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Jaffer A. Ajani
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Journal Articles

Abstract 166: Spatial subtypes and cellular interactions of cancer-associated fibroblasts revealed by single-cell spatial omics

Yunhe Liu, Ansam Sinjab, Jimin Min, Guangchun Han, Francesca Paradiso, Yuanyuan Zhang, Yang Liu, Ruiping Wang, Guangsheng Pei, Kyung Serk Cho, Enyu Dai, Akshay Basi, Jared K. Burks, Kimal I. Rajapakshe, Yanshuo Chu, Jiahui Jiang, Daiwei Zhang, Xinmiao Yan, Paola A. Guerrero, Alejandra Serrano, Mingyao Li, Tae Hyun Hwang, Andrew Futreal, Jaffer A. Ajani, Luisa M Solis Soto, Amir A. Jazaeri, Humam Kadara, Anirban Maitra, Linghua Wang
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 166.
https://doi.org/10.1158/1538-7445.AM2025-166
Published: 21 April 2025
View articletitled, Abstract 166: Spatial subtypes and cellular interactions of cancer-associated fibroblasts revealed by single-cell spatial omics
Journal Articles

Abstract 516: SOX4 dictates gastric cancer progression by modulating the tumor immune microenvironment

Gengyi Zou, Katsuhiro Yoshimura, Yibo Fan, Ruiping Wang, Kohei Yamashita, Shan Shao, Ailing Scott, Jiankang Jin, Melissa P. Pizzi, Matheus Silva, Xiaodan Yao, Calena Brown, Rebecca Waters, Shumei Song, Linghua Wang, Shilpa Dhar, Jaffer A. Ajani
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 516.
https://doi.org/10.1158/1538-7445.AM2025-516
Published: 21 April 2025
View articletitled, Abstract 516: SOX4 dictates gastric cancer progression by modulating the tumor immune microenvironment
Journal Articles

Abstract 1186: microRNA-targeted small molecule inhibitors in metastatic cancers

Maria-Ancuta Jurj, Michael A. Attathikhun, Meng Chen, Corina Minciuna, Venkata Narayana Vidadala, Gabriele Varani, Jaffer A. Ajani, George A. Calin
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 1186.
https://doi.org/10.1158/1538-7445.AM2025-1186
Published: 21 April 2025
View articletitled, Abstract 1186: microRNA-targeted small molecule inhibitors in metastatic cancers
Journal Articles

Abstract 7475: A comprehensive single-cell atlas of gastric cancer reveals malignant cell state dynamics and plasticity in tumor progression and metastasis

Enyu Dai, Yanshuo Chu, Yang Liu, Ruiping Wang, Yibo Dai, Jaffer A. Ajani, Linghua Wang
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 7475.
https://doi.org/10.1158/1538-7445.AM2025-7475
Published: 21 April 2025
View articletitled, Abstract 7475: A comprehensive single-cell atlas of gastric cancer reveals malignant cell state dynamics and plasticity in tumor progression and metastasis
Journal Articles

Abstract P28: Comprehensive Molecular Phenotyping of ARID1A-deficient Gastric Cancer Reveals Pervasive Epigenomic Reprogramming and Therapeutic Opportunities

Chang Xu, Kie Kyon Huang, Jia Hao Law, Joy Shijia Chua, Taotao Sheng, Natasha M. Flores, Melissa Pool Pizzi, Atsushi Okabe, Angie Lay Keng Tan, Feng Zhu, Vikrant Kumar, Xiaoyin Lu, Ana Morales Benitez, Benedict Shi Xiang Lian, Haoran Ma, Shamaine Wei Ting Ho, Kalpana Ramnarayanan, Chukwuemeka George Anene-Nzelu, Milad Razavi-Mohseni, Siti Aishah Binte Abdul Ghani, Su Ting Tay, Xuewen Ong, Ming Hui Lee, Yu Amanda Guo, Hassan Ashktorab, Duane Smoot, Shang Li, Anders Jacobsen Skanderup, Michael A. Beer, Roger Sik Yin Foo, Joel Shi Hao Wong, Kaushal Sanghvi, Wei Peng Yong, Raghav Sundar, Atsushi Kaneda, Shyam Prabhakar, Pawel Karol Mazur, Jaffer A. Ajani, Khay Guan Yeoh, Jimmy Bok-Yan So, Patrick Tan, Singapore Gastric Cancer Consortium
Journal: Cancer Research
Cancer Res (2024) 84 (8_Supplement): P28.
https://doi.org/10.1158/1538-7445.FCS2023-P28
Published: 15 April 2024
View articletitled, Abstract P28: Comprehensive Molecular Phenotyping of ARID1A-deficient Gastric Cancer Reveals Pervasive Epigenomic Reprogramming and Therapeutic Opportunities
Journal Articles

