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Jacob A. Boyer
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Journal Articles

Tumorigenesis Driven by BRAFV600E Requires Secondary Mutations That Overcome Its Feedback Inhibition of RAC1 and Migration

Open Access
Sunyana Gadal, Jacob A. Boyer, Simon F. Roy, Noah A. Outmezguine, Malvika Sharma, Hongyan Li, Ning Fan, Eric Chan, Yevgeniy Romin, Afsar Barlas, Qing Chang, Priya Pancholi, Neilawattie Merna Timaul, Michael Overholtzer, Rona Yaeger, Katia Manova-Todorova, Elisa de Stanchina, Marcus W. Bosenberg, Neal Rosen
Journal: Cancer Research
Cancer Res (2025) 85 (9): 1611–1627.
https://doi.org/10.1158/0008-5472.CAN-24-2220
Published: 02 May 2025
View articletitled, Tumorigenesis Driven by BRAFV600E Requires Secondary Mutations That Overcome Its Feedback Inhibition of RAC1 and Migration
Open the PDF for Tumorigenesis Driven by BRAFV600E Requires Secondary Mutations That Overcome Its Feedback Inhibition of RAC1 and Migration in another window
Includes: Multimedia, Supplementary data
Journal Articles

Abstract LB055: A ketogenic diet sensitizes pancreatic cancer to inhibition of glutamine metabolism

Free
Omid Hajihassani, Mehrdad Zarei, Asael Roichman, Alexander Loftus, Christina Boutros, Jonathan Hue, Parnian Naji, Jacob A. Boyer, Soubhi Tahhan, Peter Gallagher, William Beegan, James Choi, Shihong Lei, Christine Kim, Moeez Rathore, Faith Nakazzi, Ishan Shah, Kevin Lebo, Helen Cheng, Anusha Mudigonda, Sydney Alibeckoff, Karen Ji, Hallie Graor, Priyashree Sunita, Goutam Dey, Masaru Miyagi, Ali Vaziri-Gohar, Henri Brunengraber, Rui Wang, Peder Lund, Luke Rothermel, Joshua D. Rabinowitz, Jordan M. Winter
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_2): LB055.
https://doi.org/10.1158/1538-7445.AM2025-LB055
Published: 25 April 2025
View articletitled, Abstract LB055: A ketogenic diet sensitizes pancreatic cancer to inhibition of glutamine metabolism
Journal Articles

Abstract 2422: Migration of V600E-expressing cells is suppressed by ERK-dependent feedback inhibition of RAC1 and rescued in melanoma by secondary mutations

Free
Sunyana Gadal, Jacob A. Boyer, Hongyan Li, Ning Fan, Eric Chan, Yevgeniy Romin, Elisa De Stanchina, Rona Yeager, Marcus Bosenberg, Katia M. Todorova, Neal Rosen
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2422.
https://doi.org/10.1158/1538-7445.AM2022-2422
Published: 15 June 2022
View articletitled, Abstract 2422: Migration of V600E-expressing cells is suppressed by ERK-dependent feedback inhibition of RAC1 and rescued in melanoma by secondary mutations
Journal Articles

Abstract 835: Estrogen receptor expression and ER dependent breast tumor growth are dependent on translation initiation factor EIF4A

Free
Jacob A. Boyer, Madeline A. Dorso, Corina Amor, Jason Reiter, Jianing Xu, Elisa de Stanchina, Hans-Guido Wendel, Sarat Chandarlapaty, Neal Rosen
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 835.
https://doi.org/10.1158/1538-7445.AM2022-835
Published: 15 June 2022
View articletitled, Abstract 835: Estrogen receptor expression and ER dependent breast tumor growth are dependent on translation initiation factor EIF4A
Journal Articles

Abstract 1090: Regulation of PTEN translation by PI3K signaling maintains pathway homeostasis

Free
Radha Mukherjee, Kiran Gireesan Vanaja, Jacob A. Boyer, Juan Qiu, Xiaoping Chen, Elisa de Stanchina, Sarat Chandarlapaty, Andre Levchenko, Neal Rosen
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1090.
https://doi.org/10.1158/1538-7445.AM2020-1090
Published: 15 August 2020
View articletitled, Abstract 1090: Regulation of PTEN translation by PI3K signaling maintains pathway homeostasis