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Journal Articles

Abstract 2176: NADPH production and redox homeostasis regulate acinar to ductal metaplasia

Megan D. Radyk, Barbara S. Nelson, Christopher J. Halbrook, Mengrou Shan, Jonathan Alektiar, Howard C. Crawford, Yatrik M. Shah, Costas A. Lyssiotis

Cancer Res (2022) 82 (12_Supplement): 2176.

DOI: https://doi.org/10.1158/1538-7445.AM2022-2176

Published: 15 June 2022

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Journal Articles

Apolipoprotein E Promotes Immune Suppression in Pancreatic Cancer through NF-κB–Mediated Production of CXCL1

Samantha B. Kemp, Eileen S. Carpenter, Nina G. Steele, Katelyn L. Donahue, Zeribe C. Nwosu, Amanda Pacheco, Ashley Velez-Delgado, Rosa E. Menjivar, Fatima Lima, Stephanie The, Carlos E. Espinoza, Kristee Brown, Daniel Long, Costas A. Lyssiotis, Arvind Rao, Yaqing Zhang, Marina Pasca di Magliano, Howard C. Crawford

Cancer Res (2021) 81 (16): 4305–4318.

DOI: https://doi.org/10.1158/0008-5472.CAN-20-3929

Published: 15 August 2021

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Includes: Supplementary data

Journal Articles

Abstract PO-059: Understanding the lineage of metaplastic tuft cells in the progression of PDA

Daniel J. Salas-Escabillas, Megan Hoffman, Howard C. Crawford

Cancer Res (2020) 80 (22_Supplement): PO-059.

DOI: https://doi.org/10.1158/1538-7445.PANCA20-PO-059

Published: 13 November 2020

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Journal Articles

Abstract PO-052: Determining the role of Apolipoprotein E in pancreatic cancer immune suppression

Samantha B. Kemp, Nina G. Steele, Fatima Lima, Carlos Espinoza, Yaqing Zhang, Zeribe Nwosu, Eileen S. Carpenter, Meggie Hoffman, Amanda Pacheco, Ashley Velez-Delgado, Stephanie The, Howard C. Crawford, Marina Pasca di Magliano

Cancer Res (2020) 80 (22_Supplement): PO-052.

DOI: https://doi.org/10.1158/1538-7445.PANCA20-PO-052

Published: 13 November 2020

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Journal Articles

Abstract PO-063: Regulatory T cells regulate fibroblast differentiation during pancreatic carcinogenesis

Yaqing Zhang, Katelyn L. Donahue, Wei Yan, Zeribe C. Nwosu, Kristee L. Brown, Sion Yang, Howard C. Crawford, Costas A. Lyssiotis, Timothy L. Frankel, Filip Bednar, Marina Pasca di Magliano

Cancer Res (2020) 80 (22_Supplement): PO-063.

DOI: https://doi.org/10.1158/1538-7445.PANCA20-PO-063

Published: 13 November 2020

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Journal Articles

Abstract IA-18: Epithelial cell plasticity in pancreatic cancer: The function and fate of metaplastic tuft cells

Howard C. Crawford

Cancer Res (2020) 80 (22_Supplement): IA-18.

DOI: https://doi.org/10.1158/1538-7445.PANCA20-IA-18

Published: 13 November 2020

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Journal Articles

Abstract 2577: AGO2 interaction limits wild type RAS activation yet essential for disease progression in oncogenic KRAS driven cancers

Cancer Res (2020) 80 (16_Supplement): 2577.

DOI: https://doi.org/10.1158/1538-7445.AM2020-2577

Published: 15 August 2020

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Journal Articles

Abstract I04: Regulatory T-cell depletion causes compensatory immune suppression and accelerates pancreatic carcinogenesis

Yaqing Zhang, Jenny Lazarus, Nina Steele, Ho-Joon Lee, Wei Yan, Cristopher J. Halbrook, Rosa Menjivar, Samantha B. Kemp, Veerin Sirihoracai, Eileen S. Carpenter, Anna C. Nevison, Alekya Vinta, Michelle A. Anderson, Howard C. Crawford, Costas A. Lyssiotis, Timothy L. Frankel, Filip Bednar, Marina Pasca di Magliano

Cancer Res (2019) 79 (24_Supplement): I04.