Abstract 1730: Unraveling the oncogenic potential of KDM2A with gastric organoids

Shilpa S. Dhar, Calena Brown, Constantin Zod, Jaffer A. Ajani, Min Gyu Lee
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1730.
https://doi.org/10.1158/1538-7445.AM2024-1730
Published: 22 March 2024
View articletitled, Abstract 1730: Unraveling the oncogenic potential of KDM2A with gastric organoids
Journal Articles

Abstract 6200: Single-cell analyses unravel novel immune and tumor cell characteristics linked to the response to neoadjuvant immune checkpoint blockade in patients with gastric cancer

Enyu Dai, Jiang-Jiang Qin, Can Hu, Zhiyuan Xu, Guangchun Han, Yanshuo Chu, Ruiping Wang, Minghao Dang, Yunhe Liu, Guangsheng Pei, Jiahui Jiang, Fuduan Peng, Yuanyuan Zhang, Andre Luis Faustino, Jaffer A. Ajani, Linghua Wang, Xiangdong Cheng
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6200.
https://doi.org/10.1158/1538-7445.AM2024-6200
Published: 22 March 2024
View articletitled, Abstract 6200: Single-cell analyses unravel novel immune and tumor cell characteristics linked to the response to neoadjuvant immune checkpoint blockade in patients with gastric cancer
Journal Articles

Abstract 3317: KRASmulti inhibitor BI 3706674 shows efficacy in KRAS-driven preclinical models of cancer that supports clinical testing in patients with tumors harbouring KRASG12V mutations and KRAS wild-type amplifications

Antonio Tedeschi, David H. Peng, Fiorella Schischlik, Lorenz Herdeis, Otmar Schaaf, Valeria Santoro, Daniel Gerlach, Fabio Savarese, Jesse Lipp, Christian Haslinger, Francesca Rocchetti, Johannes Popow, Heinrich J. Huber, Birgit Wilding, Matthias Treu, Julian Fuchs, Joachim Broeker, Tobias Wunber, Michael Gmachl, Klaus Rumpel, Matthew Rees, Melissa Ron, Jennifer Roth, Mariah Williams, Charles Deckard, Vandhana Ramamoorthy, Joseph R. Daniele, Jaffer A. Ajani, Funda Meric-Bernstam, Scott Kopetz, Michael Kim, Don L. Gibbons, Christopher P. Vellano, Joseph R. Marszalek, Timothy P. Heffernan, Darryl McConnell, Mark Pearson, Norbert Kraut, Dorothea Rudolph
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3317.
https://doi.org/10.1158/1538-7445.AM2024-3317
Published: 22 March 2024
View articletitled, Abstract 3317: KRASmulti inhibitor BI 3706674 shows efficacy in KRAS-driven preclinical models of cancer that supports clinical testing in patients with tumors harbouring KRASG12V mutations and KRAS wild-type amplifications
Journal Articles

Galectin-3 Cooperates with CD47 to Suppress Phagocytosis and T-cell Immunity in Gastric Cancer Peritoneal Metastases

Yibo Fan, Shumei Song, Yuan Li, Shilpa S. Dhar, Jiankang Jin, Katsuhiro Yoshimura, Xiaodan Yao, Ruiping Wang, Ailing W. Scott, Melissa Pool Pizzi, Jingjing Wu, Lang Ma, George A. Calin, Samir Hanash, Linghua Wang, Michael Curran, Jaffer A. Ajani
Journal: Cancer Research
Cancer Res (2023) 83 (22): 3726–3738.
https://doi.org/10.1158/0008-5472.CAN-23-0783
Published: 15 November 2023
View articletitled, Galectin-3 Cooperates with CD47 to Suppress Phagocytosis and T-cell Immunity in Gastric Cancer Peritoneal Metastases
Open the PDF for Galectin-3 Cooperates with CD47 to Suppress Phagocytosis and T-cell Immunity in Gastric Cancer Peritoneal Metastases in another window
Includes: Supplementary data
Journal Articles

Abstract 951: Clinical model for predicting pathological complete response in patients with esophageal and gastroesophageal junction adenocarcinoma after trimodality therapy

Kohei Yamashita, Jacob M. Maronge, Melissa Pool Pizzi, Wayne L. Hofstetter, Aileen Chen, Matheus Sewastjanow-Silva, Ernesto Rosa Vicentini, Meita S. Hirschmann, Anh Ta, Namita Shanbhag, Ying Yuan, Jaffer A. Ajani
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 951.
https://doi.org/10.1158/1538-7445.AM2023-951
Published: 04 April 2023
View articletitled, Abstract 951: Clinical model for predicting pathological complete response in patients with esophageal and gastroesophageal junction adenocarcinoma after trimodality therapy
Journal Articles

