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Howard Yang
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Journal Articles

Abstract CT257: Hyperprogressive disease following bintrafusp alfa and DNA damaging chemotherapy in relapsed small cell lung cancer

Brett Schroeder, Nobuyuki Takahashi, Howard Yang, Renee Donahue, Zachary Skidmore, Alissa Konicki, Michael Nirula, Max Greenberg, George Chrisafis, Yang Zhang, Yo-Ting Tsai, Linda Sciuto, Samantha Nichols, Melissa Abel, Parth Desai, Rajesh Kumar, Christopher Schultz, Danielle Pinkiert, Chante Graham, Ajit Sharma, Justin Malin, Manan Krishnamurthy, Sophie Zhuang, Maxwell Lee, Lorenzo Rinaldi, Jeffrey Schlom, Lalage Wakefield, Anish Thomas
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): CT257.
https://doi.org/10.1158/1538-7445.AM2024-CT257
Published: 05 April 2024
View article titled, Abstract CT257: Hyperprogressive disease following bintrafusp alfa and DNA damaging chemotherapy in relapsed small cell lung cancer
Journal Articles

Dysregulation of Mitochondrial Translation Caused by CBFB Deficiency Cooperates with Mutant PIK3CA and Is a Vulnerability in Breast Cancer

Navdeep Malik, Young-Im Kim, Hualong Yan, Yu-Chou Tseng, Wendy du Bois, Gamze Ayaz, Andy D. Tran, Laura Vera-Ramirez, Howard Yang, Aleksandra M. Michalowski, Michael Kruhlak, Maxwell Lee, Kent W. Hunter, Jing Huang
Journal: Cancer Research
Cancer Res (2023) 83 (8): 1280–1298.
https://doi.org/10.1158/0008-5472.CAN-22-2525
Published: 14 April 2023
View article titled, Dysregulation of Mitochondrial Translation Caused by <em>CBFB</em> Deficiency Cooperates with Mutant PIK3CA and Is a Vulnerability in Breast Cancer
Open the PDF for Dysregulation of Mitochondrial Translation Caused by <em>CBFB</em> Deficiency Cooperates with Mutant PIK3CA and Is a Vulnerability in Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 141: Interrogating subclonal mechanisms of immune evasion and immunotherapy resistance in melanoma

Isabella Church, Charli Gruen, Antonella Sassano, Julio Valencia, Emily Wu, Howard Yang, Gabe Needle, Cari Smith, Sung Chin, Jessica Ebersole, Christina Marcelus, Anyen Fon, Huaitian Liu, Chi-Ping Day, Howard Young, Maxwell Lee, Glenn Merlino, Eva Pérez-Guijarro
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 141.
https://doi.org/10.1158/1538-7445.AM2023-141
Published: 04 April 2023
View article titled, Abstract 141: Interrogating subclonal mechanisms of immune evasion and immunotherapy resistance in melanoma
Journal Articles

Abstract 2393: Characterization and validation of a Smad3/TGFb pathway reporter mouse for analysis of TGFβ signaling in normal homeostasis and cancer

Yuan Yang, Zachary Millman, Christina Stuelten, Madhu Gargesha, Mark Simpson, Howard Yang, Maxwell Lee, Lalage M. Wakefield
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2393.
https://doi.org/10.1158/1538-7445.AM2023-2393
Published: 04 April 2023
View article titled, Abstract 2393: Characterization and validation of a Smad3/TGFb pathway reporter mouse for analysis of TGFβ signaling in normal homeostasis and cancer
Journal Articles

Abstract P1-05-08: Targeting tumor heterogeneity and breast cancer metastasis through the metastatic microenvironment mediated epigenetic reprogramming

Li Yang, Jae Young So, Nicolas Skrypek, Anand Merchant, George Nelson, Howard Yang, Maxwell Lee
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P1-05-08.
https://doi.org/10.1158/1538-7445.SABCS21-P1-05-08
Published: 15 February 2022
View article titled, Abstract P1-05-08: Targeting tumor heterogeneity and breast cancer metastasis through the metastatic microenvironment mediated epigenetic reprogramming
Journal Articles