DOI: https://doi.org/10.1158/1538-7445.PANCA19-I04

Published: 13 December 2019

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Journal Articles

Abstract A62: Regulatory T-cell depletion promotes oncogenic Kras-driven pancreatic carcinogenesis

Yaqing Zhang, Jenny Lazarus, Nina Steele, Wei Yan, Ho-Joon Lee, Christopher J. Halbrook, Rosa Menjivar, Samantha B. Kemp, Veerin Sirihorachai, Eileen S. Carpenter, Anna C. Nevison, Alekya Vinta, Michelle A. Anderson, Howard C. Crawford, Costas A. Lyssiotis, Timothy L. Frankel, Filip Bednar, Marina Pasca di Magliano

Cancer Res (2019) 79 (24_Supplement): A62.

DOI: https://doi.org/10.1158/1538-7445.PANCA19-A62

Published: 13 December 2019

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Journal Articles

Abstract A19: The role of metaplastic tuft cell chemosensory signaling in pancreatic cancer

Megan T. Hoffman, Stephanie The, Daniel J. Salas-Escabillas, Kathleen E. DelGiorno, Filip Bednar, Robert F. Margolskee, Arvind Rao, Howard C. Crawford

Cancer Res (2019) 79 (24_Supplement): A19.

DOI: https://doi.org/10.1158/1538-7445.PANCA19-A19

Published: 13 December 2019

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Journal Articles

Abstract C56: Bmi1 is widely expressed in acini and regulates Kras-driven transcription factor networks in early pancreatic neoplasia

Joyce K. Thompson, Emily Wu, Osama Alkhalili, Howard C. Crawford, Marina Pasca di Magliano, Filip Bednar

Cancer Res (2019) 79 (24_Supplement): C56.

DOI: https://doi.org/10.1158/1538-7445.PANCA19-C56

Published: 13 December 2019

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Journal Articles

Abstract 4087: Investigating the novel role of Hippo signaling in mouse pancreas

Ming Gao, Jun Liu, Francis E. Sharkey, Howard C. Crawford, Randy L. Johnson, Yidong Chen, Pei Wang

Cancer Res (2018) 78 (13_Supplement): 4087.

DOI: https://doi.org/10.1158/1538-7445.AM2018-4087

Published: 01 July 2018

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Journal Articles

Abstract A65: Initiation of pancreatic metaplasia requires ADAM17-mediated autocrine signaling, not paracrine signaling derived from macrophages

Hui-Ju Wen, Howard C. Crawford

Cancer Res (2016) 76 (24_Supplement): A65.

DOI: https://doi.org/10.1158/1538-7445.PANCA16-A65

Published: 14 December 2016

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Journal Articles

Abstract A62: ATDC is required for KRAS-induced pancreatic tumorigenesis

Lidong Wang, Huibin Yang, Ethan V. Abel, Phillip L. Palmbos, Christophe Halbrook, Kenneth Takeuchi, Jiaqi Shi, Yaqing Zhang, Sumithra Urs, Meghna Waghray, Marina Pasca di Magliano, Andrew D. Rhim, Howard C. Crawford, Diane M. Simeone

Cancer Res (2016) 76 (24_Supplement): A62.

DOI: https://doi.org/10.1158/1538-7445.PANCA16-A62

Published: 14 December 2016

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Journal Articles

Abstract PR01: Oncogenic Kras-induced mitochondrial oxidative stress in pancreatic acini modulates the formation of precancerous lesions through autocrine EGFR signaling

Geou-Yarh Liou, Heike Doeppler, Kathleen E. DelGirono, Howard C. Crawford, Michael P. Murphy, Peter Storz

Cancer Res (2016) 76 (3_Supplement): PR01.

DOI: https://doi.org/10.1158/1538-7445.FBCR15-PR01

Published: 07 April 2016

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Journal Articles

Abstract A77: Investigating the role of ADAM10 in pancreatic tumor differentiation

Louise V. Peverley, Christopher J. Halbrook, Jason C. Hall, Christine M. Ardito, Howard C. Crawford

Cancer Res (2015) 75 (13_Supplement): A77.

