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Journal Articles

Abstract LB052: Melanoma-secreted amyloid beta suppresses neuroinflammation and promotes brain metastasis

Kevin Kleffman, Grace Levinson, Indigo V. Rose, Lili Blumenberg, Sorin A. Shadaloey, Avantika Dhabaria, Eitan Wong, Francisco Galán-Echevarría, Alcida Karz, Diana Argibay, Richard Von-Itter, Alfredo Floristán, Gillian Baptiste, Nicole Eskow, James Tranos, Jenny Chen, Eleazar C. Vega Saenz de Miera, Melissa Call, Robert Rogers, George Jour, Youssef Zaim Wadghiri, Iman Osman, Yue Ming Li, Paul Mathews, Ronald Demattos, Beatrix Ueberheide, Kelly Ruggles, Shane A. Liddelow, Robert J. Schneider, Eva Hernando
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): LB052.
https://doi.org/10.1158/1538-7445.AM2022-LB052
Published: 15 June 2022
View article titled, Abstract LB052: Melanoma-secreted amyloid beta suppresses neuroinflammation and promotes brain metastasis
Journal Articles

Abstract PR04: Epigenetic silencing of CDR1as drives IGF2BP3-mediated melanoma invasion and metastasis

Douglas Hanniford, Alejandro Ulloa-Morales, Beatriz Sánchez-Sendra, Alcida Karz, Rana Moubarak, Tommaso Tabaglio, Maria Gabriela Berzoti-Coelho, Veronica Davalos, Pamela Wu, Varshini Vasudevaraja, Andreas Kloetgen, Karin Lilja, Jochen Imig, Carlos Monteagudo, Ernesto Guccione, Aristotelis Tsirigos, Iman Osman, Iannis Aifantis, Eva Hernando
Journal: Cancer Research
Cancer Res (2020) 80 (19_Supplement): PR04.
https://doi.org/10.1158/1538-7445.MEL2019-PR04
Published: 02 October 2020
View article titled, Abstract PR04: Epigenetic silencing of <em>CDR1as</em> drives IGF2BP3-mediated melanoma invasion and metastasis
Journal Articles

Abstract B30: The histone demethylase PHF8 epigenetically regulates the TGFbeta pathway to promote melanoma metastasis

Rana Moubarak, Ana De Pablos-Aragoneses, Vanessa Ortiz-Barahona, Richard Von Itter, Yixiao Gong, Michael Gowen, Sebastian Stefan, Diana Argibay, Eleazar De Miera-Vega, Igor Dolgalev, Elena Sokolova, Farbod Darvishian, Aristotelis Tsirigos, Iman Osman, Eva Hernando
Journal: Cancer Research
Cancer Res (2020) 80 (19_Supplement): B30.
https://doi.org/10.1158/1538-7445.MEL2019-B30
Published: 02 October 2020
View article titled, Abstract B30: The histone demethylase PHF8 epigenetically regulates the TGFbeta pathway to promote melanoma metastasis
Journal Articles

Abstract 4704: Identification of melanoma mutational tumor heterogeneity using BRAF, NRAS and TERT-promoter mutation-detection assays

Gregory Chang, Broderick Corless, Nathaniel Fleming, Cindy Spittle, Farbod Darvishian, Anna Pavlick, Russell Berman, Richard Shapiro, George Karlin-Neumann, Iman Osman, David Polsky
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4704.
https://doi.org/10.1158/1538-7445.AM2019-4704
Published: 01 July 2019
View article titled, Abstract 4704: Identification of melanoma mutational tumor heterogeneity using BRAF, NRAS and TERT-promoter mutation-detection assays
Journal Articles

Abstract 2239: Analysis of nucleosomal DNA as an extraction control for plasma-based circulating tumor DNA assays

Mahrukh M. Syeda, George Karlin-Neumann, Iman Osman, David Polsky
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2239.
https://doi.org/10.1158/1538-7445.AM2019-2239
Published: 01 July 2019
View article titled, Abstract 2239: Analysis of nucleosomal DNA as an extraction control for plasma-based circulating tumor DNA assays
Journal Articles

Abstract 3236: T-cell intrinsic mechanisms of resistance to PD-1 checkpoint blockade

Duane Moogk, Lin Wang, Kaitao Li, Zhou Yuan, Jeffrey Weber, Iman Osman, Cheng Zhu, Michelle Krogsgaard
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3236.
https://doi.org/10.1158/1538-7445.AM2019-3236
Published: 01 July 2019
View article titled, Abstract 3236: T-cell intrinsic mechanisms of resistance to PD-1 checkpoint blockade
Journal Articles

Abstract 5534: Analysis of TERTmutant circulating tumor DNA as a potential biomarker of disease activity in patients with unresectable stage III/IV melanoma receiving immuno-oncology therapies