Abstract 1305: Cellular and molecular landscape of metastatic gastric cancer

Enyu Dai, Jiang-Jiang Qin, Jibo Wu, Natasha M. Flores, Yanshuo Chu, Ruiping Wang, Minghao Dang, Zhiyuan Xu, Guangchun Han, Xuanye Cao, Can Hu, Jieer Ying, Yian Du, Litao Yang, Xiaoqing Guan, Shaowei Mo, Xiaoyin Lu, Ana Morales Benitez, Rebecca E. Waters, Melissa Pool Pizzi, Namita Shanbhag, Yibo Fan, Fuduan Peng, Andrew Futreal, Shumei Song, Cassian Yee, Pawel K. Mazur, Xiangdong Cheng, Jaffer A. Ajani, Linghua Wang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1305.
https://doi.org/10.1158/1538-7445.AM2023-1305
Published: 04 April 2023
View articletitled, Abstract 1305: Cellular and molecular landscape of metastatic gastric cancer
Journal Articles

Abstract 1194: Evolution of immune and stromal cell states during the gastric cancer continuum

Ruiping Wang, Shumei Song, Jiangjiang Qin, Katsuhiro Yoshimura, Fuduan Peng, Yanshuo Chu, Yuan Li, Yibo Fan, Jiankang Jin, Minghao Dang, Enyu Dai, Guangsheng Pei, Guangchun Han, Yating Li, Deyali Chatterjee, Melissa P. Pizzi, Ailing W. Scott, Ghia Tatlonghari, Xinmiao Yan, Matheus Da Silva Sewastjanow, Ahmed Adel Fouad Abdelhakeem, Pawel K. Mazur, Xiangdong Cheng, Jaffer A. Ajani, Linghua Wang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1194.
https://doi.org/10.1158/1538-7445.AM2023-1194
Published: 04 April 2023
View articletitled, Abstract 1194: Evolution of immune and stromal cell states during the gastric cancer continuum
Journal Articles

Abstract 1612: Therapeutic co-targeting YAP1 and TAZ using antisense oligos (ASOs) suppress gastric cancer progression and peritoneal metastases

Jingjing Wu, Ailing Scott, Yan Xu, Yuan Li, Yibo Fan, Ruiping Wang, Xiaodan Yao, Katsuhiro Yoshimura, Melissa Pool Pizzi, Kohei Yamashita, Shan Shao, Christopher Vellano, Linghua Wang, Alexey Revenko, Eric Dolinski, Jaffer A. Ajani, Shumei Song
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1612.
https://doi.org/10.1158/1538-7445.AM2023-1612
Published: 04 April 2023
View articletitled, Abstract 1612: Therapeutic co-targeting YAP1 and TAZ using antisense oligos (ASOs) suppress gastric cancer progression and peritoneal metastases
Journal Articles

Abstract 5017: A single-cell atlas of tumor microenvironment defines the continuum of gastric adenocarcinoma tumorigenesis and progression

Ruiping Wang, Shumei Song, Jiangjiang Qin, Yuan Li, Yibo Fan, Deyali Chatterjee, Ghia Tatlonghari, Zhiyuan Xu, Can Hu, Shaowei Mo, Matheus D. Sewastjanow, Ahmed Adel Fouad Abdelhakeem, Zhenning Wang, Xiangdong Cheng, Jaffer A. Ajani, Linghua Wang
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5017.
https://doi.org/10.1158/1538-7445.AM2022-5017
Published: 15 June 2022
View articletitled, Abstract 5017: A single-cell atlas of tumor microenvironment defines the continuum of gastric adenocarcinoma tumorigenesis and progression
Journal Articles

Abstract 1588: Discordance of HER2 expression and/or amplification on repeat testing

Timothy D. DiPeri, Kathleen Kong, Daniel D. Karp, Jaffer A. Ajani, Shubham Pant, Sarina A. Piha-Payl, Ecaterina E. Dumbrava, Funda Meric-Bernstam
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1588.
https://doi.org/10.1158/1538-7445.AM2022-1588
Published: 15 June 2022
View articletitled, Abstract 1588: Discordance of HER2 expression and/or amplification on repeat testing
Journal Articles

Abstract 327: Antitumor efficacy of trastuzumab deruxtecan in combination with adavosertib in HER2-expressing Cyclin E amplified gastroesophageal cancers

