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James J. Gibbons
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Journal Articles

Abstract CT088: Phase I/II trial of X-396, a novel anaplastic lymphoma kinase (ALK) inhibitor, in patients with ALK+ non-small cell lung cancer (NSCLC)

Christine M. Lovly, Jeffrey R. Infante, George R. Blumenschein, Karen Reckamp, Heather Wakelee, Corey A. Carter, Saiama N. Waqar, Joel Neal, Jon P. Gockerman, Gary Dukart, Kimberly Harrow, Chris Liang, James J. Gibbons, Leora Horn
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): CT088.
https://doi.org/10.1158/1538-7445.AM2016-CT088
Published: 15 July 2016
View article titled, Abstract CT088: Phase I/II trial of X-396, a novel anaplastic lymphoma kinase (ALK) inhibitor, in patients with ALK+ non-small cell lung cancer (NSCLC)
Journal Articles

Beyond Rapalog Therapy: Preclinical Pharmacology and Antitumor Activity of WYE-125132, an ATP-Competitive and Specific Inhibitor of mTORC1 and mTORC2

Ker Yu, Celine Shi, Lourdes Toral-Barza, Judy Lucas, Boris Shor, Jae Eun Kim, Wei-Guo Zhang, Robert Mahoney, Christine Gaydos, LuAnna Tardio, Sung Kyoo Kim, Roger Conant, Kevin Curran, Joshua Kaplan, Jeroen Verheijen, Semiramis Ayral-Kaloustian, Tarek S. Mansour, Robert T. Abraham, Arie Zask, James J. Gibbons
Journal: Cancer Research
Cancer Res (2010) 70 (2): 621–631.
https://doi.org/10.1158/0008-5472.CAN-09-2340
Published: 13 January 2010
View article titled, Beyond Rapalog Therapy: Preclinical Pharmacology and Antitumor Activity of WYE-125132, an ATP-Competitive and Specific Inhibitor of mTORC1 and mTORC2
Open the PDF for Beyond Rapalog Therapy: Preclinical Pharmacology and Antitumor Activity of WYE-125132, an ATP-Competitive and Specific Inhibitor of mTORC1 and mTORC2 in another window
Includes: Supplementary data
Journal Articles

Biochemical, Cellular, and In vivo Activity of Novel ATP-Competitive and Selective Inhibitors of the Mammalian Target of Rapamycin

Ker Yu, Lourdes Toral-Barza, Celine Shi, Wei-Guo Zhang, Judy Lucas, Boris Shor, Jamie Kim, Jeroen Verheijen, Kevin Curran, David J. Malwitz, Derek C. Cole, John Ellingboe, Semiramis Ayral-Kaloustian, Tarek S. Mansour, James J. Gibbons, Robert T. Abraham, Pawel Nowak, Arie Zask
Journal: Cancer Research
Cancer Res (2009) 69 (15): 6232–6240.
https://doi.org/10.1158/0008-5472.CAN-09-0299
Published: 29 July 2009
View article titled, Biochemical, Cellular, and <em>In vivo</em> Activity of Novel ATP-Competitive and Selective Inhibitors of the Mammalian Target of Rapamycin
Open the PDF for Biochemical, Cellular, and <em>In vivo</em> Activity of Novel ATP-Competitive and Selective Inhibitors of the Mammalian Target of Rapamycin in another window
Includes: Supplementary data
Journal Articles

A New Pharmacologic Action of CCI-779 Involves FKBP12-Independent Inhibition of mTOR Kinase Activity and Profound Repression of Global Protein Synthesis

Boris Shor, Wei-Guo Zhang, Lourdes Toral-Barza, Jessica Lucas, Robert T. Abraham, James J. Gibbons, Ker Yu
Journal: Cancer Research
Cancer Res (2008) 68 (8): 2934–2943.
https://doi.org/10.1158/0008-5472.CAN-07-6487
Published: 15 April 2008
View article titled, A New Pharmacologic Action of CCI-779 Involves FKBP12-Independent Inhibition of mTOR Kinase Activity and Profound Repression of Global Protein Synthesis
Open the PDF for A New Pharmacologic Action of CCI-779 Involves FKBP12-Independent Inhibition of mTOR Kinase Activity and Profound Repression of Global Protein Synthesis in another window
Includes: Supplementary data
Journal Articles

TTI-237: A Novel Microtubule-Active Compound with In vivo Antitumor Activity

Carl F. Beyer, Nan Zhang, Richard Hernandez, Danielle Vitale, Judy Lucas, Thai Nguyen, Carolyn Discafani, Semiramis Ayral-Kaloustian, James J. Gibbons
Journal: Cancer Research
Cancer Res (2008) 68 (7): 2292–2300.
https://doi.org/10.1158/0008-5472.CAN-07-1420
Published: 01 April 2008
View article titled, TTI-237: A Novel Microtubule-Active Compound with <em>In vivo</em> Antitumor Activity
Open the PDF for TTI-237: A Novel Microtubule-Active Compound with <em>In vivo</em> Antitumor Activity in another window
Includes: Supplementary data