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Ignacio Melero
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Journal Articles

Abstract CT181: First-in-human phase I of anti-VISTA monoclonal antibody W0180 with and without anti-PD-1 pembrolizumab in patients with locally advanced or metastatic solid tumors

Carlos Gomez-Roca, Stéphane Champiat, Philippe Cassier, David Jegou, Marie Primard, Aurélie Pétain, Geneviève Gueguen-Dorbes, Claire Fabre, Ignacio Melero, Aurélien Marabelle
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): CT181.
https://doi.org/10.1158/1538-7445.AM2024-CT181
Published: 05 April 2024
View article titled, Abstract CT181: First-in-human phase I of anti-VISTA monoclonal antibody W0180 with and without anti-PD-1 pembrolizumab in patients with locally advanced or metastatic solid tumors
Journal Articles

Abstract 5000: Low dose ionizing radiation elicits the extrusion of neutrophil extracellular traps

Alvaro Teijeira, Ana Martinez-Riaño, Beatrice Pinci, Almudena Manzanal, Paula Molero, Maria E. Rodriguez- Ruiz, Ignacio Melero
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5000.
https://doi.org/10.1158/1538-7445.AM2024-5000
Published: 22 March 2024
View article titled, Abstract 5000: Low dose ionizing radiation elicits the extrusion of neutrophil extracellular traps
Journal Articles

Abstract 2736: Locoregional modified vaccinia ankara (MVA) encoding a single-chain IL-12 achieves efficacy antitumor immune response in peritoneal carcinomatosis

Ángela Bella, Leire Arrizabalaga, Claudia Augusta Di Trani, José González-Gomariz, Assunta Cirella, Irene Olivera, Maite Alvarez, Álvaro Teijeira, Cigdem Atay Langbein, José Medina-Echeverz, Maria Hinterberger, Hubertus Hochrein, Ignacio Melero, Pedro Berraondo, Fernando Aranda
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2736.
https://doi.org/10.1158/1538-7445.AM2023-2736
Published: 04 April 2023
View article titled, Abstract 2736: Locoregional modified vaccinia ankara (MVA) encoding a single-chain IL-12 achieves efficacy antitumor immune response in peritoneal carcinomatosis
Journal Articles

Abstract 1100: 4-1BBL agonist targeted to fibroblast activation protein α synergizes with radiotherapy in murine breast tumor

Eneko Garate-Soraluze, Irantzu Serrano-Mendioroz, Carlos E de Andrea, Toni Rullan, Christina Claus, Pablo Umana, Christian klein, Ignacio Melero, Maria E. Rodriguez-Ruiz
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1100.
https://doi.org/10.1158/1538-7445.AM2023-1100
Published: 04 April 2023
View article titled, Abstract 1100: 4-1BBL agonist targeted to fibroblast activation protein α synergizes with radiotherapy in murine breast tumor
Journal Articles

Abstract 614: CD137 (4-1BB) requires physically associated cIAPs for signal transduction and antitumor effects

Javier Glez-Vaz, Arantza Azpilikueta, Maria Carmen Ochoa, Irene Olivera, Gabriel Gomis, Asunta Cirella, Carlos Luri-Rey, Maite Álvarez, Sergio Ciordia, Pedro Berraondo, Álvaro Teijeira, Fernando Corrales, Juan M Zapata, Ignacio Melero
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 614.
https://doi.org/10.1158/1538-7445.AM2023-614
Published: 04 April 2023
View article titled, Abstract 614: CD137 (4-1BB) requires physically associated cIAPs for signal transduction and antitumor effects
Journal Articles

Abstract 2915: Intratumoral co-injections of NK cells and neutralizing antibodies against the NKG2A inhibitory pathway achieve efficacious anti-tumor responses in a CD8 T cell and cDC1-dependent manner

Maite Alvarez, Maria C. Ochoa, Carmen Molina, Alvaro Teijeira, Saray Garasa, Sandra Sanchez-Gregorio, Irene Olivera, Javier Glez-Vaz, Asunta Cirella, Gabriel Gomis, Jose Gonzalez-Gomariz, Pedro Berraondo, Ignacio Melero
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2915.
https://doi.org/10.1158/1538-7445.AM2023-2915
Published: 04 April 2023
View article titled, Abstract 2915: Intratumoral co-injections of NK cells and neutralizing antibodies against the NKG2A inhibitory pathway achieve efficacious anti-tumor responses in a CD8 T cell and cDC1-dependent manner
Journal Articles