Abstract NG15: Progesterone-mediated immune evasion in breast cancer

Christy R. Hagan, Lauryn Werner, Emma Helm, Margaret Axelrod, Justin Balko, Zachary Hartman, Kent Hunter, Howard Yang, Prabhakar Chalise, Mary Markiewicz
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): NG15.
https://doi.org/10.1158/1538-7445.AM2021-NG15
Published: 01 July 2021
View article titled, Abstract NG15: Progesterone-mediated immune evasion in breast cancer
Journal Articles

Abstract 1549: Undesirable metastasis-stimulating effects of anti-TGF-β therapy in breast cancer models involve interference with tumor cell-autonomous tumor suppressive activity

Yu-an Yang, Howard Yang, Binwu Tang, Alex Wu, Nellie Moshkovich, Maxwell Lee, Lalage Wakefield
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1549.
https://doi.org/10.1158/1538-7445.AM2019-1549
Published: 01 July 2019
View article titled, Abstract 1549: Undesirable metastasis-stimulating effects of anti-TGF-β therapy in breast cancer models involve interference with tumor cell-autonomous tumor suppressive activity
Journal Articles

Abstract 5720: Functional characterization of neoantigens determining immune checkpoint blockade response in mouse models of human melanoma

Eva Perez Guijarro, Chi-Ping Day, Zoe W. Ohler, Rajaa El Meskini, Howard Yang, Suman Vodnala, Cari Graff-Cherry, Sung Chin, Anyen Fon, Helen Michael, Maxwell Lee, Terry Van Dyke, Shyam Sharan, Glenn Merlino
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5720.
https://doi.org/10.1158/1538-7445.AM2018-5720
Published: 01 July 2018
View article titled, Abstract 5720: Functional characterization of neoantigens determining immune checkpoint blockade response in mouse models of human melanoma
Journal Articles

Abstract 1768: An anti-TGF-β1/2 antibody that spares TGF-β3 retains full anti-tumor efficacy and generates an improved metabolic profile

Yu-an Yang, Srividya Vasu, Howard Yang, Maxwell P. Lee, Sushil Rane, Amer M. Mirza, Lalage M. Wakefield
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1768.
https://doi.org/10.1158/1538-7445.AM2018-1768
Published: 01 July 2018
View article titled, Abstract 1768: An anti-TGF-β1/2 antibody that spares TGF-β3 retains full anti-tumor efficacy and generates an improved metabolic profile
Journal Articles

Abstract 5678: Developing a preclinical immunotherapy platform using syngeneic mouse models of human melanoma

Corinne Rauck, Eva Perez-Guijarro, Zoe W. Ohler, Rajaa El E. Meskini, Howard Yang, Suman Vodnala, Cari Graff-Cherry, Sung Chin, Anyen Fon, Helen Michael, Maxwell Lee, Terry Van Dyke, Shyam Sharan, Glenn Merlino, Chi-Ping Day
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5678.
https://doi.org/10.1158/1538-7445.AM2018-5678
Published: 01 July 2018
View article titled, Abstract 5678: Developing a preclinical immunotherapy platform using syngeneic mouse models of human melanoma
Journal Articles

Abstract 1037: Progression from melanocytic nevi to melanoma is associated with increased genomic mutations in a UV-induced mouse model of human melanoma

Helen Michael, Chi-Ping Day, Howard Yang, Aleksandra Michalowski, Maxwell Lee, Glenn Merlino
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1037.
https://doi.org/10.1158/1538-7445.AM2017-1037
Published: 01 July 2017
View article titled, Abstract 1037: Progression from melanocytic nevi to melanoma is associated with increased genomic mutations in a UV-induced mouse model of human melanoma
Journal Articles

Abstract 2623: Identification of neo-antigens driving melanoma response to immune checkpoint blockers via in vivo screening

Chi-Ping Day, Eva Perez-Guijarro, Rajaa El Meskini, Zoe Weaver Ohler, Maxwell Lee, Howard Yang, Suman Vodnala, Shyam Sharan, Glenn Merlino
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2623.
https://doi.org/10.1158/1538-7445.AM2017-2623
Published: 01 July 2017
View article titled, Abstract 2623: Identification of neo-antigens driving melanoma response to immune checkpoint blockers via <em>in vivo</em> screening
Journal Articles

Abstract 2843: DNMT3B mediated DNA methylation and epigenetic reprogramming of metastatic cancer cells

