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James H. Doroshow
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Journal Articles

Abstract 489: Unveiling markers of response to ATR inhibitor and TMZ combinations in rare tumor PDXs

Free
Yingdong Zhao, Mariam M. Konate, Ming-Chung Li, Peter I. Wu, Li Chen, Lindsay Dutko, Alyssa Chapman, Nikitha Nair, Melinda G. Hollingshead, Shahanawaz Jiwani, Biswajit Das, Julia Krushkal, Andrea R. Voth, Larry V. Rubinstein, Howard Stotler, Shannon Uzelac, Justine Mills, Tiffanie Chase-Miner, Suzanne D. Borgel, Cindy R. Timme, Lijun Chen, Yingwei Hu, Hui Zhang, Alice P. Chen, Chris A. Karlovich, P Mickey Williams, Yvonne A. Evrard, Lisa M. McShane, James H. Doroshow
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 489.
https://doi.org/10.1158/1538-7445.AM2025-489
Published: 21 April 2025
View articletitled, Abstract 489: Unveiling markers of response to ATR inhibitor and TMZ combinations in rare tumor PDXs
Journal Articles

Abstract 1675: Evaluation of combination strategies with RAS-targeted inhibitors in multi-cell type spheroids

Free
Thomas S. Dexheimer, Nathan P. Coussens, Thomas E. Silvers, Eric M. Jones, Naoko Takebe, James H. Doroshow, Beverly A. Teicher
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 1675.
https://doi.org/10.1158/1538-7445.AM2025-1675
Published: 21 April 2025
View articletitled, Abstract 1675: Evaluation of combination strategies with RAS-targeted inhibitors in multi-cell type spheroids
Journal Articles

Abstract 834: In vivo, ex vivo, and in vitro (2D and 3D) tumor models: Uses, strengths and limitations

Free
Beverly A. Teicher, Melinda G. Hollingshead, Nathan P. Coussens, Thomas S. Dexheimer, Thomas E. Silvers, Eric M. Jones, Larry Rubinstein, James H. Doroshow
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 834.
https://doi.org/10.1158/1538-7445.AM2025-834
Published: 21 April 2025
View articletitled, Abstract 834: In vivo, ex vivo, and in vitro (2D and 3D) tumor models: Uses, strengths and limitations
Journal Articles

Abstract 4387: Identification of new drug combinations that cooperatively target KRAS-dependent nuclear protein export to treat mutant KRAS-driven pancreatic adenocarcinoma

Free
Brajendra K. Tripathi, Sophia M. Shahin, Xiaolan Qian, Marian E. Durkin, Ross Lake, James H. Doroshow, Dunrui Wang, Douglas R. Lowy
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 4387.
https://doi.org/10.1158/1538-7445.AM2025-4387
Published: 21 April 2025
View articletitled, Abstract 4387: Identification of new drug combinations that cooperatively target KRAS-dependent nuclear protein export to treat mutant KRAS-driven pancreatic adenocarcinoma
Journal Articles

Abstract 3441: IL-1β/IL-6 co-stimulation synergistically mediates DUOX2/DUOXA2 complex up-regulation via Jak/Stat and p38 signaling events

Free
Jennifer L. Meitzler, Becky A. Diebold, David J. Mallick, Yongzhong Wu, Smitha Antony, Jiamo Lu, Guojian Jiang, Mariam M. Konaté, Krishnendu Roy, James H. Doroshow
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 3441.
https://doi.org/10.1158/1538-7445.AM2025-3441
Published: 21 April 2025
View articletitled, Abstract 3441: IL-1β/IL-6 co-stimulation synergistically mediates DUOX2/DUOXA2 complex up-regulation via Jak/Stat and p38 signaling events
Journal Articles

Abstract 5078: Single-cell characterization of a carcinosarcoma patient-derived xenograft model

Free
Alida Palmisano, Yuri Kotliarov, Parimal Kumar, Ting-Chia Chang, Li Chen, Brandie Fullmer, Alyssa Chapman, Amanda Peach, Biswajit Das, Tomas Vilimas, Thomas Forbes, Shahanawaz Jiwani, Melinda G. Hollingshead, Yvonne A. Evrard, Sarah Shin, Hari Sankaran, Julia Krushkal, Alice Chen, Yingdong Zhao, Chris A. Karlovich, Mickey Williams, Lisa M. McShane, James H. Doroshow
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 5078.
https://doi.org/10.1158/1538-7445.AM2025-5078
Published: 21 April 2025
View articletitled, Abstract 5078: Single-cell characterization of a carcinosarcoma patient-derived xenograft model
Journal Articles

