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Journal Articles

AXL/WRNIP1 Mediates Replication Stress Response and Promotes Therapy Resistance and Metachronous Metastasis in HER2⁺ Breast Cancer

Cancer Res (2024) 84 (5): 675–687.

https://doi.org/10.1158/0008-5472.CAN-23-1459

Published: 04 March 2024

View articletitled, AXL/WRNIP1 Mediates Replication Stress Response and Promotes Therapy Resistance and Metachronous Metastasis in HER2+ Breast Cancer

Includes: Supplementary data

Journal Articles

Abstract 2087: AXL inhibition enhances Type 1 interferon (IFN) response and potentiates chemo-immunotherapy

Sushil Dhakal, Sébastien Bougnaud, James B. Lorens, Gro Gausdal, Emmanuel E. Moutoussamy, Hani Gabra

Cancer Res (2022) 82 (12_Supplement): 2087.

https://doi.org/10.1158/1538-7445.AM2022-2087

Published: 15 June 2022

View articletitled, Abstract 2087: AXL inhibition enhances Type 1 interferon (IFN) response and potentiates chemo-immunotherapy

Journal Articles

Abstract 3774: BGB324, a selective small-molecule inhibitor of receptor tyrosine kinase AXL, targets tumor immune suppression and enhances immune checkpoint inhibitor efficacy

Kjersti Davidsen, Katarzyna Wnuk-Lipinska, Wenting Du, Magnus Blø, Agnete Engelsen, Stephane Terry, Stacey D´mello, Maria Lie, Jing Kang, Linn Hodneland, Sebastien Bougnaud, Kristina Aguilera, Oddbjørn Straume, Salem Chouaib, Rolf A. Brekken, Gro Gausdal, James B. Lorens

Cancer Res (2018) 78 (13_Supplement): 3774.

https://doi.org/10.1158/1538-7445.AM2018-3774

Published: 01 July 2018

View articletitled, Abstract 3774: BGB324, a selective small-molecule inhibitor of receptor tyrosine kinase AXL, targets tumor immune suppression and enhances immune checkpoint inhibitor efficacy

Journal Articles

Small-Molecule Inhibition of Axl Targets Tumor Immune Suppression and Enhances Chemotherapy in Pancreatic Cancer

Kathleen F. Ludwig, Wenting Du, Noah B. Sorrelle, Katarzyna Wnuk-Lipinska, Mary Topalovski, Jason E. Toombs, Victoria H. Cruz, Shinichi Yabuuchi, N.V. Rajeshkumar, Anirban Maitra, James B. Lorens, Rolf A. Brekken

Cancer Res (2018) 78 (1): 246–255.

https://doi.org/10.1158/0008-5472.CAN-17-1973

Published: 02 January 2018

View articletitled, Small-Molecule Inhibition of Axl Targets Tumor Immune Suppression and Enhances Chemotherapy in Pancreatic Cancer

Includes: Supplementary data

Journal Articles

Abstract 626: BGB324, a selective small molecule inhibitor of receptor tyrosine kinase AXL, abrogates tumor intrinsic and microenvironmental immune suppression and enhances immune checkpoint inhibitor efficacy in lung and mammary adenocarcinoma models

Katarzyna Wnuk-Lipinska, Kjersti Davidsen, Magnus Blø, Agnete Engelsen, Jing Kang, Linn Hodneland, Maria Lie, Sebastien Bougnaud, Kristina Aguilera, Lavina Ahmed, Agata Rybicka, Eline Milde Nævdal, Paulina Deyna, Anna Boniecka, Straume Oddbjørn, Salem Chouaib, Rolf Brekken, Gro Gausdal, James B. Lorens

Cancer Res (2017) 77 (13_Supplement): 626.

https://doi.org/10.1158/1538-7445.AM2017-626

Published: 01 July 2017

View articletitled, Abstract 626: BGB324, a selective small molecule inhibitor of receptor tyrosine kinase AXL, abrogates tumor intrinsic and microenvironmental immune suppression and enhances immune checkpoint inhibitor efficacy in lung and mammary adenocarcinoma models

