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Journal Articles

Abstract 1233: Myeloperoxidase (MPO) activity in myeloid-derived suppressor cells (MDSCs): effects on anticancer drug activity

Jack C. Yalowich, Ragu Kanagasabai, Colleen S. Netherby, Michelle N. Messmer, Scott I. Abrams

Cancer Res (2019) 79 (13_Supplement): 1233.

https://doi.org/10.1158/1538-7445.AM2019-1233

Published: 01 July 2019

View article titled, Abstract 1233: Myeloperoxidase (MPO) activity in myeloid-derived suppressor cells (MDSCs): effects on anticancer drug activity

Journal Articles

Abstract 904: The novel C-terminal truncated 90-kDa isoform of topoisomerase IIα, TOP2α/90, is a determinant of etoposide resistance in K562 leukemia cells via heterodimerization with the TOP2α/170 isoform

Ragu Kanagasabai, Soumendra Karmahapatra, Yang Yu, Victor A. Hernandez, Corey A. Kientz, Evan E. Kania, Terry S. Elton, Jack C. Yalowich

Cancer Res (2018) 78 (13_Supplement): 904.

https://doi.org/10.1158/1538-7445.AM2018-904

Published: 01 July 2018

View article titled, Abstract 904: The novel C-terminal truncated 90-kDa isoform of topoisomerase IIα, TOP2α/90, is a determinant of etoposide resistance in K562 leukemia cells via heterodimerization with the TOP2α/170 isoform

Journal Articles

Abstract 3181: A novel topoisomerase IIα 90 kDa isoform in etoposide resistant human leukemia K562 cells produced as a result of alternative RNA processing

Ragu Kanagasabai, Lucas Serdar, Soumendrakrishna Karmahapatra, Corey A. Kientz, Mary K. Ritke, Terry S. Elton, Jack C. Yalowich

Cancer Res (2017) 77 (13_Supplement): 3181.

https://doi.org/10.1158/1538-7445.AM2017-3181

Published: 01 July 2017

View article titled, Abstract 3181: A novel topoisomerase IIα 90 kDa isoform in etoposide resistant human leukemia K562 cells produced as a result of alternative RNA processing

Journal Articles

Abstract 4792: The effects of KPT-330, a selective inhibitor of nuclear export, on nuclear topoisomerase II alpha levels and etoposide activity in human myeloid leukemia HL-60 cells

Erica Godley, Ragu Kanagasabai, Soumendrakrishna Karmahapatra, Jack C. Yalowich

Cancer Res (2016) 76 (14_Supplement): 4792.

https://doi.org/10.1158/1538-7445.AM2016-4792

Published: 15 July 2016

View article titled, Abstract 4792: The effects of KPT-330, a selective inhibitor of nuclear export, on nuclear topoisomerase II alpha levels and etoposide activity in human myeloid leukemia HL-60 cells

Journal Articles

Abstract 1659: The non-cardiotoxic anticancer drug pixantrone targets topoisomerase II

Brian B. Hasinoff, Xing Wu, Daywin Patel, Jack C. Yalowich

Cancer Res (2015) 75 (15_Supplement): 1659.

https://doi.org/10.1158/1538-7445.AM2015-1659

Published: 01 August 2015

View article titled, Abstract 1659: The non-cardiotoxic anticancer drug pixantrone targets topoisomerase II

Journal Articles

Abstract 1660: Impact of antioxidants on myeloperoxidase (MPO)-dependent DNA damage and genotoxicity induced by etoposide (VP-16):implications for therapy-induced second malignancies

Jason Goodspeed, Soumendra Karmahapatra, Ragu Kanagasabai, Alex Klausing, Jack C. Yalowich

Cancer Res (2015) 75 (15_Supplement): 1660.

https://doi.org/10.1158/1538-7445.AM2015-1660

Published: 01 August 2015

View article titled, Abstract 1660: Impact of antioxidants on myeloperoxidase (MPO)-dependent DNA damage and genotoxicity induced by etoposide (VP-16):implications for therapy-induced second malignancies

Journal Articles

Abstract 826: Myeloperoxidase (MPO) dependency for DNA damage, genotoxicity and cytotoxicity induced by etoposide (VP-16): Implications for therapy-induced second malignancies

Ragu Kanagasabai, Jason Goodspeed, Soumendra Krishna Karmahapatra, Alex Klausing, Anna Skwarska, Michael Darby, Yuan Zhao, Jiang Wang, Mitchell A. Phelps, Jack C. Yalowich

Cancer Res (2014) 74 (19_Supplement): 826.

https://doi.org/10.1158/1538-7445.AM2014-826

Published: 01 October 2014

View article titled, Abstract 826: Myeloperoxidase (MPO) dependency for DNA damage, genotoxicity and cytotoxicity induced by etoposide (VP-16): Implications for therapy-induced second malignancies

Journal Articles

Abstract 786: Alternative RNA processing leads to decreased DNA topoisomerase IIα in etoposide (VP-16) resistant human leukemia K562 cells

