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J. Silvio Gutkind
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Journal Articles

Abstract SY39-03: Illuminating the tumor immune GPCRome: Novel immunotherapy targets

J. Silvio Gutkind
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): SY39-03.
https://doi.org/10.1158/1538-7445.AM2024-SY39-03
Published: 05 April 2024
View article titled, Abstract SY39-03: Illuminating the tumor immune GPCRome: Novel immunotherapy targets
Journal Articles

Abstract CT260: A phase II trial of defactinib combined with avutometinib in patients with metastatic uveal melanoma

Rino S. Seedor, Mizue Terai, Amry Majeed, Ryota Tanaka, Andrew E. Aplin, Marlana Orloff, Alfredo A. Molinolo, J Silvio Gutkind, Takami Sato
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): CT260.
https://doi.org/10.1158/1538-7445.AM2024-CT260
Published: 05 April 2024
View article titled, Abstract CT260: A phase II trial of defactinib combined with avutometinib in patients with metastatic uveal melanoma
Journal Articles

Abstract 5996: Genome-wide CRISPR screening reveals a central role for ferroptotic cell death in the anti-tumor response to mTOR inhibitors in HNSCC

Keiichi Koshizuka, Xingyu Wu, Kuniaki Sato, Pham Thuy Vo, Gosia M. Murawska, Tomohiko Ishikawa, Zhiyong Wang, Alfredo A. Molinolo, Edward A. Dennis, Prashant Mali, J. Silvio Gutkind
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5996.
https://doi.org/10.1158/1538-7445.AM2024-5996
Published: 22 March 2024
View article titled, Abstract 5996: Genome-wide CRISPR screening reveals a central role for ferroptotic cell death in the anti-tumor response to mTOR inhibitors in HNSCC
Journal Articles

Abstract 1707: YAP-driven epigenetic reprogramming in head and neck cancer

Adam Officer, Farhoud Faraji, Sydney Ramirez, Alon Goren, Pablo Tamayo, J. Silvio Gutkind
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1707.
https://doi.org/10.1158/1538-7445.AM2024-1707
Published: 22 March 2024
View article titled, Abstract 1707: YAP-driven epigenetic reprogramming in head and neck cancer
Journal Articles

Abstract 4745: A novel combination therapy targeting RAF, MEK and FAK to overcome skin cutaneous melanoma treatment resistance

Simone Lubrano, Farhoud Faraji, Rodolfo Daniel Cervantes-Villagrana, Sydney Ramirez, Nadia Arang, Adam Officer, Damiano C. Rigiracciolo, Paola Y. Anguiano Quiroz, Antonieta Bacchiocchi, Ruth Halaban, Silvia Coma, Sheri Holmen, Claudia Martini, Jonathan Pachter, Andrew Aplin, J. Silvio Gutkind
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4745.
https://doi.org/10.1158/1538-7445.AM2024-4745
Published: 22 March 2024
View article titled, Abstract 4745: A novel combination therapy targeting RAF, MEK and FAK to overcome skin cutaneous melanoma treatment resistance
Journal Articles

Tipifarnib Potentiates the Antitumor Effects of PI3Kα Inhibition in PIK3CA- and HRAS-Dysregulated HNSCC via Convergent Inhibition of mTOR Activity

Alison E. Smith, Stacia Chan, Zhiyong Wang, Asako McCloskey, Quinn Reilly, Jayden Z. Wang, Hetika Vora Patel, Keiichi Koshizuka, Harris S. Soifer, Linda Kessler, Ashley Dayoub, Victoria Villaflor, Douglas R. Adkins, Justine Y. Bruce, Alan L. Ho, Cesar A. Perez, Glenn J. Hanna, Amaya Gascó Hernández, Andrew Saunders, Stephen Dale, J. Silvio Gutkind, Francis Burrows, Shivani Malik
Journal: Cancer Research
Cancer Res (2023) 83 (19): 3252–3263.
https://doi.org/10.1158/0008-5472.CAN-23-0282
Published: 02 October 2023
View article titled, Tipifarnib Potentiates the Antitumor Effects of PI3Kα Inhibition in <em>PIK3CA</em>- and <em>HRAS</em>-Dysregulated HNSCC via Convergent Inhibition of mTOR Activity
Open the PDF for Tipifarnib Potentiates the Antitumor Effects of PI3Kα Inhibition in <em>PIK3CA</em>- and <em>HRAS</em>-Dysregulated HNSCC via Convergent Inhibition of mTOR Activity in another window
Includes: Supplementary data
Journal Articles

