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James Bradner
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Journal Articles

Abstract 1075: JQ1 induces DNA damage, inhibits expression of DNA repair proteins, and synergizes with PARP inhibitors in pancreatic cancer cells

Aubrey Lynn Miller, Tracy Gamblin, Leona Council, Robert van Waardenburg, Eddy Yang, James Bradner, Karina Yoon
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1075.
https://doi.org/10.1158/1538-7445.AM2017-1075
Published: 01 July 2017
View article titled, Abstract 1075: JQ1 induces DNA damage, inhibits expression of DNA repair proteins, and synergizes with PARP inhibitors in pancreatic cancer cells
Journal Articles

Abstract 2326: A high-throughput screen identified cancer selective small molecules that kill independent of mitochondrial apoptosis

Catriona M. Dowling, Micheal Hemann, James Bradner, Anthony Letai, Triona Ni Chonghaile
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2326.
https://doi.org/10.1158/1538-7445.AM2017-2326
Published: 01 July 2017
View article titled, Abstract 2326: A high-throughput screen identified cancer selective small molecules that kill independent of mitochondrial apoptosis
Journal Articles

Abstract 5490: Non-overlapping promoter and super-enhancer-associated dependencies in multiple myeloma

Mariateresa Fulciniti, Charles Y. Lin, Mehmet K. Samur, Richard Young, Herve Avet-loiseau, Kenneth Anderson, James Bradner, Nikhil Munshi
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 5490.
https://doi.org/10.1158/1538-7445.AM2017-5490
Published: 01 July 2017
View article titled, Abstract 5490: Non-overlapping promoter and super-enhancer-associated dependencies in multiple myeloma
Journal Articles

Abstract 981: The design and characterization of a selective TRIM24 degrader

Lara N. Gechijian, Dennis Buckley, Matthew Lawlor, Thomas Scott, Joshiawa Paulk, Jaime Reyes, Georg Winter, Michael Erb, Chris Ott, Sirano Dhe-Paganon, James Bradner
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 981.
https://doi.org/10.1158/1538-7445.AM2017-981
Published: 01 July 2017
View article titled, Abstract 981: The design and characterization of a selective TRIM24 degrader
Journal Articles

Abstract 481: Diminished microRNA-29b results in overexpression of BRD4 and BRD4-regulated oncogenes in cutaneous T-cell lymphoma

Rebecca Kohnken, Jing Wen, Bethany Mundy-Bosse, Max Yano, Leah Grinshpun, Kathleen McConnell, Ashleigh Keiter, Alex Hartlage, James Bradner, Michael Caligiuri, Pierluigi Porcu, Anjali Mishra
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 481.
https://doi.org/10.1158/1538-7445.AM2017-481
Published: 01 July 2017
View article titled, Abstract 481: Diminished microRNA-29b results in overexpression of BRD4 and BRD4-regulated oncogenes in cutaneous T-cell lymphoma
Journal Articles

Abstract 4165: Myc vs. Akt therapy in RapidCap, a GEM model for metastatic prostate cancer

Carlos E. Stahlhut, Alexandra J. Ambrico, Kaitlin E. Watrud, Hyejin Cho, Lily Wang, Jun Qi, Lewis C. Cantley, James Bradner, Lloyd Trotman
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4165.
https://doi.org/10.1158/1538-7445.AM2016-4165
Published: 15 July 2016
View article titled, Abstract 4165: Myc vs. Akt therapy in RapidCap, a GEM model for metastatic prostate cancer
Journal Articles

Abstract IA11: Targeting enhancers in CNS tumors

James Bradner
Journal: Cancer Research
Cancer Res (2015) 75 (23_Supplement): IA11.
https://doi.org/10.1158/1538-7445.BRAIN15-IA11
Published: 09 December 2015
View article titled, Abstract IA11: Targeting enhancers in CNS tumors
Journal Articles

Abstract 2636: Myc vs. Akt therapy in RapidCap, a GEM model for metastatic prostate cancer