Lucas D. Serdar, Ragu Kanagasabai, Jack C. Yalowich

Cancer Res (2014) 74 (19_Supplement): 786.

https://doi.org/10.1158/1538-7445.AM2014-786

Published: 01 October 2014

View article titled, Abstract 786: Alternative RNA processing leads to decreased DNA topoisomerase IIα in etoposide (VP-16) resistant human leukemia K562 cells

Journal Articles

Abstract 830: Disulfiram is a potent inhibitor of topoisomerase II

Xing Wu, Jack C. Yalowich, Daywin Patel, Brian B. Hasinoff

Cancer Res (2014) 74 (19_Supplement): 830.

https://doi.org/10.1158/1538-7445.AM2014-830

Published: 01 October 2014

View article titled, Abstract 830: Disulfiram is a potent inhibitor of topoisomerase II

Journal Articles

Abstract 4481: Myeloperoxidase as a determinant for activity of etoposide (VP-16) and other phenolic and non-phenolic anticancer agents: implications for drug-induced leukemogenesis.

Jack C. Yalowich, Anna Skwarska, Andrew J. Rabovsky, Yuan Zhao, Mitch A. Phelps, Billy W. Day, Ragu Kanagasabai

Cancer Res (2013) 73 (8_Supplement): 4481.

https://doi.org/10.1158/1538-7445.AM2013-4481

Published: 15 April 2013

View article titled, Abstract 4481: Myeloperoxidase as a determinant for activity of etoposide (VP-16) and other phenolic and non-phenolic anticancer agents: implications for drug-induced leukemogenesis.

Journal Articles

Abstract 5559: Molecular mechanisms of elesclomol cytotoxicity.

Brian B. Hasinoff, Jack C. Yalowich, Daywin Patel, Aron Yadav, Xing Wu

Cancer Res (2013) 73 (8_Supplement): 5559.

https://doi.org/10.1158/1538-7445.AM2013-5559

Published: 15 April 2013

View article titled, Abstract 5559: Molecular mechanisms of elesclomol cytotoxicity.

Journal Articles

Abstract 1757: Elesclomol (STA-4783) is a potent inhibitor of topoisomerase II

Xing Wu, Jack C. Yalowich, Brian B. Hasinoff

Cancer Res (2012) 72 (8_Supplement): 1757.

https://doi.org/10.1158/1538-7445.AM2012-1757

Published: 15 April 2012

View article titled, Abstract 1757: Elesclomol (STA-4783) is a potent inhibitor of topoisomerase II

Journal Articles

Abstract 2530: The anticancer kinase inhibitor dovitinib (TKI258/CHIR258) may have multiple modes of action because it also binds DNA and inhibits topoisomerase I and topoisomerase IIα

Xing Wu, Jack C. Yalowich, Brian Hasinoff

Cancer Res (2011) 71 (8_Supplement): 2530.

https://doi.org/10.1158/1538-7445.AM2011-2530

Published: 15 April 2011

View article titled, Abstract 2530: The anticancer kinase inhibitor dovitinib (TKI258/CHIR258) may have multiple modes of action because it also binds DNA and inhibits topoisomerase I and topoisomerase IIα

Journal Articles

Abstract 3510: The molecular docking-based design and biological evaluation of a novel series of bisintercalating DNA-binding bisanthrapyrazole compounds containing amine linkers

Xing Wu, Rui Zhang, Lynn Guziec, Frank Guziec, Jack C. Yalowich, Brian B. Hasinoff

Cancer Res (2010) 70 (8_Supplement): 3510.

https://doi.org/10.1158/1538-7445.AM10-3510

Published: 15 April 2010

View article titled, Abstract 3510: The molecular docking-based design and biological evaluation of a novel series of bisintercalating DNA-binding bisanthrapyrazole compounds containing amine linkers

Journal Articles

Abstract 3509: Design, synthesis and biological evaluation of a novel series of anthrapyrazoles linked with netropsin-like oligopyrrole carboxamides as anticancer agents

Rui Zhang, Xing Wu, Lynn Guziec, Frank Guziec, Jack C. Yalowich, Gaik-Lean Chee, Brian B. Hasinoff

Cancer Res (2010) 70 (8_Supplement): 3509.

https://doi.org/10.1158/1538-7445.AM10-3509

Published: 15 April 2010

View article titled, Abstract 3509: Design, synthesis and biological evaluation of a novel series of anthrapyrazoles linked with netropsin-like oligopyrrole carboxamides as anticancer agents

Journal Articles

Abstract 3498: The cytotoxicity and genotoxicity of etoposide and other phenolic and non-phenolic agents in human myeloid leukemia HL-60 cells: role of myeloperoxidase (MPO)

Jack C. Yalowich, Marisa Hornbaker, Andrew J. Bodnar, ShunQian Jin, Yuxun Zhang, Billy W. Day, James R. Fuchs, Pui-Kai Li

Cancer Res (2010) 70 (8_Supplement): 3498.

https://doi.org/10.1158/1538-7445.AM10-3498

Published: 15 April 2010

View article titled, Abstract 3498: The cytotoxicity and genotoxicity of etoposide and other phenolic and non-phenolic agents in human myeloid leukemia HL-60 cells: role of myeloperoxidase (MPO)

Journal Articles

Myeloperoxidase-catalyzed metabolism of etoposide to its quinone and glutathione adduct forms in HL60 cells.

