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Journal Articles

PICH activates Cyclin A1 transcription to drive S-phase progression and chemoresistance in gastric cancer.

Huili Ye, Wengui Shi, Jing Yang, Long Wang, Xiangyan Jiang, Huiming Zhao, Long Qin, Juejie Qin, Lianshun Li, Weiwen Cai, Junhong Guan, Hanteng Yang, Huinian Zhou, Zeyuan Yu, Hui Sun, Zuoyi Jiao
Journal: Cancer Research
Cancer Res (2023)
https://doi.org/10.1158/0008-5472.CAN-23-1331
Published: 30 August 2023
View article titled, PICH activates Cyclin A1 transcription to drive S-phase progression and chemoresistance in gastric cancer.
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Includes: Supplementary data
Journal Articles

Abstract 152: A machine learning approach to detect FFPE artefacts leads to accurate estimation of tumor mutational burden from sequencing data without a matched normal

Hui Sun Leong, Emma O'Connor, Nuala McCabe, Sinead Donegan, Steven M. Walker, Jayna Mistry, Karen Keating, Denis P. Harkin, Richard D. Kennedy, Laura A. Knight, James R. Bradford
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 152.
https://doi.org/10.1158/1538-7445.AM2021-152
Published: 01 July 2021
View article titled, Abstract 152: A machine learning approach to detect FFPE artefacts leads to accurate estimation of tumor mutational burden from sequencing data without a matched normal
Journal Articles

CKAP2L Promotes Non–Small Cell Lung Cancer Progression through Regulation of Transcription Elongation

Tiziana Monteverde, Sudhakar Sahoo, Manuela La Montagna, Peter Magee, Lei Shi, Dave Lee, Robert Sellers, Alexander R. Baker, Hui Sun Leong, Matteo Fassan, Michela Garofalo
Journal: Cancer Research
Cancer Res (2021) 81 (7): 1719–1731.
https://doi.org/10.1158/0008-5472.CAN-20-1968
Published: 01 April 2021
View article titled, CKAP2L Promotes Non–Small Cell Lung Cancer Progression through Regulation of Transcription Elongation
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Includes: Supplementary data
Journal Articles

Abstract 4761: Transcriptomic overview of EML4-ALK lung cancer cells resistant to ALK inhibitors highlights a vulnerability to CDK inhibitors

Athanasios R. Paliouras, Peter Magee, Sudhakar Sahoo, Hui Sun Leong, Matthew Krebs, Fiona Blackhall, Christine M. Lovly, Michela Garofalo
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4761.
https://doi.org/10.1158/1538-7445.AM2019-4761
Published: 01 July 2019
View article titled, Abstract 4761: Transcriptomic overview of EML4-ALK lung cancer cells resistant to ALK inhibitors highlights a vulnerability to CDK inhibitors
Journal Articles

Abstract 2591: Role of EGFR-AS1 lncRNA in growth factor addiction and treatment response in squamous cell cancers

Daniel SW Tan, Fui-Teen Chong, Hui-Sun Leong, Shen Yon Toh, Dawn P. Lau, Xue Lin Kwang, Xiaoqian Zhang, Gek San Tan, Anders J. Skanderup, Tony KH Lim, Ramanuj Dasgupta, N Gopalakrishna Iyer
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2591.
https://doi.org/10.1158/1538-7445.AM2018-2591
Published: 01 July 2018
View article titled, Abstract 2591: Role of EGFR-AS1 lncRNA in growth factor addiction and treatment response in squamous cell cancers
Journal Articles

Abstract 89: Reduced kinase D-interacting substrate of 220kDa (Kidins220) in pancreatic cancer promotes EGFR/ERK signaling and disease progression

Shuo Cai, Ping-Hui Sun, Xiangyu Gao, Ke Ji, Xiuyun Tian, Chunyi Hao, Bilal Al-Sarireh, Paul Griffiths, Steven Hiscox, Jared Tonkington, Jun Cai, Wen G. Jiang, Lin Ye
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 89.
https://doi.org/10.1158/1538-7445.AM2018-89
Published: 01 July 2018
View article titled, Abstract 89: Reduced kinase D-interacting substrate of 220kDa (Kidins220) in pancreatic cancer promotes EGFR/ERK signaling and disease progression
Journal Articles

Abstract 5602: Detection of circulating cell-free tumor DNA (ctDNA) in patients with small cell lung cancer (SCLC)

Sumitra Mohan, Victoria Foy, Hui Sun Leong, Pietà G. Schofield, Mahmood Ayub, Nigel K. Smith, Sudhakar Sahoo, Chang Sik-Kim, Lynsey Priest, Mathew Carter, Hedley T. Carr, Crispin Miller, Corinne Finn-Faivre, Fiona Blackhall, Dominic G. Rothwell, Caroline Dive, Gerard Brady
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5602.
https://doi.org/10.1158/1538-7445.AM2018-5602
Published: 01 July 2018
View article titled, Abstract 5602: Detection of circulating cell-free tumor DNA (ctDNA) in patients with small cell lung cancer (SCLC)
Journal Articles

