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James W. Hodge
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Journal Articles

Abstract 1740: Epigenetic reprogramming of the tumor microenvironment by entinostat increases tumor sensitivity to multivalent immunotherapy combinations with an IL-15 superagonist plus vaccine or immune checkpoint blockade

Kristin C. Hicks, Karin M. Knudson, Frank R. Jones, Peter Ordentlich, Shahrooz Rabizadeh, Hing C. Wong, James W. Hodge, Jeffrey Schlom, Sofia R. Gameiro
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1740.
https://doi.org/10.1158/1538-7445.AM2018-1740
Published: 01 July 2018
View article titled, Abstract 1740: Epigenetic reprogramming of the tumor microenvironment by entinostat increases tumor sensitivity to multivalent immunotherapy combinations with an IL-15 superagonist plus vaccine or immune checkpoint blockade
Journal Articles

Abstract 3644: Combination of OX40L fusion protein with an anti-tumor vaccine reduces lung metastasis and prolongs survival in a murine model of metastatic triple negative breast cancer

Anthony S. Malamas, Scott A. Hammond, Jeffrey Schlom, James W. Hodge
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3644.
https://doi.org/10.1158/1538-7445.AM2017-3644
Published: 01 July 2017
View article titled, Abstract 3644: Combination of OX40L fusion protein with an anti-tumor vaccine reduces lung metastasis and prolongs survival in a murine model of metastatic triple negative breast cancer
Journal Articles

Abstract 1696: High-dose versus low-dose fractionated ionizing radiation to enhance antigen-specific antitumor immunity

Megan V. Morisada, Ellen C. Moore, Jay A. Friedman, James W. Hodge, James B. Mitchell, Clint T. Allen
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1696.
https://doi.org/10.1158/1538-7445.AM2017-1696
Published: 01 July 2017
View article titled, Abstract 1696: High-dose versus low-dose fractionated ionizing radiation to enhance antigen-specific antitumor immunity
Journal Articles

Abstract 3245: IL-15 superagonist/IL-15RαSushi-Fc fusion complex (IL-15SA/IL-15RαSu-Fc; ALT-803) markedly enhances specific subpopulations of NK and memory CD8+ T cells, and mediates potent anti-tumor activity of murine breast and colon carcinomas

Peter S. Kim, Anna R. Kwilas, Wenxin Xu, Sarah Alter, Emily K. Jeng, Hing C. Wong, Jeffrey Schlom, James W. Hodge
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3245.
https://doi.org/10.1158/1538-7445.AM2016-3245
Published: 15 July 2016
View article titled, Abstract 3245: IL-15 superagonist/IL-15RαSushi-Fc fusion complex (IL-15SA/IL-15RαSu-Fc; ALT-803) markedly enhances specific subpopulations of NK and memory CD8+ T cells, and mediates potent anti-tumor activity of murine breast and colon carcinomas
Journal Articles

Abstract 4726: Inhibitors of histone deacetylase 1 reverse the immune evasion phenotype to enhance T-cell-mediated lysis of prostate and breast carcinoma cells

Sofia R. Gameiro, Anthony S. Malamas, Massimo Fantini, Kwong Y. Tsang, Soldano Ferrone, James W. Hodge
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4726.
https://doi.org/10.1158/1538-7445.AM2016-4726
Published: 15 July 2016
View article titled, Abstract 4726: Inhibitors of histone deacetylase 1 reverse the immune evasion phenotype to enhance T-cell-mediated lysis of prostate and breast carcinoma cells
Journal Articles

Abstract 1341: Endocrine deprivation therapy increases the sensitivity of breast cancer cells to T cell-mediated lysis independently of estrogen receptor or androgen receptor status

Anna R. Kwilas, Andressa Ardiani, Sofia R. Gameiro, James W. Hodge
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1341.
https://doi.org/10.1158/1538-7445.AM2015-1341
Published: 01 August 2015
View article titled, Abstract 1341: Endocrine deprivation therapy increases the sensitivity of breast cancer cells to T cell-mediated lysis independently of estrogen receptor or androgen receptor status
Journal Articles