Mahrukh M. Syeda, Broderick Corless, Melissa Wilson, Yesung Lee, Jeremy Tchack, Todd Wechter, Una Moran, George Karlin-Neumann, Anna C. Pavlick, Iman Osman, Yongzhao Shao, David Polsky
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5534.
https://doi.org/10.1158/1538-7445.AM2018-5534
Published: 01 July 2018
View article titled, Abstract 5534: Analysis of <em>TERT</em><em><sup>mutant</sup></em> circulating tumor DNA as a potential biomarker of disease activity in patients with unresectable stage III/IV melanoma receiving immuno-oncology therapies
Journal Articles

Abstract 5531: Detection of co-occurring and potential resistance mutations in cell-free, circulating tumor DNA from patients with BRAFmutant metastatic melanoma undergoing treatment with BRAF-targeted therapies

Broderick Corless, Greg Chang, Weihua Liu, Jin Li, Andre Marziali, Laura Mai, Matthew Wiggin, Melissa Wilson, Anna Pavlick, Iman Osman, George Karlin-Neumann, Cindy Spittle, David Polsky
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5531.
https://doi.org/10.1158/1538-7445.AM2018-5531
Published: 01 July 2018
View article titled, Abstract 5531: Detection of co-occurring and potential resistance mutations in cell-free, circulating tumor DNA from patients with <em>BRAF</em><em><sup>mutant</sup></em> metastatic melanoma undergoing treatment with BRAF-targeted therapies
Journal Articles

Abstract 743: Detection of TERT C228T and C250T promoter mutations in melanoma tumor and plasma samples using novel mutation-specific droplet digital PCR assays

Broderick Corless, Gregory Chang, Samantha Cooper, Mahrukh Syeda, Iman Osman, George Karlin-Neumann, David Polsky
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 743.
https://doi.org/10.1158/1538-7445.AM2017-743
Published: 01 July 2017
View article titled, Abstract 743: Detection of TERT C228T and C250T promoter mutations in melanoma tumor and plasma samples using novel mutation-specific droplet digital PCR assays
Journal Articles

Abstract 3047: PRC2-mediated silencing of circRNA CDR1as drives miR-7-independent melanoma metastasis

Doug Hanniford, Rana Moubarak, Jochen Imig, Alejandro Ulloa, Beatriz Sanchez Sendra, Alcida Karz, Iman Osman, Ioannis Aifantis, Eva Hernando
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3047.
https://doi.org/10.1158/1538-7445.AM2017-3047
Published: 01 July 2017
View article titled, Abstract 3047: PRC2-mediated silencing of circRNA <em>CDR1as</em> drives <em>miR-7</em>-independent melanoma metastasis
Journal Articles

ErbB3–ErbB2 Complexes as a Therapeutic Target in a Subset of Wild-type BRAF/NRAS Cutaneous Melanomas

Claudia Capparelli, Sheera Rosenbaum, Lisa D. Berman-Booty, Amel Salhi, Nadège Gaborit, Tingting Zhan, Inna Chervoneva, Jason Roszik, Scott E. Woodman, Michael A. Davies, Yulius Y. Setiady, Iman Osman, Yosef Yarden, Andrew E. Aplin
Journal: Cancer Research
Cancer Res (2015) 75 (17): 3554–3567.
https://doi.org/10.1158/0008-5472.CAN-14-2959
Published: 31 August 2015
View article titled, ErbB3–ErbB2 Complexes as a Therapeutic Target in a Subset of Wild-type BRAF/NRAS Cutaneous Melanomas
Open the PDF for ErbB3–ErbB2 Complexes as a Therapeutic Target in a Subset of Wild-type BRAF/NRAS Cutaneous Melanomas in another window
Includes: Supplementary data
Journal Articles

Abstract LB-239: The Hippo effector YAP promotes resistance to RAF and MEK targeted therapies

Luping Lin, Amit Sabnis, Elton Chan, Victor Olivas, Lindsay Cade, Evangelos Pazarentzos, Saurabh Asthana, Dana Neel, Jenny Jiacheng Yan, Xinyuan Lu, Luu Pham, Mingxue Wang, Niki Karachaliou, Maria G. Cao, Jose L. Manzano, Jose L. Ramirez, Jose M. Torres, Fiamma Buttitta, Charles M. Rudin, Eric A. Collisson, Alain Algazi, Eric Robinson, Iman Osman, Eva Munoz-Couselo, Javier Cortes, Dennie T. Frederick, Zachary A. Cooper, Martin McMahon, Antonio Marchetti, Rafael Rosell, Keith T. Flaherty, Jennifer A. Wargo, Trever G. Bivona
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): LB-239.
https://doi.org/10.1158/1538-7445.AM2015-LB-239
Published: 01 August 2015
View article titled, Abstract LB-239: The Hippo effector YAP promotes resistance to RAF and MEK targeted therapies
Journal Articles