Abstract 3887: GNA13 is a theranostic target that drives drug resistance and cancer stem-like phenotypes in solid tumors

Suhail Ahmed Kabeer Rasheed, Hui Sun Leong, Manikandan Lakshmanan, Anandhkumar Raju, Dhivya Dadlani, Fui-Teen Chong, Ravisankar Rajarethinam, Thakshayeni Skanthakumar, Ern Yu Tan, Jacqueline Siok Gek Hwang, Kok Hing Lim, Daniel Shao-Weng Tan, Paolo Ceppi, Mei Wang, Vinay Tergaonkar, Patrick J. Casey, N. Gopalakrishna Iyer
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3887.
https://doi.org/10.1158/1538-7445.AM2017-3887
Published: 01 July 2017
View article titled, Abstract 3887: GNA13 is a theranostic target that drives drug resistance and cancer stem-like phenotypes in solid tumors
Journal Articles

Abstract 3393: Genomic analysis of multi-site fresh prostate samples

Marina A. Parry, Shambhavi Srivastava, Alessio Cannistraci, Hui Sun Leong, Syed Ali, Jenny Antonello, Vijay Ramani, Maurice Lau, Jonathan Shanks, Daisuke Nonaka, Pedro Oliveira, Noel Clarke, Crispin Miller, Ged Brady, Nathalie Dhomen, Esther Baena, Richard Marais
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3393.
https://doi.org/10.1158/1538-7445.AM2017-3393
Published: 01 July 2017
View article titled, Abstract 3393: Genomic analysis of multi-site fresh prostate samples
Journal Articles

Abstract 2505: GNA13 induction of stemness and resistance to chemotherapy in breast and head and neck cancers

Hui Sun Leong, Suhail Ahmed Kabber Rasheed, Manikandan Lakshmanan, Anandh Kumar Raju, Vinay Tergaonkar, Daniel shao-Weng Tan, Patrick Casey, N.Gopalakrishna Iyer
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2505.
https://doi.org/10.1158/1538-7445.AM2016-2505
Published: 15 July 2016
View article titled, Abstract 2505: GNA13 induction of stemness and resistance to chemotherapy in breast and head and neck cancers
Journal Articles

Abstract 3371: Genetic, phenotypic and functional characterisation of vasculogenic mimicry in small-cell lung cancer

Francesca Trapani, Stuart Williamson, Robert L. Metcalf, Hui Sun Leong, Benjamin Abbott, Jenny Antonello, Cassandra Hodgkinson, Lynsey Franklin, Mary J. Hendrix, Richard E b Seftor, Elisabeth Seftor, Dominic Rothwell, Ged Brady, Crispin Miller, Fiona H. Blackhall, Kathryn L. Simpson, Caroline Dive
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3371.
https://doi.org/10.1158/1538-7445.AM2016-3371
Published: 15 July 2016
View article titled, Abstract 3371: Genetic, phenotypic and functional characterisation of vasculogenic mimicry in small-cell lung cancer
Journal Articles

Abstract 3960: Combined circulating tumour cell (CTC) and circulating tumor DNA (ctDNA) analysis of blood from patients with pancreatic cancer

Ged Brady, Dominic Rothwell, Mahmood Ayub, Nigel Smith, Sumitra Mohan, Jakub Chudziak, Kyaw Aung, Richard Hubner, Crispin Miller, Alison Backen, Hui Sun Leong, Sakshi Gulati, Chang Sik Kim, Angela Lamarca, Mairéad McNamara, Juan Valle, Caroline Dive
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3960.
https://doi.org/10.1158/1538-7445.AM2016-3960
Published: 15 July 2016
View article titled, Abstract 3960: Combined circulating tumour cell (CTC) and circulating tumor DNA (ctDNA) analysis of blood from patients with pancreatic cancer
Journal Articles

Abstract 2109: Clonal heterogeneity of EGFR TKI-resistant NSCLC revealed through single-cell dilutional cloning and high-throughput functional screens

Dawn Pingxi Lau, Shivaji Rikka, Hui Sun Leong, Gek San Tan, Eleni G Christodoulou, Sai Sakktee Krisna, Shen Yon Toh, Xue Lin Kwang, Fui Teen Chong, Audrey Ann Liew, Tony Kiat Hon Lim, DasGupta Ramanuj, N Gopalakrishna Iyer, Daniel Shao-Weng Tan
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2109.
https://doi.org/10.1158/1538-7445.AM2016-2109
Published: 15 July 2016
View article titled, Abstract 2109: Clonal heterogeneity of EGFR TKI-resistant NSCLC revealed through single-cell dilutional cloning and high-throughput functional screens
Journal Articles

