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Journal Articles

A Cell Surface-Binding Antibody Atlas Nominates a MUC18-Directed Antibody–Drug Conjugate for Targeting Melanoma

Jing Shi, Tao Jiao, Qian Guo, Weining Weng, Linjie Ma, Qing Zhang, Lijun Wang, Jianjian Zhang, Caiwei Chen, Yaling Huang, Mingqiao Wang, Rong Pan, Yanfang Tang, Wenhao Hu, Tao Meng, Shu-Hui Liu, Jun Guo, Yan Kong, Xun Meng
Journal: Cancer Research
Cancer Res (2023) 83 (22): 3783–3795.
https://doi.org/10.1158/0008-5472.CAN-23-1356
Published: 15 November 2023
View article titled, A Cell Surface-Binding Antibody Atlas Nominates a MUC18-Directed Antibody–Drug Conjugate for Targeting Melanoma
Open the PDF for A Cell Surface-Binding Antibody Atlas Nominates a MUC18-Directed Antibody–Drug Conjugate for Targeting Melanoma in another window
Includes: Supplementary data
Journal Articles

Fructose-induced mTORC1 Activation Promotes Pancreatic Cancer Progression through Inhibition of Autophagy

Yanfen Cui, Jianfei Tian, Zhaosong Wang, Hui Guo, He Zhang, Zhiyong Wang, Hui Liu, Weijie Song, Liming Liu, Ruinan Tian, Xiaoyan Zuo, Sixin Ren, Ruifang Niu, Fei Zhang
Journal: Cancer Research
Cancer Res (2023)
https://doi.org/10.1158/0008-5472.CAN-23-0464
Published: 22 September 2023
View article titled, Fructose-induced mTORC1 Activation Promotes Pancreatic Cancer Progression through Inhibition of Autophagy
Open the PDF for Fructose-induced mTORC1 Activation Promotes Pancreatic Cancer Progression through Inhibition of Autophagy in another window
Includes: Supplementary data
Journal Articles

Abstract CT167: Efficacy of pirtobrutinib, a highly selective, non-covalent (reversible) BTK inhibitor in Richter transformation: Results from the phase 1/2 BRUIN study

Joanna Rhodes, David Lewis, Paolo Ghia, Nirav N. Shah, Catherine C. Coombs, Chan Y. Cheah, Jennifer Woyach, Nicole Lamanna, Marc S. Hoffmann, Shuo Ma, Toby A. Eyre, Talha Munir, Manish R. Patel, Alvaro J. Alencar, Constantine S. Tam, John F. Seymour, Wojciech Jurczak, Ewa Lech-Maranda, Lindsey E. Roeker, Philip A. Thompson, Paolo B. Abada, Chunxiao Wang, Binoj Nair, Hui Liu, Donald E. Tsai, Anthony R. Mato, William G. Wierda
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): CT167.
https://doi.org/10.1158/1538-7445.AM2023-CT167
Published: 14 April 2023
View article titled, Abstract CT167: Efficacy of pirtobrutinib, a highly selective, non-covalent (reversible) BTK inhibitor in Richter transformation: Results from the phase 1/2 BRUIN study
Journal Articles

Abstract CT098: A first-in-human phase 1 study of LY3410738, a covalent inhibitor of mutant IDH, in advanced IDH-mutant cholangiocarcinoma and other solid tumors

Jordi Rodon, Lipika Goyal, Teresa Macarulla Mercade, Masafumi Ikeda, Shunsuke Kondo, Do-Youn Oh, Li-Yuan Bai, Makoto Ueno, Antoine Italiano, Kyriakos Papadopoulos, David Spigel, Sani H. Kizilbash, Rasha Cosman, Joon Oh Park, Li-Tzong Chen, Tomoya Yokota, Anita A. Turk, Chih-Yi Liao, Rachna Shroff, Anthony El-Khoueiry, Taroh Satoh, Antoine Hollebecque, Mitesh J. Borad, Nilofer Azad, Kurt A. Jaeckle, Herbert H. Loong, Jorge Adeva, Wei Peng Yong, Junjie Zhao, Hui Liu, Anna M. Szpurka, Ivelina Gueorguieva, Kamnesh R. Pradhan, Xiaojian Xu, James J. Harding
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): CT098.
https://doi.org/10.1158/1538-7445.AM2023-CT098
Published: 14 April 2023
View article titled, Abstract CT098: A first-in-human phase 1 study of LY3410738, a covalent inhibitor of mutant IDH, in advanced IDH-mutant cholangiocarcinoma and other solid tumors
Journal Articles