Carlos E. Stahlhut, Kaitlin E. Watrud, Alexandra J. Ambrico, Hyejin Cho, Lily Wang, Jun Qi, Lewis C. Cantley, James Bradner, Lloyd C. Trotman
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2636.
https://doi.org/10.1158/1538-7445.AM2015-2636
Published: 01 August 2015
View article titled, Abstract 2636: Myc vs. Akt therapy in RapidCap, a GEM model for metastatic prostate cancer
Journal Articles

Targeting the MYC and PI3K Pathways Eliminates Leukemia-Initiating Cells in T-cell Acute Lymphoblastic Leukemia

Suzanne Schubbert, Anjelica Cardenas, Harrison Chen, Consuelo Garcia, Wei Guo, James Bradner, Hong Wu
Journal: Cancer Research
Cancer Res (2014) 74 (23): 7048–7059.
https://doi.org/10.1158/0008-5472.CAN-14-1470
Published: 30 November 2014
View article titled, Targeting the MYC and PI3K Pathways Eliminates Leukemia-Initiating Cells in T-cell Acute Lymphoblastic Leukemia
Open the PDF for Targeting the MYC and PI3K Pathways Eliminates Leukemia-Initiating Cells in T-cell Acute Lymphoblastic Leukemia in another window
Includes: Supplementary data
Journal Articles

Abstract 4782: Epigenetic resistance to Notch inhibition in T cell acute lymphoblastic leukemia

Birgit Knoechel, Justine Roderick, Kaylyn Williamson, Jiang Zhu, Jens Lohr, Matthew Cotton, Shawn Gillespie, Daniel Fernandez, Manching Ku, Hongfang Wang, Federica Piccioni, Serena Silver, Mohit Jain, Daniel Pearson, Michael Kluk, Christopher Ott, Dale Greiner, Michael Brehm, Leonard Shultz, Alejandro Gutierrez, Kimberly Stegmaier, Marian Harris, Lewis Silverman, Stephen Sallan, Andrew Kung, David Root, James Bradner, Jon Aster, Michelle Kelliher, Bradley Bernstein
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4782.
https://doi.org/10.1158/1538-7445.AM2014-4782
Published: 01 October 2014
View article titled, Abstract 4782: Epigenetic resistance to Notch inhibition in T cell acute lymphoblastic leukemia
Journal Articles

Abstract 1689: Synergistic effect of JQ1 and rapamycin for treatment of human osteosarcoma

Dhong Hyun Tony Lee, Jun Qi, James Bradner, Jonathan Said, Ngan Doan, Charles Forscher, H Phillip Koeffler
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1689.
https://doi.org/10.1158/1538-7445.AM2014-1689
Published: 01 October 2014
View article titled, Abstract 1689: Synergistic effect of JQ1 and rapamycin for treatment of human osteosarcoma
Journal Articles

Abstract LB-79: PRC2 loss amplifies Ras-driven transcription and sensitizes cancers to bromodomain inhibitor-based combination therapies

Thomas D. Raedt, Eline Beert, Eric Pasmant, Armelle Luscan, Hilde Brems, Nicolas Ortonne, Kristian Helin, Victor Mautner, Hildegard Kehrer-Sawatski, Wade Clapp, James Bradner, Meena Upadhyaya, Michel Vidaud, Eric Legius, Karen Cichowski
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): LB-79.
https://doi.org/10.1158/1538-7445.AM2014-LB-79
Published: 01 October 2014
View article titled, Abstract LB-79: PRC2 loss amplifies Ras-driven transcription and sensitizes cancers to bromodomain inhibitor-based combination therapies
Journal Articles

Abstract 2575: Differentiation of NUT midline carcinoma by epigenomic reprogramming

