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Journal Articles

Abstract 5346: Recurrent genomic copy alterations deregulate the transcriptome and key signaling networks in head and neck cancer cell lines and tumors with worse prognosis

Hui Cheng, Xinping Yang, Han Si, Anthony Saleh, Wenming Xiao, Jamie Coupar, Susanne M. Gollin, Robert L. Ferris, Natalia Issaeva, Wendell G. Yarbrough, Mark E. Prince, Thomas E. Carey, Carter Van Waes, Zhong Chen

Cancer Res (2018) 78 (13_Supplement): 5346.

https://doi.org/10.1158/1538-7445.AM2018-5346

Published: 01 July 2018

View article titled, Abstract 5346: Recurrent genomic copy alterations deregulate the transcriptome and key signaling networks in head and neck cancer cell lines and tumors with worse prognosis

Journal Articles

Abstract 358: LTB and LTBR mediates alternative Nf-kB activation through NIk and RELB/NF-kB2 to promote cell migration of HNSCC

Rita Das, Jamie Coupar, Anthony saleh, Paul E. Clavijo, Zhong Chen, Carter VanWaes

Cancer Res (2017) 77 (13_Supplement): 358.

https://doi.org/10.1158/1538-7445.AM2017-358

Published: 01 July 2017

View article titled, Abstract 358: LTB and LTBR mediates alternative Nf-kB activation through NIk and RELB/NF-kB2 to promote cell migration of HNSCC

Journal Articles

Abstract 4374: Chromosome 3q22-29 amplification is linked to increased expression of multiple genes in key pathways deregulated in head and neck cancer tumors and cell lines

Hui Cheng, Xinping Yang, Han Si, Anthony Saleh, Jamie Coupar, Robert L. Ferris, Wendell G. Yarbrough, Mark E. Prince, Thomas E. Carey, Carter Van Waes, Zhong Chen

Cancer Res (2017) 77 (13_Supplement): 4374.

https://doi.org/10.1158/1538-7445.AM2017-4374

Published: 01 July 2017

View article titled, Abstract 4374: Chromosome 3q22-29 amplification is linked to increased expression of multiple genes in key pathways deregulated in head and neck cancer tumors and cell lines

Journal Articles

SMAC Mimetic Birinapant plus Radiation Eradicates Human Head and Neck Cancers with Genomic Amplifications of Cell Death Genes FADD and BIRC2

Danielle F. Eytan, Grace E. Snow, Sophie Carlson, Adeeb Derakhshan, Anthony Saleh, Stephen Schiltz, Hui Cheng, Suresh Mohan, Shaleeka Cornelius, Jamie Coupar, Anastasia L. Sowers, Lidia Hernandez, James B. Mitchell, Christina M. Annunziata, Zhong Chen, Carter Van Waes

Cancer Res (2016) 76 (18): 5442–5454.

https://doi.org/10.1158/0008-5472.CAN-15-3317

Published: 15 September 2016

View article titled, SMAC Mimetic Birinapant plus Radiation Eradicates Human Head and Neck Cancers with Genomic Amplifications of Cell Death Genes <em>FADD</em> and <em>BIRC2</em>

Includes: Supplementary data

Journal Articles

Abstract 2904: The alternative NF-kB2/RELB pathway is activated by LTB/LTB receptor and NIK to promote cell migration and metastasis-related gene expression in HNSCC

Rita Das, Tsu-Fan Cheng, Jamie Coupar, Anthony Saleh, Paul E. Clavijo, Xinping Yang, Zhong Chen, Carter VanWaes.

Cancer Res (2016) 76 (14_Supplement): 2904.

https://doi.org/10.1158/1538-7445.AM2016-2904

Published: 15 July 2016

View article titled, Abstract 2904: The alternative NF-kB2/RELB pathway is activated by LTB/LTB receptor and NIK to promote cell migration and metastasis-related gene expression in HNSCC

Journal Articles

Abstract 3821: Targeted therapy for head and neck squamous cell carcinoma using the novel SMAC-mimetic birinapant

Adeeb Derakhshan, Danielle Eytan, Grace Snow, Sophie Carlson, Anthony Saleh, Hui Cheng, Stephen Schiltz, Suresh Mohan, Shaleeka Cornelius, Jamie Coupar, Anastasia Sowers, Lydia Hernandez, James Mitchell, Christina Annunziata, Zhong Chen, Carter Van Waes

Cancer Res (2016) 76 (14_Supplement): 3821.

https://doi.org/10.1158/1538-7445.AM2016-3821

Published: 15 July 2016

View article titled, Abstract 3821: Targeted therapy for head and neck squamous cell carcinoma using the novel SMAC-mimetic birinapant

Journal Articles

Abstract 3622: Novel SMAC-mimetic birinapant demonstrates antitumor activity in human head and neck cancer models exhibiting alterations in cell death pathways

Sophie Carlson, Danielle Eytan, Grace Snow, Stephen Schiltz, Suresh Mohan, Anthony Saleh, Shaleeka Cornelius, Jamie Coupar, Carter Van Waes, Zhong Chen

