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James L. Abbruzzese
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Journal Articles

Abstract C004: A window-of-opportunity trial using neoadjuvant hepatic artery chemotherapy for patients with localized pancreas cancer: Interim analysis of safety and feasibility

Ethan S Agritelley, Elishama N Kanu, Jiayin Bao, Ashley A Fletcher, Holly Skinner, Adi Molvin, Stacy Murray, Charles Y Kim, Brendan Cline, Eric Mastria, David Y Johnson, Nicholas C DeVito, Gerard C Blobe, James L Abbruzzese, Erika J Crosby, Allison Martin, Niharika B Mettu, Peter J Allen, Daniel P Nussbaum
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): C004.
https://doi.org/10.1158/1538-7445.PANCREATIC24-C004
Published: 15 September 2024
View article titled, Abstract C004: A window-of-opportunity trial using neoadjuvant hepatic artery chemotherapy for patients with localized pancreas cancer: Interim analysis of safety and feasibility
Journal Articles

Abstract LB-134: Sequential validation of blood-based protein biomarker candidates for early-stage pancreatic cancer

Michela Capello, Leonidas E. Bantis, Ghislaine Scelo, Yang Zhao, Dilsher S. Dhillon, Hong Wang, James L. Abbruzzese, Anirban Maitra, Margaret A. Tempero, Randall Brand, Matthew A. Firpo, Sean Mulvihill, Matthew H. Katz, Paul Brennan, Ziding Feng, Samir M. Hanash, Ayumu Taguchi
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): LB-134.
https://doi.org/10.1158/1538-7445.AM2016-LB-134
Published: 15 July 2016
View article titled, Abstract LB-134: Sequential validation of blood-based protein biomarker candidates for early-stage pancreatic cancer
Journal Articles

Abstract 891: FGF21 prevents high fat diet-induced pancreatic cancer in mice expressing oncogenic Kras

Weiqin Lu, Yaying Yang, Xiaojie Wang, Yan Liu, Yongde Luo, Robert A. Wolff, James L. Abbruzzese, Craig D. Logsdon
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 891.
https://doi.org/10.1158/1538-7445.AM2015-891
Published: 01 August 2015
View article titled, Abstract 891: FGF21 prevents high fat diet-induced pancreatic cancer in mice expressing oncogenic Kras
Journal Articles

Abstract 4437: Fbxw8 targets hematopoietic progenitor kinase 1 for proteasomal degradation

Hua Wang, Yue Chen, Ping Lin, Lei Li, Guisheng Zhou, Guangchao Liu, Craig Logsdon, Jianping Jin, James L. Abbruzzese, Tse-Hua Tan, Huamin Wang
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4437.
https://doi.org/10.1158/1538-7445.AM2014-4437
Published: 01 October 2014
View article titled, Abstract 4437: Fbxw8 targets hematopoietic progenitor kinase 1 for proteasomal degradation
Journal Articles

Abstract 1493: Analysis of fibrosis and stromal components in metastatic pancreatic cancer (PC) autopsy specimens

Rachna T. Shroff, Jeffrey Morris, Graciela M. Nogueras-Gonzalez, Judy M. Anderson, Michael A. Hollingsworth, James L. Abbruzzese, Huamin M. Wang
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 1493.
https://doi.org/10.1158/1538-7445.AM2012-1493
Published: 15 April 2012
View article titled, Abstract 1493: Analysis of fibrosis and stromal components in metastatic pancreatic cancer (PC) autopsy specimens
Journal Articles

Abstract 4491: Transforming growth factor (TGF) ≤ pathway and clinical outcome of pancreatic cancer

Milind M. Javle, Xiaoqun Dong, Dongfeng Tan, Yanan Li, Siddhartha P. Kar, Veera Baladandayuthapani, Jacqueline Weatherly, Sunil Krishnan, Tzu-chuan J, Huang, David R. Fogelman, James L. Abbruzzese, Robert A. Wolff, Donghui Li
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 4491.
https://doi.org/10.1158/1538-7445.AM2012-4491
Published: 15 April 2012
View article titled, Abstract 4491: Transforming growth factor (TGF) ≤ pathway and clinical outcome of pancreatic cancer
Journal Articles

Abstract 5527: Overexpression of protein phosphatase 4 is associated with poor prognosis in patients with pancreatic ductal adenocarcinoma

Shaofan Weng, Weihong Chen, Hamilton R. Stanley, Deyali Chatterjee, Matthew H. Katz, Jeffrey E. Lee, Peter W. Pisters, Henry F. Gomez, James L. Abbruzzese, Jason B. Fleming, Huamin Wang, Hua Wang
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 5527.
https://doi.org/10.1158/1538-7445.AM2012-5527
Published: 15 April 2012
View article titled, Abstract 5527: Overexpression of protein phosphatase 4 is associated with poor prognosis in patients with pancreatic ductal adenocarcinoma
Journal Articles

