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Hui Sun Leong
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Journal Articles

Abstract 152: A machine learning approach to detect FFPE artefacts leads to accurate estimation of tumor mutational burden from sequencing data without a matched normal

Free
Hui Sun Leong, Emma O'Connor, Nuala McCabe, Sinead Donegan, Steven M. Walker, Jayna Mistry, Karen Keating, Denis P. Harkin, Richard D. Kennedy, Laura A. Knight, James R. Bradford
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 152.
https://doi.org/10.1158/1538-7445.AM2021-152
Published: 01 July 2021
View articletitled, Abstract 152: A machine learning approach to detect FFPE artefacts leads to accurate estimation of tumor mutational burden from sequencing data without a matched normal
Journal Articles

CKAP2L Promotes Non–Small Cell Lung Cancer Progression through Regulation of Transcription Elongation

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Tiziana Monteverde, Sudhakar Sahoo, Manuela La Montagna, Peter Magee, Lei Shi, Dave Lee, Robert Sellers, Alexander R. Baker, Hui Sun Leong, Matteo Fassan, Michela Garofalo
Journal: Cancer Research
Cancer Res (2021) 81 (7): 1719–1731.
https://doi.org/10.1158/0008-5472.CAN-20-1968
Published: 01 April 2021
View articletitled, CKAP2L Promotes Non–Small Cell Lung Cancer Progression through Regulation of Transcription Elongation
Open the PDF for CKAP2L Promotes Non–Small Cell Lung Cancer Progression through Regulation of Transcription Elongation in another window
Includes: Supplementary data
Journal Articles

Abstract 4761: Transcriptomic overview of EML4-ALK lung cancer cells resistant to ALK inhibitors highlights a vulnerability to CDK inhibitors

Free
Athanasios R. Paliouras, Peter Magee, Sudhakar Sahoo, Hui Sun Leong, Matthew Krebs, Fiona Blackhall, Christine M. Lovly, Michela Garofalo
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4761.
https://doi.org/10.1158/1538-7445.AM2019-4761
Published: 01 July 2019
View articletitled, Abstract 4761: Transcriptomic overview of EML4-ALK lung cancer cells resistant to ALK inhibitors highlights a vulnerability to CDK inhibitors
Journal Articles

Abstract 5602: Detection of circulating cell-free tumor DNA (ctDNA) in patients with small cell lung cancer (SCLC)

Free
Sumitra Mohan, Victoria Foy, Hui Sun Leong, Pietà G. Schofield, Mahmood Ayub, Nigel K. Smith, Sudhakar Sahoo, Chang Sik-Kim, Lynsey Priest, Mathew Carter, Hedley T. Carr, Crispin Miller, Corinne Finn-Faivre, Fiona Blackhall, Dominic G. Rothwell, Caroline Dive, Gerard Brady
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5602.
https://doi.org/10.1158/1538-7445.AM2018-5602
Published: 01 July 2018
View articletitled, Abstract 5602: Detection of circulating cell-free tumor DNA (ctDNA) in patients with small cell lung cancer (SCLC)
Journal Articles

Abstract 2591: Role of EGFR-AS1 lncRNA in growth factor addiction and treatment response in squamous cell cancers

Free
Daniel SW Tan, Fui-Teen Chong, Hui-Sun Leong, Shen Yon Toh, Dawn P. Lau, Xue Lin Kwang, Xiaoqian Zhang, Gek San Tan, Anders J. Skanderup, Tony KH Lim, Ramanuj Dasgupta, N Gopalakrishna Iyer
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2591.
https://doi.org/10.1158/1538-7445.AM2018-2591
Published: 01 July 2018
View articletitled, Abstract 2591: Role of EGFR-AS1 lncRNA in growth factor addiction and treatment response in squamous cell cancers
Journal Articles

Abstract 3393: Genomic analysis of multi-site fresh prostate samples

Free
Marina A. Parry, Shambhavi Srivastava, Alessio Cannistraci, Hui Sun Leong, Syed Ali, Jenny Antonello, Vijay Ramani, Maurice Lau, Jonathan Shanks, Daisuke Nonaka, Pedro Oliveira, Noel Clarke, Crispin Miller, Ged Brady, Nathalie Dhomen, Esther Baena, Richard Marais
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3393.
https://doi.org/10.1158/1538-7445.AM2017-3393
Published: 01 July 2017
View articletitled, Abstract 3393: Genomic analysis of multi-site fresh prostate samples
Journal Articles

Abstract 3887: GNA13 is a theranostic target that drives drug resistance and cancer stem-like phenotypes in solid tumors

Free
Suhail Ahmed Kabeer Rasheed, Hui Sun Leong, Manikandan Lakshmanan, Anandhkumar Raju, Dhivya Dadlani, Fui-Teen Chong, Ravisankar Rajarethinam, Thakshayeni Skanthakumar, Ern Yu Tan, Jacqueline Siok Gek Hwang, Kok Hing Lim, Daniel Shao-Weng Tan, Paolo Ceppi, Mei Wang, Vinay Tergaonkar, Patrick J. Casey, N. Gopalakrishna Iyer
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3887.
https://doi.org/10.1158/1538-7445.AM2017-3887
Published: 01 July 2017
View articletitled, Abstract 3887: GNA13 is a theranostic target that drives drug resistance and cancer stem-like phenotypes in solid tumors
Journal Articles

