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Irene Oi-lin Ng
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Journal Articles

Abstract 6249: Single-cell RNA sequencing investigation of multi-stage NASH-related HCC mouse model

Tina Suoangbaji, Vanilla Xin Zhang, Daniel Wai-Hung Ho, Irene Oi-Lin Ng
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6249.
https://doi.org/10.1158/1538-7445.AM2024-6249
Published: 22 March 2024
View article titled, Abstract 6249: Single-cell RNA sequencing investigation of multi-stage NASH-related HCC mouse model
Journal Articles

Abstract 6982: The roles of NDRG1 in HCC progression and its clinical significance

Jingyi Lu, Lu Tian, Yu-Man Tsui, Xia Wong, Qingyang Zhang, Daniel Wai-Hung Ho, Irene Oi-Lin Ng
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6982.
https://doi.org/10.1158/1538-7445.AM2024-6982
Published: 22 March 2024
View article titled, Abstract 6982: The roles of NDRG1 in HCC progression and its clinical significance
Journal Articles

Abstract 433: BCAT1 promotes HCC metabolic reprogramming and survival through HIF-1α stabilization

Misty Shuo Zhang, Kenneth Kin-Leung Kwan, Weixing Li, Adonia E. Papathanassiu, Irene Oi-Lin Ng, Carmen Chak-Lui Wong
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 433.
https://doi.org/10.1158/1538-7445.AM2024-433
Published: 22 March 2024
View article titled, Abstract 433: BCAT1 promotes HCC metabolic reprogramming and survival through HIF-1α stabilization
Journal Articles

Abstract 1481: Disparity landscapes of HBV integration in hepatocellular carcinoma: Mechanistic characterization and functional implications

Xueying Lyu, Karen Man-Fong Sze, Joyce Man-Fong Lee, Abdullah Husain, Irene Oi-Lin Ng, Daniel Wai-Hung Ho
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1481.
https://doi.org/10.1158/1538-7445.AM2024-1481
Published: 22 March 2024
View article titled, Abstract 1481: Disparity landscapes of HBV integration in hepatocellular carcinoma: Mechanistic characterization and functional implications
Journal Articles

Abstract 425: GPD1L participates in glycerol-3-phosphate biogenesis and promotes tumor initiation and invasion in hepatocellular carcinoma

Tiffany Ching-Yun Yu, Luqing Zhao, Lu Tian, Charles Shing Kam, Joyce Man-Fong Lee, Daniel Wai-Hung Ho, Lo-Kong Chan, Yu-Man Tsui, Karen Man-Fong Sze, Irene Oi-Lin Ng
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 425.
https://doi.org/10.1158/1538-7445.AM2024-425
Published: 22 March 2024
View article titled, Abstract 425: GPD1L participates in glycerol-3-phosphate biogenesis and promotes tumor initiation and invasion in hepatocellular carcinoma
Journal Articles

Abstract 3985: S100A10 promotes HCC development and progression via transfer in extracellular vesicles and regulating their protein cargos

Lu TIAN, Xia WANG, Jingyi LU, HongYang Huang, Goofy Yu-Man Tsui, Karen Man-Fong Sze, Tan-To Cheung, Irene Oi-Lin NG
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3985.
https://doi.org/10.1158/1538-7445.AM2023-3985
Published: 04 April 2023
View article titled, Abstract 3985: S100A10 promotes HCC development and progression via transfer in extracellular vesicles and regulating their protein cargos
Journal Articles

Caspase-3–Induced Activation of SREBP2 Drives Drug Resistance via Promotion of Cholesterol Biosynthesis in Hepatocellular Carcinoma

Etienne Ho Kit Mok, Carmen Oi Ning Leung, Lei Zhou, Martina Mang Leng Lei, Hoi Wing Leung, Man Tong, Tin Lok Wong, Eunice Yuen Ting Lau, Irene Oi Lin Ng, Jin Ding, Jing Ping Yun, Jun Yu, Hui Lian Zhu, Chi Ho Lin, Dan Lindholm, Kit Sum Leung, Jonathan D. Cybulski, David M. Baker, Stephanie Ma, Terence Kin Wah Lee
Journal: Cancer Research
Cancer Res (2022) 82 (17): 3102–3115.
https://doi.org/10.1158/0008-5472.CAN-21-2934
Published: 02 September 2022
View article titled, Caspase-3–Induced Activation of SREBP2 Drives Drug Resistance via Promotion of Cholesterol Biosynthesis in Hepatocellular Carcinoma
Open the PDF for Caspase-3–Induced Activation of SREBP2 Drives Drug Resistance via Promotion of Cholesterol Biosynthesis in Hepatocellular Carcinoma in another window
Includes: Supplementary data
Journal Articles

Suppression of ACADM-Mediated Fatty Acid Oxidation Promotes Hepatocellular Carcinoma via Aberrant CAV1/SREBP1 Signaling

