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Journal Articles

Abstract 423: CDK2 activation mediates response of acute myeloid leukemia to CHK1, ATR and WEE1 inhibitors

Free
Annapoorna Venkatachalam, Husheng Ding, Nicole Vincelette, Cordelia McGehee, Kevin Peterson, Paula Schneider, Cristina Correia, Hu Li, Scott Kaufmann
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 423.
https://doi.org/10.1158/1538-7445.AM2025-423
Published: 21 April 2025
View article titled, Abstract 423: CDK2 activation mediates response of acute myeloid leukemia to CHK1, ATR and WEE1 inhibitors
Journal Articles

Abstract 4658: Genome wide CRISPR/Cas9 library screening identifies aurora kinase A as a regulator of elraglusib sensitivity in pancreatic cancer

Free
Li Ding, Easton Maeder, Cheng Zhang, Taylor Weiskittel, Daniel Schmitt, Andrew Mazar, Hu Li, Daniel Billadeau
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4658.
https://doi.org/10.1158/1538-7445.AM2024-4658
Published: 22 March 2024
View article titled, Abstract 4658: Genome wide CRISPR/Cas9 library screening identifies aurora kinase A as a regulator of elraglusib sensitivity in pancreatic cancer
Journal Articles

Abstract 6426: Identification of potential immune biomarkers for GSK-3 inhibitor elraglusib (9-ING-41) in patients with relapsed/refractory metastatic cancer

Free
Taylor Weiskittel, Kelsey Huntington, Leiqing Zhang, Austin Koukol, Benedito A. Carneiro, Hu Li, Andrey Ugolkov, Wafik El-Deiry, Andrew Mazar
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6426.
https://doi.org/10.1158/1538-7445.AM2024-6426
Published: 22 March 2024
View article titled, Abstract 6426: Identification of potential immune biomarkers for GSK-3 inhibitor elraglusib (9-ING-41) in patients with relapsed/refractory metastatic cancer
Journal Articles

Abstract B012: Transcriptomic insights reveal role of BCL2 proteins in replication checkpoint inhibitor response

Free
Annapoorna Venkatachalam, Cristina Correia, Kevin L. Peterson, Xiaonan Hou, Annabella R. Strathman, Paula A Schneider, Karen S. Flatten, Laura N. Duffield, Cordelia D. McGehee, Melissa C. Larson, Xue Meng, Nicole D Vincelette, Ann L. Oberg, Hu Li, John Weroha, Scott H Kaufmann
Journal: Cancer Research
Cancer Res (2024) 84 (5_Supplement_2): B012.
https://doi.org/10.1158/1538-7445.OVARIAN23-B012
Published: 04 March 2024
View article titled, Abstract B012: Transcriptomic insights reveal role of BCL2 proteins in replication checkpoint inhibitor response
Journal Articles

Abstract CT222: Multimodal mechanism of action of the GSK-3 inhibitor 9-ING-41 (elraglusib) includes an immunomodulatory component: preliminary results from the 1801 phase 1/2 trial

Free
Taylor Weiskittel, Joseph McDermott, Daniel Billadeau, Hu Li, Anwaar Saeed, Devalingam Mahalingam, Solmaz Sahebjam, Pamela Munster, Ludimila Cavalcante, Frank J. Giles, Andrew Mazar, Benedito Carneiro
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): CT222.
https://doi.org/10.1158/1538-7445.AM2023-CT222
Published: 14 April 2023
View article titled, Abstract CT222: Multimodal mechanism of action of the GSK-3 inhibitor 9-ING-41 (elraglusib) includes an immunomodulatory component: preliminary results from the 1801 phase 1/2 trial
Journal Articles

Abstract 5355: Elraglusib response prediction and mechanistic discovery using iterative machine learning

