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Journal Articles

Acquired Resistance to Fractionated Radiotherapy Can Be Overcome by Concurrent PD-L1 Blockade

Simon J. Dovedi, Amy L. Adlard, Grazyna Lipowska-Bhalla, Conor McKenna, Sherrie Jones, Eleanor J. Cheadle, Ian J. Stratford, Edmund Poon, Michelle Morrow, Ross Stewart, Hazel Jones, Robert W. Wilkinson, Jamie Honeychurch, Tim M. Illidge

Cancer Res (2014) 74 (19): 5458–5468.

https://doi.org/10.1158/0008-5472.CAN-14-1258

Published: 30 September 2014

View articletitled, Acquired Resistance to Fractionated Radiotherapy Can Be Overcome by Concurrent PD-L1 Blockade

Includes: Supplementary data

Journal Articles

Abstract 4123: Monocarboxylate transporter 4 expression is a prognostic factor for radiotherapy outcome in squamous cell carcinoma of the head and neck

Amy L. Chadwick, Chris Womack, Gillian Watkins, Becky M. Bola, Nick Slevin, Jarrod Homer, Paul Smith, Susan E. Critchlow, Catharine M. West, Stephen R. Wedge, Ian J. Stratford

Cancer Res (2011) 71 (8_Supplement): 4123.

https://doi.org/10.1158/1538-7445.AM2011-4123

Published: 15 April 2011

View articletitled, Abstract 4123: Monocarboxylate transporter 4 expression is a prognostic factor for radiotherapy outcome in squamous cell carcinoma of the head and neck

Journal Articles

Abstract 5088: Exploring ATM deficiency as a potential therapeutic target for the PARP inhibitor olaparib in head and neck squamous cell carcinoma

Joana M. Senra, Emma L. Donald, Victoria S. Williams, Helen Wombwell, Gillian Hall, Chris G. Harbron, Brian A. Telfer, John Morten, Chris Womack, Catharine M. West, Darren Hodgson, Mark J. O'Connor, Steve R. Wedge, Ian J. Stratford

Cancer Res (2011) 71 (8_Supplement): 5088.

https://doi.org/10.1158/1538-7445.AM2011-5088

Published: 15 April 2011

View articletitled, Abstract 5088: Exploring ATM deficiency as a potential therapeutic target for the PARP inhibitor olaparib in head and neck squamous cell carcinoma

Journal Articles

Abstract 1713: Mechanisms of resistance to platinum based drugs uncovered by protection caused by substituted coumarins

Karen A. Nolan, Katherine A. Scott, Gareth Griffiths, Ian J. Stratford

Cancer Res (2011) 71 (8_Supplement): 1713.

https://doi.org/10.1158/1538-7445.AM2011-1713

Published: 15 April 2011

View articletitled, Abstract 1713: Mechanisms of resistance to platinum based drugs uncovered by protection caused by substituted coumarins

Journal Articles

Abstract 3713: Inhibition of NQO2 by imidozoacridinones, including C1311 (Symadex, NSC645809): Implications for their mechanism of action

Matthew P. Humphries, John Barnes, Mary C. Caraher, Richard Bryce, Ian J. Stratford, Karen A. Nolan

Cancer Res (2010) 70 (8_Supplement): 3713.

https://doi.org/10.1158/1538-7445.AM10-3713

Published: 15 April 2010

View articletitled, Abstract 3713: Inhibition of NQO2 by imidozoacridinones, including C1311 (Symadex, NSC645809): Implications for their mechanism of action

Journal Articles

Abstract SY34-03: Hypoxia-metabolic targets for drug development: Identification of targets and their validation

Ian J. Stratford

Cancer Res (2010) 70 (8_Supplement): SY34-03.

https://doi.org/10.1158/1538-7445.AM10-SY34-03

Published: 15 April 2010

View articletitled, Abstract SY34-03: Hypoxia-metabolic targets for drug development: Identification of targets and their validation

Journal Articles

Abstract 5635: Analysis of monocarboxylate transporter 4 as a biomarker shows prognostic significance as an indicator of radiotherapy in squamous cell carcinoma of the head and neck

Amy L. Chadwick, Christopher Womack, Catharine M. West, Susan E. Critchlow, Stephen R. Wedge, Ian J. Stratford

Cancer Res (2010) 70 (8_Supplement): 5635.

https://doi.org/10.1158/1538-7445.AM10-5635

Published: 15 April 2010

View articletitled, Abstract 5635: Analysis of monocarboxylate transporter 4 as a biomarker shows prognostic significance as an indicator of radiotherapy in squamous cell carcinoma of the head and neck

Journal Articles

Combining the highly potent, orally bioavailable, VEGF signaling inhibitor AZD2171 with radiotherapy in human tumor xenografts.

