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Howard I. Scher
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Journal Articles

Abstract 5819: Anti-cancer immune effects of PT-112 monotherapy across two disease indications

Arun Rajan, Tyler D. Ames, Carolina Celades-Errando, Christina Y. Yim, Shannon Swift, Meredith J. McAdams, Laercio DaSilva, Wiem Lassoued, Hana Bagheri, Maria T. Congenie, Howard I. Scher, Alan H. Bryce, James L. Gulley, Jeffrey Schlom, Renee N. Donahue
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 5819.
https://doi.org/10.1158/1538-7445.AM2025-5819
Published: 21 April 2025
View articletitled, Abstract 5819: Anti-cancer immune effects of PT-112 monotherapy across two disease indications
Journal Articles

Abstract NG10: Chromatin profiles classify castration-resistant prostate cancers suggesting therapeutic targets

Fanying Tang, Duo Xu, Shangqian Wang, Chen Khuan Wong, Alexander Martinez-Fundichely, Cindy J. Lee, Sandra Cohen, Jane Park, Corinne E. Hill, Kenneth Eng, Rohan Bareja, Teng Han, Eric Minwei Liu, Ann Palladino, Wei Di, Dong Gao, Wassim Abida, Shaham Beg, Loredana Puca, Maximiliano Meneses, Elisa de Stanchina, Michael F. Berger, Anuradha Gopalan, Lukas E. Dow, Juan Miguel Mosquera, Himisha Beltran, Cora N. Sternberg, Ping Chi, Howard I. Scher, Andrea Sboner, Yu Chen, Ekta Khurana
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): NG10.
https://doi.org/10.1158/1538-7445.AM2023-NG10
Published: 04 April 2023
View articletitled, Abstract NG10: Chromatin profiles classify castration-resistant prostate cancers suggesting therapeutic targets
Journal Articles

Abstract 941: Assessment of the completeness, accuracy, and scalability of commercial abstraction for a large prostate cancer biospecimen repository

Emily A. Carbone, Ethan S. Barnett, Niamh M. Keegan, Samantha E. Vasselman, Barbara Nweji, Ria N. Gajar, Karen A. Autio, Wassim Abida, Howard I. Scher, Konrad H. Stopsack
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 941.
https://doi.org/10.1158/1538-7445.AM2023-941
Published: 04 April 2023
View articletitled, Abstract 941: Assessment of the completeness, accuracy, and scalability of commercial abstraction for a large prostate cancer biospecimen repository
Journal Articles

Abstract 463: Features consistent with a small-cell neuroendocrine like (SC/NE-L) transformation can be readily detected and quantified in circulating tumor cells (CTCs)

Howard I. Scher, Adam Jendrisak, Cole Gilbertson, Audrey Gill, Ethan Barnett, Anuradha Gopalan, Niamh Keegan, Samir Zaidi, Hannah Benoliel, Carbone Emily, Eva Wang, James Lu, Alisa Tubbs, Amanda Anderson, Joshua Jones, Joseph D. Schonhoft, Rick Wenstrup
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 463.
https://doi.org/10.1158/1538-7445.AM2021-463
Published: 01 July 2021
View articletitled, Abstract 463: Features consistent with a small-cell neuroendocrine like (SC/NE-L) transformation can be readily detected and quantified in circulating tumor cells (CTCs)
Journal Articles

Morphology-Predicted Large-Scale Transition Number in Circulating Tumor Cells Identifies a Chromosomal Instability Biomarker Associated with Poor Outcome in Castration-Resistant Prostate Cancer

Joseph D. Schonhoft, Jimmy L. Zhao, Adam Jendrisak, Emily A. Carbone, Ethan S. Barnett, Melanie A. Hullings, Audrey Gill, Ramsay Sutton, Jerry Lee, Angel E. Dago, Mark Landers, Samuel F. Bakhoum, Yipeng Wang, Mithat Gonen, Ryan Dittamore, Howard I. Scher
Journal: Cancer Research
Cancer Res (2020) 80 (22): 4892–4903.
https://doi.org/10.1158/0008-5472.CAN-20-1216
Published: 13 November 2020
View articletitled, Morphology-Predicted Large-Scale Transition Number in Circulating Tumor Cells Identifies a Chromosomal Instability Biomarker Associated with Poor Outcome in Castration-Resistant Prostate Cancer
Open the PDF for Morphology-Predicted Large-Scale Transition Number in Circulating Tumor Cells Identifies a Chromosomal Instability Biomarker Associated with Poor Outcome in Castration-Resistant Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 1531: The Polycomb repressor complex 1 promotes recruitment of myeloid-derived suppressor cells and immune evasion during bone colonization in castration-resistant prostate cancer

