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Howard Scher
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Journal Articles

Abstract B026: Chromatin profiles classify castration-resistant prostate cancers suggesting therapeutic targets

Fanying Tang, Duo Xu, Shangqian Wang, Chen Khuan Wong, Alexander Martinez-Fundichely, Cindy Lee, Sandra Cohen, Jane Park, Corinne Hill, Kenneth Eng, Rohan Bareja, Teng Han, Eric Minwei Liu, Ann Palladino, Wei Di, Dong Gao, Wassim Abida, Shaham Beg, Loredana Puca, Maximiliano Meneses, Elisa De Stanchina, Michael Berger, Anuradha Gopalan, Lukas Dow, Juan Miguel Mosquera, Himisha Beltran, Cora Sternberg, Ping Chi, Howard Scher, Andrea Sboner, Yu Chen, Ekta Khurana
Journal: Cancer Research
Cancer Res (2022) 82 (23_Supplement_2): B026.
https://doi.org/10.1158/1538-7445.CancEpi22-B026
Published: 01 December 2022
View article titled, Abstract B026: Chromatin profiles classify castration-resistant prostate cancers suggesting therapeutic targets
Journal Articles

Abstract 2200: Multilineage plasticity in prostate cancer through expansion of stem-like luminal epithelial cells with elevated inflammatory signaling

Samir Zaidi, Jimmy Zhao, Joseph Chan, Roudier Martine, Kristine Wadosky, Anuradha Gopalan, Wouter Karthaus, Philip Watson, Lawrence True, Peter Nelson, Howard Scher, Michael Morris, Michael Haffner, David Goodrich, Dana Pe'er, Charles Sawyers
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2200.
https://doi.org/10.1158/1538-7445.AM2022-2200
Published: 15 June 2022
View article titled, Abstract 2200: Multilineage plasticity in prostate cancer through expansion of stem-like luminal epithelial cells with elevated inflammatory signaling
Journal Articles

Abstract PO-134: Identification of the cells of origin and tumor heterogeneity in neuroendocrine prostate cancer (NEPC) by single-cell analysis

Jimmy L. Zhao, Samir Zaidi, Joseph Chan, Kristine Wadosky, Wouter Karthaus, Danielle Choi, Aura Agudelo Rivera, Anuradha Gopalan, Dana Rathkopf, Brett Carver, Wassim Abida, Howard Scher, Yu Chen, David Goodrich, Dana Pe’er, Charles L. Sawyers
Journal: Cancer Research
Cancer Res (2020) 80 (21_Supplement): PO-134.
https://doi.org/10.1158/1538-7445.TUMHET2020-PO-134
Published: 03 November 2020
View article titled, Abstract PO-134: Identification of the cells of origin and tumor heterogeneity in neuroendocrine prostate cancer (NEPC) by single-cell analysis
Journal Articles

Abstract 1308: CDK12 alterations define a distinct molecular subtype of prostate cancers with unique genomic and clinical characteristics

Bastien Nguyen, Jose Mauricio Mota, Subhiksha Nandakumar, Konrad H. Stopsack, Emily Weg, Dana Rathkopf, Michael J. Morris, Howard Scher, Philip W. Kantoff, Anuradha Gopalan, Dmitriy Zamarin, David B. Solit, Nikolaus Schultz, Wassim Abida
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1308.
https://doi.org/10.1158/1538-7445.AM2020-1308
Published: 15 August 2020
View article titled, Abstract 1308: <em>CDK12</em> alterations define a distinct molecular subtype of prostate cancers with unique genomic and clinical characteristics
Journal Articles

Abstract 5703: Oncologic therapy shapes the fitness landscape of clonal hematopoiesis

Kelly L. Bolton, Ryan N. Ptashkin, Teng Gao, Lior Braunstein, Sean M. Devlin, Minal Patel, Antonin Berthon, Aijazuddin Syed, Mariko Yabe, Catherine Coombs, Nicole M. Caltabellotta, Mike Walsh, Ken Offit, Zsofia Stadler, Choonsik Lee, Paul Pharoah, Konrad H. Stopsack, Barbara Spitzer, Simon Mantha, James Fagin, Laura Boucai, Christopher J. Gibson, Benjamin Ebert, Andrew L. Young, Todd Druley, Koichi Takahashi, Nancy Gillis, Markus Ball, Eric Padron, David Hyman, Jose Baselga, Larry Norton, Stuart Gardos, Virginia Klimek, Howard Scher, Dean Bajorin, Eder Paraiso, Ryma Benayed, Maria Arcilla, Marc Ladanyi, David Solit, Michael Berger, Martin Tallman, Montserrat Garcia-Closas, Nilanjan Chatterjee, Luis Diaz, Ross Levine, Lindsay Morton, Ahmet Zehir, Elli Papaemmanuil
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5703.
https://doi.org/10.1158/1538-7445.AM2020-5703
Published: 15 August 2020
View article titled, Abstract 5703: Oncologic therapy shapes the fitness landscape of clonal hematopoiesis
Journal Articles