Abstract 3874: Mutational landscapes of oral tongue squamous cell carcinoma reveal recurrent mutations in genes of therapeutic and prognostic relevance

Andre L. Vettore, Kalpana Ramnarayanan, Choon Kiat Ong, Hui Sun Leong, Weng Khong Lim, Ioana Cutcutache, John R. Mcpherson, Shenli Zhang, Thankshayeni Skanthakumar, Daniel SW Tan, Bin Tean Teh, Steve Rozen, Patrick Tan, N Gopalakrishna Iyer
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 3874.
https://doi.org/10.1158/1538-7445.AM2015-3874
Published: 01 August 2015
View article titled, Abstract 3874: Mutational landscapes of oral tongue squamous cell carcinoma reveal recurrent mutations in genes of therapeutic and prognostic relevance
Journal Articles

Abstract 258: Growth factor signaling is critical in the maintenance of cancer stem cell population in head and neck squamous cell cancer.

Hui Sun Leong, Pui Hoon Sew, Fui Teen Chong, Daniel Shao-Weng Tan, Narayanan Gopalakrishna Iyer
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 258.
https://doi.org/10.1158/1538-7445.AM2013-258
Published: 15 April 2013
View article titled, Abstract 258: Growth factor signaling is critical in the maintenance of cancer stem cell population in head and neck squamous cell cancer.
Journal Articles

Insulin-Like Growth Factor-I Regulates the Liver Microenvironment in Obese Mice and Promotes Liver Metastasis

Yingjie Wu, Pnina Brodt, Hui Sun, Wilson Mejia, Ruslan Novosyadlyy, Nomeli Nunez, Xiaoli Chen, Arnulfo Mendoza, Sung-Hyeok Hong, Chand Khanna, Shoshana Yakar
Journal: Cancer Research
Cancer Res (2010) 70 (1): 57–67.
https://doi.org/10.1158/0008-5472.CAN-09-2472
Published: 04 January 2010
View article titled, Insulin-Like Growth Factor-I Regulates the Liver Microenvironment in Obese Mice and Promotes Liver Metastasis
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Includes: Supplementary data
Journal Articles

Abstract #448: Knockdown of survivin gene suppresses the tumorigenicity and enhances chemosensitivity in hepatocellular carcinoma (HCC)

Yvonne Or, Zhen Yang, Yue Xiong, Hui Sun, Zhao Tang, Ronnie Poon
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 448.
Published: 01 May 2009
View article titled, Abstract #448: Knockdown of survivin gene suppresses the tumorigenicity and enhances chemosensitivity in hepatocellular carcinoma (HCC)
Journal Articles

IGF-I deficiency protects obese mice from accelerated tumor growth

Shoshana Yakar, Nomeli Nunez, Pnina Brodt, Hui Sun, Stephen D. Hursting
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 856.
Published: 15 April 2006
View article titled, IGF-I deficiency protects obese mice from accelerated tumor growth
Journal Articles

Pharmacologic Modulation of Glycogen Synthase Kinase-3β Promotes p53-Dependent Apoptosis through a Direct Bax-Mediated Mitochondrial Pathway in Colorectal Cancer Cells

Jing Tan, Li Zhuang, Hui-Sun Leong, N. Gopalakrishna Iyer, Edison T. Liu, Qiang Yu
Journal: Cancer Research
Cancer Res (2005) 65 (19): 9012–9020.
https://doi.org/10.1158/0008-5472.CAN-05-1226
Published: 03 October 2005
View article titled, Pharmacologic Modulation of Glycogen Synthase Kinase-3β Promotes p53-Dependent Apoptosis through a Direct Bax-Mediated Mitochondrial Pathway in Colorectal Cancer Cells
Open the PDF for Pharmacologic Modulation of Glycogen Synthase Kinase-3β Promotes p53-Dependent Apoptosis through a Direct Bax-Mediated Mitochondrial Pathway in Colorectal Cancer Cells in another window
Journal Articles

Overexpression of the Tumor Suppressor Gene Phosphatase and Tensin Homologue Partially Inhibits Wnt-1–Induced Mammary Tumorigenesis

Hong Zhao, Yongzhi Cui, Joelle Dupont, Hui Sun, Lothar Hennighausen, Shoshana Yakar
Journal: Cancer Research
Cancer Res (2005) 65 (15): 6864–6873.
https://doi.org/10.1158/0008-5472.CAN-05-0181
Published: 01 August 2005
View article titled, Overexpression of the Tumor Suppressor Gene Phosphatase and Tensin Homologue Partially Inhibits Wnt-1–Induced Mammary Tumorigenesis
Open the PDF for Overexpression of the Tumor Suppressor Gene Phosphatase and Tensin Homologue Partially Inhibits Wnt-1–Induced Mammary Tumorigenesis in another window