Abstract 632: Radiation-induced immunogenic modulation of tumor enhances antigen processing and calreticulin exposure, resulting in enhanced T-cell killing

Sofia R. Gameiro, Momodou L. Jammeh, Max M. Wattenberg, Kwong Y. Tsang, Soldano Ferrone, James W. Hodge
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 632.
https://doi.org/10.1158/1538-7445.AM2014-632
Published: 01 October 2014
View article titled, Abstract 632: Radiation-induced immunogenic modulation of tumor enhances antigen processing and calreticulin exposure, resulting in enhanced T-cell killing
Journal Articles

Vaccine-Mediated Immunotherapy Directed against a Transcription Factor Driving the Metastatic Process

Andressa Ardiani, Sofia R. Gameiro, Claudia Palena, Duane H. Hamilton, Anna Kwilas, Thomas H. King, Jeffrey Schlom, James W. Hodge
Journal: Cancer Research
Cancer Res (2014) 74 (7): 1945–1957.
https://doi.org/10.1158/0008-5472.CAN-13-2045
Published: 31 March 2014
View article titled, Vaccine-Mediated Immunotherapy Directed against a Transcription Factor Driving the Metastatic Process
Open the PDF for Vaccine-Mediated Immunotherapy Directed against a Transcription Factor Driving the Metastatic Process in another window
Includes: Supplementary data
Journal Articles

Abstract 1489: The T-box transcription factor Brachyury blocks cell cycle progression and mediates tumor resistance to chemotherapy and radiation.

Bruce K. Huang, Joseph Cohen, Romaine I. Fernando, Duane H. Hamilton, Mary T. Litzinger, James W. Hodge, Claudia M. Palena
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 1489.
https://doi.org/10.1158/1538-7445.AM2013-1489
Published: 15 April 2013
View article titled, Abstract 1489: The T-box transcription factor Brachyury blocks cell cycle progression and mediates tumor resistance to chemotherapy and radiation.
Journal Articles

Abstract 1232: Immunomodulatory effects of a tyrosine kinase inhibitor and vascular remodeling properties of a cancer vaccine potentiate combinatorial immunotherapy.

Renee N. Donahue, Italia Grenga, Peter S. Kim, Michael A. Coplin, James W. Hodge, Jeffrey Schlom, Benedetto P. Farsaci
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 1232.
https://doi.org/10.1158/1538-7445.AM2013-1232
Published: 15 April 2013
View article titled, Abstract 1232: Immunomodulatory effects of a tyrosine kinase inhibitor and vascular remodeling properties of a cancer vaccine potentiate combinatorial immunotherapy.
Journal Articles

Abstract 1676: Chemotherapy-induced immunogenic modulation of tumor cells enhances killing by cytotoxic T lymphocytes and is distinct from immunogenic cell death.

James W. Hodge, Charlie T. Garnett, Benedetto Farsaci, Claudia Palena, Kwong-Yok Tsang, Soldano Ferrone, Sofia R. Gameiro
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 1676.
https://doi.org/10.1158/1538-7445.AM2013-1676
Published: 15 April 2013
View article titled, Abstract 1676: Chemotherapy-induced immunogenic modulation of tumor cells enhances killing by cytotoxic T lymphocytes and is distinct from immunogenic cell death.
Journal Articles

Abstract SY24-02: Development of recombinant vaccines for the prevention and therapy of human carcinomas

Jeffrey Schlom, James L. Gulley, Ravi A. Madan, Kwong-Yok Tsang, John W. Greiner, Claudia Palena, James W. Hodge
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): SY24-02.
https://doi.org/10.1158/1538-7445.AM2011-SY24-02
Published: 15 April 2011
View article titled, Abstract SY24-02: Development of recombinant vaccines for the prevention and therapy of human carcinomas
Journal Articles

Abstract 4790: Docetaxel modulates phenotype of human carcinoma cells, including drug-resistant tumor cells, resulting in enhanced killing by CTLs