Kaye J. Williams, Brian A. Telfer, Ian J. Stratford, Stephen R. Wedge

Cancer Res (2006) 66 (8_Supplement): 1343.

Published: 15 April 2006

View articletitled, Combining the highly potent, orally bioavailable, VEGF signaling inhibitor AZD2171 with radiotherapy in human tumor xenografts.

Journal Articles

In vivo activation of the hypoxia-targeted cytotoxin AQ4N in human tumor xenografts

Mark R. Albertella, Paul M. Loadman, Kaye J. Williams, Steve D. Shnyder, Roger M. Phillips, Ian J. Stratford, Peter A. Harris, Chris R. Dunk

Cancer Res (2006) 66 (8_Supplement): 314.

Published: 15 April 2006

View articletitled, In vivo activation of the hypoxia-targeted cytotoxin AQ4N in human tumor xenografts

Journal Articles

Reduction of tumor cell chemoresistance through HIF-1 inhibition

Amanda Eustace, Kaye J. Williams, Louisa M. Brown, Darren Roberts, Brian A. Telfer, Ian J. Stratford

Cancer Res (2006) 66 (8_Supplement): 407–408.

Published: 15 April 2006

View articletitled, Reduction of tumor cell chemoresistance through HIF-1 inhibition

Journal Articles

Down regulation of bid in high HIF-1α expressing subpopulations of human colorectal cancer cells in vivo

Marlon M. Seenath, Christopher Cawthorne, Darren Roberts, Andrew Renehan, Mark Saunders, Ian J. Stratford, Sarah T. O’Dwyer, Caroline Dive

Cancer Res (2005) 65 (9_Supplement): 191.

Published: 01 May 2005

View articletitled, Down regulation of bid in high HIF-1α expressing subpopulations of human colorectal cancer cells in vivo

Journal Articles

Adenoviral delivery of inducible nitric oxide synthase (NOSII) enhances AQ4N/radiation cytotoxicity within hypoxic tumor cells

Rachel L. Cowen, Simendra Singh, Edwin C. Chinje, Rana Al-Assah, Peter Harris, Chris Dunk, Ian J. Stratford

Cancer Res (2005) 65 (9_Supplement): 314.

Published: 01 May 2005

View articletitled, Adenoviral delivery of inducible nitric oxide synthase (NOSII) enhances AQ4N/radiation cytotoxicity within hypoxic tumor cells

Journal Articles

Specifity and oxygen dependence of small molecule inhibitors of HIF-1

Camille Debray, Rachel L. Cowen, Simendra Singh, Ian J. Stratford, Kaye Williams

Cancer Res (2005) 65 (9_Supplement): 359.

Published: 01 May 2005

View articletitled, Specifity and oxygen dependence of small molecule inhibitors of HIF-1

Journal Articles

In silico identification and biochemical characterization of novel substrates and inhibitors of NQO1

Karen A. Nolan, Richard Bryce, Ian J. Stratford

Cancer Res (2005) 65 (9_Supplement): 932.

Published: 01 May 2005

View articletitled, In silico identification and biochemical characterization of novel substrates and inhibitors of NQO1

Journal Articles

Cytokine induction of iNOS in human tumor cells at various oxygen tensions enhances radiation response.

Simendra Singh, Edwin C. Chinje, Ian J. Stratford

Cancer Res (2004) 64 (7_Supplement): 722.

Published: 01 April 2004

View articletitled, Cytokine induction of iNOS in human tumor cells at various oxygen tensions enhances radiation response.

Journal Articles

Elevated inducible NOS activity in human fibrosarcoma HT1080 tumor cells enhances AQ4N reductive metabolism in vitro

Edwin C. Chinje, Rachel L. Cowen, Zhaolu Kong, Kaye J. Williams, Brian T. Telfer, Ian J. Stratford

Cancer Res (2004) 64 (7_Supplement): 130.

Published: 01 April 2004

View articletitled, Elevated inducible NOS activity in human fibrosarcoma HT1080 tumor cells enhances AQ4N reductive metabolism in vitro

Journal Articles

Design, synthesis and in vitro toxicity of propanamido-1,4-quinone-drug conjugates as tumor-specific agents.