Abstract LB-304: Oncologic therapy for solid tumors alters the risk of clonal hematopoiesis

Kelly Bolton, Ryan Ptashkin, Lior Braunstein, Teng Gao, Sean M. Devlin, Daniel Kelly, Catherine Coombs, Minal Patel, Matahi Moarii, Elsa Bernard, Antonin Berthon, Laura Boucai, Dominik Glodzik, Axel Martin, Zsofia Stadler, Michael Walsh, Diana Mandelker, Akshar Patel, Jessica Schulman, Gunes Gundem, Aijazuddin Syed, Maria Arcila, David B. Solit, Mark E. Robson, Marc Ladanyi, Choonsik Lee, John Philip, Dean Bajorin, Montserrat Garcia-Closas, Stuart Gardos, David Hyman, Martin Tallman, Mariko Yabe, Kenneth Offit, Howard Scher, Virginia Klimek, Luis Diaz, Nilanjan Chatterjee, Michael F. Berger, Lindsay Morton, Ross Levine, Ahmet Zehir, Elli Papaemmanuil
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): LB-304.
https://doi.org/10.1158/1538-7445.AM2019-LB-304
Published: 01 July 2019
View article titled, Abstract LB-304: Oncologic therapy for solid tumors alters the risk of clonal hematopoiesis
Journal Articles

Abstract 1348: Characterization of SLFN11 protein expression in circulating tumor cells (CTCs) of patients with metastatic castration resistant prostate cancer (mCRPC) prior to platinum based chemotherapy

Luisa Fernandez, John Poirier, Angel Rodriguez, Melanie Hulling, Robin Richardson, Ramsay Sutton, Rhett Jiles, Joseph Schonhoft, Jerry Lee, Nadia Ebrahim, Emily Carbone, Ethan Barnett, Mark Landers, Yipeng Wang, Ryan Dittamore, Charles Rudin, Howard Scher
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1348.
https://doi.org/10.1158/1538-7445.AM2019-1348
Published: 01 July 2019
View article titled, Abstract 1348: Characterization of SLFN11 protein expression in circulating tumor cells (CTCs) of patients with metastatic castration resistant prostate cancer (mCRPC) prior to platinum based chemotherapy
Journal Articles

Abstract 3282: Does the catalytic activity of prostate-specific antigen (PSA) or kallikrein-related peptidase 2 (hK2) secreted by novel transgenic mice models critically influence development of prostate cancer or release of PSA or hK2 in blood

Katharina Braun, David Ulmert, Christian von Bodman, Anne Byers, Dipti Mehta, Linda Johnson, Sven Wenske, Todd Hricik, Glen Heller, Howard Scher, Peter Scardino, Hans Lilja
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 3282.
https://doi.org/10.1158/1538-7445.AM2012-3282
Published: 15 April 2012
View article titled, Abstract 3282: Does the catalytic activity of prostate-specific antigen (PSA) or kallikrein-related peptidase 2 (hK2) secreted by novel transgenic mice models critically influence development of prostate cancer or release of PSA or hK2 in blood
Journal Articles

Abstract #SY29-4: Molecular imaging of androgen receptor blockade in castrate: Resistant prostate cancer

Steven Larson, Michael Morris, Howard Scher
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): SY29-4.
Published: 01 May 2009
View article titled, Abstract #SY29-4: Molecular imaging of androgen receptor blockade in castrate: Resistant prostate cancer
Journal Articles

Abstract #2608: Development of a membrane microfilter device for capture and characterization of circulating tumor cells in blood

Anthony Williams, Henry Lin, Siyang Zheng, Russell Szmulewitz, Walter Stadler, Howard Scher, Martin Fleisher, Jian Liu, Shuming Nie, Debra Hawes, Susan Groshen, Ram Datar, Yu-Chong Tai, Richard Cote
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 2608.
Published: 01 May 2009
View article titled, Abstract #2608: Development of a membrane microfilter device for capture and characterization of circulating tumor cells in blood
Journal Articles

Phase I/II study of the androgen receptor antagonist MDV3100 in castration-resistant prostate cancer