Wenjing Su, Boyu Zhang, Hyunho Han, Goutam Chakraborty, Bing Zhou, Jie Su, Guangli Yang, Ouathek Ouerfelli, Neal Rosen, Howard I. Scher, Filippo G. Giancotti
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1531.
https://doi.org/10.1158/1538-7445.AM2019-1531
Published: 01 July 2019
View articletitled, Abstract 1531: The Polycomb repressor complex 1 promotes recruitment of myeloid-derived suppressor cells and immune evasion during bone colonization in castration-resistant prostate cancer
Journal Articles

Abstract SY31-03: Predictive biomarkers in circulating tumor cells to direct management metastatic castration-resistant prostate cancer (mCRPC)

Howard I. Scher, Joseph Schonhoft, Ryan Dittamore
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): SY31-03.
https://doi.org/10.1158/1538-7445.AM2019-SY31-03
Published: 01 July 2019
View articletitled, Abstract SY31-03: Predictive biomarkers in circulating tumor cells to direct management metastatic castration-resistant prostate cancer (mCRPC)
Journal Articles

Abstract 1752: BRCA-mediated tumorigenesis is origin and cell-type dependent

Philip Jonsson, Michael L. Cheng, Chaitanya Bandlamudi, Preethi Srinivasan, Shweta S. Chavan, Noah D. Friedman, Ezra Y. Rosen, Allison L. Richards, Nancy Bouvier, S. Duygu Selcuklu, Craig Bielski, Wassim Abida, Ahmet Zehir, Nikolaus Schultz, Mark T. Donoghue, Jose Baselga, Kenneth Offit, Marc Ladanyi, Eileen M. O’Reilly, Howard I. Scher, Zsofia K. Stadler, Mark E. Robson, David M. Hyman, Michael F. Berger, David B. Solit, Barry S. Taylor
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1752.
https://doi.org/10.1158/1538-7445.AM2019-1752
Published: 01 July 2019
View articletitled, Abstract 1752: BRCA-mediated tumorigenesis is origin and cell-type dependent
Journal Articles

Abstract A074: Aberrant activation of a gastrointestinal transcriptional circuit in prostate cancer mediates castration resistance

Shipra Shukla, Joanna Cyrta, Devan Murphy, Edward Walczak, Leili Ran, Praveen Agrawal, Yuanyuan Xie, Yuedan Chen, Shangqian Wang, Yu Zhan, Wai Pung E. Wong, Andrea Sboner, Himisha Beltran, Juan-Miguel Mosquera, Jessica Sher, Zhen Cao, John Wongvipat, Richard P. Koche, Anuradha Gopalan, Deyou Zheng, Mark Rubin, Howard I. Scher, Ping Chi, Yu Chen
Journal: Cancer Research
Cancer Res (2018) 78 (16_Supplement): A074.
https://doi.org/10.1158/1538-7445.PRCA2017-A074
Published: 14 August 2018
View articletitled, Abstract A074: Aberrant activation of a gastrointestinal transcriptional circuit in prostate cancer mediates castration resistance
Journal Articles

Abstract LB-227: Estimation of tumor-derived mutant allele fractions in cfDNA by shallow whole genome sequencing and fragment size analysis

Julie Yang, Francesco Marass, Peter Ulz, Maha Shady, Michael L. Cheng, Prachi Kothari, Erika Gedvilaite, Saira Somnay, Neerav Shukla, Shakeel Modak, Emily K. Slotkin, Dana E. Rathkopf, Iyer Gopaumar, Howard I. Scher, Pedram Razavi, Darren R. Feldman, Bob T. Li, Paul B. Chapman, Jonathan E. Rosenberg, Dean F. Bajorin, Howard I. Scher, Michael F. Berger, Venkatraman E. Seshan, Nicholas D. Socci, David B. Solit, Ellen Heitzer, Dana W. Y. Tsui
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): LB-227.
https://doi.org/10.1158/1538-7445.AM2018-LB-227
Published: 01 July 2018
View articletitled, Abstract LB-227: Estimation of tumor-derived mutant allele fractions in cfDNA by shallow whole genome sequencing and fragment size analysis
Journal Articles