Mohammed Jaffar, Nathalie Abou-Zeid, Natasha S. Wind, Lee Glassbrook, Karen A. Nolan, Ian J. Stratford

Cancer Res (2004) 64 (7_Supplement): 576–577.

Published: 01 April 2004

View articletitled, Design, synthesis and in vitro toxicity of propanamido-1,4-quinone-drug conjugates as tumor-specific agents.

Journal Articles

Enhancing the efficacy of chemotherapy under hypoxic conditions using HIF-1 targeted approaches.

Kaye J. Williams, Rachel L. Cowen, Louisa M. Brown, Janine T. Erler, Giovanni Melillo, Ed Sausville, Ian J. Stratford

Cancer Res (2004) 64 (7_Supplement): 878.

Published: 01 April 2004

View articletitled, Enhancing the efficacy of chemotherapy under hypoxic conditions using HIF-1 targeted approaches.

Journal Articles

Potentiation of chemo-radiotherapy in human lung xenografts using the bioreductive agent AQ4N

Kaye J. Williams, Edwin C. Chinje, Brian A. Telfer, Natasha S. Wind, Catriona Parker, Ian J. Stratford, Peter Harris, Chris Dunk

Cancer Res (2004) 64 (7_Supplement): 954.

Published: 01 April 2004

View articletitled, Potentiation of chemo-radiotherapy in human lung xenografts using the bioreductive agent AQ4N

Journal Articles

Hypoxia Targeted Gene Therapy to Increase the Efficacy of Tirapazamine as an Adjuvant to Radiotherapy: Reversing Tumor Radioresistance and Effecting Cure

Rachel L. Cowen, Kaye J. Williams, Edwin C. Chinje, Mohammed Jaffar, Freda C. D. Sheppard, Brian A. Telfer, Natasha S. Wind, Ian J. Stratford

Cancer Res (2004) 64 (4): 1396–1402.

https://doi.org/10.1158/0008-5472.CAN-03-2698

Published: 18 February 2004

View articletitled, Hypoxia Targeted Gene Therapy to Increase the Efficacy of Tirapazamine as an Adjuvant to Radiotherapy: Reversing Tumor Radioresistance and Effecting Cure

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Acquired Resistance to Fractionated Radiotherapy Can Be Overcome by Concurrent PD-L1 Blockade

Abstract 4123: Monocarboxylate transporter 4 expression is a prognostic factor for radiotherapy outcome in squamous cell carcinoma of the head and neck

Abstract 5088: Exploring ATM deficiency as a potential therapeutic target for the PARP inhibitor olaparib in head and neck squamous cell carcinoma

Abstract 1713: Mechanisms of resistance to platinum based drugs uncovered by protection caused by substituted coumarins

Abstract 3713: Inhibition of NQO2 by imidozoacridinones, including C1311 (Symadex, NSC645809): Implications for their mechanism of action

Abstract SY34-03: Hypoxia-metabolic targets for drug development: Identification of targets and their validation

Abstract 5635: Analysis of monocarboxylate transporter 4 as a biomarker shows prognostic significance as an indicator of radiotherapy in squamous cell carcinoma of the head and neck

Combining the highly potent, orally bioavailable, VEGF signaling inhibitor AZD2171 with radiotherapy in human tumor xenografts.

In vivo activation of the hypoxia-targeted cytotoxin AQ4N in human tumor xenografts

Reduction of tumor cell chemoresistance through HIF-1 inhibition

Down regulation of bid in high HIF-1α expressing subpopulations of human colorectal cancer cells in vivo

Adenoviral delivery of inducible nitric oxide synthase (NOSII) enhances AQ4N/radiation cytotoxicity within hypoxic tumor cells

Specifity and oxygen dependence of small molecule inhibitors of HIF-1

In silico identification and biochemical characterization of novel substrates and inhibitors of NQO1

Cytokine induction of iNOS in human tumor cells at various oxygen tensions enhances radiation response.

Elevated inducible NOS activity in human fibrosarcoma HT1080 tumor cells enhances AQ4N reductive metabolism in vitro

Design, synthesis and in vitro toxicity of propanamido-1,4-quinone-drug conjugates as tumor-specific agents.

Enhancing the efficacy of chemotherapy under hypoxic conditions using HIF-1 targeted approaches.

Potentiation of chemo-radiotherapy in human lung xenografts using the bioreductive agent AQ4N

Hypoxia Targeted Gene Therapy to Increase the Efficacy of Tirapazamine as an Adjuvant to Radiotherapy: Reversing Tumor Radioresistance and Effecting Cure

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