Abstract 4560: A new IGF-1-integrated Child-Pugh score to risk-stratify patients with hepatocellular carcinoma

Ahmed O. Kaseb, Lianchun Xiao, Manal M. Hassan, Neeraj Shah, Asif Rashid, James L. Abbruzzese, Jeffrey Morris
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 4560.
https://doi.org/10.1158/1538-7445.AM2012-4560
Published: 15 April 2012
View article titled, Abstract 4560: A new IGF-1-integrated Child-Pugh score to risk-stratify patients with hepatocellular carcinoma
Journal Articles

Abstract 4672: Overexpression of NR5A2/LRH1 in pancreatic cancer and possible association with clinical outcome

Xiaoqun Dong, Yanan Li, William E. Fisher, Ping Chang, James L. Abbruzzese, Donghui Li
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 4672.
https://doi.org/10.1158/1538-7445.AM2011-4672
Published: 15 April 2011
View article titled, Abstract 4672: Overexpression of NR5A2/LRH1 in pancreatic cancer and possible association with clinical outcome
Journal Articles

Abstract 3287: Pro-inflammatory factors secreted by pancreatic cancers with evasive resistance to anti-VEGF treatment contribute to malignant progression by inducing EMT

Carmine Carbone, Tania Moccia, Cihui Zhu, Genni Paradiso, Michele Simbolo, Alfredo Budillon, Paul J. Chiao, James L. Abbruzzese, Davide Melisi
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 3287.
https://doi.org/10.1158/1538-7445.AM2011-3287
Published: 15 April 2011
View article titled, Abstract 3287: Pro-inflammatory factors secreted by pancreatic cancers with evasive resistance to anti-VEGF treatment contribute to malignant progression by inducing EMT
Journal Articles

Abstract 3750: Body mass index and obesity- and diabetes-associated genotypes and risk for pancreatic cancer

Hongwei Tang, Xiaoqun Dong, Manal M. Hassan, James L. Abbruzzese, Donghui Li
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 3750.
https://doi.org/10.1158/1538-7445.AM2011-3750
Published: 15 April 2011
View article titled, Abstract 3750: Body mass index and obesity- and diabetes-associated genotypes and risk for pancreatic cancer
Journal Articles

Abstract 3655: Mast cells promote immunosuppression and pancreatic ductal adenocarcinoma development

Ying Ma, Huamin Wang, Baoan Ji, Yan Liu, Defeng Deng, James L. Abbruzzese, Patrick Hwu, Craig Logsdon, Stephen E. Ullrich
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 3655.
https://doi.org/10.1158/1538-7445.AM2011-3655
Published: 15 April 2011
View article titled, Abstract 3655: Mast cells promote immunosuppression and pancreatic ductal adenocarcinoma development
Journal Articles

Abstract 2760: Phase I study of MK-0646, the humanized monoclonal antibody against IGF-1R in combination with gemcitabine or gemcitabine + erlotinib (E) for advanced, previously untreated pancreatic cancer

Rachna T. Shroff, Gauri R. Varadhachary, Priya Bhosale, Lerma Ukegbu, Michael J. Overman, Robert A. Wolff, James L. Abbruzzese, Milind M. Javle
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 2760.
https://doi.org/10.1158/1538-7445.AM10-2760
Published: 15 April 2010
View article titled, Abstract 2760: Phase I study of MK-0646, the humanized monoclonal antibody against IGF-1R in combination with gemcitabine or gemcitabine + erlotinib (E) for advanced, previously untreated pancreatic cancer
Journal Articles

Abstract 616: R1507, the human monoclonal antibody targeting the insulin-like growth factor receptor (IGF-1R), in combination with cetuximab, can reverse acquired resistance to cetuximab in pancreatic and colon cancer models

Davide Melisi, Roberta Rosa, Roberto Bianco, Carmine Carbone, Giampaolo Tortora, Alfredo Budillon, James L. Abbruzzese, Paul J. Chiao, Milind Javle
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 616.
https://doi.org/10.1158/1538-7445.AM10-616
Published: 15 April 2010
View article titled, Abstract 616: R1507, the human monoclonal antibody targeting the insulin-like growth factor receptor (IGF-1R), in combination with cetuximab, can reverse acquired resistance to cetuximab in pancreatic and colon cancer models
Journal Articles