Abstract 1726: Loss of NF1 drives hormone dependent mammary carcinogenesis in a rat model with intact immune system

Deeann Wallis, Christian Fay, Kelley Bradley, Erik Westin, William Bradley, Hui Liu, David Crossman, Jeremy B. Foote, Robert Kesterson
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1726.
https://doi.org/10.1158/1538-7445.AM2023-1726
Published: 04 April 2023
View article titled, Abstract 1726: Loss of NF1 drives hormone dependent mammary carcinogenesis in a rat model with intact immune system
Journal Articles

Abstract 6320: CUSP06/AMT-707, a new CDH6-targeting antibody-drug conjugate, demonstrates potent antitumor activity in preclinical models

Wei Lu, Jing Shi, Shu-Hui Liu, Nicole Covino, Xun Meng, Eric D. Slosberg
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6320.
https://doi.org/10.1158/1538-7445.AM2023-6320
Published: 04 April 2023
View article titled, Abstract 6320: CUSP06/AMT-707, a new CDH6-targeting antibody-drug conjugate, demonstrates potent antitumor activity in preclinical models
Journal Articles

Abstract P3-08-01: Loss of NF1 drives hormone dependent mammary carcinogenesis in a rat model with intact immune system

Deeann Wallis, Christian Fay, Kelley Bradley, Erik Westin, William Bradley, Hui Liu, Laura Lambert, David Crossman, Jeremy Foote, Robert Kesterson
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): P3-08-01.
https://doi.org/10.1158/1538-7445.SABCS22-P3-08-01
Published: 01 March 2023
View article titled, Abstract P3-08-01: Loss of NF1 drives hormone dependent mammary carcinogenesis in a rat model with intact immune system
Journal Articles

Postoperative Plasmacytoid Dendritic Cells Secrete IFNα to Promote Recruitment of Myeloid-Derived Suppressor Cells and Drive Hepatocellular Carcinoma Recurrence

Li Pang, Oscar W.H. Yeung, Kevin T.P. Ng, Hui Liu, Jiye Zhu, Jiang Liu, Xinxiang Yang, Tao Ding, Wenqi Qiu, Yuewen Wang, T.L. Shirley Chiu, Zhiwei Chen, Chung-Mau Lo, Kwan Man
Journal: Cancer Research
Cancer Res (2022) 82 (22): 4206–4218.
https://doi.org/10.1158/0008-5472.CAN-22-1199
Published: 15 November 2022
View article titled, Postoperative Plasmacytoid Dendritic Cells Secrete IFNα to Promote Recruitment of Myeloid-Derived Suppressor Cells and Drive Hepatocellular Carcinoma Recurrence
Open the PDF for Postoperative Plasmacytoid Dendritic Cells Secrete IFNα to Promote Recruitment of Myeloid-Derived Suppressor Cells and Drive Hepatocellular Carcinoma Recurrence in another window
Includes: Supplementary data
Journal Articles

Abstract P4-01-04: FGFR inhibitor mediated dismissal of SWI/SNF complexes from YAP-dependent enhancers induces therapeutic resistance in triple negative breast cancer

Yihao Li, Xintao Qiu, Xiaoqing Wang, Hui Liu, Renee Geck Geck, Alok Tewari, Kin-Hoe Chow, Tengfei Xiao, Paloma Cejas, Quang-Dé Nguyen, Henry Long, Shirley X Liu, Alex Toker, Myles Brown
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P4-01-04.
https://doi.org/10.1158/1538-7445.SABCS21-P4-01-04
Published: 15 February 2022
View article titled, Abstract P4-01-04: FGFR inhibitor mediated dismissal of SWI/SNF complexes from YAP-dependent enhancers induces therapeutic resistance in triple negative breast cancer
Journal Articles

Cancer Etiology and Prevention Principle: “1 + X”