Depletion of Conventional Type-1 Dendritic Cells in Established Tumors Suppresses Immunotherapy Efficacy

Alvaro Teijeira, Saray Garasa, Carlos Luri-Rey, Carlos de Andrea, Maria Gato, Carmen Molina, Tsuneyasu Kaisho, Assunta Cirella, Arantza Azpilikueta, Steffanie K. Wculek, Josune Egea, Irene Olivera, Inmaculada Rodriguez, Ana Rouzaut, Vladislav Verkhusha, Karmele Valencia, David Sancho, Pedro Berraondo, Ignacio Melero
Journal: Cancer Research
Cancer Res (2022) 82 (23): 4373–4385.
https://doi.org/10.1158/0008-5472.CAN-22-1046
Published: 02 December 2022
View article titled, Depletion of Conventional Type-1 Dendritic Cells in Established Tumors Suppresses Immunotherapy Efficacy
Open the PDF for Depletion of Conventional Type-1 Dendritic Cells in Established Tumors Suppresses Immunotherapy Efficacy in another window
Includes: Multimedia, Supplementary data
Journal Articles

Abstract 3826: A therapeutically actionable pro-tumoral axis of cytokines involving interleukin-8, TNFα and IL-1β

Irene Olivera, Rebeca Sanz-Pamplona, Elixabet Bolaños, Inmaculada Rodriguez, Iñaki Etxeberria, Assunta Cirella, Saray Garasa, Itziar Migueliz, Iñaki Eguren, Miguel F. Sanmamed, Javier Glez-Vaz, Arantza Azpilikueta, Maite Alvarez, Maria C. Ochoa, Carlos E. De Andrea, Pedro Berraondo, Álvaro Teijeira, Ignacio Melero
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3826.
https://doi.org/10.1158/1538-7445.AM2022-3826
Published: 15 June 2022
View article titled, Abstract 3826: A therapeutically actionable pro-tumoral axis of cytokines involving interleukin-8, TNFα and IL-1β
Journal Articles

Abstract 6216: Intratumoral B0112 in combination with radiotherapy synergizes to achieve CD8 T cell mediated local tumor control

Maria.E. Rodriguez-Ruiz, Irantzu serrano, Eneko Garate, Inmaculada Rodriguez, maite alvarez, Carmen Molina, Miguel Fernandez de Sanmamed, Leire Arbea, Marta Moreno, Marisol Quintero, Ignacio Melero
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 6216.
https://doi.org/10.1158/1538-7445.AM2022-6216
Published: 15 June 2022
View article titled, Abstract 6216: Intratumoral B0112 in combination with radiotherapy synergizes to achieve CD8 T cell mediated local tumor control
Journal Articles

Abstract 628: Soluble CD137 as a dynamic biomarker to monitor agonist CD137 immunotherapies

Javier Glez-Vaz, Arantza Azpilikueta, Irene Olivera, Assunta Cirella, Álvaro Teijeira, Carmen Ochoa, Maite Álvarez, Iñaki Eguren, Carlos Luri-Rey, Miguel F. Sanmamed, Ignacio Melero
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 628.
https://doi.org/10.1158/1538-7445.AM2022-628
Published: 15 June 2022
View article titled, Abstract 628: Soluble CD137 as a dynamic biomarker to monitor agonist CD137 immunotherapies
Journal Articles

Abstract CT119: A randomized, double-blind phase 2 evaluation of the anti-IL-8 monoclonal antibody BMS-986253 + nivolumab + ipilimumab vs nivolumab + ipilimumab in patients with advanced melanoma that progressed on/after anti-PD-(L)1 therapy

Matteo Simonelli, Emiliano Calvo, Diwakar Davar, Jason Melear, Donald Richards, Matthew Dallos, Martin Gutierrez, Victor Moreno, Thomas Marron, Sylvie Rottey, Angela Orcurto, Susana Barriga, Jessy Fan, Elizabeth Gibson, Santanu Dutta, Vivek Arora, Ignacio Melero
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): CT119.
https://doi.org/10.1158/1538-7445.AM2022-CT119
Published: 15 June 2022
View article titled, Abstract CT119: A randomized, double-blind phase 2 evaluation of the anti-IL-8 monoclonal antibody BMS-986253 + nivolumab + ipilimumab vs nivolumab + ipilimumab in patients with advanced melanoma that progressed on/after anti-PD-(L)1 therapy
Journal Articles

