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James T. Dalton
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Journal Articles

A Potent, Metabolically Stable Tubulin Inhibitor Targets the Colchicine Binding Site and Overcomes Taxane Resistance

Kinsie E. Arnst, Yuxi Wang, Dong-Jin Hwang, Yi Xue, Terry Costello, David Hamilton, Qiang Chen, Jinliang Yang, Frank Park, James T. Dalton, Duane D. Miller, Wei Li
Journal: Cancer Research
Cancer Res (2018) 78 (1): 265–277.
https://doi.org/10.1158/0008-5472.CAN-17-0577
Published: 02 January 2018
View article titled, A Potent, Metabolically Stable Tubulin Inhibitor Targets the Colchicine Binding Site and Overcomes Taxane Resistance
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Includes: Supplementary data
Journal Articles

Novel Selective Agents for the Degradation of Androgen Receptor Variants to Treat Castration-Resistant Prostate Cancer

Suriyan Ponnusamy, Christopher C. Coss, Thirumagal Thiyagarajan, Kate Watts, Dong-Jin Hwang, Yali He, Luke A. Selth, Iain J. McEwan, Charles B. Duke, Jayaprakash Pagadala, Geetika Singh, Robert W. Wake, Christopher Ledbetter, Wayne D. Tilley, Tudor Moldoveanu, James T. Dalton, Duane D. Miller, Ramesh Narayanan
Journal: Cancer Research
Cancer Res (2017) 77 (22): 6282–6298.
https://doi.org/10.1158/0008-5472.CAN-17-0976
Published: 14 November 2017
View article titled, Novel Selective Agents for the Degradation of Androgen Receptor Variants to Treat Castration-Resistant Prostate Cancer
Open the PDF for Novel Selective Agents for the Degradation of Androgen Receptor Variants to Treat Castration-Resistant Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 5684: Target tubulin polymerization with novel reverse ABI analogs interacting with the colchicine binding site.

Min Xiao, Sunjoo Ahn, Jianjun Chen, Jin Wang, Duane D. Miller, James T. Dalton, Wei Li
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 5684.
https://doi.org/10.1158/1538-7445.AM2013-5684
Published: 15 April 2013
View article titled, Abstract 5684: Target tubulin polymerization with novel reverse ABI analogs interacting with the colchicine binding site.
Journal Articles

Abstract 2788: GTx-230: an orally available novel tubulin inhibitor that disrupts tumor vasculature and displays single-agent antitumor efficacy in multidrug-resistant prostate cancer with less neurotoxicity

Sunjoo Ahn, Chien-Ming Li, Christina M. Barrett, Jianjun Chen, Wei Li, Yan Lu, Duane D. Miller, James T. Dalton
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 2788.
https://doi.org/10.1158/1538-7445.AM2012-2788
Published: 15 April 2012
View article titled, Abstract 2788: GTx-230: an orally available novel tubulin inhibitor that disrupts tumor vasculature and displays single-agent antitumor efficacy in multidrug-resistant prostate cancer with less neurotoxicity
Journal Articles

Abstract 1350: Novel ABI analogs target the colchicine site in tubulin and overcome multidrug resistance in metastatic melanoma

Wei Li, Jianjun Chen, Zhao Wang, Chien-Ming Li, Yan Lu, James T. Dalton, Duane Miller
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 1350.
https://doi.org/10.1158/1538-7445.AM2011-1350
Published: 15 April 2011
View article titled, Abstract 1350: Novel ABI analogs target the colchicine site in tubulin and overcome multidrug resistance in metastatic melanoma
Journal Articles

Biological Activity of 4-Substituted Methoxybenzoyl- Aryl-Thiazole: An Active Microtubule Inhibitor

Chien-Ming Li, Zhao Wang, Yan Lu, Sunjoo Ahn, Ramesh Narayanan, Jeffrey D. Kearbey, Deanna N. Parke, Wei Li, Duane D. Miller, James T. Dalton
Journal: Cancer Research
Cancer Res (2011) 71 (1): 216–224.
https://doi.org/10.1158/0008-5472.CAN-10-1725
Published: 02 January 2011
View article titled, Biological Activity of 4-Substituted Methoxybenzoyl- Aryl-Thiazole: An Active Microtubule Inhibitor
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Journal Articles

Abstract 730: Targeting colchicine binding site in tubulin for the treatment of advanced melanoma

Wei Li, Zhao Wang, Jianjun Chen, Yan Lu, Chien-Ming Li, James T. Dalton, Duane Miller
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 730.
https://doi.org/10.1158/1538-7445.AM10-730
Published: 15 April 2010
View article titled, Abstract 730: Targeting colchicine binding site in tubulin for the treatment of advanced melanoma
Journal Articles