Abstract 898: Glucose metabolism Gene Polymorphisms and Clinical Outcome in Pancreatic Cancer

Xiaoqun Dong, Hongwei Tang, Kenneth R. Hess, James L. Abbruzzese, Donghui Li
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 898.
https://doi.org/10.1158/1538-7445.AM10-898
Published: 15 April 2010
View article titled, Abstract 898: Glucose metabolism Gene Polymorphisms and Clinical Outcome in Pancreatic Cancer
Journal Articles

Epithelial to Mesenchymal Transition Contributes to Drug Resistance in Pancreatic Cancer

Thiruvengadam Arumugam, Vijaya Ramachandran, Keith F. Fournier, Huamin Wang, Lauren Marquis, James L. Abbruzzese, Gary E. Gallick, Craig D. Logsdon, David J. McConkey, Woonyoung Choi
Journal: Cancer Research
Cancer Res (2009) 69 (14): 5820–5828.
https://doi.org/10.1158/0008-5472.CAN-08-2819
Published: 15 July 2009
View article titled, Epithelial to Mesenchymal Transition Contributes to Drug Resistance in Pancreatic Cancer
Open the PDF for Epithelial to Mesenchymal Transition Contributes to Drug Resistance in Pancreatic Cancer in another window
Includes: Supplementary data
Journal Articles

Synergistic Activity of the Src Family Kinase Inhibitor Dasatinib and Oxaliplatin in Colon Carcinoma Cells Is Mediated by Oxidative Stress

Scott Kopetz, Donald P. Lesslie, Nikolas A. Dallas, Serk I. Park, Marjorie Johnson, Nila U. Parikh, Michael P. Kim, James L. Abbruzzese, Lee M. Ellis, Joya Chandra, Gary E. Gallick
Journal: Cancer Research
Cancer Res (2009) 69 (9): 3842–3849.
https://doi.org/10.1158/0008-5472.CAN-08-2246
Published: 30 April 2009
View article titled, Synergistic Activity of the Src Family Kinase Inhibitor Dasatinib and Oxaliplatin in Colon Carcinoma Cells Is Mediated by Oxidative Stress
Open the PDF for Synergistic Activity of the Src Family Kinase Inhibitor Dasatinib and Oxaliplatin in Colon Carcinoma Cells Is Mediated by Oxidative Stress in another window
Includes: Supplementary data
Journal Articles

Acquisition of Epithelial-Mesenchymal Transition Phenotype of Gemcitabine-Resistant Pancreatic Cancer Cells Is Linked with Activation of the Notch Signaling Pathway

Zhiwei Wang, Yiwei Li, Dejuan Kong, Sanjeev Banerjee, Aamir Ahmad, Asfar Sohail Azmi, Shadan Ali, James L. Abbruzzese, Gary E. Gallick, Fazlul H. Sarkar
Journal: Cancer Research
Cancer Res (2009) 69 (6): 2400–2407.
https://doi.org/10.1158/0008-5472.CAN-08-4312
Published: 17 March 2009
View article titled, Acquisition of Epithelial-Mesenchymal Transition Phenotype of Gemcitabine-Resistant Pancreatic Cancer Cells Is Linked with Activation of the Notch Signaling Pathway
Open the PDF for Acquisition of Epithelial-Mesenchymal Transition Phenotype of Gemcitabine-Resistant Pancreatic Cancer Cells Is Linked with Activation of the Notch Signaling Pathway in another window
Journal Articles

Proteasome-Mediated Degradation and Functions of Hematopoietic Progenitor Kinase 1 in Pancreatic Cancer

Hua Wang, Xianzhou Song, Craig Logsdon, Guisheng Zhou, Douglas B. Evans, James L. Abbruzzese, Stanley R. Hamilton, Tse-Hua Tan, Huamin Wang
Journal: Cancer Research
Cancer Res (2009) 69 (3): 1063–1070.
https://doi.org/10.1158/0008-5472.CAN-08-1751
Published: 29 January 2009
View article titled, Proteasome-Mediated Degradation and Functions of Hematopoietic Progenitor Kinase 1 in Pancreatic Cancer
Open the PDF for Proteasome-Mediated Degradation and Functions of Hematopoietic Progenitor Kinase 1 in Pancreatic Cancer in another window
Journal Articles

Significant effects of mismatch repair gene polymorphisms on clinical outcome of pancreatic cancer

Xiaoqun Dong, Li Jiao, Yanan Li, Douglas B. Evans, James L. Abbruzzese, Donghui Li
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 1900.
Published: 01 May 2008
View article titled, Significant effects of mismatch repair gene polymorphisms on clinical outcome of pancreatic cancer