Journal Articles

Abstract 3010: Broad reduction in cancer incidence in patients treated with warfarin: a prospective cohort study

Gry S. Haaland, Ragnhild S. Falk, Oddbjørn Straume, James B. Lorens

Cancer Res (2017) 77 (13_Supplement): 3010.

https://doi.org/10.1158/1538-7445.AM2017-3010

Published: 01 July 2017

View articletitled, Abstract 3010: Broad reduction in cancer incidence in patients treated with warfarin: a prospective cohort study

Journal Articles

Abstract 566: BGB324, a selective small molecule inhibitor of the receptor tyrosine kinase AXL, enhances immune checkpoint inhibitor efficacy

Gro Gausdal, Kjersti Davidsen, Katarzyna Wnuk-Lipinska, Kathleen Wiertel, Jing Kang, Agnete Engelsen, Sébastien Bougnaud, Monica Hellesøy, Magnus Blø, Lavina Ahmed, Linn Hodneland, Sergej Kiprijanov, Oddbjørn Straume, Rolf A. Brekken, James B. Lorens

Cancer Res (2016) 76 (14_Supplement): 566.

https://doi.org/10.1158/1538-7445.AM2016-566

Published: 15 July 2016

View articletitled, Abstract 566: BGB324, a selective small molecule inhibitor of the receptor tyrosine kinase AXL, enhances immune checkpoint inhibitor efficacy

Journal Articles

Abstract 5182: A rapid in vivo screen for pancreatic ductal adenocarcinoma therapeutics using the tumor marker Rgs16::GFP

Ozhan Ocal, Victor Pashkov, Rahul K. Kollipara, James B. Lorens, Galvin H. Swift, Rolf A. Brekken, Thomas M. Wilkie

Cancer Res (2016) 76 (14_Supplement): 5182.

https://doi.org/10.1158/1538-7445.AM2016-5182

Published: 15 July 2016

View articletitled, Abstract 5182: A rapid in vivo screen for pancreatic ductal adenocarcinoma therapeutics using the tumor marker Rgs16::GFP

Journal Articles

Warfarin Blocks Gas6-Mediated Axl Activation Required for Pancreatic Cancer Epithelial Plasticity and Metastasis

Amanda Kirane, Kathleen F. Ludwig, Noah Sorrelle, Gry Haaland, Tone Sandal, Renate Ranaweera, Jason E. Toombs, Miao Wang, Sean P. Dineen, David Micklem, Michael T. Dellinger, James B. Lorens, Rolf A. Brekken

Cancer Res (2015) 75 (18): 3699–3705.

https://doi.org/10.1158/0008-5472.CAN-14-2887-T

Published: 14 September 2015

View articletitled, Warfarin Blocks Gas6-Mediated Axl Activation Required for Pancreatic Cancer Epithelial Plasticity and Metastasis

Includes: Supplementary data

Journal Articles

Abstract B78: Warfarin blocks Gas6-mediated Axl activation required for pancreatic tumor plasticity and metastasis

Amanda Kirane, Kathleen W. Ludwig, Gry Haaland, Tone Sandal, Renata Ranaweera, Jason E. Toombs, Laura A. Sullivan, Miao Wang, Noah Sorrelle, Sean P. Dineen, Michael T. Dellinger, James B. Lorens, Rolf A. Brekken

Cancer Res (2015) 75 (13_Supplement): B78.

https://doi.org/10.1158/1538-7445.PANCA2014-B78

Published: 30 June 2015

View articletitled, Abstract B78: Warfarin blocks Gas6-mediated Axl activation required for pancreatic tumor plasticity and metastasis

Journal Articles

Vimentin–ERK Signaling Uncouples Slug Gene Regulatory Function

Reetta Virtakoivu, Anja Mai, Elina Mattila, Nicola De Franceschi, Susumu Y. Imanishi, Garry Corthals, Riina Kaukonen, Markku Saari, Fang Cheng, Elin Torvaldson, Veli-Matti Kosma, Arto Mannermaa, Ghaffar Muharram, Christine Gilles, John Eriksson, Ylermi Soini, James B. Lorens, Johanna Ivaska

