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Journal Articles

Carbon Monoxide Activates PERK-Regulated Autophagy to Induce Immunometabolic Reprogramming and Boost Antitumor T-cell Function

Cancer Res (2022) 82 (10): 1969–1990.

DOI: https://doi.org/10.1158/0008-5472.CAN-21-3155

Published: 16 May 2022

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Includes: Supplementary data

Journal Articles

Abstract 501: Aldh2 mutation promotes oral and esophageal cancer stem cells via autophagy-mediated redox homeostasis

Masataka Shimonosono, Takashi Kijima, Hisatsugu Maekawa, Satoshi Takada, Koji Tanaka, Varun Sahu, Manti Guha, Andres J. Klein-Szanto, J. Alan Diehl, Adam J. Bass, Anil K. Rustgi, Elizabeth Philipone, Angela J. Yoon, Hiroshi Nakagawa

Cancer Res (2020) 80 (16_Supplement): 501.

DOI: https://doi.org/10.1158/1538-7445.AM2020-501

Published: 15 August 2020

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Journal Articles

IL-6 Mediates Cross-Talk between Tumor Cells and Activated Fibroblasts in the Tumor Microenvironment

Cancer Res (2018) 78 (17): 4957–4970.

DOI: https://doi.org/10.1158/0008-5472.CAN-17-2268

Published: 04 September 2018

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Includes: Supplementary data

Journal Articles

Abstract A043: Bypass kinase pathways lead to acquired CDK4/6 inhibitor resistance in prostate cancer

Renee de Leeuw, Christopher M. McNair, Matthew J. Schiewer, Neermala P. Neupane, Michael A. Augello, Zhen Li, Larry Cheng, Akihiro Yoshida, J. Alan Diehl, E Starr Hazard, Sean M. McCourtney, Gary Hardiman, Maha H. Hussain, Justin M. Drake, Wm. Kevin Kelly, Karen E. Knudsen

Cancer Res (2018) 78 (16_Supplement): A043.

DOI: https://doi.org/10.1158/1538-7445.PRCA2017-A043

Published: 14 August 2018

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Journal Articles

Abstract 5874: Cdk4/6 kinase inhibitor resistance in prostate cancer

Renee de Leeuw, Matthew J. Schiewer, Christopher McNair, Michael A. Augello, Akihiro Yoshida, Edward S. Hazard, Sean Courtney, Gerard T. Hardiman, Justin Drake, Felix Y. Feng, Scott Tomlins, Maha H. Hussain, J Alan Diehl, William K. Kelly, Karen E. Knudsen

Cancer Res (2017) 77 (13_Supplement): 5874.

DOI: https://doi.org/10.1158/1538-7445.AM2017-5874

Published: 01 July 2017

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Journal Articles

Abstract 2678: Notch1 regulates epithelial-mesenchymal transition and tumor-initiating capability in esophageal squamous-cell carcinoma

Koji Tanaka, Kelly A. Whelan, Naryan L. Rustgi, Prasanna M. Chandramouleeswaran, Seiji Naganuma, Shingo Kagawa, Mitsuteru Natsuizaka, Yoshiaki Kita, Shoji Natsugoe, Que Jianwen, Devraj Basu, Andres J. Klein-Szanto, Adam Bass, J. Alan Diehl, Hiroshi Nakagawa

Cancer Res (2016) 76 (14_Supplement): 2678.

DOI: https://doi.org/10.1158/1538-7445.AM2016-2678

Published: 15 July 2016

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Journal Articles

Induction of Therapeutic Senescence in Vemurafenib-Resistant Melanoma by Extended Inhibition of CDK4/6

Akihiro Yoshida, Eric K. Lee, J. Alan Diehl

Cancer Res (2016) 76 (10): 2990–3002.

DOI: https://doi.org/10.1158/0008-5472.CAN-15-2931

Published: 12 May 2016

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Includes: Supplementary data

Journal Articles

Abstract 1262: The transcription factor ATF4 regulates resistance to anoikis and promotes metastasis in fibrosarcoma via cooperative upregulation of Heme Oxygenase-1 with Nrf2

Souvik Dey, Carly M. Sayers, Stacey L. Lehman, Yi Cheng, George J. Cerniglia, Stephen W. Tuttle, Michael D. Feldman, Paul J.L. Zhang, Serge Y. Fuchs, J. Alan Diehl, Constantinos Koumenis

Cancer Res (2015) 75 (15_Supplement): 1262.

DOI: https://doi.org/10.1158/1538-7445.AM2015-1262

Published: 01 August 2015

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Journal Articles

Abstract 486: Uncovering novel PERK signaling pathways through chemical-genetic screening

Nancy L. Maas, Rebecca Levin, Nickpreet Singh, Kevan Shokat, J. Alan Diehl

Cancer Res (2014) 74 (19_Supplement): 486.