Free
Joseph McDermott, Taylor Weiskittel, Daniel Billadeau, Benedito Carneiro, Hu Li, Andrew Mazar
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5355.
https://doi.org/10.1158/1538-7445.AM2023-5355
Published: 04 April 2023
View article titled, Abstract 5355: Elraglusib response prediction and mechanistic discovery using iterative machine learning
Journal Articles

Abstract 3857: Exploring mechanisms of resistance to elraglusib in pancreatic cancer PDX models

Free
Taylor Weiskittel, Ding Li, Lingling Han, Joseph McDermott, Benedito Caneiro, Hu Li, Daniel Billadeau, Andrew Mazar
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3857.
https://doi.org/10.1158/1538-7445.AM2023-3857
Published: 04 April 2023
View article titled, Abstract 3857: Exploring mechanisms of resistance to elraglusib in pancreatic cancer PDX models
Journal Articles

Abstract 5621: Multi-parametric MRI maps regional heterogeneity of high grade glioma phenotypes

Free
Matthew Flick, Taylor Weiskittel, Kevin Meng-Lin, Fulvio D'Angelo, Francesca Caruso, Shannon Ensign, Mylan Blomquist, Luija Wang, Christopher Sereduk, Gustavo De Leon, Ashley Nespodzany, Javier Urcuyo, Ashlynn Gonzalez, Lee Curtin, Kyle Singleton, Aliya Anil, Natenael Simmineh, Erika Lewis, Teresa Noviello, Reyna Patel, Panwen Wang, Junwen Wang, Jennifer Eschbacher, Andrea Hawkins-Daarud, Pamela Jackson, Kris Smith, Peter Nakaji, Bernard Bendok, Richard Zimmerman, Chandan Krishna, Devi Patra, Naresh Patel, Mark Lyons, Matthew Neal, Kliment Donev, Maciej Mrugala, Alyx Porter, Scott Beeman, Yuxiang Zhou, Leslie Baxter, Christopher Plaisier, Jing Li, Hu Li, Anna Lasorella, Chad Quarles, Kristin Swanson, Michele Ceccarelli, Antonio Iavarone, Nhan Tran, Leland Hu
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5621.
https://doi.org/10.1158/1538-7445.AM2023-5621
Published: 04 April 2023
View article titled, Abstract 5621: Multi-parametric MRI maps regional heterogeneity of high grade glioma phenotypes
Journal Articles

Abstract 1832: CHK1 inhibitor prexasertib induces NOXA-dependent apoptosis in ovarian cancer

Free
Annapoorna Venkatachalam, Kevin L. Peterson, Cristina Correia, Karen S. Flatten, Xianon Hou, Paula A. Schneider, Emily Balczewski, Cordelia McGehee, Rachel M. Hurley, Xue W. Meng, Chance Sine, Rameen Shah, Nicole Vincelettte, Husheng Ding, Hu Li, Saravut (John) Weroha, Scott H. Kaufmann
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1832.
https://doi.org/10.1158/1538-7445.AM2022-1832
Published: 15 June 2022
View article titled, Abstract 1832: CHK1 inhibitor prexasertib induces NOXA-dependent apoptosis in ovarian cancer
Journal Articles

Abstract 490: De novo individualized disease modules reveal the synthetic penetrance of genes and inform personalized treatment regimens

Free
Taylor Weiskittel, Cristina Correia, Choong Ung, Cheng Zhang, Hu Li
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 490.
https://doi.org/10.1158/1538-7445.AM2022-490
Published: 15 June 2022
View article titled, Abstract 490: De novo individualized disease modules reveal the synthetic penetrance of genes and inform personalized treatment regimens
Journal Articles

Abstract 1226: A genome wide pharmacological perturbation platform

Free
Cristina Correia, Choong Yong Ung, Cheng Zhang, Scott H. Kaufmann, Hu Li
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1226.
https://doi.org/10.1158/1538-7445.AM2022-1226
Published: 15 June 2022
View article titled, Abstract 1226: A genome wide pharmacological perturbation platform
Journal Articles

