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Jaclyn F. Hechtman
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Journal Articles

Abstract CT020: Long-term outcomes of patients with TRK fusion cancer treated with larotrectinib

Free
Alexander Drilon, Shivaani Kummar, Catherine M. Albert, Ramamoorthy Nagasubramanian, Jaclyn F. Hechtman, John A. Reeves, Georg Beckmann, Marion Rudolph, Justyna A. Wierzbińska, Laura Dima, Nicoletta Brega, Theodore W. Laetsch, David S. Hong
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): CT020.
https://doi.org/10.1158/1538-7445.AM2021-CT020
Published: 01 July 2021
View articletitled, Abstract CT020: Long-term outcomes of patients with TRK fusion cancer treated with larotrectinib
Journal Articles

Abstract 6095: Unique tumor microbiome in microsatellite instability high (MSI-H) colon carcinoma

Free
Chad Michael Vanderbilt, Ajaratu Keshinro, Chin-Tung Chen, Esther Babady, Michael F. Berger, Ahmet Zehir, Marc Ladanyi, Jaclyn F. Hechtman, Zsofia K. Stadler, Jinru Shia, Martin R. Weiser
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 6095.
https://doi.org/10.1158/1538-7445.AM2020-6095
Published: 15 August 2020
View articletitled, Abstract 6095: Unique tumor microbiome in microsatellite instability high (MSI-H) colon carcinoma
Journal Articles

Abstract 5280: Kinase fusions drive endocrine resistance in estrogen receptor-positive breast cancer

Free
Bo Liu, Dara S. Ross, Alison M. Schram, Pedram Razavi, Stephen M. Lagana, Yanming Zhang, Maurizio Scaltriti, Jacqueline F. Bromberg, Marc Ladanyi, David M. Hyman, Alexander Drilon, Ahmet Zahir, Ryma Benayed, Jaclyn F. Hechtman, Sarat Chandarlapaty
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5280.
https://doi.org/10.1158/1538-7445.AM2020-5280
Published: 15 August 2020
View articletitled, Abstract 5280: Kinase fusions drive endocrine resistance in estrogen receptor-positive breast cancer
Journal Articles

Abstract LB-118: Resistance to TRK inhibition mediated by convergent MAP kinase pathway activation

Free
Emiliano Cocco, Amanda Kulick, Sandra Misale, Rona Yaeger, Pedram Razavi, Helen H. Won, Ryan Ptashkin, Jaclyn F. Hechtman, Eneda Toska, James Cownie, Romel Somwar, Sophie Shifman, Marissa Mattar, S Duygu Selçuklu, Aliaksandra Samoila, Sean Guzman, Brian B. Tuch, Kevin Ebata, Elisa de Stanchina, Rebecca J. Nagy, Richard B. Lanman, Michael F. Berger, Marc Ladanyi, David M. Hyman, Alexander Drilon, Maurizio Scaltriti, Alison M. Schram
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): LB-118.
https://doi.org/10.1158/1538-7445.AM2019-LB-118
Published: 01 July 2019
View articletitled, Abstract LB-118: Resistance to TRK inhibition mediated by convergent MAP kinase pathway activation
Journal Articles

Detection of NTRK Fusions: Merits and Limitations of Current Diagnostic Platforms

Free
James P. Solomon, Jaclyn F. Hechtman
Journal: Cancer Research
Cancer Res (2019) 79 (13): 3163–3168.
https://doi.org/10.1158/0008-5472.CAN-19-0372
Published: 01 July 2019
View articletitled, Detection of NTRK Fusions: Merits and Limitations of Current Diagnostic Platforms
Open the PDF for Detection of NTRK Fusions: Merits and Limitations of Current Diagnostic Platforms in another window
Journal Articles

Colorectal Carcinomas Containing Hypermethylated MLH1 Promoter and Wild-Type BRAF/KRAS Are Enriched for Targetable Kinase Fusions

Free
Emiliano Cocco, Jamal Benhamida, Sumit Middha, Ahmet Zehir, Kerry Mullaney, Jinru Shia, Rona Yaeger, Liying Zhang, Donna Wong, Liliana Villafania, Khedoudja Nafa, Maurizio Scaltriti, Alexander Drilon, Leonard Saltz, Alison M. Schram, Zsofia K. Stadler, David M. Hyman, Ryma Benayed, Marc Ladanyi, Jaclyn F. Hechtman
Journal: Cancer Research
Cancer Res (2019) 79 (6): 1047–1053.
https://doi.org/10.1158/0008-5472.CAN-18-3126
Published: 15 March 2019
View articletitled, Colorectal Carcinomas Containing Hypermethylated MLH1 Promoter and Wild-Type BRAF/KRAS Are Enriched for Targetable Kinase Fusions
Open the PDF for Colorectal Carcinomas Containing Hypermethylated MLH1 Promoter and Wild-Type BRAF/KRAS Are Enriched for Targetable Kinase Fusions in another window
Journal Articles

Mechanisms of Acquired Resistance to BRAF V600E Inhibition in Colon Cancers Converge on RAF Dimerization and Are Sensitive to Its Inhibition

Free
Rona Yaeger, Zhan Yao, David M. Hyman, Jaclyn F. Hechtman, Efsevia Vakiani, HuiYong Zhao, Wenjing Su, Lu Wang, Andrew Joelson, Andrea Cercek, Jose Baselga, Elisa de Stanchina, Leonard Saltz, Michael F. Berger, David B. Solit, Neal Rosen
Journal: Cancer Research
Cancer Res (2017) 77 (23): 6513–6523.
https://doi.org/10.1158/0008-5472.CAN-17-0768
Published: 30 November 2017
View articletitled, Mechanisms of Acquired Resistance to BRAF V600E Inhibition in Colon Cancers Converge on RAF Dimerization and Are Sensitive to Its Inhibition
Open the PDF for Mechanisms of Acquired Resistance to BRAF V600E Inhibition in Colon Cancers Converge on RAF Dimerization and Are Sensitive to Its Inhibition in another window
Includes: Supplementary data
Journal Articles

Abstract LB-302: Potential role of larotrectinib (LOXO-101), a selective pan-TRK inhibitor, in NTRK fusion-positive recurrent glioblastoma

Free
Alison M. Schram, Barry S. Taylor, Jaclyn F. Hechtman, Ryma Benayed, Lu Wang, Bethany Hanusch, Robert Young, Christian Grommes, Nora Ku, David M. Hyman, Thomas Kaley, Alexander Drilon
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): LB-302.
https://doi.org/10.1158/1538-7445.AM2017-LB-302
Published: 01 July 2017
View articletitled, Abstract LB-302: Potential role of larotrectinib (LOXO-101), a selective pan-TRK inhibitor, in NTRK fusion-positive recurrent glioblastoma
Journal Articles

Abstract 4380: Integrative genomics analysis of metastatic colorectal cancer

Free
Marla Lipsyc, Walid Chatila, Jaclyn F. Hechtman, Francisco Sanchez-Vega, Sumit Middha, Andrea Cercek, Zsofia Stadler, Ritika Kundra, Aijazuddin Syed, David M. Hyman, Ahmet Zehir, Armin Shahrokni, Anna Varghese, Diane Reidy, Neil H. Segal, Efsevia Vakiani, David B. Solit, Marc Ladanyi, Michael F. Berger, Nancy Kemeny, Leonard Saltz, Nikolaus Schultz, Rona Yaeger
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4380.
https://doi.org/10.1158/1538-7445.AM2017-4380
Published: 01 July 2017
View articletitled, Abstract 4380: Integrative genomics analysis of metastatic colorectal cancer