Cancer Res (2015) 75 (15_Supplement): 3622.

https://doi.org/10.1158/1538-7445.AM2015-3622

Published: 01 August 2015

View article titled, Abstract 3622: Novel SMAC-mimetic birinapant demonstrates antitumor activity in human head and neck cancer models exhibiting alterations in cell death pathways

Journal Articles

Abstract 4804: High throughput whole exome DNA and transcriptome RNA sequencing to identify genetic drivers and alterations in HPV-negative and HPV-positive HNSCC cell lines

Hui Cheng, Xinping Yang, Han Si, Anthony Saleh, Jamie Coupar, Robert L. Ferris, Wendell G. Yarbrough, Mark E. Prince, Thomas E. Carey, Carter Van Waes, Zhong Chen

Cancer Res (2015) 75 (15_Supplement): 4804.

https://doi.org/10.1158/1538-7445.AM2015-4804

Published: 01 August 2015

View article titled, Abstract 4804: High throughput whole exome DNA and transcriptome RNA sequencing to identify genetic drivers and alterations in HPV-negative and HPV-positive HNSCC cell lines

Journal Articles

Abstract 5253: LTβ receptor and NIK signaling activates the alternative NF-kB pathway in head and neck squamous cell carcinoma

Rita Das, Tsu-Fang Cheng, Jamie coupar, Anthony Saleh, Xingping Yang, jialing Zhang, shaleeka Cornelius, Carter Van Waes, zhong Chen

Cancer Res (2015) 75 (15_Supplement): 5253.

https://doi.org/10.1158/1538-7445.AM2015-5253

Published: 01 August 2015

View article titled, Abstract 5253: LTβ receptor and NIK signaling activates the alternative NF-kB pathway in head and neck squamous cell carcinoma

Journal Articles

Abstract 3019: Aberrant NF-κB and Notch pathways promote CD133+ cancer stem cells in human primary cutaneous squamous cell carcinoma

Xinxin Quan, Nga Voong, Weiping Chen, Jamie Coupar, Steven Lee, David W. Petersen, Daniel C. Edelman, Paul S. Meltzer, Andrew Montemarano, Martin Braun, Jonathan Vogel, Carter Van Waes, Zhong Chen

Cancer Res (2014) 74 (19_Supplement): 3019.

https://doi.org/10.1158/1538-7445.AM2014-3019

Published: 01 October 2014

View article titled, Abstract 3019: Aberrant NF-κB and Notch pathways promote CD133+ cancer stem cells in human primary cutaneous squamous cell carcinoma

Journal Articles

Abstract 3435: Genome-wide RNA and DNA high throughput sequencing reveals proinflammatory and death gene signatures in head and neck squamous cell carcinoma lines with different HPV status

Xinping Yang, Hui Cheng, Han Si, Anthony Saleh, Emine Guven Maiorov, Jamie Coupar, Ozlem Keskin, Attila Gursoy, Ruth Nussinov, Robert L. Ferris, Wendell G. Yarbrough, Mark E. Prince, Thomas E. Carey, Carter Van Waes, Zhong Chen

Cancer Res (2014) 74 (19_Supplement): 3435.

https://doi.org/10.1158/1538-7445.AM2014-3435

Published: 01 October 2014

View article titled, Abstract 3435: Genome-wide RNA and DNA high throughput sequencing reveals proinflammatory and death gene signatures in head and neck squamous cell carcinoma lines with different HPV status

Journal Articles

Abstract 3434: Genomic exome DNA sequencing identifies top driver genetic alterations in head and neck cancer cell lines of different HPV status

Hui Cheng, Xinping Yang, Han Si, Anthony Saleh, Jamie Coupar, Robert L. Ferris, Wendell G. Yarbrough, Mark E. Prince, Thomas E. Carey, Carter Van Waes, Zhong Chen

Cancer Res (2014) 74 (19_Supplement): 3434.

https://doi.org/10.1158/1538-7445.AM2014-3434

Published: 01 October 2014

View article titled, Abstract 3434: Genomic exome DNA sequencing identifies top driver genetic alterations in head and neck cancer cell lines of different HPV status

Journal Articles

Abstract 3050: Transcriptome sequencing identifies oncogenic microRNA signatures related to NF-kB, TP53 and Notch family members in head and neck squamous cell carcinoma.

Anthony D. Saleh, Han Si, Xingping Yang, Jamie Coupar, Zhong Chen, Carter Van Waes

Cancer Res (2013) 73 (8_Supplement): 3050.

https://doi.org/10.1158/1538-7445.AM2013-3050

Published: 15 April 2013

View article titled, Abstract 3050: Transcriptome sequencing identifies oncogenic microRNA signatures related to NF-kB, TP53 and Notch family members in head and neck squamous cell carcinoma.

Journal Articles

Abstract 4717: Lymphotoxins activate NF-κB-mediated inflammatory and survival pathways in head and neck squamous cell carcinomas.

