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Journal Articles

Abstract 1181: PTEN loss-of-function mutations prevalent in HRAS-mutant cancers results in resistance to targeted therapy

Aradhya Nigam, Walid K. Chatila, Gnana P. Krishnamoorthy, Alan L. Ho, James A. Fagin, Nikolaus D. Schultz, Brian R. Untch

Cancer Res (2022) 82 (12_Supplement): 1181.

DOI: https://doi.org/10.1158/1538-7445.AM2022-1181

Published: 15 June 2022

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Journal Articles

Abstract 986: RBM10 loss in thyroid cancer leads to aberrant splicing of cytoskeletal and extracellular matrix mRNAs and increased metastatic fitness

Gnana P. Krishnamoorthy, Anthony Glover, Brian Untch, Mahesh Saqcena, Dina Vukel, Katherine Berman, Omar Abdel-Wahab, Robert K. Bradley, Jeffrey A. Knauf, James A. Fagin

Cancer Res (2022) 82 (12_Supplement): 986.

DOI: https://doi.org/10.1158/1538-7445.AM2022-986

Published: 15 June 2022

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Journal Articles

Abstract 913: Tert mutant promoter mouse model induces cancer progression in Braf^V600E-driven thyroid tumors: A novel tool to understand the biology of telomerase-reactivated cancers

Inigo Landa, Jingzhu Hao, Bin Xu, Joseph Giacalone, Zach Herbert, Maria A. Blasco, Jeffrey A. Knauf, Ronald Ghossein, James A. Fagin

Cancer Res (2022) 82 (12_Supplement): 913.

DOI: https://doi.org/10.1158/1538-7445.AM2022-913

Published: 15 June 2022

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Journal Articles

Targeting Novel Sodium Iodide Symporter Interactors ADP-Ribosylation Factor 4 and Valosin-Containing Protein Enhances Radioiodine Uptake

Alice Fletcher, Martin L. Read, Caitlin E.M. Thornton, Dean P. Larner, Vikki L. Poole, Katie Brookes, Hannah R. Nieto, Mohammed Alshahrani, Rebecca J. Thompson, Gareth G. Lavery, Iñigo Landa, James A. Fagin, Moray J. Campbell, Kristien Boelaert, Andrew S. Turnell, Vicki E. Smith, Christopher J. McCabe

Cancer Res (2020) 80 (1): 102–115.

DOI: https://doi.org/10.1158/0008-5472.CAN-19-1957

Published: 03 January 2020

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Includes: Multimedia, Supplementary data

Journal Articles

Tipifarnib Inhibits HRAS-Driven Dedifferentiated Thyroid Cancers

Brian R. Untch, Vanessa Dos Anjos, Maria E.R. Garcia-Rendueles, Jeffrey A. Knauf, Gnana P. Krishnamoorthy, Mahesh Saqcena, Umeshkumar K. Bhanot, Nicholas D. Socci, Alan L. Ho, Ronald Ghossein, James A. Fagin

Cancer Res (2018) 78 (16): 4642–4657.

DOI: https://doi.org/10.1158/0008-5472.CAN-17-1925

Published: 14 August 2018

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Journal Articles

Abstract 1225: A unified model of RAF inhibitor action determines inhibitor activity in BRAF-dependent tumors

Zoi Karoulia, Yang Wu, Tamer A. Ahmed, Qisheng Xin, Julien Bollard, Clemens Krepler, Xuewei Wu, Chao Zhang, Gideon Bollag, Meenhard Herlyn, James A. Fagin, Amaia Lujambio, Evripidis Gavathiotis, Poulikos I. Poulikakos

Cancer Res (2017) 77 (13_Supplement): 1225.

DOI: https://doi.org/10.1158/1538-7445.AM2017-1225

Published: 01 July 2017

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Journal Articles

Abstract 2063: The farnesyltransferase inhibitor tipifarnib causes dramatic tumor regression and increases survival in murine Hras^G12V driven aggressive thyroid cancers: Consequent adaptive and acquired resistance mechanisms inform combination treatments with improved responses

Brian R. Untch, Vanessa Dos Anjos, Maria ER Garcia-Rendueles, Jeff A. Knauf, Alan L. Ho, James A. Fagin

Cancer Res (2017) 77 (13_Supplement): 2063.

DOI: https://doi.org/10.1158/1538-7445.AM2017-2063

Published: 01 July 2017

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Journal Articles

Abstract 892: Functional characterization of EIF1AX mutations in thyroid cancer predicts for gain of function by increasing translational rate with concomitant derepression of upstream inputs from mTOR

Gnana P. Krishnamoorthy, Inigo Landa, Jeffrey A. Knauf, James Nagarajah, Gunnar Rätsch, Hans-Guido Wendel, James A. Fagin

Cancer Res (2016) 76 (14_Supplement): 892.

