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J. Carl Barrett
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Journal Articles

Abstract 963: Comprehensive epigenomic profiling from plasma to inform therapy selection: A proof-of-concept study in cancer

Travis Clark, Ji-Heui Seo, Anthony D'Ippolito, Aparna Gorthi, Jonathan Beagan, Jamey Guess, Amy Donahue, Mandy Greene, Alyssa Lau, Fernando Ramirez, Kristian Cibulskis, Hyun-Hwan Jeong, Matthew Davidsohn, Gitanjali Lakshminarayanam, Michael Coyne, Baovy Tran, Tyrone Tamakloe, Hathairat Sawaengsri, Marc Eid, Karl Semaan, Brad Fortunato, Corrie A. Painter, Juliann Chmielecki, Toni K. Choueiri, J Carl Barrett, Geoff Otto, Matthew L. Freedman, Matthew L. Eaton, Sylvan C. Baca
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 963.
https://doi.org/10.1158/1538-7445.AM2024-963
Published: 22 March 2024
View article titled, Abstract 963: Comprehensive epigenomic profiling from plasma to inform therapy selection: A proof-of-concept study in cancer
Journal Articles

Abstract 4643: A novel epigenomic profiling assay reveals disease biology and therapeutic targets in gastro-esophageal cancer from 1 ml of plasma

Jonathan Beagan, Aparna Gorthi, Anthony D'Ippolito, Travis Clark, Michael Coyne, Tyrone Tamakloe, Amy Donahue, Baovy Tran, Hyun-Hwan Jeong, Kristian Cibulskis, Hathairat Sawaengsri, Corrie A. Painter, Juliann Chmielecki, J Carl Barrett, Mosammat Faria Afreen, Aditya Pandey, Ilexa Ashley Schechter, Martin S. Taylor, Matthew R. Strickland, Matthew Eaton, Samuel J. Klempner
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4643.
https://doi.org/10.1158/1538-7445.AM2024-4643
Published: 22 March 2024
View article titled, Abstract 4643: A novel epigenomic profiling assay reveals disease biology and therapeutic targets in gastro-esophageal cancer from 1 ml of plasma
Journal Articles

Abstract 2492: Enhanced patient selection for anti-PD-L1 treatment in metastatic NSCLC with quantitative continuous scoring of PD-L1

Jan Martin Lesniak, Markus Schick, Thomas Kunzke, Federico Pollastri, Juan Pedro Vigueras-Guillén, Harald Hessel, Susanne Haneder, Pallavi Sontakke, Karma DaCosta, Regina Alleze, Hadassah Sade, J Carl Barrett, Günter Schmidt, Ross Stewart
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2492.
https://doi.org/10.1158/1538-7445.AM2024-2492
Published: 22 March 2024
View article titled, Abstract 2492: Enhanced patient selection for anti-PD-L1 treatment in metastatic NSCLC with quantitative continuous scoring of PD-L1
Journal Articles

Abstract 7558: Novel liquid biopsy based determination of lung cancer histology using a comprehensive epigenomic platform reveals enhancer activity as a key determinant for accurate classification

Jamey Guess, Aparna Gorthi, Anthony D'ippolity, Jonathan Beagan, Travis Clark, Michael Coyne, Tyrone Tamakloe, Baovy Tran, Hyun-Hwan Jeong, Kristian Cibulskis, Hathairat Sawaengsri, Juliann Chmielecki, Corrie A. Painter, J Carl Barrett, Matthew Eaton
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 7558.
https://doi.org/10.1158/1538-7445.AM2024-7558
Published: 22 March 2024
View article titled, Abstract 7558: Novel liquid biopsy based determination of lung cancer histology using a comprehensive epigenomic platform reveals enhancer activity as a key determinant for accurate classification
Journal Articles

Abstract CT039: Immunomodulatory effects of ceralasertib in combination with durvalumab in patients with NSCLC and progression on anti-PD-(L)1 treatment (HUDSON, NCT03334617)

Sonia Iyer, James Conway, Deanna Russell, Avinash Reddy, Jan Cosaert, Simon Barry, Marlene Dressman, Ilhem Mensi, Boaz Aronson, Jane Peters, Helen Ambrose, Keunchil Park, Patrick Forde, Benjamin Besse, John V. Heymach, J. Carl Barrett
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): CT039.
https://doi.org/10.1158/1538-7445.AM2023-CT039
Published: 14 April 2023
View article titled, Abstract CT039: Immunomodulatory effects of ceralasertib in combination with durvalumab in patients with NSCLC and progression on anti-PD-(L)1 treatment (HUDSON, NCT03334617)
Journal Articles

