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James H. Doroshow
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Journal Articles

ROADMAPS: An online database of response data, dosing regimens, and toxicities of approved oncology drugs as single agents to guide preclinical in vivo studies

Melinda G. Hollingshead, Nathaniel Greenberg, Michelle Gottholm Ahalt, Richard Camalier, Barry C. Johnson, Jerry M. Collins, James H. Doroshow
Journal: Cancer Research
Cancer Res canres.4151.2021.
DOI: https://doi.org/10.1158/0008-5472.CAN-21-4151
Published: 26 April 2022
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Journal Articles

Abstract 1755: E. coli genomic DNA fragments induce cGAS-STING-mediated DUOX2 expression in human pancreatic cancer cells that is associated with H2O2-related DNA damage

Yongzhong Wu, Stephen L. Wang, Smitha Antony, Jennifer L. Meitzler, Jiamo Lu, Guojian Jiang, Becky Diebold, Mallick David, Mariam M. Konate, Roy Krishnendu, James H. Doroshow
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1755.
DOI: https://doi.org/10.1158/1538-7445.AM2021-1755
Published: 01 July 2021
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Abstract CT138: Phase I trial of the combination of bortezomib and clofarabine in adults with refractory solid tumors, lymphomas, or myelodysplastic syndromes

James Q. Nguyen, Geraldine O'Sullivan Coyne, Larry Rubinstein, Shivaani Kummar, Lamin Juwara, Jennifer Zlott, Abdul Rafeh Naqash, Murielle Hogu, Jerry Collins, Apurva Srivastava, Brandon Miller, Ralph E. Parchment, Robert Meehan, Christopher S. Hourigan, Steven Pavletic, James H. Doroshow, Alice P. Chen, Naoko Takebe
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): CT138.
DOI: https://doi.org/10.1158/1538-7445.AM2021-CT138
Published: 01 July 2021
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Abstract CT115: Phase I trial of the triplet berzosertib (M6620, VX-970), veliparib and cisplatin (BVP) in patients with advanced solid tumors

Geraldine O'Sullivan Coyne, Khanh T. Do, Shivaani Kummar, Naoko Takebe, Sarina Piha-Paul, Richard Piekarz, Deborah Wilsker, Brandon Miller, Katherine Ferry-Galow, Ralph Parchment, Lamin Juwara DNP, Mary Jane Ong, Arjun Mittra, James H. Doroshow, Alice P. Chen
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): CT115.
DOI: https://doi.org/10.1158/1538-7445.AM2021-CT115
Published: 01 July 2021
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Abstract 2508: Targeting mutant KRAS tumors by inhibiting cytoplasmic EZH2, which directly methylates and destabilizes the DLC1 tumor suppressor protein

Brajendra K. Tripathi, Disha Bhargava, Xiaolan Qian, Dunrui Wang, Marian E. Durkin, Fernando J. de Miguel, Katerina Politi, Kylie J. Walters, James H. Doroshow, Douglas R. Lowy
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2508.
DOI: https://doi.org/10.1158/1538-7445.AM2021-2508
Published: 01 July 2021
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Abstract 2915: Synergistic, cytokine mediated stimulation (IL-1α/β + IL-6) of colon cancer cells reveals a novel mechanism of DNA damage facilitated by up-regulation of NOX1 and DUOX2

Jennifer L. Meitzler, Yongzhong Wu, Agnes Juhasz, Annamaria Rapisarda, Petreena Campbell, Becky A. Diebold, Smitha Antony, Guojian Jiang, Jiamo Lu, David J. Mallick, Mariam M. Konaté, Krishnendu Roy, James H. Doroshow
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2915.
DOI: https://doi.org/10.1158/1538-7445.AM2021-2915
Published: 01 July 2021
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Abstract 3009: A systematic review of the tumor growth metrics of patient-derived xenograft (PDX) models in the literature and in NCI PDXNet centers

Dali Li, Min Jin Ha, Yvonne A. Evrard, Huiqin Chen, Lisa M. McShane, Jeffrey Grover, Jing Wang, Bingliang Fang, Timothy DiPeri, Michael T. Lewis, Lawrence Rubinstein, Jack A. Roth, Jeffrey H. Chuang, James H. Doroshow, Jeffrey A. Moscow, Funda Meric-Bernstam
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 3009.
DOI: https://doi.org/10.1158/1538-7445.AM2021-3009
Published: 01 July 2021
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Abstract 3015: Applications of immunohistochemistry in characterization of patient derived xenograft models