Mutated HRAS Activates YAP1–AXL Signaling to Drive Metastasis of Head and Neck Cancer

Sankar Jagadeeshan, Manu Prasad, Mai Badarni, Talal Ben-Lulu, Vijayasteltar Belsamma Liju, Sooraj Mathukkada, Claire Saunders, Avital Beeri Shnerb, Jonathan Zorea, Ksenia M. Yegodayev, Monica Wainer, Liza Vtorov, Irit Allon, Ofir Cohen, Gro Gausdal, Dinorah Friedmann-Morvinski, Sok Ching Cheong, Alan L. Ho, Ari J. Rosenberg, Linda Kessler, Francis Burrows, Dexin Kong, Jennifer R. Grandis, J. Silvio Gutkind, Moshe Elkabets
Journal: Cancer Research
Cancer Res (2023) 83 (7): 1031–1047.
https://doi.org/10.1158/0008-5472.CAN-22-2586
Published: 04 April 2023
View article titled, Mutated HRAS Activates YAP1–AXL Signaling to Drive Metastasis of Head and Neck Cancer
Open the PDF for Mutated HRAS Activates YAP1–AXL Signaling to Drive Metastasis of Head and Neck Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 2868: A chemogenetic approach reveals a GPCR-Gαs-PKA signaling axis promoting T cell dysfunction and cancer immunotherapy failure

Bryan S. Yung, Victoria H. Wu, Farhoud Faraji, Robert Saddawi-Konefka, Zhiyong Wang, Alexander T. Wenzel, Miranda Song, Meghana S. Pagadala, Lauren M. Clubb, Joshua Chiou, Sanju Sinha, Marin Matic, Francesco Raimondi, Thomas Hoang, Rebecca Berdeaux, Dario A. Vignali, Ramiro Iglesias-Bartolome, Hannah Carter, Eytan Ruppin, Jill P. Mesirov, J. Silvio Gutkind
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2868.
https://doi.org/10.1158/1538-7445.AM2023-2868
Published: 04 April 2023
View article titled, Abstract 2868: A chemogenetic approach reveals a GPCR-Gαs-PKA signaling axis promoting T cell dysfunction and cancer immunotherapy failure
Journal Articles

Challenges and Emerging Opportunities for Targeting mTOR in Cancer

Kris C. Wood, J. Silvio Gutkind
Journal: Cancer Research
Cancer Res (2022) 82 (21): 3884–3887.
https://doi.org/10.1158/0008-5472.CAN-22-0602
Published: 02 November 2022
View article titled, Challenges and Emerging Opportunities for Targeting mTOR in Cancer
Open the PDF for Challenges and Emerging Opportunities for Targeting mTOR in Cancer in another window
Journal Articles

Abstract 3825: Germline modifiers of the tumor immune microenvironment reveal drivers of immunotherapy response

Meghana Pagadala, Victoria Wu, Eva Pérez-Guijarro, Hyo Kim, Andrea Castro, James Talwar, Cristian Gonzalez-Colin, Steven Cao, Benjamin J. Schmiedel, Timothy Sears, Shervin Goudarzi, Divya Kirani, Rany M. Salem, Gerald P. Morris, Olivier Harismendy, Sandip P. Patel, Jill P. Mesirov, Maurizio Zanetti, Chi-Ping Day, Chun C. Fan, Wesley K. Thompson, Glenn Merlino, J. Silvio Gutkind, Pandurangan Vijayanand, Hannah Carter
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3825.
https://doi.org/10.1158/1538-7445.AM2022-3825
Published: 15 June 2022
View article titled, Abstract 3825: Germline modifiers of the tumor immune microenvironment reveal drivers of immunotherapy response
Journal Articles

