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J. Alan Diehl
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Journal Articles

Abstract 5390: Metabolic reprogramming and glutamine addiction in squamous cell carcinoma driven by mutant cyclin D1

Free
Shuyuan Zhang, Polly Phillips-Mason, J. Alan Diehl
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 5390.
https://doi.org/10.1158/1538-7445.AM2025-5390
Published: 21 April 2025
View articletitled, Abstract 5390: Metabolic reprogramming and glutamine addiction in squamous cell carcinoma driven by mutant cyclin D1
Journal Articles

Abstract 3077: Leveraging a 3D organoid library to identify novel therapeutic targets during ESCC initiation and progression

Free
Samuel Flashner, Masataka Shimonosono, Satoshi Takada, Norihiro Matsuura, Yasuto Tomita, Xiao Chen, Alison Taylor, Andres Klein-Szanto, Fatameh Momen-Heravi, J. Alan Diehl, Chao Lu, Hiroshi Nakagawa
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3077.
https://doi.org/10.1158/1538-7445.AM2022-3077
Published: 15 June 2022
View articletitled, Abstract 3077: Leveraging a 3D organoid library to identify novel therapeutic targets during ESCC initiation and progression
Journal Articles

Abstract LB014: Carbon monoxide induced PERK regulated autophagy reprograms anti-tumor T cells with robust immunometabolic phenotype

Free
Paramita Chakraborty, Rasesh Y. Parikh, Seungho Choi, Meenal Mehrotra, Eduardo N. Maldonado, Hongjun Wang, J. Alan Diehl, Vamsi K. Gangaraju, Shikhar Mehrotra
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): LB014.
https://doi.org/10.1158/1538-7445.AM2022-LB014
Published: 15 June 2022
View articletitled, Abstract LB014: Carbon monoxide induced PERK regulated autophagy reprograms anti-tumor T cells with robust immunometabolic phenotype
Journal Articles

Carbon Monoxide Activates PERK-Regulated Autophagy to Induce Immunometabolic Reprogramming and Boost Antitumor T-cell Function

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Paramita Chakraborty, Rasesh Y. Parikh, Seungho Choi, Danh Tran, Monika Gooz, Zachariah T. Hedley, Do-Sung Kim, Dariusz Pytel, Inhong Kang, Satish N. Nadig, Gyda C. Beeson, Lauren Ball, Meenal Mehrotra, Hongjun Wang, Stefano Berto, Viswanathan Palanisamy, Hong Li, Shilpak Chatterjee, Paulo C. Rodriguez, Eduardo N. Maldonado, J. Alan Diehl, Vamsi K. Gangaraju, Shikhar Mehrotra
Journal: Cancer Research
Cancer Res (2022) 82 (10): 1969–1990.
https://doi.org/10.1158/0008-5472.CAN-21-3155
Published: 16 May 2022
View articletitled, Carbon Monoxide Activates PERK-Regulated Autophagy to Induce Immunometabolic Reprogramming and Boost Antitumor T-cell Function
Open the PDF for Carbon Monoxide Activates PERK-Regulated Autophagy to Induce Immunometabolic Reprogramming and Boost Antitumor T-cell Function in another window
Includes: Supplementary data
Journal Articles

Abstract 501: Aldh2 mutation promotes oral and esophageal cancer stem cells via autophagy-mediated redox homeostasis

Free
Masataka Shimonosono, Takashi Kijima, Hisatsugu Maekawa, Satoshi Takada, Koji Tanaka, Varun Sahu, Manti Guha, Andres J. Klein-Szanto, J. Alan Diehl, Adam J. Bass, Anil K. Rustgi, Elizabeth Philipone, Angela J. Yoon, Hiroshi Nakagawa
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 501.
https://doi.org/10.1158/1538-7445.AM2020-501
Published: 15 August 2020
View articletitled, Abstract 501: Aldh2 mutation promotes oral and esophageal cancer stem cells via autophagy-mediated redox homeostasis
Journal Articles

IL-6 Mediates Cross-Talk between Tumor Cells and Activated Fibroblasts in the Tumor Microenvironment

