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Abstract 4725: Inhibition of DNA methyltransferase by RX-3117 (fluorocyclopentenylcytosine) leads to upregulation of hypomethylated targets

Godefridus J. Peters, Dzjemma Sarkisjan, Joris J. Julsing, Ahmed Hassan, Kees Smid, Ietje Kathmann, Young Lee, Deog J. Kim

Cancer Res (2016) 76 (14_Supplement): 4725.

DOI: https://doi.org/10.1158/1538-7445.AM2016-4725

Published: 15 July 2016

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Journal Articles

Abstract 4425: Characterisation of cellular transport and accumulation of six clinically approved tyrosine kinase inhibitors (TKIs) in colon cancer cells.

Richard J. Honeywell, Sarina Hitzerd, Ietje Kathmann, Elisa Giovannetti, Henk Verheul, Frits Peters

Cancer Res (2013) 73 (8_Supplement): 4425.

DOI: https://doi.org/10.1158/1538-7445.AM2013-4425

Published: 15 April 2013

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Journal Articles

Abstract 1770: Metabolism and mechanism of action of fluorocyclopentenylcytosine (RX-3117)

Godefridus J. Peters, Kees Smid, Leonardo Vecchi, Ietje Kathmann, Nienke Loosekoot, Young B. Lee, Deog J. Kim, Chang-Ho Ahn, Lak S. Jeong, Aric Orbach, Osnat Ohne, Eran Blaugrund

Cancer Res (2012) 72 (8_Supplement): 1770.

DOI: https://doi.org/10.1158/1538-7445.AM2012-1770

Published: 15 April 2012

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Journal Articles

BCRP-mediated resistance to the EGFR tyrosine kinase inhibitors (TKIs) gefitinib and erlotinib

Clara Lemos, Ietje Kathmann, Elisa Giovannetti, Gerrit Jansen, Godefridus Peters

Cancer Res (2008) 68 (9_Supplement): 3246.

Published: 01 May 2008

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Journal Articles

Impact of cellular folate status on multidrug resistance transporters BCRP and MRP expression in a panel of high (HF) and low folate (LF) cells

Clara Lemos, Ietje Kathmann, Gerrit Jansen, Godefridus Peters

Cancer Res (2007) 67 (9_Supplement): 2297.

Published: 01 May 2007

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Journal Articles

Folate deprivation/supplementation modulates BCRP and MRP1 expression in cancer cells from a different origin

Clara Lemos, Ietje Kathmann, Jan H. Hooijberg, Gerrit Jansen, Godefridus J. Peters

Cancer Res (2006) 66 (8_Supplement): 146.

Published: 15 April 2006

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Journal Articles

ABCG2 Harboring the Gly482 Mutation Confers High-Level Resistance to Various Hydrophilic Antifolates

Assaf Shafran, Ilan Ifergan, Eran Bram, Gerrit Jansen, Ietje Kathmann, Godefridus J. Peters, Robert W. Robey, Susan E. Bates, Yehuda G. Assaraf

Cancer Res (2005) 65 (18): 8414–8422.

DOI: https://doi.org/10.1158/0008-5472.CAN-04-4547

Published: 15 September 2005

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Journal Articles

The Human Multidrug Resistance Protein MRP5 Transports Folates and Can Mediate Cellular Resistance against Antifolates

Peter Wielinga, Jan Hendrik Hooijberg, Sjofn Gunnarsdottir, Ietje Kathmann, Glen Reid, Noam Zelcer, Kasper van der Born, Marcel de Haas, Ingrid van der Heijden, Gertjan Kaspers, Jan Wijnholds, Gerrit Jansen, Godefridus Peters, Piet Borst

Cancer Res (2005) 65 (10): 4425–4430.

DOI: https://doi.org/10.1158/0008-5472.CAN-04-2810

Published: 16 May 2005

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Journal Articles

Membrane Transport of Natural Folates and Antifolate Compounds in Murine L1210 Leukemia Cells: Role of Carrier- and Receptor-mediated Transport Systems

G. Robbin Westerhof, Gerrit Jansen, Nancy van Emmerik, Ietje Kathmann, Gert Rijksen, Ann L. Jackman, Jan H. Schornagel

Cancer Res (1991) 51 (20): 5507–5513.

Published: 01 October 1991

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Journal Articles

Identification of a Membrane-associated Folate-binding Protein in Human Leukemic CCRF-CEM Cells with Transport-related Methotrexate Resistance

Gerrit Jansen, G. Robbin Westerhof, Ietje Kathmann, Bauk C. Rademaker, Gert Rijksen, Jan H. Schornagel

Cancer Res (1989) 49 (9): 2455–2459.

Published: 01 May 1989

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Journal Articles

Expression of a Folate Binding Protein in L1210 Cells Grown in Low Folate Medium

Gerrit Jansen, Ietje Kathmann, Bauk C. Rademaker, Boudewijn J. M. Braakhuis, G. Robbin Westerhof, Gert Rijksen, Jan H. Schornagel

Cancer Res (1989) 49 (8): 1959–1963.

Published: 01 April 1989

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NARROW

Abstract 4725: Inhibition of DNA methyltransferase by RX-3117 (fluorocyclopentenylcytosine) leads to upregulation of hypomethylated targets

Abstract 4425: Characterisation of cellular transport and accumulation of six clinically approved tyrosine kinase inhibitors (TKIs) in colon cancer cells.

Abstract 1770: Metabolism and mechanism of action of fluorocyclopentenylcytosine (RX-3117)

BCRP-mediated resistance to the EGFR tyrosine kinase inhibitors (TKIs) gefitinib and erlotinib

Impact of cellular folate status on multidrug resistance transporters BCRP and MRP expression in a panel of high (HF) and low folate (LF) cells

Folate deprivation/supplementation modulates BCRP and MRP1 expression in cancer cells from a different origin

ABCG2 Harboring the Gly482 Mutation Confers High-Level Resistance to Various Hydrophilic Antifolates

The Human Multidrug Resistance Protein MRP5 Transports Folates and Can Mediate Cellular Resistance against Antifolates

Membrane Transport of Natural Folates and Antifolate Compounds in Murine L1210 Leukemia Cells: Role of Carrier- and Receptor-mediated Transport Systems

Identification of a Membrane-associated Folate-binding Protein in Human Leukemic CCRF-CEM Cells with Transport-related Methotrexate Resistance

Expression of a Folate Binding Protein in L1210 Cells Grown in Low Folate Medium

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