Abstract 1674: Combinatorial screen with standard of care and selected anticancer agents identifies multiple combinations with activity against a panel of patient-derived colorectal organoids

Free
Nathan P. Coussens, Thomas S. Dexheimer, Phillip R. Sanchez, Thomas Silvers, Eric M. Jones, Bryce M. Butler, John R. Britt, Carmen Allegra, James H. Doroshow, Beverly A. Teicher
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 1674.
https://doi.org/10.1158/1538-7445.AM2025-1674
Published: 21 April 2025
View articletitled, Abstract 1674: Combinatorial screen with standard of care and selected anticancer agents identifies multiple combinations with activity against a panel of patient-derived colorectal organoids
Journal Articles

The DNA Methyltransferase Inhibitor 5-Aza-4′-thio-2′-Deoxycytidine Induces C>G Transversions and Acute Lymphoid Leukemia Development

Available to Purchase
Ryan M. Bertoli, Yang Jo Chung, Michael J. Difilippantonio, Anthony Wokasch, Madison R.B. Marasco, Haley Klimaszewski, Susannah Gammell, Yuelin J. Zhu, Robert L. Walker, Dengchao Cao, Ajay Khanna, Matthew J. Walter, James H. Doroshow, Paul S. Meltzer, Peter D. Aplan
Journal: Cancer Research
Cancer Res (2024) 84 (15): 2518–2532.
https://doi.org/10.1158/0008-5472.CAN-23-2785
Published: 01 August 2024
View articletitled, The DNA Methyltransferase Inhibitor 5-Aza-4′-thio-2′-Deoxycytidine Induces C>G Transversions and Acute Lymphoid Leukemia Development
Open the PDF for The DNA Methyltransferase Inhibitor 5-Aza-4′-thio-2′-Deoxycytidine Induces C>G Transversions and Acute Lymphoid Leukemia Development in another window
Includes: Supplementary data
Journal Articles

HTS384 NCI60: The Next Phase of the NCI60 Screen

Open Access
Mark W. Kunkel, Nathan P. Coussens, Joel Morris, Ronald C. Taylor, Thomas S. Dexheimer, Eric M. Jones, James H. Doroshow, Beverly A. Teicher
Journal: Cancer Research
Cancer Res (2024) 84 (15): 2403–2416.
https://doi.org/10.1158/0008-5472.CAN-23-3031
Published: 01 August 2024
View articletitled, HTS384 NCI60: The Next Phase of the NCI60 Screen
Open the PDF for HTS384 NCI60: The Next Phase of the NCI60 Screen in another window
Includes: Supplementary data
Journal Articles

A Pan-Cancer Patient-Derived Xenograft Histology Image Repository with Genomic and Pathologic Annotations Enables Deep Learning Analysis

Open Access
Brian S. White, Xing Yi Woo, Soner Koc, Todd Sheridan, Steven B. Neuhauser, Shidan Wang, Yvonne A. Evrard, Li Chen, Ali Foroughi pour, John D. Landua, R. Jay Mashl, Sherri R. Davies, Bingliang Fang, Maria Gabriela Raso, Kurt W. Evans, Matthew H. Bailey, Yeqing Chen, Min Xiao, Jill C. Rubinstein, Brian J. Sanderson, Michael W. Lloyd, Sergii Domanskyi, Lacey E. Dobrolecki, Maihi Fujita, Junya Fujimoto, Guanghua Xiao, Ryan C. Fields, Jacqueline L. Mudd, Xiaowei Xu, Melinda G. Hollingshead, Shahanawaz Jiwani, Saul Acevedo, PDXNet Consortium, Brandi N. Davis-Dusenbery, Peter N. Robinson, Jeffrey A. Moscow, James H. Doroshow, Nicholas Mitsiades, Salma Kaochar, Chong-xian Pan, Luis G. Carvajal-Carmona, Alana L. Welm, Bryan E. Welm, Ramaswamy Govindan, Shunqiang Li, Michael A. Davies, Jack A. Roth, Funda Meric-Bernstam, Yang Xie, Meenhard Herlyn, Li Ding, Michael T. Lewis, Carol J. Bult, Dennis A. Dean, II, Jeffrey H. Chuang
Journal: Cancer Research
Cancer Res (2024) 84 (13): 2060–2072.
https://doi.org/10.1158/0008-5472.CAN-23-1349
Published: 02 July 2024
View articletitled, A Pan-Cancer Patient-Derived Xenograft Histology Image Repository with Genomic and Pathologic Annotations Enables Deep Learning Analysis
Open the PDF for A Pan-Cancer Patient-Derived Xenograft Histology Image Repository with Genomic and Pathologic Annotations Enables Deep Learning Analysis in another window
Includes: Supplementary data
Journal Articles