Free
Tatiana A. Karakasheva, Eric W. Lin, Qiaosi Tang, Edmund Qiao, Todd J. Waldron, Monica Soni, Andres J. Klein-Szanto, Varun Sahu, Devraj Basu, Shinya Ohashi, Kiichiro Baba, Zachary T. Giaccone, Sarah R. Walker, David A. Frank, E. Paul Wileyto, Qi Long, Margaret C. Dunagin, Arjun Raj, J. Alan Diehl, K.K. Wong, Adam J. Bass, Anil K. Rustgi
Journal: Cancer Research
Cancer Res (2018) 78 (17): 4957–4970.
https://doi.org/10.1158/0008-5472.CAN-17-2268
Published: 04 September 2018
View articletitled, IL-6 Mediates Cross-Talk between Tumor Cells and Activated Fibroblasts in the Tumor Microenvironment
Open the PDF for IL-6 Mediates Cross-Talk between Tumor Cells and Activated Fibroblasts in the Tumor Microenvironment in another window
Includes: Supplementary data
Journal Articles

Abstract A043: Bypass kinase pathways lead to acquired CDK4/6 inhibitor resistance in prostate cancer

Free
Renee de Leeuw, Christopher M. McNair, Matthew J. Schiewer, Neermala P. Neupane, Michael A. Augello, Zhen Li, Larry Cheng, Akihiro Yoshida, J. Alan Diehl, E Starr Hazard, Sean M. McCourtney, Gary Hardiman, Maha H. Hussain, Justin M. Drake, Wm. Kevin Kelly, Karen E. Knudsen
Journal: Cancer Research
Cancer Res (2018) 78 (16_Supplement): A043.
https://doi.org/10.1158/1538-7445.PRCA2017-A043
Published: 14 August 2018
View articletitled, Abstract A043: Bypass kinase pathways lead to acquired CDK4/6 inhibitor resistance in prostate cancer
Journal Articles

Abstract 5874: Cdk4/6 kinase inhibitor resistance in prostate cancer

Free
Renee de Leeuw, Matthew J. Schiewer, Christopher McNair, Michael A. Augello, Akihiro Yoshida, Edward S. Hazard, Sean Courtney, Gerard T. Hardiman, Justin Drake, Felix Y. Feng, Scott Tomlins, Maha H. Hussain, J Alan Diehl, William K. Kelly, Karen E. Knudsen
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 5874.
https://doi.org/10.1158/1538-7445.AM2017-5874
Published: 01 July 2017
View articletitled, Abstract 5874: Cdk4/6 kinase inhibitor resistance in prostate cancer
Journal Articles

Abstract 2678: Notch1 regulates epithelial-mesenchymal transition and tumor-initiating capability in esophageal squamous-cell carcinoma

Free
Koji Tanaka, Kelly A. Whelan, Naryan L. Rustgi, Prasanna M. Chandramouleeswaran, Seiji Naganuma, Shingo Kagawa, Mitsuteru Natsuizaka, Yoshiaki Kita, Shoji Natsugoe, Que Jianwen, Devraj Basu, Andres J. Klein-Szanto, Adam Bass, J. Alan Diehl, Hiroshi Nakagawa
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2678.
https://doi.org/10.1158/1538-7445.AM2016-2678
Published: 15 July 2016
View articletitled, Abstract 2678: Notch1 regulates epithelial-mesenchymal transition and tumor-initiating capability in esophageal squamous-cell carcinoma
Journal Articles

Induction of Therapeutic Senescence in Vemurafenib-Resistant Melanoma by Extended Inhibition of CDK4/6

Free
Akihiro Yoshida, Eric K. Lee, J. Alan Diehl
Journal: Cancer Research
Cancer Res (2016) 76 (10): 2990–3002.
https://doi.org/10.1158/0008-5472.CAN-15-2931
Published: 12 May 2016
View articletitled, Induction of Therapeutic Senescence in Vemurafenib-Resistant Melanoma by Extended Inhibition of CDK4/6
Open the PDF for Induction of Therapeutic Senescence in Vemurafenib-Resistant Melanoma by Extended Inhibition of CDK4/6 in another window
Includes: Supplementary data
Journal Articles

