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Hongyun Wang
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Journal Articles

Abstract LB-122: Combinations of SHP2 inhibitor to overcome RAS activation by receptor tyrosine kinases in response to ERK inhibition

Huaixiang Hao, Chen Liu, Hongyun Wang, Hengyu Lu, Scott Delach, Matthew LaMarche, Jeffrey Engelman, Peter Hammerman, Giordano Caponigro, Susan Moody, Morvarid Mohseni
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): LB-122.
https://doi.org/10.1158/1538-7445.AM2020-LB-122
Published: 15 August 2020
View article titled, Abstract LB-122: Combinations of SHP2 inhibitor to overcome RAS activation by receptor tyrosine kinases in response to ERK inhibition
Journal Articles

Abstract LB-005: Allosteric SHP2 phosphatase inhibition: Multiple mechanisms and chemotypes

Matthew J. LaMarche, Jeff Bagdanoff, Mike Acker, Ying-Nan Chen, Homan Chan, Michael Dore, Brant Firestone, Michelle Fodor, Jorge Garcia-Fortanet, Murphy Hentemann, Mitsunori Kato, Robert Koenig, Laura La Bonte, Shumei Liu, Movarid Mohseni, Rukundo Ntaganda, Patrick Sarver, Troy Smith, Martin Sendzik, Travis Stams, Stan Spence, Chris Towler, Hongyun Wang, Ping Wang, Sarah Williams, Zhouliang Chen, Huaixiang Hao, Gang Liu, Chen Liu, Eric McNeill, Bing Yu
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): LB-005.
https://doi.org/10.1158/1538-7445.AM2019-LB-005
Published: 01 July 2019
View article titled, Abstract LB-005: Allosteric SHP2 phosphatase inhibition: Multiple mechanisms and chemotypes
Journal Articles

Abstract 954: SHP2 inhibition overcomes RTK-mediated pathway reactivation in KRAS mutant tumors treated with MEK inhibitors

Hengyu Lu, Chen Liu, Roberto Velazquez, Hongyun Wang, Lukas M. Dunkl, Malika Kazic-Legueux, Anne Haberkorn, Eric Billy, Eusebio Manchado, Saskia M. Brachmann, Susan Moody, Jeffrey A. Engelman, Peter S. Hammerman, Giordano Caponigro, Morvarid Mohseni, Huaixiang Hao
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 954.
https://doi.org/10.1158/1538-7445.AM2019-954
Published: 01 July 2019
View article titled, Abstract 954: SHP2 inhibition overcomes RTK-mediated pathway reactivation in KRAS mutant tumors treated with MEK inhibitors
Journal Articles

Abstract 4406: CARD11 is critical for in vitro and in vivo growth of ABC-DLBCL cells.

Joshua C. Murtie, Julia Zhu, Hongyun Wang, Beatriz Ospina, May Cindhuchao, Dietmar Hoffman, Rita Greco, Marion Dorsch, Francisco Adrian
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4406.
https://doi.org/10.1158/1538-7445.AM2013-4406
Published: 15 April 2013
View article titled, Abstract 4406: CARD11 is critical for in vitro and in vivo growth of ABC-DLBCL cells.
Journal Articles

Abstract 4553: Design and validation of a screening strategy for the identification of novel inhibitors of wild type and mutant CARD11 mediated BCR/NF-κB signaling.

Julia Zhu, Joshua C. Murtie, Rita Greco, Hongyun Wang, Monsif Bouaboula, Marion Dorsch, Francisco Adrian
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4553.
https://doi.org/10.1158/1538-7445.AM2013-4553
Published: 15 April 2013
View article titled, Abstract 4553: Design and validation of a screening strategy for the identification of novel inhibitors of wild type and mutant CARD11 mediated BCR/NF-κB signaling.
Journal Articles

Abstract 3135: In vitro and in vivo synthetic lethal screens to identify novel targets in the context of PTEN deficiency.