Angel P.Y. Ma, Cherlie L.S. Yeung, Sze Keong Tey, Xiaowen Mao, Samuel W.K. Wong, Tung Him Ng, Frankie C.F. Ko, Ernest M.L. Kwong, Alexander H.N. Tang, Irene Oi-Lin Ng, Shao Hang Cai, Jing Ping Yun, Judy W.P. Yam
Journal: Cancer Research
Cancer Res (2021) 81 (13): 3679–3692.
https://doi.org/10.1158/0008-5472.CAN-20-3944
Published: 01 July 2021
View article titled, Suppression of ACADM-Mediated Fatty Acid Oxidation Promotes Hepatocellular Carcinoma via Aberrant CAV1/SREBP1 Signaling
Open the PDF for Suppression of ACADM-Mediated Fatty Acid Oxidation Promotes Hepatocellular Carcinoma via Aberrant CAV1/SREBP1 Signaling in another window
Includes: Supplementary data
Journal Articles

EPHB2 Activates β-Catenin to Enhance Cancer Stem Cell Properties and Drive Sorafenib Resistance in Hepatocellular Carcinoma

Hoi Wing Leung, Carmen Oi Ning Leung, Eunice Y. Lau, Katherine Po Sin Chung, Etienne H. Mok, Martina Mang Leng Lei, Rainbow Wing Hei Leung, Man Tong, Vincent W. Keng, Cong Ma, Qian Zhao, Irene Oi Lin Ng, Stephanie Ma, Terence K. Lee
Journal: Cancer Research
Cancer Res (2021) 81 (12): 3229–3240.
https://doi.org/10.1158/0008-5472.CAN-21-0184
Published: 15 June 2021
View article titled, EPHB2 Activates β-Catenin to Enhance Cancer Stem Cell Properties and Drive Sorafenib Resistance in Hepatocellular Carcinoma
Open the PDF for EPHB2 Activates β-Catenin to Enhance Cancer Stem Cell Properties and Drive Sorafenib Resistance in Hepatocellular Carcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract 2589: Dysregulation of RalGAPA2 in hepatocellular carcinoma

Lu Tian, Lo Kong Chan, Daniel Wai Hung HO, LuQing Zhao, Irene Oi Lin NG
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 2589.
https://doi.org/10.1158/1538-7445.AM2020-2589
Published: 15 August 2020
View article titled, Abstract 2589: Dysregulation of RalGAPA2 in hepatocellular carcinoma
Journal Articles

Abstract 882: Thioredoxin system inhibition using auranofin represents a new therapeutic approach for hepatocellular carcinoma

Derek Lee, Iris Ming-Jing Xu, David Kung-Chun Chiu, Robin Kit-Ho Lai, Chun-Ming Wong, Irene Oi-Lin Ng, Carmen Chak-Lui Wong
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 882.
https://doi.org/10.1158/1538-7445.AM2019-882
Published: 01 July 2019
View article titled, Abstract 882: Thioredoxin system inhibition using auranofin represents a new therapeutic approach for hepatocellular carcinoma
Journal Articles

Abstract 2415: HEY1 counteracts hypoxia-induced oxidative stress via transcriptionally repressing PINK1 in hepatocellular carcinoma

David Kung-Chun Chiu, Iris Ming-Jing Xu, Robin Kit-Ho Lai, Aki Pui-Wah Tse, Dicky Cheuk-Ting Law, Vincent Wai-Hin Yuen, Larry Lai Wei, Hui-Yu Koh, Chun-Ming Wong, Irene Oi-Lin Ng, Carmen Chak-Lui Wong
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2415.
https://doi.org/10.1158/1538-7445.AM2018-2415
Published: 01 July 2018
View article titled, Abstract 2415: HEY1 counteracts hypoxia-induced oxidative stress via transcriptionally repressing PINK1 in hepatocellular carcinoma
Journal Articles

Abstract 468: Antioxidant supplements may accelerate the formation and progression of hepatocellular carcinoma in vitro and in vivo

Xin Zhang, Eva Lee, Yu-Man Tsui, Man-Fong Sze, Yung-Tuen Chiu, Lo-Kong Chan, Daniel Wai-Hung Ho, Lu-Qing Zhao, Macrina Wai-Ling Lam, Lu Tian, Joyce Man-Fong Lee, Derek Lee, Carmen Chak-Lui Wong, Irene Oi-Lin Ng
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 468.
https://doi.org/10.1158/1538-7445.AM2018-468
Published: 01 July 2018
View article titled, Abstract 468: Antioxidant supplements may accelerate the formation and progression of hepatocellular carcinoma in vitro and in vivo
Journal Articles

Abstract 2445: Oxidative stress induction through TXNRD1 inhibition as a therapeutic strategy in hepatocellular carcinoma treatment