Timothy P. DiPeri, Kurt W. Evans, Gabriela Raso, Yasmeen Q. Rizvi, Xiaofeng Zheng, Bryce Kirby, Kathleen Kong, Khandan Keyomarsi, Jaffer A. Ajani, Timothy A. Yap, Funda Meric-Bernstam
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 327.
https://doi.org/10.1158/1538-7445.AM2022-327
Published: 15 June 2022
View articletitled, Abstract 327: Antitumor efficacy of trastuzumab deruxtecan in combination with adavosertib in HER2-expressing Cyclin E amplified gastroesophageal cancers
Journal Articles

Abstract CT023: Nivolumab (NIVO) plus chemotherapy (chemo) vs chemo as first-line (1L) treatment for advanced gastric cancer/gastroesophageal junction cancer/esophageal adenocarcinoma (GC/GEJC/EAC): CheckMate 649 biomarker analyses

Ming Lei, Yelena Y. Janjigian, Jaffer A. Ajani, Markus Moehler, Xuya Wang, Lin Shen, Marcelo Garrido, Carlos Gallardo, Kensei Yamaguchi, Lucjan Wyrwicz, Tomasz Skoczylas, Arinilda Bragagnoli, Tianshu Liu, Mustapha Tehfe, Elena Elimova, Mingshun Li, Valerie Poulart, Yu Wang, Parul Doshi, Kohei Shitara
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): CT023.
https://doi.org/10.1158/1538-7445.AM2022-CT023
Published: 15 June 2022
View articletitled, Abstract CT023: Nivolumab (NIVO) plus chemotherapy (chemo) vs chemo as first-line (1L) treatment for advanced gastric cancer/gastroesophageal junction cancer/esophageal adenocarcinoma (GC/GEJC/EAC): CheckMate 649 biomarker analyses
Journal Articles

Extracellular Vesicles from Cancer-Associated Fibroblasts Containing Annexin A6 Induces FAK-YAP Activation by Stabilizing β1 Integrin, Enhancing Drug Resistance

Tomoyuki Uchihara, Keisuke Miyake, Atsuko Yonemura, Yoshihiro Komohara, Rumi Itoyama, Mayu Koiwa, Tadahito Yasuda, Kota Arima, Kazuto Harada, Kojiro Eto, Hiromitsu Hayashi, Masaaki Iwatsuki, Shiro Iwagami, Yoshifumi Baba, Naoya Yoshida, Masakazu Yashiro, Mari Masuda, Jaffer A. Ajani, Patrick Tan, Hideo Baba, Takatsugu Ishimoto
Journal: Cancer Research
Cancer Res (2020) 80 (16): 3222–3235.
https://doi.org/10.1158/0008-5472.CAN-19-3803
Published: 14 August 2020
View articletitled, Extracellular Vesicles from Cancer-Associated Fibroblasts Containing Annexin A6 Induces FAK-YAP Activation by Stabilizing β1 Integrin, Enhancing Drug Resistance
Open the PDF for Extracellular Vesicles from Cancer-Associated Fibroblasts Containing Annexin A6 Induces FAK-YAP Activation by Stabilizing β1 Integrin, Enhancing Drug Resistance in another window
Includes: Multimedia, Supplementary data
Journal Articles

Abstract 4362: Glucose transporter 1 regulates cell glycolysis and proliferation in gastrointestinal stromal tumor and its clinicopathological significance

Masaaki Iwatsuki, Hiroshi Sawayama, Daisuke Kuroda, Yuki Koga, Kohei Yamashita, Kazuto Harada, Shiro Iwagami, Kojiro Eto, Takatsugu Ishimoto, Yoshifumi Baba, Naoya Yoshida, Jaffer A. Ajani, Hideo Baba
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4362.
https://doi.org/10.1158/1538-7445.AM2019-4362
Published: 01 July 2019
View articletitled, Abstract 4362: Glucose transporter 1 regulates cell glycolysis and proliferation in gastrointestinal stromal tumor and its clinicopathological significance
Journal Articles

Abstract 1071: Overexpression of SHH and GLI1 contributes to poor prognosis and peritoneal metastases in gastric adenocarcinoma

Yan Xu, Yuan Li, Bovey Liu, Melissa Pool Pizzi, Yongxi Song, Kazuto Harada, Ailing Scott, Lang Ma, Jiankang Jin, Xiaochuan Dong, Ying Wang, Brian D. Badgwell, Jeannelyn S. Estrella, Roy-Chowdhuri Sinchita, Fatemeh G. Amlashi, Zhenning Wang, Shumei Song, Jaffer A. Ajani
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1071.
https://doi.org/10.1158/1538-7445.AM2018-1071
Published: 01 July 2018
View articletitled, Abstract 1071: Overexpression of SHH and GLI1 contributes to poor prognosis and peritoneal metastases in gastric adenocarcinoma