Jing-xin Zhang, Joshua Murtie, Oleg Iartchouk, Hui Cao, Gary Shapiro, Zhifang Li, Hongyun Wang, Zhihu Ding, Yu-an Zhang, Madelyn Light, Dietmar Hoffman, May Cindhuchao, Saurin Jani, Richard Newcombe, Eva Bric-Furlong, Bin Wu, Angela Virone-Oddos, Stephan Reiling, Joachim Theihaber, Christoph Lengauer, Jack Pollard, James Watters, Serena Silver, Venkat Reddy
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 3135.
https://doi.org/10.1158/1538-7445.AM2013-3135
Published: 15 April 2013
View article titled, Abstract 3135: <em>In vitro</em> and <em>in vivo</em> synthetic lethal screens to identify novel targets in the context of PTEN deficiency.
Journal Articles

Intratumoral De Novo Steroid Synthesis Activates Androgen Receptor in Castration-Resistant Prostate Cancer and Is Upregulated by Treatment with CYP17A1 Inhibitors

Changmeng Cai, Sen Chen, Patrick Ng, Glenn J. Bubley, Peter S. Nelson, Elahe A. Mostaghel, Brett Marck, Alvin M. Matsumoto, Nicholas I. Simon, Hongyun Wang, Shaoyong Chen, Steven P. Balk
Journal: Cancer Research
Cancer Res (2011) 71 (20): 6503–6513.
https://doi.org/10.1158/0008-5472.CAN-11-0532
Published: 12 October 2011
View article titled, Intratumoral <em>De Novo</em> Steroid Synthesis Activates Androgen Receptor in Castration-Resistant Prostate Cancer and Is Upregulated by Treatment with CYP17A1 Inhibitors
Open the PDF for Intratumoral <em>De Novo</em> Steroid Synthesis Activates Androgen Receptor in Castration-Resistant Prostate Cancer and Is Upregulated by Treatment with CYP17A1 Inhibitors in another window
Includes: Supplementary data
Journal Articles

Reactivation of Androgen Receptor–Regulated TMPRSS2:ERG Gene Expression in Castration-Resistant Prostate Cancer

Changmeng Cai, Hongyun Wang, Youyuan Xu, Shaoyong Chen, Steven P. Balk
Journal: Cancer Research
Cancer Res (2009) 69 (15): 6027–6032.
https://doi.org/10.1158/0008-5472.CAN-09-0395
Published: 29 July 2009
View article titled, Reactivation of Androgen Receptor–Regulated <em>TMPRSS2:ERG</em> Gene Expression in Castration-Resistant Prostate Cancer
Open the PDF for Reactivation of Androgen Receptor–Regulated <em>TMPRSS2:ERG</em> Gene Expression in Castration-Resistant Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

Androgen Receptor Expression in Prostate Cancer Cells Is Suppressed by Activation of Epidermal Growth Factor Receptor and ErbB2

Changmeng Cai, David C. Portnoy, Hongyun Wang, Xinnong Jiang, Shaoyong Chen, Steven P. Balk
Journal: Cancer Research
Cancer Res (2009) 69 (12): 5202–5209.
https://doi.org/10.1158/0008-5472.CAN-09-0026
Published: 15 June 2009
View article titled, Androgen Receptor Expression in Prostate Cancer Cells Is Suppressed by Activation of Epidermal Growth Factor Receptor and ErbB2
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Journal Articles

SOX9 enhances prostate cancer xenograft establishment and invasion

Hongyun Wang, Irwin Leav, Michael Wegner, Michael Lu, Steve Balk, Xin Yuan
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 5262.
Published: 01 May 2008
View article titled, SOX9 enhances prostate cancer xenograft establishment and invasion
Journal Articles

SOX9 Is Expressed in Human Fetal Prostate Epithelium and Enhances Prostate Cancer Invasion

Hongyun Wang, Irwin Leav, Soichiro Ibaragi, Michael Wegner, Guo-fu Hu, Michael L. Lu, Steven P. Balk, Xin Yuan
Journal: Cancer Research
Cancer Res (2008) 68 (6): 1625–1630.
https://doi.org/10.1158/0008-5472.CAN-07-5915
Published: 13 March 2008
View article titled, SOX9 Is Expressed in Human Fetal Prostate Epithelium and Enhances Prostate Cancer Invasion
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Journal Articles

SOX9 Is Expressed in Normal Prostate Basal Cells and Regulates Androgen Receptor Expression in Prostate Cancer Cells

Hongyun Wang, Nicole C. McKnight, Tao Zhang, Michael L. Lu, Steven P. Balk, Xin Yuan
Journal: Cancer Research
Cancer Res (2007) 67 (2): 528–536.
https://doi.org/10.1158/0008-5472.CAN-06-1672
Published: 18 January 2007
View article titled, SOX9 Is Expressed in Normal Prostate Basal Cells and Regulates Androgen Receptor Expression in Prostate Cancer Cells
Open the PDF for SOX9 Is Expressed in Normal Prostate Basal Cells and Regulates Androgen Receptor Expression in Prostate Cancer Cells in another window