Abstract 2107: CHMP2A regulates NK cell-mediated anti-tumor activity in a syngeneic HNSCC model

Jiyoung Yun, Robert Saddawi-Konefka, Benjamin Goldenson, Riyam Al-msari, J Silvio Gutkind, Dan S. Kaufman
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2107.
https://doi.org/10.1158/1538-7445.AM2022-2107
Published: 15 June 2022
View article titled, Abstract 2107: CHMP2A regulates NK cell-mediated anti-tumor activity in a syngeneic HNSCC model
Journal Articles

Abstract 3027: Elucidating the role of glutamine metabolism in head & neck squamous cell carcinoma

Michael Allevato, Yumi Yokoyama, Robert Wild, J. Silvio Gutkind
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3027.
https://doi.org/10.1158/1538-7445.AM2022-3027
Published: 15 June 2022
View article titled, Abstract 3027: Elucidating the role of glutamine metabolism in head &amp; neck squamous cell carcinoma
Journal Articles

Abstract 1425: Synergistic antitumor efficacy of the dual RAF/MEK inhibitor VS-6766 with FAK inhibition for treatment of RAS-dependent solid tumors

Silvia Coma, Justine S. Paradis, J Silvio Gutkind, Jonathan A. Pachter
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1425.
https://doi.org/10.1158/1538-7445.AM2021-1425
Published: 01 July 2021
View article titled, Abstract 1425: Synergistic antitumor efficacy of the dual RAF/MEK inhibitor VS-6766 with FAK inhibition for treatment of RAS-dependent solid tumors
Journal Articles

Abstract 1610: Local delivery of anti CTLA4 mediates cDC1 dependent eradication of HNSCC with limited IRAEs in a preclinical model of oral squamous cell carcinoma

Mara Gilardi, Zhiyong Wang, Victoria H. Wu, Miguel Angel Lopez-Ramirez, Fernando Soto-Alvarez, Robert Saddawi-Konefka, Dana Steffen, Marco Proietto, Zbigniew Mikulski, Haruka Miki, Jayanth Shankara Narayanan, Alfredo Molinolo, Joseph Wang, J. Silvio Gutkind
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1610.
https://doi.org/10.1158/1538-7445.AM2021-1610
Published: 01 July 2021
View article titled, Abstract 1610: Local delivery of anti CTLA4 mediates cDC1 dependent eradication of HNSCC with limited IRAEs in a preclinical model of oral squamous cell carcinoma
Journal Articles

Abstract 6406: FAK and MEK co-targeting: A new multimodal precision therapy for GNAQ-driven uveal melanoma

Justine S. Paradis, Monica Acosta, Nadia Arang, Robert Saddawi-Konefka, Ayush Kishore, Takahito Sugase, Xiaodong Feng, Kris C. Wood, Silvia Coma, Mizue Terai, Takami Sato, Jonathan A. Pachter, J. Silvio Gutkind
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 6406.
https://doi.org/10.1158/1538-7445.AM2020-6406
Published: 15 August 2020
View article titled, Abstract 6406: FAK and MEK co-targeting: A new multimodal precision therapy for <em>GNAQ</em>-driven uveal melanoma
Journal Articles

Abstract LB-386: Novel multimodal precision immunotherapy by co-targeting the HER3 oncogenic signaling circuitry and PD-1 for head and neck squamous cell carcinoma

Zhiyong Wang, Yusuke Goto, Mara Gilardi, Michael Allevato, Victoria Wu, Robert Saddawi-konefka, Diego Alvarado, Alfredo Molinolo, J. Silvio Gutkind
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): LB-386.
https://doi.org/10.1158/1538-7445.AM2020-LB-386
Published: 15 August 2020
View article titled, Abstract LB-386: Novel multimodal precision immunotherapy by co-targeting the HER3 oncogenic signaling circuitry and PD-1 for head and neck squamous cell carcinoma
Journal Articles