Abstract CT120: Phase 1 trial of bortezomib and clofarabine combination in adults with refractory solid tumors

Free
Andre L. De Souza, Naoko Takebe, Alice P. Chen, James H. Doroshow, Ralph E. Parchment, Apurva K. Srivastava, Lawrence Rubistein, Deborah Wilsker, Brandon L. Miller, Murielle Hogu, Geraldine O`Sullivan Coney, Shivaani Kummar, Jeevan Govindharajulu, Robert Meehan, William G. Herrick, Angie Dull, Donna Ketchum, Shaowei Li, Jiuping Ji, Richard Piekarz
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): CT120.
https://doi.org/10.1158/1538-7445.AM2024-CT120
Published: 05 April 2024
View articletitled, Abstract CT120: Phase 1 trial of bortezomib and clofarabine combination in adults with refractory solid tumors
Journal Articles

Abstract CT263: Atezolizumab clinical trial biopsies reveal varied immune landscapes in clear cell sarcoma and chondrosarcoma

Free
Katherine V. Ferry-Galow, Kristin K. Fino, Geraldine O'Sullivan Coyne, Nancy Moore, Elad Sharon, Melissa Burgess, James Chen, Anthony P. Conley, Elizabeth J. Davis, Priscilla Merriam, Albiruni R. Abdul Razak, Brian Van Tine, Jared C. Foster, Naoko Takebe, Christina L. Rosenberger, James H. Doroshow, Alice P. Chen, Ralph E. Parchment
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): CT263.
https://doi.org/10.1158/1538-7445.AM2024-CT263
Published: 05 April 2024
View articletitled, Abstract CT263: Atezolizumab clinical trial biopsies reveal varied immune landscapes in clear cell sarcoma and chondrosarcoma
Journal Articles

Abstract LB215: Polymerase θ (POLθ) inhibitors (novobiocin, ART-558, RP6685) were tested with 22 approved and investigational agents in multi-cell type spheroids of genetically selected patient-derived human tumor cell lines

Free
Beverly A. Teicher, Thomas S. Dexheimer, Thomas Silvers, Nathan P. Coussens, J Paul Eder, James H. Doroshow
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): LB215.
https://doi.org/10.1158/1538-7445.AM2024-LB215
Published: 05 April 2024
View articletitled, Abstract LB215: Polymerase θ (POLθ) inhibitors (novobiocin, ART-558, RP6685) were tested with 22 approved and investigational agents in multi-cell type spheroids of genetically selected patient-derived human tumor cell lines
Journal Articles

Abstract 6911: Expanding reported molecular characteristics for the NCI Patient-Derived Models Repository

Free
Cindy R. Timme, Yvonne A. Evrard, Biswajit Das, Ting-Chia Chang, Alice Chen, Li Chen, Michelle A. Crespo-Eugeni, Shahanawaz Jiwani, Chris A. Karlovich, Rini Pauly, Peter I-Fan Wu, Dianne L. Newton, P. Mickey Williams, Melinda G. Hollingshead, James H. Doroshow
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6911.
https://doi.org/10.1158/1538-7445.AM2024-6911
Published: 22 March 2024
View articletitled, Abstract 6911: Expanding reported molecular characteristics for the NCI Patient-Derived Models Repository
Journal Articles

Abstract 5327: Interleukin-1 upregulates dual oxidase 2 expression and ROS production in human pancreatic cancer cells

Free
David J. Mallick, Yongzhong Wu, Mariam M. Konaté, Becky Diebold, Smitha Antony, Jennifer L. Meitzler, Guojian Jiang, Jiamo Lu, Krishnendu Roy, James H. Doroshow
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5327.
https://doi.org/10.1158/1538-7445.AM2024-5327
Published: 22 March 2024
View articletitled, Abstract 5327: Interleukin-1 upregulates dual oxidase 2 expression and ROS production in human pancreatic cancer cells
Journal Articles