Tsu-Fan Cheng, Xinping Yang, Jamie Coupar, Han Si, Steven Lee, Jialing Zhang, Carter van Waes, Zhong Chen

Cancer Res (2013) 73 (8_Supplement): 4717.

https://doi.org/10.1158/1538-7445.AM2013-4717

Published: 15 April 2013

View article titled, Abstract 4717: Lymphotoxins activate NF-κB-mediated inflammatory and survival pathways in head and neck squamous cell carcinomas.

Journal Articles

Abstract LB-314: Preclinical investigation of antitumor effects of dual PI3K/mTOR inhibitor PF-04691502 in human xenograft and murine Pten/Tgfbr1 deficient head and neck cancer models.

Robert Vander Broek, Yansong Bian, Amanda Herzog, Bradford Hall, Jamie Coupar, Zhong Chen, Ashok B. Kulkarni, Carter Van Waes

Cancer Res (2013) 73 (8_Supplement): LB-314.

https://doi.org/10.1158/1538-7445.AM2013-LB-314

Published: 15 April 2013

View article titled, Abstract LB-314: Preclinical investigation of antitumor effects of dual PI3K/mTOR inhibitor PF-04691502 in human xenograft and murine Pten/Tgfbr1 deficient head and neck cancer models.

Journal Articles

Abstract 3177: Transcriptome sequencing identifies oncogenic microRNA signatures that interact with NF-kappaB, TP53 and Notch signaling in head and neck squamous cell carcinoma

Anthony D. Saleh, Han Si, Hai Lu, Xinping Yang Yang, Zhong Chen, Carter Van Waes, Jamie Coupar

Cancer Res (2012) 72 (8_Supplement): 3177.

https://doi.org/10.1158/1538-7445.AM2012-3177

Published: 15 April 2012

View article titled, Abstract 3177: Transcriptome sequencing identifies oncogenic microRNA signatures that interact with NF-kappaB, TP53 and Notch signaling in head and neck squamous cell carcinoma

Journal Articles

Abstract 2770: Antitumor activity of heat shock protein 90 (HSP90) inhibitor AT13387 in head and neck squamous cell carcinoma

Kristy Truong, Christopher Gouveia, Jamie Coupar, Tomoko Smyth, John Lyons, Zhong Chen, Carter Van Waes

Cancer Res (2012) 72 (8_Supplement): 2770.

https://doi.org/10.1158/1538-7445.AM2012-2770

Published: 15 April 2012

View article titled, Abstract 2770: Antitumor activity of heat shock protein 90 (HSP90) inhibitor AT13387 in head and neck squamous cell carcinoma

NARROW

Abstract 5346: Recurrent genomic copy alterations deregulate the transcriptome and key signaling networks in head and neck cancer cell lines and tumors with worse prognosis

Abstract 358: LTB and LTBR mediates alternative Nf-kB activation through NIk and RELB/NF-kB2 to promote cell migration of HNSCC

Abstract 4374: Chromosome 3q22-29 amplification is linked to increased expression of multiple genes in key pathways deregulated in head and neck cancer tumors and cell lines

SMAC Mimetic Birinapant plus Radiation Eradicates Human Head and Neck Cancers with Genomic Amplifications of Cell Death Genes FADD and BIRC2

Abstract 2904: The alternative NF-kB2/RELB pathway is activated by LTB/LTB receptor and NIK to promote cell migration and metastasis-related gene expression in HNSCC

Abstract 3821: Targeted therapy for head and neck squamous cell carcinoma using the novel SMAC-mimetic birinapant

Abstract 3622: Novel SMAC-mimetic birinapant demonstrates antitumor activity in human head and neck cancer models exhibiting alterations in cell death pathways

Abstract 4804: High throughput whole exome DNA and transcriptome RNA sequencing to identify genetic drivers and alterations in HPV-negative and HPV-positive HNSCC cell lines

Abstract 5253: LTβ receptor and NIK signaling activates the alternative NF-kB pathway in head and neck squamous cell carcinoma

Abstract 3019: Aberrant NF-κB and Notch pathways promote CD133+ cancer stem cells in human primary cutaneous squamous cell carcinoma

Abstract 3435: Genome-wide RNA and DNA high throughput sequencing reveals proinflammatory and death gene signatures in head and neck squamous cell carcinoma lines with different HPV status

Abstract 3434: Genomic exome DNA sequencing identifies top driver genetic alterations in head and neck cancer cell lines of different HPV status

Abstract 3050: Transcriptome sequencing identifies oncogenic microRNA signatures related to NF-kB, TP53 and Notch family members in head and neck squamous cell carcinoma.

Abstract 4717: Lymphotoxins activate NF-κB-mediated inflammatory and survival pathways in head and neck squamous cell carcinomas.

Abstract LB-314: Preclinical investigation of antitumor effects of dual PI3K/mTOR inhibitor PF-04691502 in human xenograft and murine Pten/Tgfbr1 deficient head and neck cancer models.

Abstract 3177: Transcriptome sequencing identifies oncogenic microRNA signatures that interact with NF-kappaB, TP53 and Notch signaling in head and neck squamous cell carcinoma

Abstract 2770: Antitumor activity of heat shock protein 90 (HSP90) inhibitor AT13387 in head and neck squamous cell carcinoma

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