Abstract 2887: Three dimensional colon cancer organoids model the response to CEA CD3 T cell engagers

Alvaro Teijeira, Itziar Migueliz, Saray Garasa, Marina Bacac, Christian Klein, Ignacio Melero
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2887.
https://doi.org/10.1158/1538-7445.AM2022-2887
Published: 15 June 2022
View article titled, Abstract 2887: Three dimensional colon cancer organoids model the response to CEA CD3 T cell engagers
Journal Articles

Abstract 2145: Genomic and transcriptomic analyses related to the clinical efficacy of first-line nivolumab in advanced hepatocellular carcinoma from the phase 3 CheckMate 459 trial

Jaclyn Neely, Jin Yao, Masatoshi Kudo, Richard S. Finn, Bruno Sangro, Ignacio Melero, Anthony El-Khoueiry, Marina Tschaika, Damir Begic, Ashwin Sama, Parul Doshi, Thomas Yau, Robin Kate Kelley
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2145.
https://doi.org/10.1158/1538-7445.AM2022-2145
Published: 15 June 2022
View article titled, Abstract 2145: Genomic and transcriptomic analyses related to the clinical efficacy of first-line nivolumab in advanced hepatocellular carcinoma from the phase 3 CheckMate 459 trial
Journal Articles

Abstract 1698: Cellular cytotoxicity is a form of immunogenic cell death

Luna Minute, Alvaro Teijeira, Alfonso Rodriguez Sánchez-Paulete, Maria del Carmen Ochoa, Maite Alvarez, Itziar Otano, Iñaki Etxeberria, Elixabet Bolaños, Arantza Azpilikueta, Saray Garasa, Noelia Casares, José Luiz Pérez-Gracia, Maria Esperanza Rodríguez-Ruiz, Pedro Berraondo, Ignacio Melero
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1698.
https://doi.org/10.1158/1538-7445.AM2020-1698
Published: 15 August 2020
View article titled, Abstract 1698: Cellular cytotoxicity is a form of immunogenic cell death
Journal Articles

Abstract CT302: Phase Ia/Ib dose-escalation study of the anti-TIGIT antibody tiragolumab as a single agent and in combination with atezolizumab in patients with advanced solid tumors

Johanna C. Bendell, Philippe Bedard, Yung-Jue Bang, Patricia LoRusso, Stephen Hodi, Michael Gordon, Sandra D'Angelo, Sandra D'Angelo, Jayesh Desai, Elena Garralda, Antoine Italiano, Myung-Ju Ahn, Andres Cervantes, Zev Wainberg, Emiliano Calvo, Marta Gil-Martin, Maria Martinez-Garcia, Rastilav Bahleda, Philippe Cassier, Jean-Pierre Delord, Amy Prawira, Ignacio Melero, Leisha Emens, Emanuela Romano, Karen Miller, Robert W. Hsieh, Cloris Xue, Kari Morrissey, Patrick Twomey, Kelly Gash, Namrata S. Patil, Jane Grogan, Raymond Meng, Byoung Cho, Tae Won Kim
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): CT302.
https://doi.org/10.1158/1538-7445.AM2020-CT302
Published: 15 August 2020
View article titled, Abstract CT302: Phase Ia/Ib dose-escalation study of the anti-TIGIT antibody tiragolumab as a single agent and in combination with atezolizumab in patients with advanced solid tumors
Journal Articles

Abstract CT301: A phase Ib study to evaluate RO7198457, an individualized Neoantigen Specific immunoTherapy (iNeST), in combination with atezolizumab in patients with locally advanced or metastatic solid tumors