DOI: https://doi.org/10.1158/1538-7445.PANCA2014-A77

Published: 30 June 2015

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Journal Articles

Abstract IA13: Acinar cell transdifferentiation sets the stage for early tumor heterogeneity

Kenneth K. Takeuchi, Kathleen E. Delgiorno, Christopher J. Halbrook, Howard C. Crawford

Cancer Res (2015) 75 (13_Supplement): IA13.

DOI: https://doi.org/10.1158/1538-7445.PANCA2014-IA13

Published: 30 June 2015

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Journal Articles

Abstract A27: Redefining the role of Notch in acinar to ductal metaplasia

Christopher J. Halbrook, Howard C. Crawford

Cancer Res (2015) 75 (13_Supplement): A27.

DOI: https://doi.org/10.1158/1538-7445.PANCA2014-A27

Published: 30 June 2015

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Journal Articles

Abstract A04: PI3K regulation of RAC1 is required for Kras-induced pancreatic tumorigenesis

Kenneth K. Takeuchi, Eileen Carpenter, Claire Wu, Christopher J. Halbrook, Richard Z. Lin, Howard C. Crawford

Cancer Res (2015) 75 (13_Supplement): A04.

DOI: https://doi.org/10.1158/1538-7445.PANCA2014-A04

Published: 30 June 2015

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Journal Articles

SCCA1/SERPINB3 Promotes Oncogenesis and Epithelial–Mesenchymal Transition via the Unfolded Protein Response and IL6 Signaling

Namratha Sheshadri, Joseph M. Catanzaro, Alex J. Bott, Yu Sun, Erica Ullman, Emily I. Chen, Ji-An Pan, Song Wu, Howard C. Crawford, Jianhua Zhang, Wei-Xing Zong

Cancer Res (2014) 74 (21): 6318–6329.

DOI: https://doi.org/10.1158/0008-5472.CAN-14-0798

Published: 30 October 2014

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Includes: Supplementary data

NARROW

Abstract 2176: NADPH production and redox homeostasis regulate acinar to ductal metaplasia

Apolipoprotein E Promotes Immune Suppression in Pancreatic Cancer through NF-κB–Mediated Production of CXCL1

Abstract PO-059: Understanding the lineage of metaplastic tuft cells in the progression of PDA

Abstract PO-052: Determining the role of Apolipoprotein E in pancreatic cancer immune suppression

Abstract PO-063: Regulatory T cells regulate fibroblast differentiation during pancreatic carcinogenesis

Abstract IA-18: Epithelial cell plasticity in pancreatic cancer: The function and fate of metaplastic tuft cells

Abstract 2577: AGO2 interaction limits wild type RAS activation yet essential for disease progression in oncogenic KRAS driven cancers

Abstract I04: Regulatory T-cell depletion causes compensatory immune suppression and accelerates pancreatic carcinogenesis

Abstract A62: Regulatory T-cell depletion promotes oncogenic Kras-driven pancreatic carcinogenesis

Abstract A19: The role of metaplastic tuft cell chemosensory signaling in pancreatic cancer

Abstract C56: Bmi1 is widely expressed in acini and regulates Kras-driven transcription factor networks in early pancreatic neoplasia

Abstract 4087: Investigating the novel role of Hippo signaling in mouse pancreas

Abstract A65: Initiation of pancreatic metaplasia requires ADAM17-mediated autocrine signaling, not paracrine signaling derived from macrophages

Abstract A62: ATDC is required for KRAS-induced pancreatic tumorigenesis

Abstract PR01: Oncogenic Kras-induced mitochondrial oxidative stress in pancreatic acini modulates the formation of precancerous lesions through autocrine EGFR signaling

Abstract A77: Investigating the role of ADAM10 in pancreatic tumor differentiation

Abstract IA13: Acinar cell transdifferentiation sets the stage for early tumor heterogeneity

Abstract A27: Redefining the role of Notch in acinar to ductal metaplasia

Abstract A04: PI3K regulation of RAC1 is required for Kras-induced pancreatic tumorigenesis

SCCA1/SERPINB3 Promotes Oncogenesis and Epithelial–Mesenchymal Transition via the Unfolded Protein Response and IL6 Signaling

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