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James V. Alvarez
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Journal Articles

Targeting the Dependence on PIK3C3-mTORC1 Signaling in Dormancy-Prone Breast Cancer Cells Blunts Metastasis Initiation

Open Access
Islam E. Elkholi, Amélie Robert, Camille Malouf, Joshua L. Wu, Hellen Kuasne, Stanislav Drapela, Graham Macleod, Steven Hébert, Alain Pacis, Virginie Calderon, Claudia L. Kleinman, Ana P. Gomes, James V. Alvarez, Julio A. Aguirre-Ghiso, Morag Park, Stéphane Angers, Jean-François Côté
Journal: Cancer Research
Cancer Res OF1–OF20.
https://doi.org/10.1158/0008-5472.CAN-23-2654
Published: 15 May 2025
View articletitled, Targeting the Dependence on PIK3C3-mTORC1 Signaling in Dormancy-Prone Breast Cancer Cells Blunts Metastasis Initiation
Open the PDF for Targeting the Dependence on PIK3C3-mTORC1 Signaling in Dormancy-Prone Breast Cancer Cells Blunts Metastasis Initiation in another window
Includes: Supplementary data
Journal Articles

Oxidative Phosphorylation Is a Metabolic Vulnerability of Endocrine Therapy–Tolerant Persister Cells in ER+ Breast Cancer

Available to Purchase
Steven Tau, Mary D. Chamberlin, Huijuan Yang, Jonathan D. Marotti, Patricia C. Muskus, Alyssa M. Roberts, Melissa M. Carmichael, Lauren Cressey, Christo Philip C. Dragnev, Eugene Demidenko, Riley A. Hampsch, Shannon M. Soucy, Fred W. Kolling, Kimberley S. Samkoe, James V. Alvarez, Arminja N. Kettenbach, Todd W. Miller
Journal: Cancer Research
Cancer Res (2025) 85 (6): 1145–1161.
https://doi.org/10.1158/0008-5472.CAN-24-1204
Published: 14 March 2025
View articletitled, Oxidative Phosphorylation Is a Metabolic Vulnerability of Endocrine Therapy–Tolerant Persister Cells in ER+ Breast Cancer
Open the PDF for Oxidative Phosphorylation Is a Metabolic Vulnerability of Endocrine Therapy–Tolerant Persister Cells in ER+ Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract B014: NRF2 regulation of the immune microenvironment in breast cancer

Free
Yasemin Ceyhan Ozdemir, James V. Alvarez
Journal: Cancer Research
Cancer Res (2024) 84 (22_Supplement): B014.
https://doi.org/10.1158/1538-7445.TUMBODY-B014
Published: 17 November 2024
View articletitled, Abstract B014: NRF2 regulation of the immune microenvironment in breast cancer
Journal Articles

Abstract PR09: Clonal dynamics during breast cancer dormancy and recurrence

Free
Jeffrey Damrauer, James V. Alvarez
Journal: Cancer Research
Cancer Res (2018) 78 (10_Supplement): PR09.
https://doi.org/10.1158/1538-7445.MOUSEMODELS17-PR09
Published: 14 May 2018
View articletitled, Abstract PR09: Clonal dynamics during breast cancer dormancy and recurrence
Journal Articles

Abstract 4947: Her2 inhibition and dormant cell metabolism

Free
Douglas B. Fox, James V. Alvarez
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4947.
https://doi.org/10.1158/1538-7445.AM2017-4947
Published: 01 July 2017
View articletitled, Abstract 4947: Her2 inhibition and dormant cell metabolism
Journal Articles

Oncogene Pathway Activation in Mammary Tumors Dictates FDG-PET Uptake

Free
James V. Alvarez, George K. Belka, Tien-Chi Pan, Chien-Chung Chen, Eric Blankemeyer, Abass Alavi, Joel S. Karp, Lewis A. Chodosh
Journal: Cancer Research
Cancer Res (2014) 74 (24): 7583–7598.
https://doi.org/10.1158/0008-5472.CAN-14-1235
Published: 14 December 2014
View articletitled, Oncogene Pathway Activation in Mammary Tumors Dictates FDG-PET Uptake
Open the PDF for Oncogene Pathway Activation in Mammary Tumors Dictates FDG-PET Uptake in another window
Includes: Supplementary data
Journal Articles

Selective induction of apoptosis by cyclin D1

Free
Yuki Ishii, James V. Alvarez, David A. Frank, Samuel Waxman, Doris Germain
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 305.
Published: 15 April 2006
View articletitled, Selective induction of apoptosis by cyclin D1
Journal Articles

Signal Transducer and Activator of Transcription 3 Is Required for the Oncogenic Effects of Non–Small-Cell Lung Cancer–Associated Mutations of the Epidermal Growth Factor Receptor

Free
James V. Alvarez, Heidi Greulich, William R. Sellers, Matthew Meyerson, David A. Frank
Journal: Cancer Research
Cancer Res (2006) 66 (6): 3162–3168.
https://doi.org/10.1158/0008-5472.CAN-05-3757
Published: 15 March 2006
View articletitled, Signal Transducer and Activator of Transcription 3 Is Required for the Oncogenic Effects of Non–Small-Cell Lung Cancer–Associated Mutations of the Epidermal Growth Factor Receptor
Open the PDF for Signal Transducer and Activator of Transcription 3 Is Required for the Oncogenic Effects of Non–Small-Cell Lung Cancer–Associated Mutations of the Epidermal Growth Factor Receptor in another window
Includes: Supplementary data
Journal Articles

Identification of a Genetic Signature of Activated Signal Transducer and Activator of Transcription 3 in Human Tumors

Free
James V. Alvarez, Phillip G. Febbo, Sridhar Ramaswamy, Massimo Loda, Andrea Richardson, David A. Frank
Journal: Cancer Research
Cancer Res (2005) 65 (12): 5054–5062.
https://doi.org/10.1158/0008-5472.CAN-04-4281
Published: 15 June 2005
View articletitled, Identification of a Genetic Signature of Activated Signal Transducer and Activator of Transcription 3 in Human Tumors
Open the PDF for Identification of a Genetic Signature of Activated Signal Transducer and Activator of Transcription 3 in Human Tumors in another window
Includes: Supplementary data