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Isabelle Ray-Coquard
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Journal Articles

Abstract CT188: BEHOLD-1: A Phase 1 Dose Escalation Study of GSK5733584, a B7-H4-Targeted Antibody-Drug Conjugate, in Patients With Advanced Solid Tumors, Including Dose Expansion in Patients With Endometrial and Platinum-Resistant Ovarian Cancer

William McKean, Philippe L. Bedard, Phuong Dinh, Dhabusha Sabanathan, Toon Van Gorp, John Hilton, Katriina Jalkanen, Isabelle Ray-Coquard, Domenica Lorusso, Shigehisa Kitano, Marloes GJ Van Rijn-Van Drongen, Valentina Boni, Victor Moreno, Lisa Liu Burström, Alexander Philipovskiy, Alina Goetz, Julie Holden, Shruti Shah, Jeremy Waight, Francisco J. Gonzalez Carreras, Antonio Riccio, Morrys C. Kaisermann, Jennifer Veneris, Minal Barve
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_2): CT188.
https://doi.org/10.1158/1538-7445.AM2025-CT188
Published: 25 April 2025
View articletitled, Abstract CT188: BEHOLD-1: A Phase 1 Dose Escalation Study of GSK5733584, a B7-H4-Targeted Antibody-Drug Conjugate, in Patients With Advanced Solid Tumors, Including Dose Expansion in Patients With Endometrial and Platinum-Resistant Ovarian Cancer
Journal Articles

Abstract 5273: Changes in the tumor immune microenvironment during disease progression in gynecological carcinosarcoma: Exploratory analysis from the randomized ROCSAN GINECO trial

Sonia Canjura-Rodriguez, Cassandra Assaf, Victor Heurtier, Annalisa Pesavento, Justine Berthet, Audrey Bellesoeur, Coriolan Lebreton, Sheik Emambux, Dominique Berton, Magali Provansal, Guillaume Bataillon, Lucas Michon, Jessie Auclair, Alexandra Lainé, Valéry Attignon, Christophe Caux, Anthony Ferrari, Ivan Bièche, Bertrand Dubois, Isabelle Ray-Coquard, Pierre Saintigny
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 5273.
https://doi.org/10.1158/1538-7445.AM2025-5273
Published: 21 April 2025
View articletitled, Abstract 5273: Changes in the tumor immune microenvironment during disease progression in gynecological carcinosarcoma: Exploratory analysis from the randomized ROCSAN GINECO trial
Journal Articles

Abstract 6360: A tumor agnostic composite gene expression signature identifies three groups of patients treated with immune checkpoint blockade with distinct clinical outcome

Mehdi Lamkhioued, Guillaume Robert-Siegwald, Roxane Pommier, Deborah Tricoli, Camille Brodin, Valery Attignon, Nicolas Gadot, Severine Tabone-Eglinger, Fayette Jerome, Aurelie Swalduz, Isabelle Ray-Coquard, Eve-Marie Neidhardt, Clélia Coutzac, Loic Verlingue, Olivier Tredan, Jean-Yves Blay, Christophe Caux, Alain Viari, Nicolas Poirier, Aurore Morello, Isabelle Girault, Pierre Saintigny
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 6360.
https://doi.org/10.1158/1538-7445.AM2025-6360
Published: 21 April 2025
View articletitled, Abstract 6360: A tumor agnostic composite gene expression signature identifies three groups of patients treated with immune checkpoint blockade with distinct clinical outcome
Journal Articles

Abstract CT058: TROPION-PanTumor03: Phase 2, multicenter study of datopotamab deruxtecan (Dato-DXd) as monotherapy and in combination with anticancer agents in patients (pts) with advanced/metastatic solid tumors

Funda Meric-Bernstam, Yelena Janjigian, Joshua Lang, Kristen K. Ciombor, Isabelle Ray-Coquard, Amit Oza, Kan Yonemori, Ruihua Xu, Jimmy L. Zhao, Srikanth Gajavelli, Justyna Filant, Tina Hovey, Ana Oaknin
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): CT058.
https://doi.org/10.1158/1538-7445.AM2023-CT058
Published: 14 April 2023
View articletitled, Abstract CT058: TROPION-PanTumor03: Phase 2, multicenter study of datopotamab deruxtecan (Dato-DXd) as monotherapy and in combination with anticancer agents in patients (pts) with advanced/metastatic solid tumors
Journal Articles