HPV16 E5 Mediates Resistance to PD-L1 Blockade and Can Be Targeted with Rimantadine in Head and Neck Cancer

Sayuri Miyauchi, P. Dominick Sanders, Kripa Guram, Sangwoo S. Kim, Francesca Paolini, Aldo Venuti, Ezra E.W. Cohen, J. Silvio Gutkind, Joseph A. Califano, Andrew B. Sharabi
Journal: Cancer Research
Cancer Res (2020) 80 (4): 732–746.
https://doi.org/10.1158/0008-5472.CAN-19-1771
Published: 14 February 2020
View article titled, HPV16 E5 Mediates Resistance to PD-L1 Blockade and Can Be Targeted with Rimantadine in Head and Neck Cancer
Open the PDF for HPV16 E5 Mediates Resistance to PD-L1 Blockade and Can Be Targeted with Rimantadine in Head and Neck Cancer in another window
Includes: Supplementary data
Journal Articles

Metformin Inhibits Progression of Head and Neck Squamous Cell Carcinoma by Acting Directly on Carcinoma-Initiating Cells

Xingyu Wu, Huwate Yeerna, Yusuke Goto, Toshinori Ando, Victoria H. Wu, Xuefeng Zhang, Zhiyong Wang, Panomwat Amornphimoltham, Anne N. Murphy, Pablo Tamayo, Qianming Chen, Scott M. Lippman, J. Silvio Gutkind
Journal: Cancer Research
Cancer Res (2019) 79 (17): 4360–4370.
https://doi.org/10.1158/0008-5472.CAN-18-3525
Published: 03 September 2019
View article titled, Metformin Inhibits Progression of Head and Neck Squamous Cell Carcinoma by Acting Directly on Carcinoma-Initiating Cells
Open the PDF for Metformin Inhibits Progression of Head and Neck Squamous Cell Carcinoma by Acting Directly on Carcinoma-Initiating Cells in another window
Includes: Supplementary data
Journal Articles

Abstract LB-149: Genome-wide prediction of synthetic rescue mediators of resistance to targeted and immunotherapy

Avinash Das, Joo Sang Lee, Gao Zhang, Zhiyong Wang, Arnaud Amzallag, Genevieve Boland, Sridhar Hannenhalli, Meenhard Herlyn, Cyril Benes, J. Silvio Gutkind, Keity Flaherty, Eytan Ruppin
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): LB-149.
https://doi.org/10.1158/1538-7445.AM2019-LB-149
Published: 01 July 2019
View article titled, Abstract LB-149: Genome-wide prediction of synthetic rescue mediators of resistance to targeted and immunotherapy
Journal Articles

4E-BP1 Is a Tumor Suppressor Protein Reactivated by mTOR Inhibition in Head and Neck Cancer

Zhiyong Wang, Xiaodong Feng, Alfredo A. Molinolo, Daniel Martin, Lynn Vitale-Cross, Nijiro Nohata, Mizuo Ando, Amy Wahba, Panomwat Amornphimoltham, Xingyu Wu, Mara Gilardi, Michael Allevato, Victoria Wu, Dana J. Steffen, Philip Tofilon, Nahum Sonenberg, Joseph Califano, Qianming Chen, Scott M. Lippman, J. Silvio Gutkind
Journal: Cancer Research
Series: Author Choice
Cancer Res (2019) 79 (7): 1438–1450.
https://doi.org/10.1158/0008-5472.CAN-18-1220
Published: 01 April 2019
View article titled, 4E-BP1 Is a Tumor Suppressor Protein Reactivated by mTOR Inhibition in Head and Neck Cancer
Open the PDF for 4E-BP1 Is a Tumor Suppressor Protein Reactivated by mTOR Inhibition in Head and Neck Cancer in another window
Includes: Supplementary data