Derek Lee, Iris Ming Jing Xu, David Kung Chun Chiu, Robin Kit Ho Lai, Chun Ming Wong, Irene Oi Lin Ng, Carmen Chak Lui Wong
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2445.
https://doi.org/10.1158/1538-7445.AM2018-2445
Published: 01 July 2018
View article titled, Abstract 2445: Oxidative stress induction through TXNRD1 inhibition as a therapeutic strategy in hepatocellular carcinoma treatment
Journal Articles

Abstract 2429: HIF-1α repressed glycerol-3-phosphate shuttle to reduce oxidative stress in liver cancer

Shuo ZHANG, Robin Kit-Ho LAI, David Kung-Chun CHIU, Iris Mingjing XU, Aki Pui Wah TSE, Chun-Ming WONG, Irene Oi Lin NG, Carmen Chak Lui WONG
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2429.
https://doi.org/10.1158/1538-7445.AM2018-2429
Published: 01 July 2018
View article titled, Abstract 2429: HIF-1α repressed glycerol-3-phosphate shuttle to reduce oxidative stress in liver cancer
Journal Articles

Abstract 1986: IRAK1 augments cancer stemness and drug resistance via the AP-1/AKR1B10 signaling cascade in hepatocellular carcinoma

Bowie Yik Ling Cheng, Doris Hoi Wing Leung, Eunice Yuen Ting Lau, Irene Oi Lin Ng, Kin Wah Lee
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1986.
https://doi.org/10.1158/1538-7445.AM2018-1986
Published: 01 July 2018
View article titled, Abstract 1986: IRAK1 augments cancer stemness and drug resistance via the AP-1/AKR1B10 signaling cascade in hepatocellular carcinoma
Journal Articles

Abstract 91: RalA is frequently up-regulated in human hepatocellular carcinoma and promotes metastasis and cancer stemness

Luqing Zhao, Lo-Kong Chan, Daniel Wai-Hung Ho, Goofy Yu-Man Tsui, Macrina Wai-Ling Lam, Charles Shing Kam, Karen Man-Fong Sze, Vanilla Xin Zhang, Abdullah Husain, Joyce Man-Fong Lee, Irene Oi-Lin Ng
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 91.
https://doi.org/10.1158/1538-7445.AM2018-91
Published: 01 July 2018
View article titled, Abstract 91: RalA is frequently up-regulated in human hepatocellular carcinoma and promotes metastasis and cancer stemness
Journal Articles

IRAK1 Augments Cancer Stemness and Drug Resistance via the AP-1/AKR1B10 Signaling Cascade in Hepatocellular Carcinoma

Bowie Y. Cheng, Eunice Y. Lau, Hoi-Wing Leung, Carmen Oi-Ning Leung, Nicole P. Ho, Shilpa Gurung, Lily K. Cheng, Chi Ho Lin, Regina Cheuk-Lam Lo, Stephanie Ma, Irene Oi-Lin Ng, Terence K. Lee
Journal: Cancer Research
Cancer Res (2018) 78 (9): 2332–2342.
https://doi.org/10.1158/0008-5472.CAN-17-2445
Published: 30 April 2018
View article titled, IRAK1 Augments Cancer Stemness and Drug Resistance via the AP-1/AKR1B10 Signaling Cascade in Hepatocellular Carcinoma
Open the PDF for IRAK1 Augments Cancer Stemness and Drug Resistance via the AP-1/AKR1B10 Signaling Cascade in Hepatocellular Carcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract 2941: Inhibition of hypoxia-induced ectonucleoside triphosphate diphosphohydrolase 2 (ENTPD2) restrains myeloid-derived suppressor cell (MDSC) accumulation and sensitizes tumors to immune checkpoint inhibition

David Kung-Chun Chiu, Aki Pui-Wah Tse, Iris Ming-Jing Xu, Robin Kit-Ho Lai, Hui-yu Koh, Felice Ho-Ching Tsang, Larry Lai Wei, Chun-Ming Wong, Irene Oi-Lin Ng, Carmen Chak-Lui Wong
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2941.
https://doi.org/10.1158/1538-7445.AM2017-2941
Published: 01 July 2017
View article titled, Abstract 2941: Inhibition of hypoxia-induced ectonucleoside triphosphate diphosphohydrolase 2 (ENTPD2) restrains myeloid-derived suppressor cell (MDSC) accumulation and sensitizes tumors to immune checkpoint inhibition
Journal Articles

Abstract 4848: The functional synergism and pro-metastatic role of FOXM1 and CENPF in hepatocellular carcinoma

Wai Ling Macrina Lam, Lo Kong Chan, Daniel Wai-Hung Ho, Charles Shing Kam, Irene Oi-Lin Ng
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4848.
https://doi.org/10.1158/1538-7445.AM2017-4848
Published: 01 July 2017
View article titled, Abstract 4848: The functional synergism and pro-metastatic role of FOXM1 and CENPF in hepatocellular carcinoma