Juanita S. Lopez, Ross Camidge, Marco Iafolla, Sylvie Rottey, Martin Schuler, Matthew Hellmann, Ani Balmanoukian, Luc Dirix, Michael Gordon, Ryan Sullivan, Brian S. Henick, Charles Drake, Kit Wong, Patricia LoRusso, Patrick Ott, Lawrence Fong, Aglaia Schiza, Jeffery Yachnin, Christian Ottensmeier, Fadi Braiteh, Johanna Bendell, Rom Leidner, George Fisher, Guy Jerusalem, Laura Molenaar-Kuijsten, Marcus Schmidt, Scott A. Laurie, Raid Aljumaily, Achim Rittmeyer, Eelke Gort, Ignacio Melero, Lars Mueller, Rachel Sabado, Patrick Twomey, Jack Huang, Manesh Yadav, Jingbin Zhang, Felicitas Mueller, Evelyna Derhovanessian, Ugur Sahin, Özlem Türeci, Thomas Powles
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): CT301.
https://doi.org/10.1158/1538-7445.AM2020-CT301
Published: 15 August 2020
View article titled, Abstract CT301: A phase Ib study to evaluate RO7198457, an individualized Neoantigen Specific immunoTherapy (iNeST), in combination with atezolizumab in patients with locally advanced or metastatic solid tumors
Journal Articles

Abstract 2675: Assessment of inflammation biomarkers in relation to clinical outcomes in nivolumab-treated patients with advanced hepatocellular carcinoma in CheckMate 040

Ignacio Melero, Jaclyn Neely, Bruno Sangro, Richard Finn, Ghassan K. Abou-Alfa, Ann-Lii Cheng, Thomas Yau, Junji Furuse, Joong-Won Park, Samir Wadhawan, Hao Tang, Christine Delacruz, Carlos Baccan, Zach Boyd, Anthony El-Khoueiry
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2675.
https://doi.org/10.1158/1538-7445.AM2019-2675
Published: 01 July 2019
View article titled, Abstract 2675: Assessment of inflammation biomarkers in relation to clinical outcomes in nivolumab-treated patients with advanced hepatocellular carcinoma in CheckMate 040
Journal Articles

Abstract 1474: Repurposing the yellow fever vaccine for intratumoral immunotherapy

M. Angela Aznar, Carmen Molina, Alvaro Teijeira, Arantza Azpilikueta, Saray Garasa, Alfonso R. Sanchez-Paulete, Iñaki Etxeberria, Maite Alvarez, Pedro Berraondo, Ignacio Melero
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1474.
https://doi.org/10.1158/1538-7445.AM2019-1474
Published: 01 July 2019
View article titled, Abstract 1474: Repurposing the yellow fever vaccine for intratumoral immunotherapy
Journal Articles

Abstract 2331: Intratumor adoptive transfer of IL-12 mRNA transiently engineered anti-tumor CD8+ T cells

Inaki Etxeberria, Elixabet Bolaños, Alvaro Teijeira, Arantza Azpilicueta, Jose Ignacio Quetglas, Alfonso Rodriguez Sanchez-Paulete, Itziar Otano, Uxua Mancheño, Sandra Hervas-Stubbs, Susana Inoges, Saray Garasa, Maite Alvarez, Pedro Berraondo, Ignacio Melero
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2331.
https://doi.org/10.1158/1538-7445.AM2019-2331
Published: 01 July 2019
View article titled, Abstract 2331: Intratumor adoptive transfer of IL-12 mRNA transiently engineered anti-tumor CD8+ T cells
Journal Articles

Intratumoral Immunotherapy with XCL1 and sFlt3L Encoded in Recombinant Semliki Forest Virus–Derived Vectors Fosters Dendritic Cell–Mediated T-cell Cross-Priming

Alfonso R. Sánchez-Paulete, Álvaro Teijeira, José I. Quetglas, María E. Rodríguez-Ruiz, Álvaro Sánchez-Arráez, Sara Labiano, Iñaki Etxeberria, Arantza Azpilikueta, Elixabet Bolaños, María Cristina Ballesteros-Briones, Noelia Casares, Sergio A. Quezada, Pedro Berraondo, David Sancho, Cristian Smerdou, Ignacio Melero
Journal: Cancer Research
Cancer Res (2018) 78 (23): 6643–6654.
https://doi.org/10.1158/0008-5472.CAN-18-0933
Published: 03 December 2018
View article titled, Intratumoral Immunotherapy with XCL1 and sFlt3L Encoded in Recombinant Semliki Forest Virus–Derived Vectors Fosters Dendritic Cell–Mediated T-cell Cross-Priming
Open the PDF for Intratumoral Immunotherapy with XCL1 and sFlt3L Encoded in Recombinant Semliki Forest Virus–Derived Vectors Fosters Dendritic Cell–Mediated T-cell Cross-Priming in another window
Includes: Supplementary data