Lindsay Dutko, Gloryvee Rivera, Erin Cantu, Vishnuprabha Rahulkannan, Kelly Benauer, Tiffanie Chase, Emily Delaney, Jesse Stottlemyer, Chelsea McGlynn, Howard Stotler, John Carter, Suzanne Borgel, Michelle M. Gottholm Ahalt, Michelle Eugeni, Melinda Hollingshead, Yvonne Evrard, Chris Karlovich, Biswajit Das, Mickey Williams, James H. Doroshow, Shahanawaz Jiwani
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 3015.
DOI: https://doi.org/10.1158/1538-7445.AM2021-3015
Published: 01 July 2021
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Abstract 3010: Single agent response comparisons in a large-scale, preclinical trial of rare cancer PDXs by the National Cancer Institute's patient-derived models repository

Yvonne A. Evrard, Sergio Y. Alcoser, Suzanne Borgel, Devynn Breen, John Carter, Tiffanie Chase, Alice Chen, Li Chen, Kristen Cooley, Biswajit Das, Emily Delaney, Lyndsay Dutko, Shannon Ecker, Thomas Forbes, Kyle Georgius, Michelle M. Gottholm-Ahalt, Tara Grinnage-Pulley, Sierra Hoffman, Chris Karlovich, Kimberly Klarmann, Shahanawaz Jiwani, Justine Mills, Malorie Morris, Michael Mullendore, Dianne Newton, Gloryvee Rivera, Howard Stotler, Jesse Stottlemyer, Savanna Styers, Cindy R. Timme, Debbie Trail, Shannon Uzelac, Tomas Vilimas, Thomas Walsh, Nikki Walters, P. Mickey Williams, Melinda G. Hollingshead, James H. Doroshow
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 3010.
DOI: https://doi.org/10.1158/1538-7445.AM2021-3010
Published: 01 July 2021
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Abstract 3007: Imaging characterization of NCI patient derived model repository (PDMR) xenografts

Paula M. Jacobs, James L. Tatum, Joseph D. Kalen, Lilia V. Ileva, Lisa A. Riffle, Keita Saito, Nimit L. Patel, Jessica Phillips, Melinda Hollingshead, Yvonne A. Evrard, Michelle Gottholm-Ahalt, Chelsea Sanders, Amy James, Simone Difilippantonio, Elijah F. Edmondson, James H. Doroshow
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 3007.
DOI: https://doi.org/10.1158/1538-7445.AM2021-3007
Published: 01 July 2021
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Abstract 3012: Patient-derived models of rare cancers in the National Cancer Institute's patient-derived models repository

Cindy R. Timme, Sergio Y. Alcoser, Devynn Breen, John Carter, Ting-Chia Chang, Alice Chen, Li Chen, Kristen Cooley, Biswajit Das, Emily Delaney, Michelle A. Eugeni, Michelle M. Gottholm-Ahalt, Tara Grinnage-Polley, Jenna Hull, Chris Karlovich, Kimberly Klarmann, Shahanawaz Jiwani, Candace Mallow, Chelsea McGlynn, Justine Mills, Malorie Morris, Michael Mullendore, Dianne Newton, Tia Shearer, Jesse Stottlemyer, Shannon Uzelac, Thomas Walsh, P. Mickey Williams, Yvonne A. Evrard, Melinda G. Hollingshead, James H. Doroshow
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 3012.
DOI: https://doi.org/10.1158/1538-7445.AM2021-3012
Published: 01 July 2021
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Abstract 3017: Advancing PDX research through model, data, and bioinformatics with the PDXNet Portal

Soner Koc, Mike Lloyd, Steven Neuhauser, Javad Noodbakhsh, Anuj Srivastava, Xing Yi Woo, Ryan Jeon, Jeffrey Grover, Sara Seepo, Christian Frech, Jack DiGiovanna, PDXNet Consortium, Yvonne A. Evard, Tiffany Wallace, Jeffrey Moscow, James H. Doroshow, Nicholas Mitsuade, Salma Kaochar, Chong-xian Pan, Moon S. Chen, Luis Carvarjal-Carmona, Alana Welm, Bryan Welm, Michael T. Lewis, Govindan Ramaswamy, Li Ding, Shunquang Li, Meenherd Herlyn, Mike Davies, Jack Roth, Funda Meric-Bernstam, Peter Robinson, Carol J. Bult, Brandi Davis-Dusenbery, Dennis A. Dean, Jeffrey H. Chuang
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 3017.
DOI: https://doi.org/10.1158/1538-7445.AM2021-3017
Published: 01 July 2021
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Abstract 3139: Study of tumor heterogeneity and subclonality in primary pancreatic and metastatic sites from rapid autopsy patients in PDMR