Abstract 2299: Misclassification of clonal hematopoietic mutations as tumor-derived confound accurate ctDNA-response assessment in patients with metastatic non-small-cell lung cancer: analyses from the phase 3 MYSTIC trial

Chris Abbosh, Michael Kuziora, Daniel Stetson, Zhongwu Lai, Yashaswi Shrestha, Paul Labrousse, Xiaojin Shi, Helen Mann, Diana Merino Vega, Matthew D. Hellmann, Solange Peters, J. Carl Barrett, Darren Hodgson
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2299.
https://doi.org/10.1158/1538-7445.AM2023-2299
Published: 04 April 2023
View article titled, Abstract 2299: Misclassification of clonal hematopoietic mutations as tumor-derived confound accurate ctDNA-response assessment in patients with metastatic non-small-cell lung cancer: analyses from the phase 3 MYSTIC trial
Journal Articles

Abstract 1052: Background variability in plasma ctDNA levels in patients with advanced lung cancer in the absence of treatment

Diana M. Vega, Aleksandra Markovets, Christopher Abbosh, Katie Quinn, Kyle Chang, Sara Wienke, Ryan Hartmaier, Matthew Hellmann, J Carl Barrett, Darren Hodgson
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1052.
https://doi.org/10.1158/1538-7445.AM2023-1052
Published: 04 April 2023
View article titled, Abstract 1052: Background variability in plasma ctDNA levels in patients with advanced lung cancer in the absence of treatment
Journal Articles

Abstract 5388: A unified computational pathology method to quantify HER2 expression from raw IHC and IF images in breast cancer

Nicolas Brieu, Joshua Z. Drago, Ansh Kapil, Zonera Hassan, Anatoliy Shumilov, Claire Myers, Fatemeh Derakhshan, Fresia Pareja, Fanni Ratzon, Dana Ross, Jorge Reis-Filho, Thomas Padel, Andreas Spitzmuller, Christian C. Sachs, Felix Fegerer, Sihem Khelifa, J. Carl Barrett, Günter Schmidt, Hadassah Sade, Mark Gustavson, Sarat Chandarlapaty
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5388.
https://doi.org/10.1158/1538-7445.AM2023-5388
Published: 04 April 2023
View article titled, Abstract 5388: A unified computational pathology method to quantify HER2 expression from raw IHC and IF images in breast cancer
Journal Articles

Abstract 452: Development and implementation of image analysis-based Quantitative Continuous Score (QCS) for B7-H4 IHC to understand AZD8205 pharmacodynamics

Philipp Wortmann, Tze Heng Tan, Susanne Haneder, Andrea Ennio Storti, Ansh Kapil, Jon Chesebrough, Daniel Sutton, Michal Sulikowski, Arthur Lewis, Sofia Koch, Steve Sweet, Zifeng Song, David Chain, Yeoun Jin Kim, Nadia Luheshi, Krista Kinneer, Zachary A. Cooper, Marlon Rebelatto, Günter Schmidt, Hadassah Sade, J. Carl Barrett
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 452.
https://doi.org/10.1158/1538-7445.AM2022-452
Published: 15 June 2022
View article titled, Abstract 452: Development and implementation of image analysis-based Quantitative Continuous Score (QCS) for B7-H4 IHC to understand AZD8205 pharmacodynamics
Journal Articles

Abstract CT024: Durvalumab (D) + platinum-etoposide (EP) in 1L extensive-stage small-cell lung cancer (ES-SCLC): Exploratory analysis of SCLC molecular subtypes in CASPIAN

Mingchao Xie, Priti Chugh, Helen Broadhurst, Zhongwu Lai, David Whitston, Luis Paz-Ares, Carl Gay, Lauren Byers, Charles M. Rudin, Ross Stewart, J. Carl Barrett, Yashaswi Shrestha
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): CT024.
https://doi.org/10.1158/1538-7445.AM2022-CT024
Published: 15 June 2022
View article titled, Abstract CT024: Durvalumab (D) + platinum-etoposide (EP) in 1L extensive-stage small-cell lung cancer (ES-SCLC): Exploratory analysis of SCLC molecular subtypes in CASPIAN
Journal Articles

Abstract 468: Quantitative assessment of IHC using computational pathology allows superior patient selection for biomarker-informed patients

Hadassah Sade, Ansh Kapil, Philipp Wortmann, Andreas Spitzmueller, Nicolas Triltsch, Lina Meinecke, Susanne Haneder, Anatoliy Shumilov, Jan Lesniak, Valeria Bertani, Tze-Heng Tan, Ana Hidalgo-Sastre, Simon Christ, Andrea Storti, Regina Alleze, Dasa Medrikova, Jessica Chan, Simon Lanzmich, Markus Schick, Guenter Schmidt, J. Carl Barrett
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 468.
https://doi.org/10.1158/1538-7445.AM2022-468
Published: 15 June 2022
View article titled, Abstract 468: Quantitative assessment of IHC using computational pathology allows superior patient selection for biomarker-informed patients
Journal Articles

Abstract 390: Identification of a novel immunosuppressive myeloid gene expression signature for clinical biomarker development

Srimathi S. Srinivasan, Gozde Kar, Deanna L. Russell, Peter Gathungu, Minoo Rafati, David Whitston, Grant Duclos, Ben Sidders, J Carl Barrett, Tim Slidel, Patricia McCoon
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 390.
https://doi.org/10.1158/1538-7445.AM2021-390
Published: 01 July 2021
View article titled, Abstract 390: Identification of a novel immunosuppressive myeloid gene expression signature for clinical biomarker development
Journal Articles

Abstract PD6-01: Novel approach to HER2 quantification: Digital pathology coupled with AI-based image and data analysis delivers objective and quantitative HER2 expression analysis for enrichment of responders to trastuzumab deruxtecan (T-DXd; DS-8201), specifically in HER2-low patients

Mark Gustavson, Susanne Haneder, Andreas Spitzmueller, Ansh Kapil, Katrin Schneider, Fabiola Cecchi, Sriram Sridhar, Guenter Schmidt, Sotirios Lakis, Regina Teichert, Anatoliy Shumilov, Ana Hidalgo-Sastre, Magdalena Wienken, Hadassah Sade, J. Carl Barrett, Danielle Carroll
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): PD6-01.
https://doi.org/10.1158/1538-7445.SABCS20-PD6-01
Published: 15 February 2021
View article titled, Abstract PD6-01: Novel approach to HER2 quantification: Digital pathology coupled with AI-based image and data analysis delivers objective and quantitative HER2 expression analysis for enrichment of responders to trastuzumab deruxtecan (T-DXd; DS-8201), specifically in HER2-low patients
Journal Articles

Abstract 5671: Alignment of TMB measured on clinical samples: Phase IIB of the Friends of Cancer Research TMB Harmonization Project

Diana M. MERINO, Laura M. Yee, Lisa M. McShane, P. Mickey Williams, Tomas Vilimas, Rajesh Patidar, J. Carl Barrett, Shu-Jen Chen, Jen-Hao Cheng, Jeffrey M. Conroy, Dinesh Cyanam, Kenneth R. Eyring, David A. Fabrizio, Vincent Funari, Elizabeth P. Garcia, Sean T. Glenn, Christopher D. Gocke, Vikas Gupta, Lisa M. Haley, Matthew D. Hellmann, Laurel Keefer, Lauryn R. Keeler, Brett Kennedy, Alexander J. Lazar, Laura E. MacConaill, Kristen L. Meier, Arnaud Papin, Naiyer A. Rizvi, Ethan Sokol, Phillip Stafford, John F. Thompson, Warren Tom, Victor J. Weigman, Mingchao Xie, Chen Zhao, Mark D. Stewart, Jeff Allen
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5671.
https://doi.org/10.1158/1538-7445.AM2020-5671
Published: 15 August 2020
View article titled, Abstract 5671: Alignment of TMB measured on clinical samples: Phase IIB of the Friends of Cancer Research TMB Harmonization Project
Journal Articles

Abstract 5427: Genomic prevalence analysis in TNBC patients in the Phase 2 VIOLETTE study

Joshua Armenia, Zhongwu Lai, Andrew Tutt, Emma Dean, Bienvenu Loembe, Hannah McGarvey, Sarah Edgington, J Carl Barrett, Andrew J. Pierce, Elizabeth A. Harrington, Natalia Lukashchuk
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5427.
https://doi.org/10.1158/1538-7445.AM2020-5427
Published: 15 August 2020
View article titled, Abstract 5427: Genomic prevalence analysis in TNBC patients in the Phase 2 VIOLETTE study
Journal Articles

Abstract 749: Multi-layer molecular characterization of high grade serous ovarian carcinomas

Robert L. Hollis, Alison M. Meynert, Michael Churchman, Tzyvia Rye, Patricia Roxburgh, Daniel Stetson, Athena Matakidou, Brian Dougherty, J. Carl Barrett, Ruth E. March, Colin A. Semple, C. Simon Herrington, Charlie Gourley
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 749.
https://doi.org/10.1158/1538-7445.AM2019-749
Published: 01 July 2019
View article titled, Abstract 749: Multi-layer molecular characterization of high grade serous ovarian carcinomas
Journal Articles

Abstract 932: Reversing PARP inhibitor resistance by targeting the replication stress response

Mark J. O'Connor, Cristina Cruz, Marta Castroviejo-Bermejo, Urszula M. Polanska, Gemma N. Jones, Anderson Wang, Zhongwu Lai, Josep Forment, Krishna Bulusu, Alba Llop-Guevara, Brian Dougherty, Cristina Saura, Rachel Brough, Chris J. Lord, Alejandra Bruna, Carlos Caldas, Stephen Fawell, J Carl Barrett, Susan E. Critchlow, Judith Balmaña, Elaine Cadogan, Violeta Serra
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 932.
https://doi.org/10.1158/1538-7445.AM2019-932
Published: 01 July 2019
View article titled, Abstract 932: Reversing PARP inhibitor resistance by targeting the replication stress response
Journal Articles

Abstract 4897: Detection of MET-mediated EGFR tyrosine kinase inhibitor (TKI) resistance in advanced non-small cell lung cancer (NSCLC): biomarker analysis of the TATTON study

Ryan J. Hartmaier, Ji-Youn Han, Byoung Chul Cho, Melanie M. Frigault, Aleksandra Markovets, Anne L’Hernault, David Duncan, Pierre Lao-Sirieix, J. Carl Barrett, Remy B. Verheijen, Dana Ghiorghiu, Jonathan Wessen, Geoffrey R. Oxnard
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4897.
https://doi.org/10.1158/1538-7445.AM2019-4897
Published: 01 July 2019
View article titled, Abstract 4897: Detection of MET-mediated EGFR tyrosine kinase inhibitor (TKI) resistance in advanced non-small cell lung cancer (NSCLC): biomarker analysis of the TATTON study
Journal Articles

Abstract 3503: Biomarkers for inhibitors of the replication stress response proteins WEE1 and ATR in triple negative breast cancer

Violeta Serra, Cristina Cruz, Zhongwu Lai, Marta Castroviejo-Bermejo, Marta Palafox, Urszula M. Polanska, Gemma N. Jones, Anderson Wang, Filippos Michopoulos, Rachel Brough, Brian Dougherty, Elaine Cadogan, Susan Critchlow, Alejandra Bruna, J. Carl Barrett, Cristina Saura, Christopher J. Lord, Carlos Caldas, Joaquin Arribas, Judith Balmaña, Mark J. O’Connor
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3503.
https://doi.org/10.1158/1538-7445.AM2019-3503
Published: 01 July 2019
View article titled, Abstract 3503: Biomarkers for inhibitors of the replication stress response proteins WEE1 and ATR in triple negative breast cancer
Journal Articles

Abstract 3215: STAT3 antisense oligonucleotide (ASO) reverses immunosuppression and enhances cytotoxic cell function to enhance PDL1 blockade

Srimathi Srinivasan, Yang Xu, Theresa Proia, Nanhua Deng, J. Carl Barrett, Alexandra-Chloe Villani, Patricia E. McCoon
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3215.
https://doi.org/10.1158/1538-7445.AM2019-3215
Published: 01 July 2019
View article titled, Abstract 3215: STAT3 antisense oligonucleotide (ASO) reverses immunosuppression and enhances cytotoxic cell function to enhance PDL1 blockade