DOI: https://doi.org/10.1158/1538-7445.AM2014-486

Published: 01 October 2014

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Journal Articles

Abstract SY44-02: Insights into pro-survival signaling by PERK

J. Alan Diehl

Cancer Res (2014) 74 (19_Supplement): SY44-02.

DOI: https://doi.org/10.1158/1538-7445.AM2014-SY44-02

Published: 01 October 2014

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Journal Articles

Abstract IA16: Dysregulated mTORC1 renders cells critically dependent on desaturated lipids for survival under tumor-like stress

Regina Young, Daniel Ackerman, Zachary Quinn, Anthony Mancuso, Michaela Gruber, Liping Liu, Dionysios Giannoukos, Ekaterina Bobovnikova-Marjon, J. Alan Diehl, Brian Keith, M. Celeste Simon

Cancer Res (2013) 73 (19_Supplement): IA16.

DOI: https://doi.org/10.1158/1538-7445.FBCR13-IA16

Published: 15 May 2014

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Journal Articles

A NOTCH3-Mediated Squamous Cell Differentiation Program Limits Expansion of EMT-Competent Cells That Express the ZEB Transcription Factors

Shinya Ohashi, Mitsuteru Natsuizaka, Seiji Naganuma, Shingo Kagawa, Sotai Kimura, Hiroshi Itoh, Ross A. Kalman, Momo Nakagawa, Douglas S. Darling, Devraj Basu, Phyllis A. Gimotty, Andres J. Klein-Szanto, J. Alan Diehl, Meenhard Herlyn, Hiroshi Nakagawa

Cancer Res (2011) 71 (21): 6836–6847.

DOI: https://doi.org/10.1158/0008-5472.CAN-11-0846

Published: 30 October 2011

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Includes: Supplementary data

Journal Articles

Abstract 5194: Notch regulates squamous differentiation, cell plasticity and tumor heterogeneity in esophageal carcinoma

Mitsuteru Natsuizaka, Shinya Ohashi, Seiji Naganuma, Ross A. Kalman, Asami Ohyama, Ben Rhoades, Maria E. Vega, Douglas B. Stairs, Andres J. Klein-Szanto, J. Alan Diehl, Devraj Basu, Meenhard Herlyn, Warren S. Pear, Hiroshi Nakagawa

Cancer Res (2011) 71 (8_Supplement): 5194.

DOI: https://doi.org/10.1158/1538-7445.AM2011-5194

Published: 15 April 2011

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Journal Articles

Abstract SY06-02: Activation of the UPR by c-Myc promotes transformation and tumorigenesis via cytoprotective autophagy

Constantinos Koumenis, Haiyan Zhang, Meixia Bi, Stacey L. Lehman, Tatini Datta, Huayi Liu, Andrei Thomas-Tikhonenko, Albert Koong, Serge Y. Fuchs, J. Alan Diehl, Davide Ruggero

Cancer Res (2011) 71 (8_Supplement): SY06-02.

DOI: https://doi.org/10.1158/1538-7445.AM2011-SY06-02

Published: 15 April 2011

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Journal Articles

Abstract 2078: PERK-mediated autophagy promotes Myc-induced transformation and tumorigenesis

Lori S. Hart, Tom Cunningham, Tatini Datta, Huayi Liu, Albert C. Koong, Serge Fuchs, J. Alan Diehl, Davide Ruggero, Constantinos Koumenis

Cancer Res (2011) 71 (8_Supplement): 2078.

DOI: https://doi.org/10.1158/1538-7445.AM2011-2078

Published: 15 April 2011

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Journal Articles

Periostin, a Cell Adhesion Molecule, Facilitates Invasion in the Tumor Microenvironment and Annotates a Novel Tumor-Invasive Signature in Esophageal Cancer

Carmen Z. Michaylira, Gabrielle S. Wong, Charles G. Miller, Christie M. Gutierrez, Hiroshi Nakagawa, Rachel Hammond, Andres J. Klein-Szanto, Ju-Seog Lee, Sang Bae Kim, Meenhard Herlyn, J. Alan Diehl, Phyllis Gimotty, Anil K. Rustgi

Cancer Res (2010) 70 (13): 5281–5292.

DOI: https://doi.org/10.1158/0008-5472.CAN-10-0704

Published: 30 June 2010

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Includes: Supplementary data

Journal Articles

Epidermal Growth Factor Receptor and Mutant p53 Expand an Esophageal Cellular Subpopulation Capable of Epithelial-to-Mesenchymal Transition through ZEB Transcription Factors

Shinya Ohashi, Mitsuteru Natsuizaka, Gabrielle S. Wong, Carmen Z. Michaylira, Katharine D. Grugan, Douglas B. Stairs, Jiri Kalabis, Maria E. Vega, Ross A. Kalman, Momo Nakagawa, Andres J. Klein-Szanto, Meenhard Herlyn, J. Alan Diehl, Anil K. Rustgi, Hiroshi Nakagawa

Cancer Res (2010) 70 (10): 4174–4184.