Brian Schwartz, Matthias Hofer, Madeleine Lemieux, Daniel Bauer, Michael Cameron, Nathan West, Elin Agoston, Tan Ince, Amanda Christie, Jon Aster, Stephen Sallan, Andrew Kung, James Bradner, Chris A. French
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 2575.
https://doi.org/10.1158/1538-7445.AM2011-2575
Published: 15 April 2011
View article titled, Abstract 2575: Differentiation of NUT midline carcinoma by epigenomic reprogramming
Journal Articles

Abstract 3693: Small molecule microarray screens for inhibitors of oncogenic ETS factors

Marius Pop, Katie Doug, James Bradner, Angela Koehler, Levi Garraway
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 3693.
https://doi.org/10.1158/1538-7445.AM10-3693
Published: 15 April 2010
View article titled, Abstract 3693: Small molecule microarray screens for inhibitors of oncogenic ETS factors
Journal Articles

Inhibitors of Deacetylases Suppress Oncogenic KIT Signaling, Acetylate HSP90, and Induce Apoptosis in Gastrointestinal Stromal Tumors

Thomas Mühlenberg, Yixiang Zhang, Andrew J. Wagner, Florian Grabellus, James Bradner, Georg Taeger, Hauke Lang, Takahiro Taguchi, Martin Schuler, Jonathan A. Fletcher, Sebastian Bauer
Journal: Cancer Research
Cancer Res (2009) 69 (17): 6941–6950.
https://doi.org/10.1158/0008-5472.CAN-08-4004
Published: 31 August 2009
View article titled, Inhibitors of Deacetylases Suppress Oncogenic KIT Signaling, Acetylate HSP90, and Induce Apoptosis in Gastrointestinal Stromal Tumors
Open the PDF for Inhibitors of Deacetylases Suppress Oncogenic KIT Signaling, Acetylate HSP90, and Induce Apoptosis in Gastrointestinal Stromal Tumors in another window
Includes: Supplementary data
Journal Articles

Abstract #5363: Rational targeting of notch receptor trafficking

Raymond Moellering, Ricardo Ramirez, Gregory Verdine, James Bradner
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 5363.
Published: 01 May 2009
View article titled, Abstract #5363: Rational targeting of notch receptor trafficking
Journal Articles

Abstract #1901: Rationale and use of single-agent histone deacetylase inhibitor therapy in poorly differentiated midline carcinoma

Matthias Hofer, Daniel Bauer, Stephen Sallan, Brian Schwartz, Michael Cameron, Nathan West, Elin Agoston, Tan Ince, Katherine Janeway, Jon Aster, James Bradner, Christopher French
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 1901.
Published: 01 May 2009
View article titled, Abstract #1901: Rationale and use of single-agent histone deacetylase inhibitor therapy in poorly differentiated midline carcinoma
Journal Articles

Abstract #841: Targeted disruption of the Notch transcription factor complex in vitro and in vivo

Raymond Moellering, Melanie Cornejo, Tina Davis, Cristina Del Bianco, Jon Aster, Stephen Blacklow, Andrew Kung, D. Gary Gilliland, Gregory Verdine, James Bradner
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 841.
Published: 01 May 2009
View article titled, Abstract #841: Targeted disruption of the Notch transcription factor complex <em>in vitro</em> and <em>in vivo</em>
Journal Articles

Direct inhibition of the Notch transactivation complex with stapled peptides in T-ALL

Raymond Moellering, Melanie Cornejo, Jennifer Rocnik, Cristina DelBianco, Steven Blacklow, Gary Gilliland, Gregory Verdine, James Bradner
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 2547.
Published: 01 May 2008
View article titled, Direct inhibition of the Notch transactivation complex with stapled peptides in T-ALL
Journal Articles

Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies

Jayne Stommel, Alec Kimmelman, Haoqiang Ying, Roustem Nabioullin, Aditya Ponugoti, Ruprecht Wiedemeyer, Alexander Stegh, James Bradner, Keith Ligon, Cameron Brennan, Lynda Chin, Ronald DePinho
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 5835.
Published: 01 May 2008
View article titled, Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies