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3019.
DOI: https://doi.org/10.1158/1538-7445.AM2020-3019
Published: 15 August 2020
View article
Journal Articles

Abstract CT013: NSABP FB-10: Phase Ib dose-escalation trial evaluating trastuzumab emtansine (T-DMI) with neratinib (N) in women with metastatic HER2+ breast cancer (MBC)

Jame Abraham, Shannon L. Puhalla, Wiliam M. Sikov, Alberto J. Montero, Jan H. Beumer, Marc E. Buyse, Laura M. Adamson, Ashok Srinivasan, Katherine L. Pogue-Geile, Samuel A. Jacobs
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): CT013.
DOI: https://doi.org/10.1158/1538-7445.AM2017-CT013
Published: 01 July 2017
View article
Journal Articles

Abstract 5270: Disease subtype independent biomarkers of breast cancer prevention by withaferin a

Eun-Ryeong Hahm, Suman K. Samanta, Anuradha Sehrawat, Su-Hyeong Kim, Subrata K. Pore, Krishna B. Singh, Susan M. Christner, Yongli Shuai, Jan H. Beumer, Ruchi Roy, Nancy E. Davidson, Shivendra V. Singh
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 5270.
DOI: https://doi.org/10.1158/1538-7445.AM2017-5270
Published: 01 July 2017
View article
Journal Articles

Abstract 2083: Toxicity, bioavailability, pharmacokinetics, tissue distribution and metabolism of a novel small molecule inhibitor of IL-6-induced STAT3 activation

Brian F. Kiesel, Robert A. Parise, Jianxia Guo, Donna M. Huryn, Paul A. Johnston, Rafaelle Colombo, Malabika Sen, Jennifer Grandis, Julie L. Eiseman, Jan H. Beumer
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2083.
DOI: https://doi.org/10.1158/1538-7445.AM2016-2083
Published: 15 July 2016
View article
Journal Articles

Abstract 4517: Plasma and tumor pharmacokinetics of IV LMP744, a novel indenoisoquinoline topoisomerase I inhibitor, in a canine phase I study

Julie L. Eiseman, Julianne Holleran, David L. McCormick, Miguel Muzzio, Joseph M. Covey, Chand Khanna, Christina Mazcko, Yves Pommier, Melissa Paolini, Amy Leblanc, Jenna H. Burton, James H. Doroshow, Joseph E. Tomaszewski, Jan H. Beumer
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4517.
DOI: https://doi.org/10.1158/1538-7445.AM2015-4517
Published: 01 August 2015
View article
Journal Articles

Abstract 4513: Pharmacokinetics and pharmacodynamics of indenoisoquinoline LMP400 (Indotecan) in BALB/c female mice bearing CT-26 colon tumors

Jianxia Guo, Julianne Holleran, John C. Schmitz, Kenneth Czambel, Jan H. Beumer, Julie L. Eiseman
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4513.
DOI: https://doi.org/10.1158/1538-7445.AM2015-4513
Published: 01 August 2015
View article
Journal Articles

Abstract CT207: Pharmacokinetic analysis of the HDAC inhibitor belinostat (PXD-101) and metabolites in patients with hepatic dysfunction

Brian Kiesel, Robert Parise, Yan Lin, Deborah Allen, Guru Reddy, Shanta Chawla, Richard Piekarz, Percy Ivy, Shivaani Kumar, Jan H. Beumer
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): CT207.
DOI: https://doi.org/10.1158/1538-7445.AM2014-CT207
Published: 01 October 2014
View article
Journal Articles

Abstract 4643: Phase I pharmacokinetics and pharmacodynamics of a novel indenoisoquinoline topoisomerase 1 (TOP1) inhibitor, LMP400, administered on a daily x 5 schedule

Jan H. Beumer, Julianne Holleran, James Doroshow, Alice Chen, Deborah Allen, Joseph Covey, Joseph Tomaszewski, Yves Pommier, Shivaani Kumar, Julie L. Eiseman
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4643.
DOI: https://doi.org/10.1158/1538-7445.AM2014-4643
Published: 01 October 2014
View article
Journal Articles

Abstract 4644: Efficacy, pharmacokinetics and tissue distribution of celastrol analogues SBI 064601, SBI 0640599 and SBI 0069272 in C.B-17 SCID mice bearing Daudi Burkitt's lymphoma xenografts

Jianxia Guo, Kathleen Paul, Edward V. Prochownik, Nicholas Cosford, Robert A. Parise, Jan H. Beumer, Julie L. Eiseman
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4644.
DOI: https://doi.org/10.1158/1538-7445.AM2014-4644
Published: 01 October 2014
View article
Journal Articles

Abstract 4632: Plasma and tumor pharmacokinetics of IV LMP400, a novel indenoisoquinoline topoisomerase I inhibitor, in a canine phase I study

Julie L. Eiseman, Julianne Holleran, David L. McCormick, Miguel Muzzio, Joseph M. Covey, Chand Khanna, Christina Mazcko, Yves Pommier, Melissa Paoloni, James D. Doroshow, Joseph E. Tomaszewski, Jan H. Beumer
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4632.
DOI: https://doi.org/10.1158/1538-7445.AM2014-4632
Published: 01 October 2014
View article
Journal Articles

Abstract 4751: 25-hydroxyvitamin D3 induces vitamin D signaling independent of CYP27B1 in non-small cell lung cancer cells

Alissa R. Verone, Suzanne Shoemaker, Robert Parise, Jan H. Beumer, Pamela A. Hershberger
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4751.
DOI: https://doi.org/10.1158/1538-7445.AM2014-4751
Published: 01 October 2014
View article
Journal Articles

Abstract 4112: Inositol hexaphosphate (IP6) and inositol against large granular lymphocytic leukemia (LGLL)

Ivana Vucenik, Jan H. Beumer, Julie L. Eiseman
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4112.
DOI: https://doi.org/10.1158/1538-7445.AM2014-4112
Published: 01 October 2014
View article
Journal Articles

Abstract 1019: Cytotoxicity in vitro, pharmacokinetics and tissue distribution of Link-N3 and Link-F3, two bivalent small molecules inhibitors of c-Myc/Max interactions in C.B-17 SCID mice bearing Daudi Burkitt's lymphoma xenografts.

Jianxia Guo, Dana M. Clausen, Edward V. Prochownik, Steven J. Metallo, Robert A. Parise, Jan H. Beumer, Julie L. Eiseman
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 1019.
DOI: https://doi.org/10.1158/1538-7445.AM2013-1019
Published: 15 April 2013
View article
Journal Articles

Abstract 4726: Novel small molecule inhibitors of MDM2/4-p53 interaction, YH264 and its ethyl ester YH263: preclinical evaluation

Susan M. Christner, Dana M. Clausen, Jan H. Beumer, Robert A. Parise, Yi Huang, Alexander S. Dömling, Julie L. Eiseman
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 4726.
DOI: https://doi.org/10.1158/1538-7445.AM2012-4726
Published: 15 April 2012
View article
Journal Articles

Abstract 563: Chemoprevention of mammary cancer in MMTV-neu transgenic mice by dietary administration of cruciferous vegetable constituent phenethyl isothiocyanate

Julie A. Arlotti, Su-Hyeong Kim, Anuradha Sehrawat, Eun-Ryeong Hahm, Anna A. Powolny, Joomin Lee, Jan H. Beumer, Kozue Sakao, Shivendra V. Singh
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 563.
DOI: https://doi.org/10.1158/1538-7445.AM2012-563
Published: 15 April 2012
View article
Journal Articles

Abstract 3782: Plasma pharmacokinetics of fluorodeoxycytidine, downstream metabolites, and tetrahydrouridine after combined administration to cynomolgus monkeys

Jan H. Beumer, Julianne L. Holleran, David L. McCormick, William D. Johnson, Joseph M. Covey, Myrtle Davis, Julie L. Eiseman
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 3782.
DOI: https://doi.org/10.1158/1538-7445.AM2012-3782
Published: 15 April 2012
View article
Journal Articles

Abstract 759: Quantitation of the HDAC inhibitor belinostat (PXD-101) and metabolites in human plasma by a novel LC-MS/MS assay.

Brian F. Kiesel, Robert A. Parise, Jette Tjornelund, Mette K. Christensen, Einars Loza, Edward Chu, Shivaani Kummar, Jan H. Beumer
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 759.
DOI: https://doi.org/10.1158/1538-7445.AM2012-759
Published: 15 April 2012
View article
Journal Articles

Abstract 1283: Phase I and pharmacokinetic evaluation of the DNA methyltransferase inhibitor 5-fluoro-2′-deoxycytidine: A California Cancer Consortium study

Edward M. Newman, Robert J. Morgan, Jan H. Beumer, Suzette M. Blanchard, Anthony B. El-Khoueiry, Shivaani Kummar, Mary I. Carroll, Timothy W. Synold, Heinz J. Lenz, James H. Doroshow
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 1283.
DOI: https://doi.org/10.1158/1538-7445.AM2011-1283
Published: 15 April 2011
View article
Journal Articles

Abstract 5441: A rapid homogeneous immunoassay for the therapeutic drug management of imatinib in plasma using a novel selective monoclonal antibody

Salvatore J. Salamone, Jodi C. Courtney, Rebecca Harney, Yunying Li, Alex Volkov, Jan H. Beumer
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 5441.
DOI: https://doi.org/10.1158/1538-7445.AM2011-5441
Published: 15 April 2011
View article
Journal Articles

Abstract 5499: Temozolomide (TMZ) cytotoxicity in human melanoma cell lines is enhanced by concomitant treatment with the histone deacetylase (HDAC) inhibitor vorinostat (SAHA) and PARP inhibitor MK-4827

Hussein Tawbi, John M. Kirkwood, Ying-Chih Lin, Shama C. Buch, Yan Lin, Lyubov Kublo, Jan H. Beumer, Merrill J. Egorin, Edward Chu, Pamela Hershberger
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 5499.
DOI: https://doi.org/10.1158/1538-7445.AM2011-5499
Published: 15 April 2011
View article