Abstract 3960: Combined circulating tumour cell (CTC) and circulating tumor DNA (ctDNA) analysis of blood from patients with pancreatic cancer

Free
Ged Brady, Dominic Rothwell, Mahmood Ayub, Nigel Smith, Sumitra Mohan, Jakub Chudziak, Kyaw Aung, Richard Hubner, Crispin Miller, Alison Backen, Hui Sun Leong, Sakshi Gulati, Chang Sik Kim, Angela Lamarca, Mairéad McNamara, Juan Valle, Caroline Dive
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3960.
https://doi.org/10.1158/1538-7445.AM2016-3960
Published: 15 July 2016
View articletitled, Abstract 3960: Combined circulating tumour cell (CTC) and circulating tumor DNA (ctDNA) analysis of blood from patients with pancreatic cancer
Journal Articles

Abstract 2109: Clonal heterogeneity of EGFR TKI-resistant NSCLC revealed through single-cell dilutional cloning and high-throughput functional screens

Free
Dawn Pingxi Lau, Shivaji Rikka, Hui Sun Leong, Gek San Tan, Eleni G Christodoulou, Sai Sakktee Krisna, Shen Yon Toh, Xue Lin Kwang, Fui Teen Chong, Audrey Ann Liew, Tony Kiat Hon Lim, DasGupta Ramanuj, N Gopalakrishna Iyer, Daniel Shao-Weng Tan
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2109.
https://doi.org/10.1158/1538-7445.AM2016-2109
Published: 15 July 2016
View articletitled, Abstract 2109: Clonal heterogeneity of EGFR TKI-resistant NSCLC revealed through single-cell dilutional cloning and high-throughput functional screens
Journal Articles

Abstract 2505: GNA13 induction of stemness and resistance to chemotherapy in breast and head and neck cancers

Free
Hui Sun Leong, Suhail Ahmed Kabber Rasheed, Manikandan Lakshmanan, Anandh Kumar Raju, Vinay Tergaonkar, Daniel shao-Weng Tan, Patrick Casey, N.Gopalakrishna Iyer
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2505.
https://doi.org/10.1158/1538-7445.AM2016-2505
Published: 15 July 2016
View articletitled, Abstract 2505: GNA13 induction of stemness and resistance to chemotherapy in breast and head and neck cancers
Journal Articles

Abstract 3371: Genetic, phenotypic and functional characterisation of vasculogenic mimicry in small-cell lung cancer

Free
Francesca Trapani, Stuart Williamson, Robert L. Metcalf, Hui Sun Leong, Benjamin Abbott, Jenny Antonello, Cassandra Hodgkinson, Lynsey Franklin, Mary J. Hendrix, Richard E b Seftor, Elisabeth Seftor, Dominic Rothwell, Ged Brady, Crispin Miller, Fiona H. Blackhall, Kathryn L. Simpson, Caroline Dive
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3371.
https://doi.org/10.1158/1538-7445.AM2016-3371
Published: 15 July 2016
View articletitled, Abstract 3371: Genetic, phenotypic and functional characterisation of vasculogenic mimicry in small-cell lung cancer
Journal Articles

Abstract 3874: Mutational landscapes of oral tongue squamous cell carcinoma reveal recurrent mutations in genes of therapeutic and prognostic relevance

Free
Andre L. Vettore, Kalpana Ramnarayanan, Choon Kiat Ong, Hui Sun Leong, Weng Khong Lim, Ioana Cutcutache, John R. Mcpherson, Shenli Zhang, Thankshayeni Skanthakumar, Daniel SW Tan, Bin Tean Teh, Steve Rozen, Patrick Tan, N Gopalakrishna Iyer
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 3874.
https://doi.org/10.1158/1538-7445.AM2015-3874
Published: 01 August 2015
View articletitled, Abstract 3874: Mutational landscapes of oral tongue squamous cell carcinoma reveal recurrent mutations in genes of therapeutic and prognostic relevance
Journal Articles

Abstract 258: Growth factor signaling is critical in the maintenance of cancer stem cell population in head and neck squamous cell cancer.

Free
Hui Sun Leong, Pui Hoon Sew, Fui Teen Chong, Daniel Shao-Weng Tan, Narayanan Gopalakrishna Iyer
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 258.
https://doi.org/10.1158/1538-7445.AM2013-258
Published: 15 April 2013
View articletitled, Abstract 258: Growth factor signaling is critical in the maintenance of cancer stem cell population in head and neck squamous cell cancer.
Journal Articles

Pharmacologic Modulation of Glycogen Synthase Kinase-3β Promotes p53-Dependent Apoptosis through a Direct Bax-Mediated Mitochondrial Pathway in Colorectal Cancer Cells

Free
Jing Tan, Li Zhuang, Hui-Sun Leong, N. Gopalakrishna Iyer, Edison T. Liu, Qiang Yu
Journal: Cancer Research
Cancer Res (2005) 65 (19): 9012–9020.
https://doi.org/10.1158/0008-5472.CAN-05-1226
Published: 03 October 2005
View articletitled, Pharmacologic Modulation of Glycogen Synthase Kinase-3β Promotes p53-Dependent Apoptosis through a Direct Bax-Mediated Mitochondrial Pathway in Colorectal Cancer Cells
Open the PDF for Pharmacologic Modulation of Glycogen Synthase Kinase-3β Promotes p53-Dependent Apoptosis through a Direct Bax-Mediated Mitochondrial Pathway in Colorectal Cancer Cells in another window