Abstract 6914: Genomic landscape and stability of preclinical models in NCI's patient-derived models repository

Free
Ting-Chia Chang, Biswajit Das, Li Chen, Peter I-Fan Wu, Yvonne A. Evrard, Rini Pauly, Dianne L. Newton, Shahanawaz Jiwani, Sergio Y. Alcoser, Luke H. Stockwin, Corinne E. Camalier, Tomas Forbes, Nikitha Nair, Alyssa Chapman, Lindsay Dutko, Michael Mullendore, Tara Grinnage-Pulley, Kimberly Klarmann, Sarah B. Miller, Chris A. Karlovich, Alice P. Chen, P Mickey Williams, Melinda G. Hollingshead, James H. Doroshow
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6914.
https://doi.org/10.1158/1538-7445.AM2024-6914
Published: 22 March 2024
View articletitled, Abstract 6914: Genomic landscape and stability of preclinical models in NCI's patient-derived models repository
Journal Articles

Abstract 4608: Combinations of Cdc-like kinase (CLK) inhibitors with targeted oncology agents or standard chemotherapy in patient-derived multi-cell type tumor spheroids

Free
Thomas Steven Dexheimer, Thomas Silvers, Nathan P. Coussens, Steven D. Gore, James H. Doroshow, Beverly A. Teicher
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4608.
https://doi.org/10.1158/1538-7445.AM2024-4608
Published: 22 March 2024
View articletitled, Abstract 4608: Combinations of Cdc-like kinase (CLK) inhibitors with targeted oncology agents or standard chemotherapy in patient-derived multi-cell type tumor spheroids
Journal Articles

Abstract 2089: A pro-oncogenic RAS-GTP:RAN-GAP complex facilitates nuclear protein export and has clinical implications

Free
Brajendra K. Tripathi, Nicole H. Hirsh, David Hansen, Xiaolan Qian, Marian E. Durkin, Dunrui Wang, Alex G. Papageorge, Ross Lake, Yvonne A. Evrard, Adam Marcus, Suresh S. Ramalingam, Mary Dasso, Karen Vousden, James H. Doroshow, Kylie J. Walters, Douglas R. Lowy
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2089.
https://doi.org/10.1158/1538-7445.AM2024-2089
Published: 22 March 2024
View articletitled, Abstract 2089: A pro-oncogenic RAS-GTP:RAN-GAP complex facilitates nuclear protein export and has clinical implications
Journal Articles

Abstract 6898: Cholangiocarcinoma patient-derived models in the NCI Patient-Derived Models Repository

Free
Yvonne A. Evrard, Cindy R. Timme, Biswajit Das, Gareth Bliss, Carrie Bonomi, Carley Border, Ting-Chia Chang, Alice Chen, Li Chen, Michelle A. Crespo-Eugeni, Kevin Cooper, Natalie Czarra, Isabella Czernia, Kelly Dougherty, Marion Gibson, Tara Grinnage-Pulley, Shahanawaz Jiwani, Keegan Kalmbach, Chris A. Karlovich, Chelsea McGlynn, Michael Mullendore, Matthew Murphy, Rini Pauly, Kevin Plater, Jessica Steed, Luke Stockwin, Shannon Uzelac, Peter I-Fan Wu, Dianne L. Newton, P. Mickey Williams, Melinda G. Hollingshead, James H. Doroshow
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6898.
https://doi.org/10.1158/1538-7445.AM2024-6898
Published: 22 March 2024
View articletitled, Abstract 6898: Cholangiocarcinoma patient-derived models in the NCI Patient-Derived Models Repository
Journal Articles

Abstract 3090: Development and performance of the National Cancer Institute’s HTS384 NCI60 screen: A modernized platform to support drug discovery and development by the worldwide cancer research community

Free
Nathan P. Coussens, Thomas S. Dexheimer, Eric M. Jones, Thomas Silvers, John R. Britt, Ronald C. Taylor, Mark W. Kunkel, James H. Doroshow, Beverly A. Teicher
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3090.
https://doi.org/10.1158/1538-7445.AM2024-3090
Published: 22 March 2024
View articletitled, Abstract 3090: Development and performance of the National Cancer Institute’s HTS384 NCI60 screen: A modernized platform to support drug discovery and development by the worldwide cancer research community