Phenotypic Heterogeneity of Circulating Tumor Cells Informs Clinical Decisions between AR Signaling Inhibitors and Taxanes in Metastatic Prostate Cancer

Howard I. Scher, Ryon P. Graf, Nicole A. Schreiber, Brigit McLaughlin, Adam Jendrisak, Yipeng Wang, Jerry Lee, Stephanie Greene, Rachel Krupa, David Lu, Pascal Bamford, Jessica E. Louw, Lyndsey Dugan, Hebert A. Vargas, Martin Fleisher, Mark Landers, Glenn Heller, Ryan Dittamore
Journal: Cancer Research
Series: Author Choice
Cancer Res (2017) 77 (20): 5687–5698.
https://doi.org/10.1158/0008-5472.CAN-17-1353
Published: 15 October 2017
View articletitled, Phenotypic Heterogeneity of Circulating Tumor Cells Informs Clinical Decisions between AR Signaling Inhibitors and Taxanes in Metastatic Prostate Cancer
Open the PDF for Phenotypic Heterogeneity of Circulating Tumor Cells Informs Clinical Decisions between AR Signaling Inhibitors and Taxanes in Metastatic Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 1740: Phenotypic, genomic, and clinical associations of Circulating Tumor Cells (CTCs) lacking epithelial biomarkers in metastatic Castration Resistant Prostate Cancer (mCRPC)

Ryon P. Graf, Yipeng Wang, Nicole Schreiber, Brigit McLaughlin, Stephanie Greene, Angel Rodriguez, Adam Jendrisak, Jerry Lee, Mark Landers, Ryan Dittamore, Howard I. Scher
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1740.
https://doi.org/10.1158/1538-7445.AM2017-1740
Published: 01 July 2017
View articletitled, Abstract 1740: Phenotypic, genomic, and clinical associations of Circulating Tumor Cells (CTCs) lacking epithelial biomarkers in metastatic Castration Resistant Prostate Cancer (mCRPC)
Journal Articles

Abstract LB-070: Next generation sequencing of prostate cancer reveals germline and somatic alterations detected at diagnosis and at metastasis that may impact clinical decision making

Wassim Abida, Michael F. Walsh, Joshua Armenia, Joseph Vijai, Anuradha Gopalan, Ryan Brennan, Kristen Curtis, Maria Arcila, Daniel Danila, Angela Arnold, Dana Rathkopf, Michael J. Morris, Mark Robson, Susin Slovin, David Hyman, Jeremy Durack, Stephen B. Solomon, Herbert A. Vargas, Barry Taylor, Victor Reuter, David Solit, Michael F. Berger, Kenneth Offit, Charles L. Sawyers, Nikolaus Schultz, Howard I. Scher
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): LB-070.
https://doi.org/10.1158/1538-7445.AM2016-LB-070
Published: 15 July 2016
View articletitled, Abstract LB-070: Next generation sequencing of prostate cancer reveals germline and somatic alterations detected at diagnosis and at metastasis that may impact clinical decision making
Journal Articles

Abstract 4954: Nuclear localized AR-V7 protein as a predictive biomarker for treatment selection in metastatic castration resistant prostate cancer (mCRPC)

Howard I. Scher, David Lu, Nicole A. Schreiber, Jessica Louw, Ryon P. Graf, Ann Johnson, Adam Jendrisak, Glenn Heller, Richard Bambury, Herbert A. Vargas Alverez, Brigit McLaughlin, Justin Wahl, Stephanie Greene, Martin Fleisher, Ryan Dittamore
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4954.
https://doi.org/10.1158/1538-7445.AM2016-4954
Published: 15 July 2016
View articletitled, Abstract 4954: Nuclear localized AR-V7 protein as a predictive biomarker for treatment selection in metastatic castration resistant prostate cancer (mCRPC)
Journal Articles

Abstract 1588: Single cell analysis of AR N terminal, AR C terminal and the ARv7 splice variant in the CTCs of metastatic castration resistant prostate cancer (mCRPC) patients

James Kelvin, David Lu, Davin Packer, Richard Bambury, Dana Rathkopf, Nicole Schreiber, Zaina Arslan, Natalie Prigozhina, David Brown, Rachel Krupa, Edward Swangren, Mark Landers, Florence Lee, Dena Marrinucci, Ryan Dittamore, Howard I. Scher
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1588.
https://doi.org/10.1158/1538-7445.AM2015-1588
Published: 01 August 2015
View articletitled, Abstract 1588: Single cell analysis of AR N terminal, AR C terminal and the ARv7 splice variant in the CTCs of metastatic castration resistant prostate cancer (mCRPC) patients
Journal Articles

