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Jan Budczies
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Journal Articles

Abstract 2487: KRAS and TP53 co-mutation predicts benefit of immune checkpoint blockade in lung adenocarcinoma

Jan Budczies, Eva Romanovsky, Martina Kirchner, Olaf Neumann, Miriam Blasi, Johannes Schnorbach, Rajiv Shah, Farastuk Bozorgmehr, Rajkumar Savai, Thorsten Stiewe, Solange Peters, Peter Schirmacher, Thomas Michael, Daniel Kazdal, Petros Christopoulos, Albrecht Stenzinger
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2487.
https://doi.org/10.1158/1538-7445.AM2024-2487
Published: 22 March 2024
View article titled, Abstract 2487: KRAS and TP53 co-mutation predicts benefit of immune checkpoint blockade in lung adenocarcinoma
Journal Articles

Abstract 2607: Homogenous TP53mut-associated tumor biology across mutation and cancer types revealed by comprehensive mRNA expression analysis

Jan Budczies, Eva Romanovsky, Klaus Kluck, Iordanis Ourailidis, Michael Menzel, Susanne Beck, Markus Ball, Daniel Kazdal, Petros Christopoulos, Peter Schirmacher, Thorsten Stiewe, Albrecht Stenzinger
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2607.
https://doi.org/10.1158/1538-7445.AM2023-2607
Published: 04 April 2023
View article titled, Abstract 2607: Homogenous TP53mut-associated tumor biology across mutation and cancer types revealed by comprehensive mRNA expression analysis
Journal Articles

Abstract 810: HRD is inversely correlated with MSI and identifies immunologically cold tumors in most cancer types

Jan Budczies, Klaus Kluck, Susanne Beck, Iordanis Ouralidis, Michael Allgäuer, Michael Menzel, Eugen Rempel, Daniel Kazdal, Lukas Perkhofer, Alexander Kleger, Peter Schirmacher, Thomas Seufferlein, Albrecht Stenzinger
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 810.
https://doi.org/10.1158/1538-7445.AM2022-810
Published: 15 June 2022
View article titled, Abstract 810: HRD is inversely correlated with MSI and identifies immunologically cold tumors in most cancer types
Journal Articles

Abstract 1571: Inter- and intra- tumorheterogeneity of the microenvironment in pulmonary adenocarcinoma

Daniel Kazdal, Jan Budczies, Martina Kirchner, Klaus Kluck, Michael Allgäuer, Olaf Neumann, Regine Brandt, Eugen Rempel, Carolin Ploeger, Moritz von Winterfeld, Marc Schneider, Steffen Dietz, Hauke Winter, Thomas Muley, Holger Sülmann, Michael Meister, Felix Herth, Claus Heussel, Roland Penzel, Volker Endris, Peter Schirmacher, Michael Thomas, Petros Christopoulos, Albrecht Stenzinger
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1571.
https://doi.org/10.1158/1538-7445.AM2020-1571
Published: 15 August 2020
View article titled, Abstract 1571: Inter- and intra- tumorheterogeneity of the microenvironment in pulmonary adenocarcinoma
Journal Articles

Abstract 3093: Quantifying the confounders of panel-based tumor mutational burden (TMB) measurement

Jan Budczies, Daniel Kazdal, Michael Allgäuer, Petros Christopoulos, Eugen Rempel, Nicole Pfarr, Wilko Weichert, Stefan Fröhling, Michael Thomas, Solange Peters, Volker Endris, Peter Schirmacher, Albrecht Stenzinger
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3093.
https://doi.org/10.1158/1538-7445.AM2020-3093
Published: 15 August 2020
View article titled, Abstract 3093: Quantifying the confounders of panel-based tumor mutational burden (TMB) measurement
Journal Articles

Abstract PD5-08: Tumor immune-cell activity assessed by RNAseq is an independent predictor of therapy response and prognosis after neoadjuvant chemotherapy in HER2 negative breast cancer patients - An analysis of the GeparSepto trial

Peter A Fasching, Carsten Denkert, Stephen Benz, Karsten E Weber, Christopher Szeto, Jan Budczies, Andreas Schneeweiss, Elmar Stickeler, Sabine Schmatloch, Christian Jackisch, Thomas Karn, Hans Peter Sinn, Mathias Warm, Marion van Mackelenbergh, Sharooz Rabizadeh, Christian Schem, Ernst Heinmöller, Volkmar Müller, Frederik Marmé, Patrick Soon-Shiong, Valentina Nekljudova, Michael Untch, Sibylle Loibl
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): PD5-08.
https://doi.org/10.1158/1538-7445.SABCS19-PD5-08
Published: 15 February 2020
View article titled, Abstract PD5-08: Tumor immune-cell activity assessed by RNAseq is an independent predictor of therapy response and prognosis after neoadjuvant chemotherapy in HER2 negative breast cancer patients - An analysis of the GeparSepto trial
Journal Articles

Abstract P6-10-04: Landscape of immune-cell signatures in early high-risk breast cancer (BC) reveals clinically-relevant enrichment of immune subpopulations