Yun Fan, Emanuel M. Schreiber, Angela M. Giorgianni, Jack C. Yalowich, Billy W. Day

Cancer Res (2006) 66 (8_Supplement): 1227.

Published: 15 April 2006

View article titled, Myeloperoxidase-catalyzed metabolism of etoposide to its quinone and glutathione adduct forms in HL60 cells.

Journal Articles

Benzoquinone-induced inhibition of DNA topoisomerase II.

Jack C. Yalowich, Elliot Asare, Angela Giorgianni

Cancer Res (2006) 66 (8_Supplement): 1300–1301.

Published: 15 April 2006

View article titled, Benzoquinone-induced inhibition of DNA topoisomerase II.

Journal Articles

Inhibition of cell growth and topoisomerase IIα catalytic activity and DNA binding of a series of new anthrapyrazole compounds

Brian B. Hasinoff, Lynn Guziec, Frank Guziec, Jack C. Yalowich, Xing Wu

Cancer Res (2005) 65 (9_Supplement): 282–283.

Published: 01 May 2005

View article titled, Inhibition of cell growth and topoisomerase IIα catalytic activity and DNA binding of a series of new anthrapyrazole compounds

Journal Articles

Etoposide ortho-quinone and electrophilic isothiocyanates inhibit DNA topoisomerase II catalytic activity by thiolation

Jack C. Yalowich, Angela Giorgianni, Duc Do, Shaohua Yang, Siva Tejomoortula, Billy W. Day, Yun Fan, Shivendra V. Singh, Brian B. Hasinoff

Cancer Res (2005) 65 (9_Supplement): 561.

Published: 01 May 2005

View article titled, Etoposide ortho-quinone and electrophilic isothiocyanates inhibit DNA topoisomerase II catalytic activity by thiolation

NARROW

Abstract 1233: Myeloperoxidase (MPO) activity in myeloid-derived suppressor cells (MDSCs): effects on anticancer drug activity

Abstract 904: The novel C-terminal truncated 90-kDa isoform of topoisomerase IIα, TOP2α/90, is a determinant of etoposide resistance in K562 leukemia cells via heterodimerization with the TOP2α/170 isoform

Abstract 3181: A novel topoisomerase IIα 90 kDa isoform in etoposide resistant human leukemia K562 cells produced as a result of alternative RNA processing

Abstract 4792: The effects of KPT-330, a selective inhibitor of nuclear export, on nuclear topoisomerase II alpha levels and etoposide activity in human myeloid leukemia HL-60 cells

Abstract 1659: The non-cardiotoxic anticancer drug pixantrone targets topoisomerase II

Abstract 1660: Impact of antioxidants on myeloperoxidase (MPO)-dependent DNA damage and genotoxicity induced by etoposide (VP-16):implications for therapy-induced second malignancies

Abstract 826: Myeloperoxidase (MPO) dependency for DNA damage, genotoxicity and cytotoxicity induced by etoposide (VP-16): Implications for therapy-induced second malignancies

Abstract 786: Alternative RNA processing leads to decreased DNA topoisomerase IIα in etoposide (VP-16) resistant human leukemia K562 cells

Abstract 830: Disulfiram is a potent inhibitor of topoisomerase II

Abstract 4481: Myeloperoxidase as a determinant for activity of etoposide (VP-16) and other phenolic and non-phenolic anticancer agents: implications for drug-induced leukemogenesis.

Abstract 5559: Molecular mechanisms of elesclomol cytotoxicity.

Abstract 1757: Elesclomol (STA-4783) is a potent inhibitor of topoisomerase II

Abstract 2530: The anticancer kinase inhibitor dovitinib (TKI258/CHIR258) may have multiple modes of action because it also binds DNA and inhibits topoisomerase I and topoisomerase IIα

Abstract 3510: The molecular docking-based design and biological evaluation of a novel series of bisintercalating DNA-binding bisanthrapyrazole compounds containing amine linkers

Abstract 3509: Design, synthesis and biological evaluation of a novel series of anthrapyrazoles linked with netropsin-like oligopyrrole carboxamides as anticancer agents

Abstract 3498: The cytotoxicity and genotoxicity of etoposide and other phenolic and non-phenolic agents in human myeloid leukemia HL-60 cells: role of myeloperoxidase (MPO)

Myeloperoxidase-catalyzed metabolism of etoposide to its quinone and glutathione adduct forms in HL60 cells.

Benzoquinone-induced inhibition of DNA topoisomerase II.

Inhibition of cell growth and topoisomerase IIα catalytic activity and DNA binding of a series of new anthrapyrazole compounds

Etoposide ortho-quinone and electrophilic isothiocyanates inhibit DNA topoisomerase II catalytic activity by thiolation

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