Abstract CT134: Androgen receptor (AR) mutations in patients (pts) with castration-resistant prostate cancer (CRPC) with and without prior abiraterone acetate (AA) treatment

Dana E. Rathkopf, Matthew R. Smith, Emmanuel S. Antonarakis, Charles J. Ryan, William R. Berry, Neal D. Shore, Glenn Liu, Celestia Higano, Joshi J. Alumkal, Ralph Hauke, Ronald Tutrone, Mansoor Saleh, Edna Chow Maneval, Shibu Thomas, Deborah Ricci, Margaret K. Yu, Carla J. de Boer, Angela Trinh, Thian Kheoh, Rajesh Bandekar, Howard I. Scher
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): CT134.
https://doi.org/10.1158/1538-7445.AM2015-CT134
Published: 01 August 2015
View articletitled, Abstract CT134: Androgen receptor (AR) mutations in patients (pts) with castration-resistant prostate cancer (CRPC) with and without prior abiraterone acetate (AA) treatment
Journal Articles

Abstract 4310: Predictive biomarkers of tumor sensitivity to STEAP1 antibody-drug conjugate (ADC) in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC)

Daniel C. Danila, Howard I. Scher, Edith Szafer-Glusman, Amrita Herkal, Rebecca Suttmann, Martin Fleisher, Nicole A. Schreiber, Kristen Curtis, Houston Gilbert, Daniel Maslyar, Bernard Fine, Ron Firestein, Michael Mamounas, Mark R. Lackner, Omar Kabbarah
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4310.
https://doi.org/10.1158/1538-7445.AM2015-4310
Published: 01 August 2015
View articletitled, Abstract 4310: Predictive biomarkers of tumor sensitivity to STEAP1 antibody-drug conjugate (ADC) in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC)
Journal Articles

Abstract 4722: Inactivation of neogenin promotes castration resistance and bone metastasis in prostate cancer models

Goutam Chakraborty, Mayur Gadiya, Myriam Kossai, Dong Gao, Weijing Su, Hua Gao, Yu Chen, Howard I. Scher, Mark A. Rubin, Filippo Giancotti
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4722.
https://doi.org/10.1158/1538-7445.AM2015-4722
Published: 01 August 2015
View articletitled, Abstract 4722: Inactivation of neogenin promotes castration resistance and bone metastasis in prostate cancer models
Journal Articles

Abstract 4774: The antitumor effects of PI3K beta inhibitors in PTEN negative prostate cancer are enhanced by inhibition of reactivated PI3K alpha signaling

Sarit Schwartz, Brett S. Carver, John Wongvipat, Vanessa Rodrik-Outmezguine, Elisa D. Stanchina, Cath Trigwell, Simon Barry, Jose Baselga, Sarat Chandarlapaty, Howard I. Scher, Charles L. Sawyers, Neal Rosen
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4774.
https://doi.org/10.1158/1538-7445.AM2014-4774
Published: 01 October 2014
View articletitled, Abstract 4774: The antitumor effects of PI3K beta inhibitors in PTEN negative prostate cancer are enhanced by inhibition of reactivated PI3K alpha signaling
Journal Articles

Abstract 2069: Initial PET imaging and pharmacokinetic results from a Phase I/II study of Zr-89-labeled anti-STEAP1 antibody in metastatic castrate-resistant prostate cancer (mCRPC) patients

Jorge A. Carrasquillo, Daniel C. Danila, Volkan Beylergil, Joseph A. O'Donoghue, Sarah M. Cheal, Shutian Ruan, Neeta Pandit-Taskar, Josef J. Fox, Stephen E. Fleming, Pat B. Zanzonico, Govind Ragupathi, Serge K. Lyashchenko, Simon P. William, Steven M. Larson, Howard I. Scher, Bernard M. Fine, Michael J. Morris
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2069.
https://doi.org/10.1158/1538-7445.AM2014-2069
Published: 01 October 2014
View articletitled, Abstract 2069: Initial PET imaging and pharmacokinetic results from a Phase I/II study of Zr-89-labeled anti-STEAP1 antibody in metastatic castrate-resistant prostate cancer (mCRPC) patients