Li Chen, Biswajit Das, Yvonne A. Evrard, Chris A. Karlovich, Tomas Vilimas, Amanda Peach, Chapman Alyssa, Nikitha Nair, Anna L. Fong, Luis Romero, Ting-Chia Chang, Shahanawaz Jiwani, Lindsay Dutko, Kelly Benauer, Marianne Morton, Kelly Dougherty, Michelle A. Eugeni, Dianne Newton, Melinda G. Hollingshead, P. Mickey Williams, James H. Doroshow
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 3139.
DOI: https://doi.org/10.1158/1538-7445.AM2021-3139
Published: 01 July 2021
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Abstract 1072: Combination screening of DNA damaging agents temozolomide and trabectedin with inhibitors of DNA repair using a complex spheroid model with a panel of patient-derived and established tumor cell lines

Nathan P. Coussens, Ralph E. Parchment, Jeffrey A. Moscow, L. Austin Doyle, René Delosh, Julie Laudeman, Russell Reinhart, Chad Ogle, Thomas Silvers, Thomas S. Dexheimer, Joel Morris, Beverly A. Teicher, James H. Doroshow
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1072.
DOI: https://doi.org/10.1158/1538-7445.AM2021-1072
Published: 01 July 2021
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Abstract 1028: Combination screening of KRASG12C specific inhibitors with other targeted therapies in patient-derived multicellular tumor spheroids

Thomas S. Dexheimer, Thomas Silvers, René Delosh, Julie Laudeman, Russell Reinhart, Chad Ogle, Nathan P. Coussens, John Wright, Beverly A. Teicher, James H. Doroshow
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1028.
DOI: https://doi.org/10.1158/1538-7445.AM2021-1028
Published: 01 July 2021
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Abstract 3913: Evaluation of patient-derived cell lines and cancer organoids for the prediction of drug responses in patient-derived xenograft models

Petreena Campbell, Curtis Hose, Lara El Touny, Erik Harris, John Connelly, Carrie Bonomi, Kelly Dougherty, Savanna Styers, Abigail Walke, Jenna Moyer, Mariah Baldwin, Anna Wade, Michael Mullendore, Kaitlyn Arthur, Matthew Murphy, Kevin Plater, Marion Gibson, Joseph Geraghty, Michelle Gottholm-Ahalt, Tara Grinnage-Pulley, Tiffanie Chase, John Carter, Howard Stotler, Debbie Trail, Luke Stockwin, Dianne Newton, Yvonne Evrard, Melinda Hollingshead, Ralph E. Parchment, Nathan P. Coussens, Beverly A. Teicher, James H. Doroshow, Annamaria Rapisarda
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3913.
DOI: https://doi.org/10.1158/1538-7445.AM2020-3913
Published: 15 August 2020
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Abstract 6495: Development of robust and reproducible controls to support clinical implementation of quantitative immunofluorescence assays for pharmacodynamic biomarkers

Gabriel J. Benton, Katherine V. Ferry-Galow, Victor E. Lonsberry, Manisha Mohandoss, Howard Stotler, Debbie Trail, Kyle Georgius, Melinda Hollingshead, Deborah Wilsker, Robert Kinders, James H. Doroshow, Ralph E. Parchment
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 6495.
DOI: https://doi.org/10.1158/1538-7445.AM2020-6495
Published: 15 August 2020
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Abstract LB-107: TET2/DNMT3A mutations and exceptional response to novel epigenetic agent in human malignancies

Sherry X. Yang, Larry Rubinstein, Dat Nguyen, Angelo B. Larenjeira, Robert Kinders, Michael Difilippantonio, James H. Doroshow
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): LB-107.
DOI: https://doi.org/10.1158/1538-7445.AM2020-LB-107
Published: 15 August 2020
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Abstract 802: Implementation of optimized research biopsy analyses for clinical pharmacodynamic (PD) studies

Katherine V. Ferry-Galow, Deborah Wilsker, Robert J. Kinders, Hala R. Makhlouf, Angie Dull, Tony Navas, Rachel E. Andrews, Geraldine O'Sullivan Coyne, Alice P. Chen, James H. Doroshow, Ralph E. Parchment
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 802.
DOI: https://doi.org/10.1158/1538-7445.AM2020-802
Published: 15 August 2020
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Abstract 805: Intra-tumoral pharmacodynamics of selumetinib in serial biopsies from patients with neurofibroma

William Herrick, Geraldine O'Sullivan Coyne, Andrea Gross, Eva Dombi, Jeevan Govindharajulu, Casey Kilpatrick, Jennifer Desanto, Amanda Marie Carbonell, Joanne Derdak, Dominique Corinne Pichard, Cecilia Maura Tibery, Bradford J. Wood, Lawrence Doyle, James H. Doroshow, Alice Chen, Ralph E. Parchment, Brigitte C. Widemann, Apurva K. Srivastava
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 805.
DOI: https://doi.org/10.1158/1538-7445.AM2020-805
Published: 15 August 2020
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