Abstract 1679: Innate immunity and cytokine signaling pathways drive resistance to HSV-1 oncolytic immunovirotherapy in glioblastoma

Free
Dileep D. Monie, Cristina Correia, Cheng Zhang, Choong Ung, Richard G. Vile, Hu Li
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1679.
https://doi.org/10.1158/1538-7445.AM2021-1679
Published: 01 July 2021
View article titled, Abstract 1679: Innate immunity and cytokine signaling pathways drive resistance to HSV-1 oncolytic immunovirotherapy in glioblastoma
Journal Articles

GAS7 Deficiency Promotes Metastasis in MYCN-Driven Neuroblastoma

Available to Purchase
Zhiwei Dong, Kok Siong Yeo, Gonzalo Lopez, Cheng Zhang, Erin N. Dankert Eggum, Jo Lynne Rokita, Choong Yong Ung, Taylor M. Levee, Zuag Paj Her, Cassie J. Howe, Xiaonan Hou, Janine H. van Ree, Shuai Li, Shuning He, Ting Tao, Karen Fritchie, Jorge Torres-Mora, Julia S. Lehman, Alexander Meves, Gina L. Razidlo, Komal S. Rathi, S. John Weroha, A. Thomas Look, Jan M. van Deursen, Hu Li, Jennifer J. Westendorf, John M. Maris, Shizhen Zhu
Journal: Cancer Research
Cancer Res (2021) 81 (11): 2995–3007.
https://doi.org/10.1158/0008-5472.CAN-20-1890
Published: 01 June 2021
View article titled, GAS7 Deficiency Promotes Metastasis in MYCN-Driven Neuroblastoma
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Includes: Supplementary data
Journal Articles

CDK2-Mediated Upregulation of TNFα as a Mechanism of Selective Cytotoxicity in Acute Leukemia

Available to Purchase
Husheng Ding, Nicole D. Vincelette, Cordelia D. McGehee, Mira A. Kohorst, Brian D. Koh, Annapoorna Venkatachalam, X. Wei Meng, Paula A. Schneider, Karen S. Flatten, Kevin L. Peterson, Cristina Correia, Sun-Hee Lee, Mrinal Patnaik, Jonathan A. Webster, Gabriel Ghiaur, B. Douglas Smith, Judith E. Karp, Keith W. Pratz, Hu Li, Larry M. Karnitz, Scott H. Kaufmann
Journal: Cancer Research
Cancer Res (2021) 81 (10): 2666–2678.
https://doi.org/10.1158/0008-5472.CAN-20-1504
Published: 15 May 2021
View article titled, CDK2-Mediated Upregulation of TNFα as a Mechanism of Selective Cytotoxicity in Acute Leukemia
Open the PDF for CDK2-Mediated Upregulation of TNFα as a Mechanism of Selective Cytotoxicity in Acute Leukemia in another window
Includes: Supplementary data
Journal Articles

BRCA1 Deficiency Upregulates NNMT, Which Reprograms Metabolism and Sensitizes Ovarian Cancer Cells to Mitochondrial Metabolic Targeting Agents

Free
Arun Kanakkanthara, Kiran Kurmi, Thomas L. Ekstrom, Xiaonan Hou, Emma R. Purfeerst, Ethan P. Heinzen, Cristina Correia, Catherine J. Huntoon, Daniel O'Brien, Andrea E. Wahner Hendrickson, Sean C. Dowdy, Hu Li, Ann L. Oberg, Taro Hitosugi, Scott H. Kaufmann, S. John Weroha, Larry M. Karnitz
Journal: Cancer Research
Cancer Res (2019) 79 (23): 5920–5929.
https://doi.org/10.1158/0008-5472.CAN-19-1405
Published: 02 December 2019
View article titled, BRCA1 Deficiency Upregulates NNMT, Which Reprograms Metabolism and Sensitizes Ovarian Cancer Cells to Mitochondrial Metabolic Targeting Agents
Open the PDF for BRCA1 Deficiency Upregulates NNMT, Which Reprograms Metabolism and Sensitizes Ovarian Cancer Cells to Mitochondrial Metabolic Targeting Agents in another window
Includes: Supplementary data
Journal Articles

