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J. Graeme Hodgson
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Journal Articles

Discovery and Characterization of SY-1365, a Selective, Covalent Inhibitor of CDK7

Shanhu Hu, Jason J. Marineau, Nisha Rajagopal, Kristin B. Hamman, Yoon Jong Choi, Darby R. Schmidt, Nan Ke, Liv Johannessen, Michael J. Bradley, David A. Orlando, Sydney R. Alnemy, Yixuan Ren, Stephane Ciblat, Dana K. Winter, Anzhelika Kabro, Kevin T. Sprott, J. Graeme Hodgson, Christian C. Fritz, John P. Carulli, Emmanuelle di Tomaso, Eric R. Olson
Journal: Cancer Research
Cancer Res (2019) 79 (13): 3479–3491.
https://doi.org/10.1158/0008-5472.CAN-19-0119
Published: 01 July 2019
View article titled, Discovery and Characterization of SY-1365, a Selective, Covalent Inhibitor of CDK7
Open the PDF for Discovery and Characterization of SY-1365, a Selective, Covalent Inhibitor of CDK7 in another window
Includes: Supplementary data
Journal Articles

Abstract 2071: Sub-clonal heterogeneity and risk of treatment failure in Philadelphia-positive leukemias

Michael W. Schmitt, Justin R. Pritchard, Lan Beppu, J. Graeme Hodgson, Victor M. Rivera, Lawrence A. Loeb, Jerald P. Radich
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2071.
https://doi.org/10.1158/1538-7445.AM2017-2071
Published: 01 July 2017
View article titled, Abstract 2071: Sub-clonal heterogeneity and risk of treatment failure in Philadelphia-positive leukemias
Journal Articles

Abstract 2395: Direct assessment of sequence heterogeneity in human cancers by Duplex Sequencing

Michael W. Schmitt, Jesse J. Salk, Edward J. Fox, Justin R. Pritchard, J Graeme Hodgson, Victor M. Rivera, Pamela S. Becker, Jerald P. Radich, Lawrence A. Loeb
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2395.
https://doi.org/10.1158/1538-7445.AM2016-2395
Published: 15 July 2016
View article titled, Abstract 2395: Direct assessment of sequence heterogeneity in human cancers by Duplex Sequencing
Journal Articles

Abstract 781: The potent ALK inhibitor AP26113 can overcome mechanisms of resistance to first- and second-generation ALK TKIs in preclinical models

Sen Zhang, Sara Nadworny, Scott D. Wardwell, Lindsey Eichinger, Biplab Das, Emily Y. Ye, J. Graeme Hodgson, Victor M. Rivera
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 781.
https://doi.org/10.1158/1538-7445.AM2015-781
Published: 01 August 2015
View article titled, Abstract 781: The potent ALK inhibitor AP26113 can overcome mechanisms of resistance to first- and second-generation ALK TKIs in preclinical models
Journal Articles

Oncogenic BRAF Mutation with CDKN2A Inactivation Is Characteristic of a Subset of Pediatric Malignant Astrocytomas

Joshua D. Schiffman, J. Graeme Hodgson, Scott R. VandenBerg, Patrick Flaherty, Mei-Yin C. Polley, Mamie Yu, Paul G. Fisher, David H. Rowitch, James M. Ford, Mitchel S. Berger, Hanlee Ji, David H. Gutmann, C. David James
Journal: Cancer Research
Cancer Res (2010) 70 (2): 512–519.
https://doi.org/10.1158/0008-5472.CAN-09-1851
Published: 13 January 2010
View article titled, Oncogenic <em>BRAF</em> Mutation with <em>CDKN2A</em> Inactivation Is Characteristic of a Subset of Pediatric Malignant Astrocytomas
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Includes: Supplementary data
Journal Articles

Whole-Body Sleeping Beauty Mutagenesis Can Cause Penetrant Leukemia/Lymphoma and Rare High-Grade Glioma without Associated Embryonic Lethality

Lara S. Collier, David J. Adams, Christopher S. Hackett, Laura E. Bendzick, Keiko Akagi, Michael N. Davies, Miechaleen D. Diers, Fausto J. Rodriguez, Aaron M. Bender, Christina Tieu, Ilze Matise, Adam J. Dupuy, Neal G. Copeland, Nancy A. Jenkins, J. Graeme Hodgson, William A. Weiss, Robert B. Jenkins, David A. Largaespada
Journal: Cancer Research
Cancer Res (2009) 69 (21): 8429–8437.
https://doi.org/10.1158/0008-5472.CAN-09-1760
Published: 28 October 2009
View article titled, Whole-Body <em>Sleeping Beauty</em> Mutagenesis Can Cause Penetrant Leukemia/Lymphoma and Rare High-Grade Glioma without Associated Embryonic Lethality
Open the PDF for Whole-Body <em>Sleeping Beauty</em> Mutagenesis Can Cause Penetrant Leukemia/Lymphoma and Rare High-Grade Glioma without Associated Embryonic Lethality in another window
Includes: Supplementary data
Journal Articles

Copy Number Aberrations in Mouse Breast Tumors Reveal Loci and Genes Important in Tumorigenic Receptor Tyrosine Kinase Signaling

J. Graeme Hodgson, Tiffany Malek, Sophia Bornstein, Sujatmi Hariono, David G. Ginzinger, William J. Muller, Joe W. Gray
Journal: Cancer Research
Cancer Res (2005) 65 (21): 9695–9704.
https://doi.org/10.1158/0008-5472.CAN-05-0755
Published: 01 November 2005
View article titled, Copy Number Aberrations in Mouse Breast Tumors Reveal Loci and Genes Important in Tumorigenic Receptor Tyrosine Kinase Signaling
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Journal Articles