Abstract 3522: BET and BRAF inhibitors act synergistically against BRAF mutant melanoma

Luca Paoluzzi, Douglas Hanniford, Elena Sokolova, Iman Osman, Farbod Darvishian, Jinhua Wang, James E. Bradner, Eva Hernando
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 3522.
https://doi.org/10.1158/1538-7445.AM2015-3522
Published: 01 August 2015
View article titled, Abstract 3522: BET and BRAF inhibitors act synergistically against BRAF mutant melanoma
Journal Articles

Abstract 2164: Revisiting the mechanisms of PTEN loss in melanoma

Keith Giles, Yang Li, Amel Salhi, Jinhua Wang, Eric Robinson, Iman Osman
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2164.
https://doi.org/10.1158/1538-7445.AM2015-2164
Published: 01 August 2015
View article titled, Abstract 2164: Revisiting the mechanisms of PTEN loss in melanoma
Journal Articles

Abstract A14: Hyperactivation of RSK1 is a hallmark of metastatic nodular melanoma

Amel Salhi, Joshua A. Farhadian, Keith M. Giles, Eleazar C. Vega-Saenz de Miera, Ines Pires Da Silva, Caitlin Bourque, Karen Yeh, Sagar Chhangawala, Jinhua Wang, Fei Ye, David Y. Zhang, Eva Hernando-Monge, Yariv Houvras, Iman Osman
Journal: Cancer Research
Cancer Res (2015) 75 (14_Supplement): A14.
https://doi.org/10.1158/1538-7445.MEL2014-A14
Published: 16 July 2015
View article titled, Abstract A14: Hyperactivation of RSK1 is a hallmark of metastatic nodular melanoma
Journal Articles

Abstract A31: Association between TERT promoter mutations and BRAF/NRAS mutations in patients with primary and metastatic melanoma tumors

Gregory A. Chang, Jyothirmayee S. Tadepalli, Nathaniel H. Fleming, Kevin Lui, Yongzhao Shao, Farbod Darvishian, Anna Pavlick, Russell Berman, Richard Shapiro, Iman Osman, David Polsky
Journal: Cancer Research
Cancer Res (2015) 75 (14_Supplement): A31.
https://doi.org/10.1158/1538-7445.MEL2014-A31
Published: 16 July 2015
View article titled, Abstract A31: Association between TERT promoter mutations and BRAF/NRAS mutations in patients with primary and metastatic melanoma tumors
Journal Articles

Abstract A35: Integration of melanoma genotyping in clinical care

Amel Salhi, Ines Pires Da Silva, Kevin P. Lui, Naima Ismaili, Chaowei Wu, Eleazar C. Vega-Saenz de Miera, Richard L. Shapiro, Russell S. Berman, Anna C. Pavlick, Judy Zhong, Adriana Heguy, Iman Osman
Journal: Cancer Research
Cancer Res (2015) 75 (14_Supplement): A35.
https://doi.org/10.1158/1538-7445.MEL2014-A35
Published: 16 July 2015
View article titled, Abstract A35: Integration of melanoma genotyping in clinical care
Journal Articles

Abstract B07: Targeting an MT1-MMP/MMP2 axis in melanoma by a novel MT1-MMP/MMP2 inhibitor

Khvaramze Shaverdashvili, Poki Wong, Jun Ma, Keman Zhang, Iman Osman, Barbara Bedogni
Journal: Cancer Research
Cancer Res (2015) 75 (14_Supplement): B07.
https://doi.org/10.1158/1538-7445.MEL2014-B07
Published: 16 July 2015
View article titled, Abstract B07: Targeting an MT1-MMP/MMP2 axis in melanoma by a novel MT1-MMP/MMP2 inhibitor
Journal Articles

Abstract 2847: Quantitative assessment of circulating BRAF DNA in stage IV melanoma patients undergoing BRAF inhibitor treatment

David Polsky, Jyothi Sakuntala Tadepalli, Gregory Chang, Nathaniel Fleming, Yongzhao Shao, Anna C. Pavlick, Iman Osman, Cindy Spittle, Manohar Furtado, Paula Stonemetz, Dawne Shelton, George Karlin-Neumann
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2847.
https://doi.org/10.1158/1538-7445.AM2014-2847
Published: 01 October 2014
View article titled, Abstract 2847: Quantitative assessment of circulating BRAF DNA in stage IV melanoma patients undergoing BRAF inhibitor treatment
Journal Articles

Abstract 4862: Reversal of NK cell exhaustion in advanced melanoma patients by Tim-3 blockade

Anne Gallois, Ines Pires Da Silva, Sonia Jimenez, Iman Osman, Nina Bhardwaj
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4862.
https://doi.org/10.1158/1538-7445.AM2014-4862
Published: 01 October 2014
View article titled, Abstract 4862: Reversal of NK cell exhaustion in advanced melanoma patients by Tim-3 blockade