DOI: https://doi.org/10.1158/0008-5472.CAN-09-4614

Published: 12 May 2010

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Includes: Supplementary data

Journal Articles

Abstract 2294: IGF-independent regulation of EMT by insulin-like growth factor binding protein-3 in transformed human esophageal cells

Mitsuteru Natsuizaka, Ross A. Kalman, Shinya Ohashi, Munenori Takaoka, Phyllis Gimotty, Wafik S. El-Deiry, Andres Klein-Szanto, J. Alan Diehl, Meenhard Herlyn, Hiroshi Nakagawa

Cancer Res (2010) 70 (8_Supplement): 2294.

DOI: https://doi.org/10.1158/1538-7445.AM10-2294

Published: 15 April 2010

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Journal Articles

Abstract #1282: Tumor-derived Fbx4 mutations disrupt SCFFbx4 activity and result in cyclin D1 accumulation

Barbash Olena, J Alan Diehl

Cancer Res (2009) 69 (9_Supplement): 1282.

Published: 01 May 2009

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Journal Articles

Cell Cycle–Dependent and Schedule-Dependent Antitumor Effects of Sorafenib Combined with Radiation

John P. Plastaras, Seok-Hyun Kim, Yingqiu Y. Liu, David T. Dicker, Jay F. Dorsey, James McDonough, George Cerniglia, Ramji R. Rajendran, Anjali Gupta, Anil K. Rustgi, J. Alan Diehl, Charles D. Smith, Keith T. Flaherty, Wafik S. El-Deiry

Cancer Res (2007) 67 (19): 9443–9454.

DOI: https://doi.org/10.1158/0008-5472.CAN-07-1473

Published: 01 October 2007

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Includes: Supplementary data

NARROW

Carbon Monoxide Activates PERK-Regulated Autophagy to Induce Immunometabolic Reprogramming and Boost Antitumor T-cell Function

Abstract 501: Aldh2 mutation promotes oral and esophageal cancer stem cells via autophagy-mediated redox homeostasis

IL-6 Mediates Cross-Talk between Tumor Cells and Activated Fibroblasts in the Tumor Microenvironment

Abstract A043: Bypass kinase pathways lead to acquired CDK4/6 inhibitor resistance in prostate cancer

Abstract 5874: Cdk4/6 kinase inhibitor resistance in prostate cancer

Abstract 2678: Notch1 regulates epithelial-mesenchymal transition and tumor-initiating capability in esophageal squamous-cell carcinoma

Induction of Therapeutic Senescence in Vemurafenib-Resistant Melanoma by Extended Inhibition of CDK4/6

Abstract 1262: The transcription factor ATF4 regulates resistance to anoikis and promotes metastasis in fibrosarcoma via cooperative upregulation of Heme Oxygenase-1 with Nrf2

Abstract 486: Uncovering novel PERK signaling pathways through chemical-genetic screening

Abstract SY44-02: Insights into pro-survival signaling by PERK

Abstract IA16: Dysregulated mTORC1 renders cells critically dependent on desaturated lipids for survival under tumor-like stress

A NOTCH3-Mediated Squamous Cell Differentiation Program Limits Expansion of EMT-Competent Cells That Express the ZEB Transcription Factors

Abstract 5194: Notch regulates squamous differentiation, cell plasticity and tumor heterogeneity in esophageal carcinoma

Abstract SY06-02: Activation of the UPR by c-Myc promotes transformation and tumorigenesis via cytoprotective autophagy

Abstract 2078: PERK-mediated autophagy promotes Myc-induced transformation and tumorigenesis

Periostin, a Cell Adhesion Molecule, Facilitates Invasion in the Tumor Microenvironment and Annotates a Novel Tumor-Invasive Signature in Esophageal Cancer

Epidermal Growth Factor Receptor and Mutant p53 Expand an Esophageal Cellular Subpopulation Capable of Epithelial-to-Mesenchymal Transition through ZEB Transcription Factors

Abstract 2294: IGF-independent regulation of EMT by insulin-like growth factor binding protein-3 in transformed human esophageal cells

Abstract #1282: Tumor-derived Fbx4 mutations disrupt SCFFbx4 activity and result in cyclin D1 accumulation

Cell Cycle–Dependent and Schedule-Dependent Antitumor Effects of Sorafenib Combined with Radiation

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