Abstract 774: Anti-Müllerian hormone type II receptor (AMHRII) found expressed in human non-gynecological solid tumors, suggesting potential broader applications for anti-AMHRII-based therapy

Jean-Marc M. Barret, Didier Meseure, Guillaume Bataillon, Noora Andersson, Aurélie Auguste, Olivier Dubreuil, Anniina Färkkilä, Emeline Perrial, Celine Bossard, Emily Loison, Anne Jarry, André Nicolas, Fanny Lemée, Solenne Gaillard, Mehdi Lahmar, Mikko Anttonen, Gabriel Champenois, Charles Dumontet, Isabelle Ray-Coquard, Alexandra Leary, Isabelle Tabah-Fisch, Anne Vincent-Salomon, Jean-François F. Prost
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 774.
https://doi.org/10.1158/1538-7445.AM2018-774
Published: 01 July 2018
View articletitled, Abstract 774: Anti-Müllerian hormone type II receptor (AMHRII) found expressed in human non-gynecological solid tumors, suggesting potential broader applications for anti-AMHRII-based therapy
Journal Articles

Abstract 2574: Interleukin-7 (CYT107) treatment in lymphopenic 1st line metastatic breast carcinoma patients treated with chemotherapy regimen (Capecitabine) favors the restoration of T-cell subsets number

Christine Menetrier-Caux, Isabelle Ray-Coquard, Claire Cropet, Estelle Verronese, Thomas Bachelot, Olivier Tredan, Gwenaelle Garin, Pierre Heudel, Axelle N'Kodia, Ana Delgado, Christine Bardin-Dit-Courageot, Chantal Rigal, Gilles Clapisson, Sylvie Chabaud, David Perol, Paul Rebattu, Thérèse Croughs, Nicolas Pasqual, Manuarii Manuel, Michel Morre, Jean-Yves Blay, Christophe Caux
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2574.
https://doi.org/10.1158/1538-7445.AM2014-2574
Published: 01 October 2014
View articletitled, Abstract 2574: Interleukin-7 (CYT107) treatment in lymphopenic 1st line metastatic breast carcinoma patients treated with chemotherapy regimen (Capecitabine) favors the restoration of T-cell subsets number
Journal Articles

Abstract CT209: A phase I study with the oral pan-CDK inhibitor BAY 1000394 in patients with advanced stage small cell lung or ovarian cancer

Rastilav Bahleda, Fabrice Barlesi, Christine Audebert, Maurice Perol, Isabelle Ray-Coquard, Dirk Strumberg, Beate Schultheis, Ramaswamy Govindan, Grace K. Dy, Gerard Zalcman, Annette O. Walter, Martin Kornacker, Matthias Ocker, Jean-Charles Soria
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): CT209.
https://doi.org/10.1158/1538-7445.AM2014-CT209
Published: 01 October 2014
View articletitled, Abstract CT209: A phase I study with the oral pan-CDK inhibitor BAY 1000394 in patients with advanced stage small cell lung or ovarian cancer
Journal Articles

Abstract 3480: Impact of a second opinion for sex cord stromal tumors through expression and molecular analysis of FOXL2: a study of the GINECO group and TMRO network.

Thibaut Goulvent, Denis Maillet, Ruth Rimokh, Philippe Cassier, Marie-Cecile Vacher-Lavenu, Pierre Meeus, Patricia Pautier, Pierre Duvillard, Jerome Alexandre, Eric Pujade-Laurraine, Mojgan Devouassoux-Shisheboran, Isabelle Treilleux, Isabelle Ray-coquard
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 3480.
https://doi.org/10.1158/1538-7445.AM2013-3480
Published: 15 April 2013
View articletitled, Abstract 3480: Impact of a second opinion for sex cord stromal tumors through expression and molecular analysis of FOXL2: a study of the GINECO group and TMRO network.
Journal Articles

Abstract 5578: IGF-1R nuclear staining in tumor cells identifies sarcoma patients with a prolonged progression free survival after IGF-1R monoclonal antibody therapy