Cancer Res (2015) 75 (11): 2349–2362.

https://doi.org/10.1158/0008-5472.CAN-14-2842

Published: 31 May 2015

View articletitled, Vimentin–ERK Signaling Uncouples Slug Gene Regulatory Function

Includes: Supplementary data

Journal Articles

Abstract 1820: TP63 regulation of epithelial to mesenchymal transition in an experimental prostate cell model.

Jan Roger Olsen, Anne Margrete Øyan, Kari Rostad, Margrete R. Hellem, Jie Liu, Lisha Li, David Micklem, Hallvard Haugen, James B. Lorens, Xisong Ke, Varda Rotter, Biaoyang Lin, Karl-Henning Kalland

Cancer Res (2013) 73 (8_Supplement): 1820.

https://doi.org/10.1158/1538-7445.AM2013-1820

Published: 15 April 2013

View articletitled, Abstract 1820: TP63 regulation of epithelial to mesenchymal transition in an experimental prostate cell model.

Journal Articles

Nitroreductase, a Near-Infrared Reporter Platform for In Vivo Time-Domain Optical Imaging of Metastatic Cancer

Emmet McCormack, Elisabeth Silden, Richard M. West, Tina Pavlin, David R. Micklem, James B. Lorens, Bengt Erik Haug, Michael E. Cooper, Bjørn Tore Gjertsen

Cancer Res (2013) 73 (4): 1276–1286.

https://doi.org/10.1158/0008-5472.CAN-12-2649

Published: 14 February 2013

View articletitled, Nitroreductase, a Near-Infrared Reporter Platform for In Vivo Time-Domain Optical Imaging of Metastatic Cancer

Includes: Supplementary data

Journal Articles

Abstract 1290: The ability of the transcription factor p63 to induce selected gene expression modules associated with mesenchymal to epithelial transition of prostate cells

Jan Roger Olsen, Xi-Song Ke, Kari Rostad, Margrete R. Hellem, Yi Qu, Biaoyang Lin, James B. Lorens, David R. Micklem, Hallvard Haugen, Karsten Gravdal, Ole Johan Halvorsen, Lars A. Akslen, Varda Rotter, Anne Margrete Oyan, Karl H. Kalland

Cancer Res (2012) 72 (8_Supplement): 1290.

https://doi.org/10.1158/1538-7445.AM2012-1290

Published: 15 April 2012

View articletitled, Abstract 1290: The ability of the transcription factor p63 to induce selected gene expression modules associated with mesenchymal to epithelial transition of prostate cells

Journal Articles

Abstract 3089: The role of p63 regulation during epithelial to mesenchymal transition (EMT) and subsequent accumulation of malignant features of primary immortalized prostate cells

Jan Roger Olsen, Xi-Song Ke, Yi Qu, Kari Rostad, Margrete R. Hellem, James B. Lorens, David R. Micklem, Hallvard Haugen, Karsten Gravdal, Ole Johan Halvorsen, Varda Rotter, Lars A. Akslen, Anne Margrete Oyan, Karl H. Kalland

Cancer Res (2011) 71 (8_Supplement): 3089.

https://doi.org/10.1158/1538-7445.AM2011-3089

Published: 15 April 2011

View articletitled, Abstract 3089: The role of p63 regulation during epithelial to mesenchymal transition (EMT) and subsequent accumulation of malignant features of primary immortalized prostate cells

Journal Articles

Multiple roles for the receptor tyrosine kinase Axl in angiogenesis and tumor formation

Cancer Res (2006) 66 (8_Supplement): 660.