Abstract 1262: The transcription factor ATF4 regulates resistance to anoikis and promotes metastasis in fibrosarcoma via cooperative upregulation of Heme Oxygenase-1 with Nrf2

Free
Souvik Dey, Carly M. Sayers, Stacey L. Lehman, Yi Cheng, George J. Cerniglia, Stephen W. Tuttle, Michael D. Feldman, Paul J.L. Zhang, Serge Y. Fuchs, J. Alan Diehl, Constantinos Koumenis
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1262.
https://doi.org/10.1158/1538-7445.AM2015-1262
Published: 01 August 2015
View articletitled, Abstract 1262: The transcription factor ATF4 regulates resistance to anoikis and promotes metastasis in fibrosarcoma via cooperative upregulation of Heme Oxygenase-1 with Nrf2
Journal Articles

Abstract 486: Uncovering novel PERK signaling pathways through chemical-genetic screening

Free
Nancy L. Maas, Rebecca Levin, Nickpreet Singh, Kevan Shokat, J. Alan Diehl
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 486.
https://doi.org/10.1158/1538-7445.AM2014-486
Published: 01 October 2014
View articletitled, Abstract 486: Uncovering novel PERK signaling pathways through chemical-genetic screening
Journal Articles

Abstract SY44-02: Insights into pro-survival signaling by PERK

Free
J. Alan Diehl
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): SY44-02.
https://doi.org/10.1158/1538-7445.AM2014-SY44-02
Published: 01 October 2014
View articletitled, Abstract SY44-02: Insights into pro-survival signaling by PERK
Journal Articles

Abstract IA16: Dysregulated mTORC1 renders cells critically dependent on desaturated lipids for survival under tumor-like stress

Free
Regina Young, Daniel Ackerman, Zachary Quinn, Anthony Mancuso, Michaela Gruber, Liping Liu, Dionysios Giannoukos, Ekaterina Bobovnikova-Marjon, J. Alan Diehl, Brian Keith, M. Celeste Simon
Journal: Cancer Research
Cancer Res (2013) 73 (19_Supplement): IA16.
https://doi.org/10.1158/1538-7445.FBCR13-IA16
Published: 15 May 2014
View articletitled, Abstract IA16: Dysregulated mTORC1 renders cells critically dependent on desaturated lipids for survival under tumor-like stress
Journal Articles

A NOTCH3-Mediated Squamous Cell Differentiation Program Limits Expansion of EMT-Competent Cells That Express the ZEB Transcription Factors

Free
Shinya Ohashi, Mitsuteru Natsuizaka, Seiji Naganuma, Shingo Kagawa, Sotai Kimura, Hiroshi Itoh, Ross A. Kalman, Momo Nakagawa, Douglas S. Darling, Devraj Basu, Phyllis A. Gimotty, Andres J. Klein-Szanto, J. Alan Diehl, Meenhard Herlyn, Hiroshi Nakagawa
Journal: Cancer Research
Cancer Res (2011) 71 (21): 6836–6847.
https://doi.org/10.1158/0008-5472.CAN-11-0846
Published: 30 October 2011
View articletitled, A NOTCH3-Mediated Squamous Cell Differentiation Program Limits Expansion of EMT-Competent Cells That Express the ZEB Transcription Factors
Open the PDF for A NOTCH3-Mediated Squamous Cell Differentiation Program Limits Expansion of EMT-Competent Cells That Express the ZEB Transcription Factors in another window
Includes: Supplementary data
Journal Articles

Abstract SY06-02: Activation of the UPR by c-Myc promotes transformation and tumorigenesis via cytoprotective autophagy

Free
Constantinos Koumenis, Haiyan Zhang, Meixia Bi, Stacey L. Lehman, Tatini Datta, Huayi Liu, Andrei Thomas-Tikhonenko, Albert Koong, Serge Y. Fuchs, J. Alan Diehl, Davide Ruggero
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): SY06-02.
https://doi.org/10.1158/1538-7445.AM2011-SY06-02
Published: 15 April 2011
View articletitled, Abstract SY06-02: Activation of the UPR by c-Myc promotes transformation and tumorigenesis via cytoprotective autophagy
Journal Articles