Charlie T. Garnett, Benedetto Farsaci, Jeffrey Schlom, James W. Hodge
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 4790.
https://doi.org/10.1158/1538-7445.AM10-4790
Published: 15 April 2010
View article titled, Abstract 4790: Docetaxel modulates phenotype of human carcinoma cells, including drug-resistant tumor cells, resulting in enhanced killing by CTLs
Journal Articles

Systemic radioimmunotherapy in synergy with vaccine renders antitumor effects in a preclinical model

Mala Chakraborty, Alexander Gelbard, Jorge A. Carrasquillo, Sarah Yu, Marcelo Mamede, Chang H. Paik, Kevin Camphausen, Jeffrey Schlom, James W. Hodge
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 275.
Published: 15 April 2006
View article titled, Systemic radioimmunotherapy in synergy with vaccine renders antitumor effects in a preclinical model
Journal Articles

Multiple costimulatory modalities enhance CTL avidity.

Charlie T. Garnett, Mala Chakraborty, Chie Kudo-Saito, Jeffrey Schlom, James W. Hodge
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 1305.
Published: 15 April 2006
View article titled, Multiple costimulatory modalities enhance CTL avidity.
Journal Articles

Sub-lethal irradiation of human tumor cells modulates phenotype resulting in enhanced killing by CTL

Charlie T. Garnett, Claudia Palena, Mala Chakarborty, Kwong-Yok Tsang, Kevin Camphausen, C. Norman Coleman, Jeffrey Schlom, James W. Hodge
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 1416–1417.
Published: 01 May 2005
View article titled, Sub-lethal irradiation of human tumor cells modulates phenotype resulting in enhanced killing by CTL
Journal Articles

Induction of an antigen cascade by diversified subcutaneous/intratumoral vaccination is associated with antitumor responses

Chie Kudo-Saito, Jeffrey Schlom, James W. Hodge
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 1215–1216.
Published: 01 May 2005
View article titled, Induction of an antigen cascade by diversified subcutaneous/intratumoral vaccination is associated with antitumor responses
Journal Articles

Sublethal Irradiation of Human Tumor Cells Modulates Phenotype Resulting in Enhanced Killing by Cytotoxic T Lymphocytes

Charlie T. Garnett, Claudia Palena, Mala Chakarborty, Kwong-Yok Tsang, Jeffrey Schlom, James W. Hodge
Journal: Cancer Research
Cancer Res (2004) 64 (21): 7985–7994.
https://doi.org/10.1158/0008-5472.CAN-04-1525
Published: 01 November 2004
View article titled, Sublethal Irradiation of Human Tumor Cells Modulates Phenotype Resulting in Enhanced Killing by Cytotoxic T Lymphocytes
Open the PDF for Sublethal Irradiation of Human Tumor Cells Modulates Phenotype Resulting in Enhanced Killing by Cytotoxic T Lymphocytes in another window
Journal Articles

External Beam Radiation of Tumors Alters Phenotype of Tumor Cells to Render Them Susceptible to Vaccine-Mediated T-Cell Killing

Mala Chakraborty, Scott I. Abrams, C. Norman Coleman, Kevin Camphausen, Jeffrey Schlom, James W. Hodge
Journal: Cancer Research
Cancer Res (2004) 64 (12): 4328–4337.
https://doi.org/10.1158/0008-5472.CAN-04-0073
Published: 17 June 2004
View article titled, External Beam Radiation of Tumors Alters Phenotype of Tumor Cells to Render Them Susceptible to Vaccine-Mediated T-Cell Killing
Open the PDF for External Beam Radiation of Tumors Alters Phenotype of Tumor Cells to Render Them Susceptible to Vaccine-Mediated T-Cell Killing in another window
Journal Articles

Intratumoral vaccination and diversified subcutaneous/intratumoral vaccination with recombinant poxviruses encoding a tumor antigen and multiple costimulatory molecules.

Chie Kudo-Saito, Jeffrey Schlom, James W. Hodge
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 498.
Published: 01 April 2004
View article titled, Intratumoral vaccination and diversified subcutaneous/intratumoral vaccination with recombinant poxviruses encoding a tumor antigen and multiple costimulatory molecules.