DOI: https://doi.org/10.1158/1538-7445.AM2016-892

Published: 15 July 2016

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Journal Articles

Abstract 790: Altiratinib is a potent inhibitor of TRK kinases and is efficacious in TRK-fusion driven cancer models

Bryan D. Smith, Cynthia B. Leary, Benjamin A. Turner, Michael D. Kaufman, Scott C. Wise, Maria E. R. Garcia-Rendueles, James A. Fagin, Daniel L. Flynn

Cancer Res (2015) 75 (15_Supplement): 790.

DOI: https://doi.org/10.1158/1538-7445.AM2015-790

Published: 01 August 2015

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Journal Articles

Abstract 3402: Relief of feedback inhibition of HER3 transcription by RAF and MEK inhibitors attenuates their antitumor effects in BRAF mutant thyroid carcinomas.

Cristina Montero-Conde, Sergio Ruiz-Llorente, Jose M. Dominguez, Jeffrey A. Knauf, Agnes Viale, Eric J. Sherman, Mabel Ryder, Ronald A. Ghossein, Neal Rosen, James A. Fagin

Cancer Res (2013) 73 (8_Supplement): 3402.

DOI: https://doi.org/10.1158/1538-7445.AM2013-3402

Published: 15 April 2013

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Journal Articles

Abstract 4290: The farnesyl transferase inhibitor SCH 66336 induces regression of Hras-driven tumors in mice with widespread endogenous expression of HrasG12V

Xu Chen, Linda K. Johnson, Jeffrey A. Knauf, James A. Fagin

Cancer Res (2011) 71 (8_Supplement): 4290.

DOI: https://doi.org/10.1158/1538-7445.AM2011-4290

Published: 15 April 2011

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Journal Articles

Genomic and Biological Characterization of Exon 4 KRAS Mutations in Human Cancer

Cancer Res (2010) 70 (14): 5901–5911.

DOI: https://doi.org/10.1158/0008-5472.CAN-10-0192

Published: 14 July 2010

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Includes: Supplementary data

Journal Articles

Mutational Profile of Advanced Primary and Metastatic Radioactive Iodine-Refractory Thyroid Cancers Reveals Distinct Pathogenetic Roles for BRAF, PIK3CA, and AKT1

Julio C. Ricarte-Filho, Mabel Ryder, Dhananjay A. Chitale, Michael Rivera, Adriana Heguy, Marc Ladanyi, Manickam Janakiraman, David Solit, Jeffrey A. Knauf, R. Michael Tuttle, Ronald A. Ghossein, James A. Fagin

Cancer Res (2009) 69 (11): 4885–4893.

DOI: https://doi.org/10.1158/0008-5472.CAN-09-0727

Published: 01 June 2009

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Includes: Supplementary data

Journal Articles

RET/PTC-Induced Cell Growth Is Mediated in Part by Epidermal Growth Factor Receptor (EGFR) Activation: Evidence for Molecular and Functional Interactions between RET and EGFR

Michelle Croyle, Nagako Akeno, Jeffrey A. Knauf, Doriano Fabbro, Xu Chen, Jacqueline E. Baumgartner, Heidi A. Lane, James A. Fagin

Cancer Res (2008) 68 (11): 4183–4191.

DOI: https://doi.org/10.1158/0008-5472.CAN-08-0413

Published: 02 June 2008

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Journal Articles

The RET Kinase Inhibitor NVP-AST487 Blocks Growth and Calcitonin Gene Expression through Distinct Mechanisms in Medullary Thyroid Cancer Cells

Nagako Akeno-Stuart, Michelle Croyle, Jeffrey A. Knauf, Roberta Malaguarnera, Donata Vitagliano, Massimo Santoro, Christine Stephan, Konstantina Grosios, Markus Wartmann, Robert Cozens, Giorgio Caravatti, Doriano Fabbro, Heidi A. Lane, James A. Fagin

Cancer Res (2007) 67 (14): 6956–6964.

DOI: https://doi.org/10.1158/0008-5472.CAN-06-4605

Published: 17 July 2007

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Journal Articles

Conditional Activation of RET/PTC3 and BRAFV600E in Thyroid Cells Is Associated with Gene Expression Profiles that Predict a Preferential Role of BRAF in Extracellular Matrix Remodeling

Cleo Mesa, Jr., Mana Mirza, Norisato Mitsutake, Maureen Sartor, Mario Medvedovic, Craig Tomlinson, Jeffrey A Knauf, Georg F. Weber, James A. Fagin

Cancer Res (2006) 66 (13): 6521–6529.

DOI: https://doi.org/10.1158/0008-5472.CAN-06-0739

Published: 03 July 2006

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Journal Articles

Targeted Expression of BRAF^V600E in Thyroid Cells of Transgenic Mice Results in Papillary Thyroid Cancers that Undergo Dedifferentiation

Jeffrey A. Knauf, Xiaolan Ma, Eric P. Smith, Lei Zhang, Norisato Mitsutake, Xiao-Hui Liao, Samuel Refetoff, Yuri E. Nikiforov, James A. Fagin

Cancer Res (2005) 65 (10): 4238–4245.