Abstract 5194: Notch regulates squamous differentiation, cell plasticity and tumor heterogeneity in esophageal carcinoma

Free
Mitsuteru Natsuizaka, Shinya Ohashi, Seiji Naganuma, Ross A. Kalman, Asami Ohyama, Ben Rhoades, Maria E. Vega, Douglas B. Stairs, Andres J. Klein-Szanto, J. Alan Diehl, Devraj Basu, Meenhard Herlyn, Warren S. Pear, Hiroshi Nakagawa
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 5194.
https://doi.org/10.1158/1538-7445.AM2011-5194
Published: 15 April 2011
View articletitled, Abstract 5194: Notch regulates squamous differentiation, cell plasticity and tumor heterogeneity in esophageal carcinoma
Journal Articles

Abstract 2078: PERK-mediated autophagy promotes Myc-induced transformation and tumorigenesis

Free
Lori S. Hart, Tom Cunningham, Tatini Datta, Huayi Liu, Albert C. Koong, Serge Fuchs, J. Alan Diehl, Davide Ruggero, Constantinos Koumenis
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 2078.
https://doi.org/10.1158/1538-7445.AM2011-2078
Published: 15 April 2011
View articletitled, Abstract 2078: PERK-mediated autophagy promotes Myc-induced transformation and tumorigenesis
Journal Articles

Periostin, a Cell Adhesion Molecule, Facilitates Invasion in the Tumor Microenvironment and Annotates a Novel Tumor-Invasive Signature in Esophageal Cancer

Free
Carmen Z. Michaylira, Gabrielle S. Wong, Charles G. Miller, Christie M. Gutierrez, Hiroshi Nakagawa, Rachel Hammond, Andres J. Klein-Szanto, Ju-Seog Lee, Sang Bae Kim, Meenhard Herlyn, J. Alan Diehl, Phyllis Gimotty, Anil K. Rustgi
Journal: Cancer Research
Cancer Res (2010) 70 (13): 5281–5292.
https://doi.org/10.1158/0008-5472.CAN-10-0704
Published: 30 June 2010
View articletitled, Periostin, a Cell Adhesion Molecule, Facilitates Invasion in the Tumor Microenvironment and Annotates a Novel Tumor-Invasive Signature in Esophageal Cancer
Open the PDF for Periostin, a Cell Adhesion Molecule, Facilitates Invasion in the Tumor Microenvironment and Annotates a Novel Tumor-Invasive Signature in Esophageal Cancer in another window
Includes: Supplementary data
Journal Articles

Epidermal Growth Factor Receptor and Mutant p53 Expand an Esophageal Cellular Subpopulation Capable of Epithelial-to-Mesenchymal Transition through ZEB Transcription Factors

Free
Shinya Ohashi, Mitsuteru Natsuizaka, Gabrielle S. Wong, Carmen Z. Michaylira, Katharine D. Grugan, Douglas B. Stairs, Jiri Kalabis, Maria E. Vega, Ross A. Kalman, Momo Nakagawa, Andres J. Klein-Szanto, Meenhard Herlyn, J. Alan Diehl, Anil K. Rustgi, Hiroshi Nakagawa
Journal: Cancer Research
Cancer Res (2010) 70 (10): 4174–4184.
https://doi.org/10.1158/0008-5472.CAN-09-4614
Published: 12 May 2010
View articletitled, Epidermal Growth Factor Receptor and Mutant p53 Expand an Esophageal Cellular Subpopulation Capable of Epithelial-to-Mesenchymal Transition through ZEB Transcription Factors
Open the PDF for Epidermal Growth Factor Receptor and Mutant p53 Expand an Esophageal Cellular Subpopulation Capable of Epithelial-to-Mesenchymal Transition through ZEB Transcription Factors in another window
Includes: Supplementary data