Irene Asmane, Emmanuel Watkin, Perrine Marec-Berard, Isabelle Ray-Coquard, Laurent Alberti, Philippe Cassier, Anne-Valerie Decouvelaere, Dominique Ranchere, Jean-Emmanuel Kurtz, Jean-Pierre Bergerat, Jean-Yves Blay
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 5578.
https://doi.org/10.1158/1538-7445.AM2012-5578
Published: 15 April 2012
View articletitled, Abstract 5578: IGF-1R nuclear staining in tumor cells identifies sarcoma patients with a prolonged progression free survival after IGF-1R monoclonal antibody therapy
Journal Articles

Quantitative and Functional Alterations of Plasmacytoid Dendritic Cells Contribute to Immune Tolerance in Ovarian Cancer

Sana Intidhar Labidi-Galy, Vanja Sisirak, Pierre Meeus, Michael Gobert, Isabelle Treilleux, Agathe Bajard, Jean-Damien Combes, Julien Faget, François Mithieux, Alexandre Cassignol, Olivier Tredan, Isabelle Durand, Christine Ménétrier-Caux, Christophe Caux, Jean-Yves Blay, Isabelle Ray-Coquard, Nathalie Bendriss-Vermare
Journal: Cancer Research
Cancer Res (2011) 71 (16): 5423–5434.
https://doi.org/10.1158/0008-5472.CAN-11-0367
Published: 11 August 2011
View articletitled, Quantitative and Functional Alterations of Plasmacytoid Dendritic Cells Contribute to Immune Tolerance in Ovarian Cancer
Open the PDF for Quantitative and Functional Alterations of Plasmacytoid Dendritic Cells Contribute to Immune Tolerance in Ovarian Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 2267: Long term prognostic impact of CD4 and CD8 lymphopenia and rapid recovery in a cohort of 220 patients with a 10 years follow-up

Julien Peron, Isabelle Ray-Coquard, Philippe Cassier, Intidhar Labidi-Galy, Olivier Tredan, Thomas Bachelor, Catherine Sebban, Pierre Biron, Guillaume Glapisson, Jean-Yves Blay
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 2267.
https://doi.org/10.1158/1538-7445.AM2011-2267
Published: 15 April 2011
View articletitled, Abstract 2267: Long term prognostic impact of CD4 and CD8 lymphopenia and rapid recovery in a cohort of 220 patients with a 10 years follow-up
Journal Articles

Abstract 1910: Infiltration of ovarian carcinoma by altered plasmacytoid dendritic cells could contribute to local immune tolerance

Sana Intidhar Labidi-Galy, Isabelle Ray-Coquard, Vanja Sisirak, Isabelle Treilleux, Pierre Meeus, François Mithieux, Alexandre Cassignol, François Bouchard, Philippe Gabelle, Jean-Paul Guastalla, Christine Ménetrier-Caux, Christophe Caux, Nathalie Bendriss-Vermare
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 1910.
https://doi.org/10.1158/1538-7445.AM10-1910
Published: 15 April 2010
View articletitled, Abstract 1910: Infiltration of ovarian carcinoma by altered plasmacytoid dendritic cells could contribute to local immune tolerance
Journal Articles

Abstract 2699: ERCC5 (XPG) status and clinical activity of trabectedin in patients with advanced soft-tissue sarcoma

Antoine Italiano, Armelle Laurand, François Moisan, Jacques Robert, Isabelle Ray-Coquard, Jean-Yves Blay, Binh Bui, Jean-Michel Coindre, Susana Benlloch, Juan-Carlos Tercero, Philippe Pourquier
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 2699.
https://doi.org/10.1158/1538-7445.AM10-2699
Published: 15 April 2010
View articletitled, Abstract 2699: ERCC5 (XPG) status and clinical activity of trabectedin in patients with advanced soft-tissue sarcoma
Journal Articles

Lymphopenia as a Prognostic Factor for Overall Survival in Advanced Carcinomas, Sarcomas, and Lymphomas

Isabelle Ray-Coquard, Claire Cropet, Martine Van Glabbeke, Catherine Sebban, Axel Le Cesne, Ian Judson, Olivier Tredan, Jaap Verweij, Pierre Biron, Inthidar Labidi, Jean-Paul Guastalla, Thomas Bachelot, David Perol, Sylvie Chabaud, Pancras C.W. Hogendoorn, Philippe Cassier, Armelle Dufresne, Jean-Yves Blay, on behalf of the European Organization for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group
Journal: Cancer Research
Cancer Res (2009) 69 (13): 5383–5391.
https://doi.org/10.1158/0008-5472.CAN-08-3845
Published: 01 July 2009
View articletitled, Lymphopenia as a Prognostic Factor for Overall Survival in Advanced Carcinomas, Sarcomas, and Lymphomas
Open the PDF for Lymphopenia as a Prognostic Factor for Overall Survival in Advanced Carcinomas, Sarcomas, and Lymphomas in another window
Journal Articles