DOI: https://doi.org/10.1158/0008-5472.CAN-05-0047

Published: 16 May 2005

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Journal Articles

Conditional BRAF^V600E Expression Induces DNA Synthesis, Apoptosis, Dedifferentiation, and Chromosomal Instability in Thyroid PCCL3 Cells

Norisato Mitsutake, Jeffrey A. Knauf, Shin Mitsutake, Cleo Mesa, Jr., Lei Zhang, James A. Fagin

Cancer Res (2005) 65 (6): 2465–2473.

DOI: https://doi.org/10.1158/0008-5472.CAN-04-3314

Published: 21 March 2005

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Journal Articles

High Prevalence of BRAF Mutations in Thyroid Cancer: Genetic Evidence for Constitutive Activation of the RET/PTC-RAS-BRAF Signaling Pathway in Papillary Thyroid Carcinoma

Edna T. Kimura, Marina N. Nikiforova, Zhaowen Zhu, Jeffrey A. Knauf, Yuri E. Nikiforov, James A. Fagin

Cancer Res (2003) 63 (7): 1454–1457.

Published: 01 April 2003

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Journal Articles

Distinct Pattern of ret Oncogene Rearrangements in Morphological Variants of Radiation-induced and Sporadic Thyroid Papillary Carcinomas in Children

Yuri E. Nikiforov, Jon M. Rowland, Kevin E. Bove, Hector Monforte-Munoz, James A. Fagin

Cancer Res (1997) 57 (9): 1690–1694.

Published: 01 May 1997

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NARROW

Abstract 1181: PTEN loss-of-function mutations prevalent in HRAS-mutant cancers results in resistance to targeted therapy

Abstract 986: RBM10 loss in thyroid cancer leads to aberrant splicing of cytoskeletal and extracellular matrix mRNAs and increased metastatic fitness

Abstract 913: Tert mutant promoter mouse model induces cancer progression in Braf^V600E-driven thyroid tumors: A novel tool to understand the biology of telomerase-reactivated cancers

Targeting Novel Sodium Iodide Symporter Interactors ADP-Ribosylation Factor 4 and Valosin-Containing Protein Enhances Radioiodine Uptake

Tipifarnib Inhibits HRAS-Driven Dedifferentiated Thyroid Cancers

Abstract 1225: A unified model of RAF inhibitor action determines inhibitor activity in BRAF-dependent tumors

Abstract 2063: The farnesyltransferase inhibitor tipifarnib causes dramatic tumor regression and increases survival in murine Hras^G12V driven aggressive thyroid cancers: Consequent adaptive and acquired resistance mechanisms inform combination treatments with improved responses

Abstract 892: Functional characterization of EIF1AX mutations in thyroid cancer predicts for gain of function by increasing translational rate with concomitant derepression of upstream inputs from mTOR

Abstract 790: Altiratinib is a potent inhibitor of TRK kinases and is efficacious in TRK-fusion driven cancer models

Abstract 3402: Relief of feedback inhibition of HER3 transcription by RAF and MEK inhibitors attenuates their antitumor effects in BRAF mutant thyroid carcinomas.

Abstract 4290: The farnesyl transferase inhibitor SCH 66336 induces regression of Hras-driven tumors in mice with widespread endogenous expression of HrasG12V

Genomic and Biological Characterization of Exon 4 KRAS Mutations in Human Cancer

Mutational Profile of Advanced Primary and Metastatic Radioactive Iodine-Refractory Thyroid Cancers Reveals Distinct Pathogenetic Roles for BRAF, PIK3CA, and AKT1

RET/PTC-Induced Cell Growth Is Mediated in Part by Epidermal Growth Factor Receptor (EGFR) Activation: Evidence for Molecular and Functional Interactions between RET and EGFR

The RET Kinase Inhibitor NVP-AST487 Blocks Growth and Calcitonin Gene Expression through Distinct Mechanisms in Medullary Thyroid Cancer Cells

Conditional Activation of RET/PTC3 and BRAFV600E in Thyroid Cells Is Associated with Gene Expression Profiles that Predict a Preferential Role of BRAF in Extracellular Matrix Remodeling

Targeted Expression of BRAF^V600E in Thyroid Cells of Transgenic Mice Results in Papillary Thyroid Cancers that Undergo Dedifferentiation

Conditional BRAF^V600E Expression Induces DNA Synthesis, Apoptosis, Dedifferentiation, and Chromosomal Instability in Thyroid PCCL3 Cells

High Prevalence of BRAF Mutations in Thyroid Cancer: Genetic Evidence for Constitutive Activation of the RET/PTC-RAS-BRAF Signaling Pathway in Papillary Thyroid Carcinoma

Distinct Pattern of ret Oncogene Rearrangements in Morphological Variants of Radiation-induced and Sporadic Thyroid Papillary Carcinomas in Children

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