Jae Young So, Nicolas Skrypek, Xiang Wang, Anand Merchant, Howard Yang, Wei-Dong Chen, Gangqing Hu, Bhagelu R Achyut, Meggie Cam, Keji Zhao, Maxwell Lee, Li Yang
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2843.
https://doi.org/10.1158/1538-7445.AM2017-2843
Published: 01 July 2017
View article titled, Abstract 2843: DNMT3B mediated DNA methylation and epigenetic reprogramming of metastatic cancer cells
Journal Articles

Abstract 1846: Immunocompetent mouse allograft models for development of therapies to target breast cancer metastasis therapies to target breast cancer metastasis

Yu-an Yang, Howard Yang, Ying Hu, Peter Watson, Huaitian Liu, Thomas R. Geiger, Miriam R. Anver, Diana Haines, Philip Martin, Maxwell P. Lee, Kent W. Hunter, Lalage M. Wakefield
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1846.
https://doi.org/10.1158/1538-7445.AM2017-1846
Published: 01 July 2017
View article titled, Abstract 1846: Immunocompetent mouse allograft models for development of therapies to target breast cancer metastasis therapies to target breast cancer metastasis
Journal Articles

Abstract 4138: Integrating SNPs, epigenetics and transcriptomics to better understand the inherited predisposition to breast cancer metastasis

Anjali Shukla, Ling Bai, Howard Yang, Anthony Doran, Ying Hu, Thomas Geiger, Maxwell Lee, Thomas Keane, Kent W. Hunter
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4138.
https://doi.org/10.1158/1538-7445.AM2015-4138
Published: 01 August 2015
View article titled, Abstract 4138: Integrating SNPs, epigenetics and transcriptomics to better understand the inherited predisposition to breast cancer metastasis
Journal Articles

Abstract 2244: Functional interactions between estrogen-related-receptor β (ESRRB) and transforming growth factor-beta (TGF-β) in the regulation of breast cancer stem cell dynamics

Nellie Moshkovich, Misako Sato, Binwu Tang, Yu-an Yang, Kathleen C. Flanders, Mitsutaka Kadota, Howard Yang, Maxwell P. Lee, Lalage M. Wakefield
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2244.
https://doi.org/10.1158/1538-7445.AM2015-2244
Published: 01 August 2015
View article titled, Abstract 2244: Functional interactions between estrogen-related-receptor β (ESRRB) and transforming growth factor-beta (TGF-β) in the regulation of breast cancer stem cell dynamics
Journal Articles

Abstract 4094: Neutralizing anti-TGF-β antibodies elicit heterogeneous therapeutic responses in a panel of murine metastatic breast cancer models

Yu-an Yang, Kathleen C. Flanders, Binwu Tang, Miriam R. Anver, Anand Merchant, Howard Yang, Maxwell Lee, Scott Lonning, John M. McPherson, Lalage M. Wakefield
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4094.
https://doi.org/10.1158/1538-7445.AM2015-4094
Published: 01 August 2015
View article titled, Abstract 4094: Neutralizing anti-TGF-β antibodies elicit heterogeneous therapeutic responses in a panel of murine metastatic breast cancer models
Journal Articles

Abstract 4310: An integrated genomic approach specifically dissects out the tumor suppressor aspect of TGF-β in breast cancer.

Misako Sato, Mitsutaka Kadota, Binwu Tang, Yu-an Yang, Mengge Shan, Jia Weng, Michael Welsh, Aleksandra Michalowski, Howard Yang, Robert Clifford, Maxwell Lee, Lalage M. Wakefield
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4310.
https://doi.org/10.1158/1538-7445.AM2013-4310
Published: 15 April 2013
View article titled, Abstract 4310: An integrated genomic approach specifically dissects out the tumor suppressor aspect of TGF-β in breast cancer.
Journal Articles

Computational Analysis and Experimental Validation of Tumor-associated Alternative RNA Splicing in Human Cancer

Zhining Wang, H. Shuen Lo, Howard Yang, Sheryl Gere, Ying Hu, Kenneth H. Buetow, Maxwell P. Lee
Journal: Cancer Research
Cancer Res (2003) 63 (3): 655–657.
Published: 01 February 2003
View article titled, Computational Analysis and Experimental Validation of Tumor-associated Alternative RNA Splicing in Human Cancer
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