Discovery and Mechanistic Characterization of a Novel Selective Nuclear Androgen Receptor Exporter for the Treatment of Prostate Cancer

Ramesh Narayanan, Muralimohan Yepuru, Adam T. Szafran, Maria Szwarc, Casey E. Bohl, Natalie L. Young, Duane D. Miller, Michael A. Mancini, James T. Dalton
Journal: Cancer Research
Cancer Res (2010) 70 (2): 842–851.
https://doi.org/10.1158/0008-5472.CAN-09-3206
Published: 13 January 2010
View article titled, Discovery and Mechanistic Characterization of a Novel Selective Nuclear Androgen Receptor Exporter for the Treatment of Prostate Cancer
Open the PDF for Discovery and Mechanistic Characterization of a Novel Selective Nuclear Androgen Receptor Exporter for the Treatment of Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

Effect of lysophosphatidic acid on lysophospholipid analog-induced cytotoxicity in prostate cancer cells

Eunju Hurh, Veeresa Gududuru, Duane D. Miller, James T. Dalton
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 151–152.
Published: 01 May 2005
View article titled, Effect of lysophosphatidic acid on lysophospholipid analog-induced cytotoxicity in prostate cancer cells
Journal Articles

Apoptosis induced by calpain inhibitors in leukemia cells and HeLa cells

Na Guan, Rajani Korukonda, Isaac O. Donkor, James T. Dalton
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 1177.
Published: 01 May 2005
View article titled, Apoptosis induced by calpain inhibitors in leukemia cells and HeLa cells
Journal Articles

The crystal structure of the androgen receptor W741L mutant ligand binding domain bound to R-bicalutamide

Casey E. Bohl, Wenqing Gao, Duane D. Miller, Charles E. Bell, James T. Dalton
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 594–595.
Published: 01 May 2005
View article titled, The crystal structure of the androgen receptor W741L mutant ligand binding domain bound to R-bicalutamide
Journal Articles

G2-M block, apoptosis, and cytotoxicity are potently induced by novel bis-indoles in prostate cancer cells

Jun Yang, Eunju Hurh, Dong-Jin Hwang, Huiping Xu, Duane D. Miller, James T. Dalton
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 1388.
Published: 01 May 2005
View article titled, G2-M block, apoptosis, and cytotoxicity are potently induced by novel bis-indoles in prostate cancer cells
Journal Articles

In vitro pharmacodynamics of electrophilic androgen receptor ligands in prostate cancer cell lines

Huiping Xu, Dong Jin Hwang, Duane D. Miller, James T. Dalton
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 1245.
Published: 01 April 2004
View article titled, <em>In vitro</em> pharmacodynamics of electrophilic androgen receptor ligands in prostate cancer cell lines
Journal Articles

2-phenylthiazolidine derivatives of lysophosphatidic acid as a new class of anticancer agents.

Eunju Hurh, Veeresa Gududuru, Duane D. Miller, James T. Dalton
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 473.
Published: 01 April 2004
View article titled, 2-phenylthiazolidine derivatives of lysophosphatidic acid as a new class of anticancer agents.
Journal Articles

In vitro anti-leukemic activity of aldehyde calpain inhibitors.

Na Guan, Eunju Hurh, Rajani Korukonda, Isaac O. Donkor, James T. Dalton
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 481.
Published: 01 April 2004
View article titled, In vitro anti-leukemic activity of aldehyde calpain inhibitors.
Journal Articles

Differential activity of acetamide derivatives against in vitro prostate cancer models.

Christina M. Barrett, Robert M. Graham, Dana L. Wilkerson, Dong Jin Hwang, Duane D. Miller, James T. Dalton, Mitchell S. Steiner, Karen A. Veverka
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 473.
Published: 01 April 2004
View article titled, Differential activity of acetamide derivatives against <em>in vitro</em> prostate cancer models.
Journal Articles

Pharmacokinetics of Intravesical Mitomycin C in Superficial Bladder Cancer Patients

James T. Dalton, M. Guillaume Wientjes, Robert A. Badalament, Joseph R. Drago, Jessie L-S. Au
Journal: Cancer Research
Cancer Res (1991) 51 (19): 5144–5152.
Published: 01 October 1991
View article titled, Pharmacokinetics of Intravesical Mitomycin C in Superficial Bladder Cancer Patients
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Journal Articles

Bladder Wall Penetration of Intravesical Mitomycin C in Dogs

M. Guillaume Wientjes, James T. Dalton, Robert A. Badalament, Joseph R. Drago, Jessie L-S. Au
Journal: Cancer Research
Cancer Res (1991) 51 (16): 4347–4354.
Published: 01 August 1991
View article titled, Bladder Wall Penetration of Intravesical Mitomycin C in Dogs
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