Abstract LB-127: Loss of function of GAS7 promotes neuroblastoma metastasis in the context of MYCN overexpression

Free
Zhiwei Dong, Gonzalo Lepez Garcia, Cheng Zhang, Erin N. Dankert, Jo Lynne Harenza, Xiaonan Hou, Hu Li, John M. Maris, Shizhen (Jane) Zhu
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): LB-127.
https://doi.org/10.1158/1538-7445.AM2019-LB-127
Published: 01 July 2019
View article titled, Abstract LB-127: Loss of function of GAS7 promotes neuroblastoma metastasis in the context of MYCN overexpression
Journal Articles

Abstract 3894: DPYD-Varifier, a computational model to identify 5-FU toxicity-associated DPYD variants

Free
Shikshya Shrestha, Cheng Zhang, Calvin R. Jerde, Hu Li, Steven M. Offer, Robert B. Diasio
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3894.
https://doi.org/10.1158/1538-7445.AM2018-3894
Published: 01 July 2018
View article titled, Abstract 3894: DPYD-Varifier, a computational model to identify 5-FU toxicity-associated DPYD variants
Journal Articles

Abstract P2-03-16: Examining 3-dimensional genome architecture and transcriptional profiles using an optimized HiC-seq protocol in breast cancer cells

Free
Jennifer D Davis, Christian Ross, Hu Li, Amy Brock
Journal: Cancer Research
Cancer Res (2015) 75 (9_Supplement): P2-03-16.
https://doi.org/10.1158/1538-7445.SABCS14-P2-03-16
Published: 01 May 2015
View article titled, Abstract P2-03-16: Examining 3-dimensional genome architecture and transcriptional profiles using an optimized HiC-seq protocol in breast cancer cells
Journal Articles

Hsp70–Bag3 Interactions Regulate Cancer-Related Signaling Networks

Free
Teresa A. Colvin, Vladimir L. Gabai, Jianlin Gong, Stuart K. Calderwood, Hu Li, Suryaram Gummuluru, Olga N. Matchuk, Svetlana G. Smirnova, Nina V. Orlova, Irina A. Zamulaeva, Mikel Garcia-Marcos, Xiaokai Li, Z.T. Young, Jennifer N. Rauch, Jason E. Gestwicki, Shinichi Takayama, Michael Y. Sherman
Journal: Cancer Research
Cancer Res (2014) 74 (17): 4731–4740.
https://doi.org/10.1158/0008-5472.CAN-14-0747
Published: 01 September 2014
View article titled, Hsp70–Bag3 Interactions Regulate Cancer-Related Signaling Networks
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Includes: Supplementary data
Journal Articles

Abstract 2915: Discovery and characterization of OSI-296, a dual inhibitor of cMET and RON kinases

Free
Arno G. Steinig, An-Hu Li, Jing Wang, Andrew Kleinberg, Hanqing Dong, Ti Wang, Kathryn M. Stolz Gavagan, Meizhong Jin, Paula Tavares-Greco, Yue Peng, Jen Kahler, Linda Castaldo, Siobhan McCormack, Julie Kan, Mark Albertella, Andy Cooke, Roy Turton, Mark Bittner, Maryland Franklin, Darla Landfair, Prafulla Gokhale, Robert Wild, Jonathan Pachter, David Epstein, Mark J. Mulvihill
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 2915.
https://doi.org/10.1158/1538-7445.AM2012-2915
Published: 15 April 2012
View article titled, Abstract 2915: Discovery and characterization of OSI-296, a dual inhibitor of cMET and RON kinases