Abstract #5626: Two different soft tissue leiomyosarcoma subtypes distinguished by protein expression patterns and FAK phosphorylation

Hiba ElSayadi, Daniel Pissaloux, Laurent Alberti, Severine Tabone-Eglinger, Dominique Ranchere, Isabelle Ray-Coquard, Olivier Tredan, Jean-Yves Blay
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 5626.
Published: 01 May 2009
View articletitled, Abstract #5626: Two different soft tissue leiomyosarcoma subtypes distinguished by protein expression patterns and FAK phosphorylation
Journal Articles

Regulatory T Cells Recruited through CCL22/CCR4 Are Selectively Activated in Lymphoid Infiltrates Surrounding Primary Breast Tumors and Lead to an Adverse Clinical Outcome

Michael Gobert, Isabelle Treilleux, Nathalie Bendriss-Vermare, Thomas Bachelot, Sophie Goddard-Leon, Vanessa Arfi, Cathy Biota, Anne Claire Doffin, Isabelle Durand, Daniel Olive, Solène Perez, Nicolas Pasqual, Christelle Faure, Isabelle Ray-Coquard, Alain Puisieux, Christophe Caux, Jean-Yves Blay, Christine Ménétrier-Caux
Journal: Cancer Research
Cancer Res (2009) 69 (5): 2000–2009.
https://doi.org/10.1158/0008-5472.CAN-08-2360
Published: 02 March 2009
View articletitled, Regulatory T Cells Recruited through CCL22/CCR4 Are Selectively Activated in Lymphoid Infiltrates Surrounding Primary Breast Tumors and Lead to an Adverse Clinical Outcome
Open the PDF for Regulatory T Cells Recruited through CCL22/CCR4 Are Selectively Activated in Lymphoid Infiltrates Surrounding Primary Breast Tumors and Lead to an Adverse Clinical Outcome in another window
Includes: Supplementary data
Journal Articles

Molecular subtypes of breast carcinomas are characterized by different lymphocytes and dendritic cells infiltrates in primary breast carcinoma: Analysis of a series of 256 patients.

Jean-Yves Blay, Isabelle Treilleux, Thomas Bachelot, Christine Caux, Michael Grobert, Jean Paul Guastalla, Isabelle Ray-Coquard, Alain Bremond, Serge Lebecque, Christophe Caux
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 1181.
Published: 15 April 2006
View articletitled, Molecular subtypes of breast carcinomas are characterized by different lymphocytes and dendritic cells infiltrates in primary breast carcinoma: Analysis of a series of 256 patients.
Journal Articles

CD3+ lymphocyte infiltrates without DC Lamp+ dendritic cells is an independent prognostic factor for poor progression free survival (PFS) in primary breast carcinoma

Jean Yves Blay, Isabelle Treilleux, Nathalie Bendriss-Vermare, Thomas Bachelot, Isabelle Ray-Coquard, Jean-Paul Guastalla, Alain Bremond, Sophie Godard, Jean-Jacques Pin, Clarisse Barthelemy, Serge Lebecque
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 736–737.
Published: 01 May 2005
View articletitled, CD3+ lymphocyte infiltrates without DC Lamp+ dendritic cells is an independent prognostic factor for poor progression free survival (PFS) in primary breast carcinoma
Journal Articles

Chemokine receptor expression expression in non tumoral stromal cells correlate with node involvment and survival in primary breast carcinoma

Jean-Yves Blay, Isabelle Treilleux, Nathalie Bendriss-Vermare, Isabelle Ray-Coquard, Thomas Bachelot, Jean-Paul Guastalla, Alain Bremond, Sophie Godard, Jean-Jacques Pin, Clarisse Barthelemy, Serge Lebecque
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 438.
Published: 01 April 2004
View articletitled, Chemokine receptor expression expression in non tumoral stromal cells correlate with node involvment and survival in primary breast carcinoma