Howard Scher, Thomaz Beer, Celestia Higano, Daniel Danila, Julia Shelkey, Mohammed Hirmand, David Hung, Michael Morris, Steve Larson, Charles Sawyers
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): LB-203.
Published: 01 May 2008
View article titled, Phase I/II study of the androgen receptor antagonist MDV3100 in castration-resistant prostate cancer
Journal Articles

Catalytic forms of human kallikrein-related peptidase 2 (hK2) promote cellular migration and invasion in vitro

Sven Wenske, Todd Hricik, Amine Benchickh, Carlos Cordon-Cardo, Pier-Paolo Pandolfi, Glenn Heller, Howard Scher, Peter Scardino, Brett Carver, Hans Lilja
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 1156.
Published: 01 May 2008
View article titled, Catalytic forms of human kallikrein-related peptidase 2 (hK2) promote cellular migration and invasion<em> in vitro</em>
Journal Articles

Androgen receptor in prostate cancer cells: Identification of novel and clinically relevant target genes

Unnati Jariwala, Jen Prescott, Li Jia, Jon Cogan, Armin Arabashden, Artem Barski, Steve Pregizer, Grant Buchanan, Howard Scher, William Gerald, Wayne Tilley, Gerry Coetzee, Baruch Frenkel
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 4931.
Published: 01 May 2007
View article titled, Androgen receptor in prostate cancer cells: Identification of novel and clinically relevant target genes
Journal Articles

Circulating angiogenic cells in metastatic prostate cancer: assessment of the bone marrow vascular and peripheral blood vascular compartments

Marco Seandel, Martin Fleisher, Andrea Hooper, Shahin Rafii, Howard Scher
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 4628.
Published: 01 May 2007
View article titled, Circulating angiogenic cells in metastatic prostate cancer: assessment of the bone marrow vascular and peripheral blood vascular compartments
Journal Articles

Comprehensive Gene Expression Analysis of Prostate Cancer Reveals Distinct Transcriptional Programs Associated with Metastatic Disease

Eva LaTulippe, Jaya Satagopan, Alex Smith, Howard Scher, Peter Scardino, Victor Reuter, William L. Gerald
Journal: Cancer Research
Cancer Res (2002) 62 (15): 4499–4506.
Published: 01 August 2002
View article titled, Comprehensive Gene Expression Analysis of Prostate Cancer Reveals Distinct Transcriptional Programs Associated with Metastatic Disease
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Includes: Supplementary data
Journal Articles

Uroplakin II Gene Is Expressed in Transitional Cell Carcinoma But Not in Bilharzial Bladder Squamous Cell Carcinoma: Alternative Pathways of Bladder Epithelial Differentiation and Tumor Formation

Ren-Long Wu, Iman Osman, Xue-Ru Wu, Ming-Lan Lu, Zuo-Feng Zhang, Feng-Xia Liang, Reda Hamza, Howard Scher, Carlos Cordon-Cardo, Tung-Tien Sun
Journal: Cancer Research
Cancer Res (1998) 58 (6): 1291–1297.
Published: 01 March 1998
View article titled, Uroplakin II Gene Is Expressed in Transitional Cell Carcinoma But Not in Bilharzial Bladder Squamous Cell Carcinoma: Alternative Pathways of Bladder Epithelial Differentiation and Tumor Formation
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Journal Articles

Anti-Epidermal Growth Factor Receptor Monoclonal Antibody 225 Up-Regulates p27KIP1 and Induces G1 Arrest in Prostatic Cancer Cell Line DU145

Ding Peng, Zhen Fan, Yang Lu, Tony DeBlasio, Howard Scher, John Mendelsohn
Journal: Cancer Research
Cancer Res (1996) 56 (16): 3666–3669.
Published: 01 August 1996
View article titled, Anti-Epidermal Growth Factor Receptor Monoclonal Antibody 225 Up-Regulates p27<sup>KIP1</sup> and Induces G<sub>1</sub> Arrest in Prostatic Cancer Cell Line DU145
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Journal Articles

Multivariate Analysis of Prognostic Variables in Patients with Metastatic Testicular Cancer

George J. Bosl, Nancy L. Geller, Constance Cirrincione, Nicholas J. Vogelzang, B. J. Kennedy, Willet F. Whitmore, Jr., Davor Vugrin, Howard Scher, Jerome Nisselbaum, Robert B. Golbery
Journal: Cancer Research
Cancer Res (1983) 43 (7): 3403–3407.
Published: 01 July 1983
View article titled, Multivariate Analysis of Prognostic Variables in Patients with Metastatic Testicular Cancer
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