Published: 15 April 2006

View articletitled, Multiple roles for the receptor tyrosine kinase Axl in angiogenesis and tumor formation

Journal Articles

Multiple Roles for the Receptor Tyrosine Kinase Axl in Tumor Formation

Cancer Res (2005) 65 (20): 9294–9303.

https://doi.org/10.1158/0008-5472.CAN-05-0993

Published: 17 October 2005

View articletitled, Multiple Roles for the Receptor Tyrosine Kinase Axl in Tumor Formation

Includes: Supplementary data

Journal Articles

Requirement for the tyrosine kinase Axl in angiogenesis and tumor growth

Weiduan Xu, Mark J. Powell, Annabelle M. Friera, Christian Franchi, Emily Chan, Yasumichi Hitoshi, Jacques E. Nor, Donald G. Payan, James B. Lorens, Sacha J. Holland

Cancer Res (2005) 65 (9_Supplement): 473.

Published: 01 May 2005

View articletitled, Requirement for the tyrosine kinase Axl in angiogenesis and tumor growth

Journal Articles

Critical role of the ubiquitin ligase activity of Np95, a nuclear RING finger protein, in tumor cell growth

Yonchu Jenkins, Vadim Markovtsov, Wayne Lang, Poonam Sharma, Denise Pearsall, Justin Warner, Christian Franci, Betty Huang, Jianing Huang, George C. Yam, Joseph P. Vistan, Erlina Pali, Jorge Vialard, Michel Janicot, James B. Lorens, Donald G. Payan, Yasumichi Hitoshi

Cancer Res (2005) 65 (9_Supplement): 1290.

Published: 01 May 2005

View articletitled, Critical role of the ubiquitin ligase activity of Np95, a nuclear RING finger protein, in tumor cell growth

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AXL/WRNIP1 Mediates Replication Stress Response and Promotes Therapy Resistance and Metachronous Metastasis in HER2⁺ Breast Cancer

Abstract 2087: AXL inhibition enhances Type 1 interferon (IFN) response and potentiates chemo-immunotherapy

Abstract 3774: BGB324, a selective small-molecule inhibitor of receptor tyrosine kinase AXL, targets tumor immune suppression and enhances immune checkpoint inhibitor efficacy

Small-Molecule Inhibition of Axl Targets Tumor Immune Suppression and Enhances Chemotherapy in Pancreatic Cancer

Abstract 626: BGB324, a selective small molecule inhibitor of receptor tyrosine kinase AXL, abrogates tumor intrinsic and microenvironmental immune suppression and enhances immune checkpoint inhibitor efficacy in lung and mammary adenocarcinoma models

Abstract 3010: Broad reduction in cancer incidence in patients treated with warfarin: a prospective cohort study

Abstract 566: BGB324, a selective small molecule inhibitor of the receptor tyrosine kinase AXL, enhances immune checkpoint inhibitor efficacy

Abstract 5182: A rapid in vivo screen for pancreatic ductal adenocarcinoma therapeutics using the tumor marker Rgs16::GFP

Warfarin Blocks Gas6-Mediated Axl Activation Required for Pancreatic Cancer Epithelial Plasticity and Metastasis

Abstract B78: Warfarin blocks Gas6-mediated Axl activation required for pancreatic tumor plasticity and metastasis

Vimentin–ERK Signaling Uncouples Slug Gene Regulatory Function

Abstract 1820: TP63 regulation of epithelial to mesenchymal transition in an experimental prostate cell model.

Nitroreductase, a Near-Infrared Reporter Platform for In Vivo Time-Domain Optical Imaging of Metastatic Cancer

Abstract 1290: The ability of the transcription factor p63 to induce selected gene expression modules associated with mesenchymal to epithelial transition of prostate cells

Abstract 3089: The role of p63 regulation during epithelial to mesenchymal transition (EMT) and subsequent accumulation of malignant features of primary immortalized prostate cells

Multiple roles for the receptor tyrosine kinase Axl in angiogenesis and tumor formation

Multiple Roles for the Receptor Tyrosine Kinase Axl in Tumor Formation

Requirement for the tyrosine kinase Axl in angiogenesis and tumor growth

Critical role of the ubiquitin ligase activity of Np95, a nuclear RING finger protein, in tumor cell growth

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