Christopher Szeto, Carsten Denkert, Peter A Fasching, Stephen Benz, Karsten E Weber, Jan Budczies, Andreas Schneeweiss, Elmar Stickeler, Sabine Schmatloch, Christian Jackisch, Thomas Karn, Hans P Sinn, Mathias Warm, Marion van Mackelenbergh, Shahrooz Rabizadeh, Christian Schem, Ernst Heinmöller, Volkmar Müller, Frederik Marmé, Patrick Soon-Shiong, Valentina Nekljudova, Sibylle Loibl, Michael Untch
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): P6-10-04.
https://doi.org/10.1158/1538-7445.SABCS19-P6-10-04
Published: 15 February 2020
View article titled, Abstract P6-10-04: Landscape of immune-cell signatures in early high-risk breast cancer (BC) reveals clinically-relevant enrichment of immune subpopulations
Journal Articles

Abstract 4101: Spatial heterogeneity of tumor mutational burden (TMB) counts in pulmonary adenocarcinoma: Separating biological effects from technical artifacts

Volker Endris, Michael Allgäuer, Jan Budczies, Jonas Leichsenring, Anna-Lena Volckmar, Martina Kirchner, Olaf Neumann, Regine Brandt, Eugen Rempel, Carolin Plöger, Moritz von Winterfeld, Alexander Harms, Mark Kriegsmann, Roland Penzel, Peter Schirmacher, Daniel Kazdal, Albrecht Stenzinger
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4101.
https://doi.org/10.1158/1538-7445.AM2019-4101
Published: 01 July 2019
View article titled, Abstract 4101: Spatial heterogeneity of tumor mutational burden (TMB) counts in pulmonary adenocarcinoma: Separating biological effects from technical artifacts
Journal Articles

Abstract 4125: Precise and reproducible measurement of tumor mutational burden using panel sequencing: the role of panel size and of mutation types

Jan Budczies, Eugen Rempel, Michael Allgäuer, Daniel Kazdal, Volker Endris, Peter Schirmacher, Albrecht Stenzinger
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4125.
https://doi.org/10.1158/1538-7445.AM2019-4125
Published: 01 July 2019
View article titled, Abstract 4125: Precise and reproducible measurement of tumor mutational burden using panel sequencing: the role of panel size and of mutation types
Journal Articles

Abstract LB-027: Mutational diversity and therapy response in breast cancer-a sequencing analysis in the neoadjuvant GeparSepto trial

Sibylle Loibl, Denise Treue, Jan Budczies, Karsten Weber, Albrecht Stenzinger, Wolfgang D. Schmitt, Wilko Weichert, Paul Jank, Jenny Furlanetto, Frederick Klauschen, Thomas Karn, Nicole Pfarr, Gunter von Minckwitz, Annika Lehmann, Christian Jackisch, Christine Sers, Andreas Schneeweiss, Peter A. Fasching, Christian Schem, Michael Hummel, Marion van Mackelenbergh, Valentina Nekljudova, Michael Untch, Carsten Denkert
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): LB-027.
https://doi.org/10.1158/1538-7445.AM2018-LB-027
Published: 01 July 2018
View article titled, Abstract LB-027: Mutational diversity and therapy response in breast cancer-a sequencing analysis in the neoadjuvant GeparSepto trial
Journal Articles

Abstract 5682: Histomorphological and molecular immune classification of head and neck cancer and its relation to prognosis

Jan Budczies, Mohamed Badr, Ingeborg Tinhofer, Carsten Denkert, Korinna Jöhrens
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5682.
https://doi.org/10.1158/1538-7445.AM2018-5682
Published: 01 July 2018
View article titled, Abstract 5682: Histomorphological and molecular immune classification of head and neck cancer and its relation to prognosis
Journal Articles

Abstract 3709: Deciphering the impact of tumor genetics on immune cell infiltration in major solid cancer types

Jan Budczies, Michael Bockmayr, Frederick Klauschen, Abrecht Stenzinger, Carsten Denkert
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3709.
https://doi.org/10.1158/1538-7445.AM2017-3709
Published: 01 July 2017
View article titled, Abstract 3709: Deciphering the impact of tumor genetics on immune cell infiltration in major solid cancer types
Journal Articles

Abstract 2652: Pan-cancer analysis of programmed death-ligand 1 (PD-L1) amplifications

Jan Budczies, Michael Bockmayr, Frederick Klauschen, Wilko Weichert, Carsten Denkert, Albrecht Stenzinger
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2652.
https://doi.org/10.1158/1538-7445.AM2016-2652
Published: 15 July 2016
View article titled, Abstract 2652: Pan-cancer analysis of programmed death-ligand 1 (PD-L1) amplifications
Journal Articles

Abstract 5010: Prediction of therapy resistance by targeted massive-parallel sequencing in primary HER2-positive breast cancer

Sibylle Loibl, Jan Budczies, Wilko Weichert, Jenny Furlanetto, Albrecht Stenzinger, Nicole Pfarr, Gunter von Minckwitz, Christian Jackisch, Andreas Schneeweiss, Peter A. Fasching, Sabine Schmatloch, Bahriye Aktas, Valentina Nekljudova, Karsten Weber, Michael Untch, Carsten Denkert [email protected]
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 5010.
https://doi.org/10.1158/1538-7445.AM2016-5010
Published: 15 July 2016
View article titled, Abstract 5010: Prediction of therapy resistance by targeted massive-parallel sequencing in primary HER2-positive breast cancer
Journal Articles

Accumulated Metabolites of Hydroxybutyric Acid Serve as Diagnostic and Prognostic Biomarkers of Ovarian High-Grade Serous Carcinomas

Mika Hilvo, Ines de Santiago, Peddinti Gopalacharyulu, Wolfgang D. Schmitt, Jan Budczies, Marc Kuhberg, Manfred Dietel, Tero Aittokallio, Florian Markowetz, Carsten Denkert, Jalid Sehouli, Christian Frezza, Silvia Darb-Esfahani, Elena Ioana Braicu
Journal: Cancer Research
Cancer Res (2016) 76 (4): 796–804.
https://doi.org/10.1158/0008-5472.CAN-15-2298
Published: 14 February 2016
View article titled, Accumulated Metabolites of Hydroxybutyric Acid Serve as Diagnostic and Prognostic Biomarkers of Ovarian High-Grade Serous Carcinomas
Open the PDF for Accumulated Metabolites of Hydroxybutyric Acid Serve as Diagnostic and Prognostic Biomarkers of Ovarian High-Grade Serous Carcinomas in another window
Includes: Supplementary data
Journal Articles

Abstract 630: Detection of copy number variations in breast cancer using targeted sequencing without normal tissue controls

Jan Budczies, Volker Endris, Nikola Bangemann, Thomas Wolf, Jens-Uwe Blohmer, Abrecht Stenzinger, Manfred Dietel, Wilko Weichert, Carsten Denkert
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 630.
https://doi.org/10.1158/1538-7445.AM2015-630
Published: 01 August 2015
View article titled, Abstract 630: Detection of copy number variations in breast cancer using targeted sequencing without normal tissue controls
Journal Articles

Abstract 2913: Glutamate-enriched breast cancer as new entity and target for metabolic drugs

Jan Budczies, Berit M. Pfitzner, Klaus-Jürgen Winzer, Cornelia Radke, Manfred Dietel, Oliver Fiehn, Carsten Denkert
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2913.
https://doi.org/10.1158/1538-7445.AM2014-2913
Published: 01 October 2014
View article titled, Abstract 2913: Glutamate-enriched breast cancer as new entity and target for metabolic drugs
Journal Articles

Abstract 4806: Association of changes in 4-aminobutyrate aminotransferase (ABAT) and beta-alanine metabolism with breast cancer and the more aggressive estrogen receptor negative subtype

Jan Budczies, Annika Lehmann, Jules L. Griffin, Matej Oresic, Oliver Fiehn, Carsten Denkert
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 4806.
https://doi.org/10.1158/1538-7445.AM2012-4806
Published: 15 April 2012
View article titled, Abstract 4806: Association of changes in 4-aminobutyrate aminotransferase (ABAT) and beta-alanine metabolism with breast cancer and the more aggressive estrogen receptor negative subtype
Journal Articles

Novel Theranostic Opportunities Offered by Characterization of Altered Membrane Lipid Metabolism in Breast Cancer Progression

Mika Hilvo, Carsten Denkert, Laura Lehtinen, Berit Müller, Scarlet Brockmöller, Tuulikki Seppänen-Laakso, Jan Budczies, Elmar Bucher, Laxman Yetukuri, Sandra Castillo, Emilia Berg, Heli Nygren, Marko Sysi-Aho, Julian L. Griffin, Oliver Fiehn, Sibylle Loibl, Christiane Richter-Ehrenstein, Cornelia Radke, Tuulia Hyötyläinen, Olli Kallioniemi, Kristiina Iljin, Matej Orešič
Journal: Cancer Research
Cancer Res (2011) 71 (9): 3236–3245.
https://doi.org/10.1158/0008-5472.CAN-10-3894
Published: 29 April 2011
View article titled, Novel Theranostic Opportunities Offered by Characterization of Altered Membrane Lipid Metabolism in Breast Cancer Progression
Open the PDF for Novel Theranostic Opportunities Offered by Characterization of Altered Membrane Lipid Metabolism in Breast Cancer Progression in another window
Includes: Supplementary data
Journal Articles

Abstract 3014: Robust microRNA expression profiling of specific cells in complex archival tissue stained by immunohistochemistry

Falk Hlubek, Claudia Schuster, Jan Budczies, Thomas Kirchner
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 3014.
https://doi.org/10.1158/1538-7445.AM10-3014
Published: 15 April 2010
View article titled, Abstract 3014: Robust microRNA expression profiling of specific cells in complex archival tissue stained by immunohistochemistry