Hui Liu, Zigang Dong
Journal: Cancer Research
Cancer Res (2021) 81 (21): 5377–5395.
https://doi.org/10.1158/0008-5472.CAN-21-1862
Published: 01 November 2021
View article titled, Cancer Etiology and Prevention Principle: “1 + X”
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Includes: Supplementary data
Journal Articles

Abstract 1400: SWI/SNF chromatin remodeling complex regulation of YAP-dependent enhancers drives therapeutic resistance in triple-negative breast cancer

Yihao Li, Xintao Qiu, Hui Liu, Xiaoqing Wang, Renee C. Geck, Alok Tewari, Kin-Hoe Chow, Paloma Cejas, Quang-Dé Nguyen, Henry Long, Shirley X. Liu, Alex Toker, Myles Brown
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1400.
https://doi.org/10.1158/1538-7445.AM2021-1400
Published: 01 July 2021
View article titled, Abstract 1400: SWI/SNF chromatin remodeling complex regulation of YAP-dependent enhancers drives therapeutic resistance in triple-negative breast cancer
Journal Articles

KIF15-Mediated Stabilization of AR and AR-V7 Contributes to Enzalutamide Resistance in Prostate Cancer

Lin Gao, Wenbo Zhang, Jing Zhang, Junmei Liu, Feifei Sun, Hui Liu, Jing Hu, Xin Wang, Xueli Wang, Peng Su, Shouzhen Chen, Sifeng Qu, Benkang Shi, Xueting Xiong, Weiwen Chen, Xuesen Dong, Bo Han
Journal: Cancer Research
Cancer Res (2021) 81 (4): 1026–1039.
https://doi.org/10.1158/0008-5472.CAN-20-1965
Published: 15 February 2021
View article titled, KIF15-Mediated Stabilization of AR and AR-V7 Contributes to Enzalutamide Resistance in Prostate Cancer
Open the PDF for KIF15-Mediated Stabilization of AR and AR-V7 Contributes to Enzalutamide Resistance in Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

Targeting CDK12 for Cancer Therapy: Function, Mechanism, and Drug Discovery

Hui Liu, Kangdong Liu, Zigang Dong
Journal: Cancer Research
Cancer Res (2021) 81 (1): 18–26.
https://doi.org/10.1158/0008-5472.CAN-20-2245
Published: 04 January 2021
View article titled, Targeting CDK12 for Cancer Therapy: Function, Mechanism, and Drug Discovery
Open the PDF for Targeting CDK12 for Cancer Therapy: Function, Mechanism, and Drug Discovery in another window
Includes: Supplementary data
Journal Articles

Abstract 1788: A high-throughput chemical genetic screen reveals SALL4-induced metabolic vulnerabilities in cancer

Justin L. Tan, Feng Li, Joanna Z. Yeo, Kol Jia Yong, Mahmoud A. Bassal, Guo Hao Ng, May Yin Lee, Chung Yan Leong, Hong Kee Tan, Chan-Shuo Wu, Bee Hui Liu, Hon Man Chan, Zi Hui Tan, Yun Shen Chan, Siyu Wang, Zhi Han Lim, Tan Boon Toh, Lissa Hooi, Kia Ngee Low, Siming Ma, Nikki R. Kong, Alicia J. Stein, Yue Wu, Matan T. Thangavelu, Atsushi Suzuki, Giridharan Periyasamy, John M. Asara, Yock Young Dan, Glenn K. Bonney, Edward K. Chow, Guo-Dong Lu, Huck Hui Ng, Yoganathan Kanagasundaram, Siew Bee Ng, Wai Leong Tam, Li Chai, Daniel G. Tenen
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1788.
https://doi.org/10.1158/1538-7445.AM2020-1788
Published: 15 August 2020
View article titled, Abstract 1788: A high-throughput chemical genetic screen reveals SALL4-induced metabolic vulnerabilities in cancer
Journal Articles

Abstract OT1-04-01: Adjuvant ovarian suppression plus aromatase inhibitor or tamoxifen for hormone receptor-positive breast cancer in women younger than 35 (ASPAIT): A multicenter randomized clinical trial