Shared Epigenetic Mechanisms in Human and Mouse Gliomas Inactivate Expression of the Growth Suppressor SLC5A8

Chibo Hong, Alika Maunakea, Peter Jun, Andrew W. Bollen, J. Graeme Hodgson, David D. Goldenberg, William A. Weiss, Joseph F. Costello
Journal: Cancer Research
Cancer Res (2005) 65 (9): 3617–3623.
https://doi.org/10.1158/0008-5472.CAN-05-0048
Published: 02 May 2005
View article titled, Shared Epigenetic Mechanisms in Human and Mouse Gliomas Inactivate Expression of the Growth Suppressor <em>SLC5A8</em>
Open the PDF for Shared Epigenetic Mechanisms in Human and Mouse Gliomas Inactivate Expression of the Growth Suppressor <em>SLC5A8</em> in another window
Includes: Supplementary data
Journal Articles

Distinct mouse chromosome 11 (human 17q) amplifications develop in mouse breast tumors induced by oncogenic ERBB2 or polyoma virus middle T antigen

J. Graeme Hodgson, Sujatmi Hariono, Sophia Bornstein, William J. Muller, Joe W. Gray
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 446.
Published: 01 May 2005
View article titled, Distinct mouse chromosome 11 (human 17q) amplifications develop in mouse breast tumors induced by oncogenic ERBB2 or polyoma virus middle T antigen
Journal Articles

Pancreatic Insulinomas in Multiple Endocrine Neoplasia, Type I Knockout Mice Can Develop in the Absence of Chromosome Instability or Microsatellite Instability

Peter C. Scacheri, Alyssa L. Kennedy, Koei Chin, Meghan T. Miller, J. Graeme Hodgson, Joe W. Gray, Stephen J. Marx, Allen M. Spiegel, Francis S. Collins
Journal: Cancer Research
Cancer Res (2004) 64 (19): 7039–7044.
https://doi.org/10.1158/0008-5472.CAN-04-1648
Published: 01 October 2004
View article titled, Pancreatic Insulinomas in Multiple Endocrine Neoplasia, Type I Knockout Mice Can Develop in the Absence of Chromosome Instability or Microsatellite Instability
Open the PDF for Pancreatic Insulinomas in Multiple Endocrine Neoplasia, Type I Knockout Mice Can Develop in the Absence of Chromosome Instability or Microsatellite Instability in another window
Journal Articles

Oncogene Expression and Genetic Background Influence the Frequency of DNA Copy Number Abnormalities in Mouse Pancreatic Islet Cell Carcinomas

Jeffrey H. Hager, J. Graeme Hodgson, Jane Fridlyand, Sujatmi Hariono, Joe W. Gray, Douglas Hanahan
Journal: Cancer Research
Cancer Res (2004) 64 (7): 2406–2410.
https://doi.org/10.1158/0008-5472.CAN-03-3522
Published: 01 April 2004
View article titled, Oncogene Expression and Genetic Background Influence the Frequency of DNA Copy Number Abnormalities in Mouse Pancreatic Islet Cell Carcinomas
Open the PDF for Oncogene Expression and Genetic Background Influence the Frequency of DNA Copy Number Abnormalities in Mouse Pancreatic Islet Cell Carcinomas in another window
Includes: Supplementary data
Journal Articles

TIMP-1 Alters Susceptibility to Carcinogenesis

Jin-Sae Rhee, Robert Diaz, Lidiya Korets, J. Graeme Hodgson, Lisa M. Coussens
Journal: Cancer Research
Cancer Res (2004) 64 (3): 952–961.
https://doi.org/10.1158/0008-5472.CAN-03-2445
Published: 10 February 2004
View article titled, TIMP-1 Alters Susceptibility to Carcinogenesis
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Journal Articles

The Role of p53 in Suppression of KSHV Cyclin-induced Lymphomagenesis

Emmy W. Verschuren, J. Graeme Hodgson, Joe W. Gray, Scott Kogan, Nic Jones, Gerard I. Evan
Journal: Cancer Research
Cancer Res (2004) 64 (2): 581–589.
https://doi.org/10.1158/0008-5472.CAN-03-1863
Published: 26 January 2004
View article titled, The Role of p53 in Suppression of KSHV Cyclin-induced Lymphomagenesis
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Journal Articles

Genome-wide Array CGH Analysis of Murine Neuroblastoma Reveals Distinct Genomic Aberrations which Parallel those in Human Tumors

Christopher S. Hackett, J. Graeme Hodgson, Mark E. Law, Jane Fridlyand, Kazutoyo Osoegawa, Pieter J. de Jong, Norma J. Nowak, Daniel Pinkel, Donna G. Albertson, Ajay Jain, Robert Jenkins, Joe W. Gray, William A. Weiss
Journal: Cancer Research
Cancer Res (2003) 63 (17): 5266–5273.
Published: 18 September 2003
View article titled, Genome-wide Array CGH Analysis of Murine Neuroblastoma Reveals Distinct Genomic Aberrations which Parallel those in Human Tumors
Open the PDF for Genome-wide Array CGH Analysis of Murine Neuroblastoma Reveals Distinct Genomic Aberrations which Parallel those in Human Tumors in another window
Includes: Supplementary data