Zhen Shan, Nan Shao, Zhongyu yuan, Qianjun Chen, Anqin Zhang, Kun Wang, Ailing Zhang, Li Cai, Yuhua Song, Herui Yao, Hongmin Ma, Heng Huang, Jianwen Li, Yuanqi Zhang, Lehong Zhang, Jincai Zhong, Hui Liu, Zhiyong Wu, Li Zhao, Feihai Ling, Weixiong Yang, Rui Zhuo, Xiangyang Song, Ying Lin
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): OT1-04-01.
https://doi.org/10.1158/1538-7445.SABCS19-OT1-04-01
Published: 15 February 2020
View article titled, Abstract OT1-04-01: Adjuvant ovarian suppression plus aromatase inhibitor or tamoxifen for hormone receptor-positive breast cancer in women younger than 35 (ASPAIT): A multicenter randomized clinical trial
Journal Articles

Abstract 1164: Pdx model of pleural effusion of lung cancer patient for testing on targeted drug sensitivity and resistance

Feifei Zhang, Zhen Zhou, Yuan Long, Wenhua Xu, Shizhu Zhao, Yang Yang, Hui Liu, Jijun Cheng, Shun Lu, Danyi Wen
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1164.
https://doi.org/10.1158/1538-7445.AM2018-1164
Published: 01 July 2018
View article titled, Abstract 1164: Pdx model of pleural effusion of lung cancer patient for testing on targeted drug sensitivity and resistance
Journal Articles

Abstract 2165: Mini-patient-derived xenograft sensitive assay: A rapid systemic detection method for assessment of cancer therapeutics

Xiaoqing Pan, Feifei Zhang, Yuan Long, Hui Liu, Lin Guo, Jijun Cheng, Danyi Wen
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2165.
https://doi.org/10.1158/1538-7445.AM2018-2165
Published: 01 July 2018
View article titled, Abstract 2165: Mini-patient-derived xenograft sensitive assay: A rapid systemic detection method for assessment of cancer therapeutics
Journal Articles

PTBP3-Mediated Regulation of ZEB1 mRNA Stability Promotes Epithelial–Mesenchymal Transition in Breast Cancer

Pingfu Hou, Lin Li, Fang Chen, Yansu Chen, Hui Liu, Jingjing Li, Jin Bai, Junnian Zheng
Journal: Cancer Research
Cancer Res (2018) 78 (2): 387–398.
https://doi.org/10.1158/0008-5472.CAN-17-0883
Published: 15 January 2018
View article titled, PTBP3-Mediated Regulation of ZEB1 mRNA Stability Promotes Epithelial–Mesenchymal Transition in Breast Cancer
Open the PDF for PTBP3-Mediated Regulation of ZEB1 mRNA Stability Promotes Epithelial–Mesenchymal Transition in Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 2649: Fc-effector function activity of the CXCR4 IgG1 antibody PF-06747143: a novel clinical candidate for the treatment of hematologic malignancies

Flavia Pernasetti, Shu-Hui Liu, Gu Yin, Bernadette Pascual, Zhengming Yan, Max Hallin, Rolla Yafawi, Cathy Zhang, Connie Fang, Wenlian Wang, Justine Lam, Mary E. Spilker, Eileen Blasi, Brett Simmons, Nanni Huser, Wei-Hsien Ho, Kevin Lindquist, Thomas-Toan Tran, Jyothirmayee Kudaravalli, Jing-Tyan Ma, Gretchen Jimenez, Ishita Barman, Colleen Brown, Sherman-Michael Chin, Maria Costa, David Shelton, Tod Smeal, Valeria R. Fantin
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2649.
https://doi.org/10.1158/1538-7445.AM2017-2649
Published: 01 July 2017
View article titled, Abstract 2649: Fc-effector function activity of the CXCR4 IgG1 antibody PF-06747143: a novel clinical candidate for the treatment of hematologic malignancies
Journal Articles

Abstract 3751: Allogeneic EGFRvIII chimeric antigen receptor T cells for treatment of glioblastoma

Oi Kwan Wong, Mathilde Dusseaux, Jing-Tyan Ma, Melinda Au, Sophie Leduc, Joyce Chou, Jessica M. Yu, Marjorie Bateman, Thomas Pertel, Kevin C. Lindquist, Julianne Smith, Barbra Sasu, Shu-Hui Liu
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3751.
https://doi.org/10.1158/1538-7445.AM2017-3751
Published: 01 July 2017
View article titled, Abstract 3751: Allogeneic EGFRvIII chimeric antigen receptor T cells for treatment of glioblastoma