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Journal Articles

Abstract PS08-07: BL-B01D1, a first-in-class EGFRxHER3 bispecific antibody-drug conjugate, in patients with Locally Advanced or Metastatic Breast Cancer and other Solid Tumor: Results from a phase 1 study

Jiong Wu, Jian Zhang, Yiqun Du, Wen Zou, Muran Ding, Hui Yang, Sa Xiao, Hongwei Wang, Hai Zhu, Martin Olivo, Yi Zhu
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PS08-07.
https://doi.org/10.1158/1538-7445.SABCS23-PS08-07
Published: 02 May 2024
View article titled, Abstract PS08-07: BL-B01D1, a first-in-class EGFRxHER3 bispecific antibody-drug conjugate, in patients with Locally Advanced or Metastatic Breast Cancer and other Solid Tumor: Results from a phase 1 study
Journal Articles

Abstract PO2-04-03: BL-M07D1, an antibody-drug conjugate directed to HER2 in patients with locally advanced or metastatic Breast Cancer with HER2-positive/low-expression and other solid tumors: Results from a first-in-human phase 1 study

Erwei Song, Herui Yao, Meili Sun, Hong Zong, Rongbo Lin, Wen Zou, Muran Ding, Jing Yu, Sa Xiao, Hongwei Wang, Hai Zhu, Martin Olivo, Yi Zhu
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PO2-04-03.
https://doi.org/10.1158/1538-7445.SABCS23-PO2-04-03
Published: 02 May 2024
View article titled, Abstract PO2-04-03: BL-M07D1, an antibody-drug conjugate directed to HER2 in patients with locally advanced or metastatic Breast Cancer with HER2-positive/low-expression and other solid tumors: Results from a first-in-human phase 1 study
Journal Articles

Abstract 4008: DASH CAR-T: accelerating CD276-targeted immunotherapy for pancreatic cancer

Haiying Wang, Tian Deng, Hao Li, Yue Yao, Yuan Tian, Hongwei Wang, Pengfei Jiang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4008.
https://doi.org/10.1158/1538-7445.AM2024-4008
Published: 22 March 2024
View article titled, Abstract 4008: DASH CAR-T: accelerating CD276-targeted immunotherapy for pancreatic cancer
Journal Articles

Abstract 6493: CRISPR-directed prime editing sensitizes EGFR inhibitor by correcting oncogenic KRAS mutants In NSCLC

Qingxiao Fang, Chao Yang, Chongbiao Huang, Hongwei Wang, Jun Yu, Jihui Hao
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6493.
https://doi.org/10.1158/1538-7445.AM2024-6493
Published: 22 March 2024
View article titled, Abstract 6493: CRISPR-directed prime editing sensitizes EGFR inhibitor by correcting oncogenic KRAS mutants In NSCLC
Journal Articles

Abstract 4741: NUDT21 regulates PIGN through APA mechanism to affect the progression of MDS and AML

Jeffrey J. Pu, Fanggang Ren, Na Zhang, Shuo Li, Lan Zhang, Eric Miller, Guirong Wang, Hongwei Wang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4741.
https://doi.org/10.1158/1538-7445.AM2023-4741
Published: 04 April 2023
View article titled, Abstract 4741: NUDT21 regulates PIGN through APA mechanism to affect the progression of MDS and AML
Journal Articles

Abstract 2781: Mechanism study of surufatinib on the optimized strategy of AG plus PD-1 antibody treatment in pancreatic cancer

Song Gao, Wenbo Zhu, Xiaofan Guo, Yuexiang Liang, Hongwei Wang, Peijun Xu, Yuning Song, Jihui Hao, Shaoshi Wen, Xing Lv, Jiancai Zhou
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2781.
https://doi.org/10.1158/1538-7445.AM2023-2781
Published: 04 April 2023
View article titled, Abstract 2781: Mechanism study of surufatinib on the optimized strategy of AG plus PD-1 antibody treatment in pancreatic cancer
Journal Articles

Mitochondrial Calcium Uniporter Drives Metastasis and Confers a Targetable Cystine Dependency in Pancreatic Cancer

Xiuchao Wang, Yunzhan Li, Zekun Li, Shengchen Lin, Hongwei Wang, Jianwei Sun, Chungen Lan, Liangliang Wu, Dongxiao Sun, Chongbiao Huang, Pankaj K. Singh, Nadine Hempel, Mohamed Trebak, Gina M. DeNicola, Jihui Hao, Shengyu Yang
Journal: Cancer Research
Cancer Res (2022) 82 (12): 2254–2268.
https://doi.org/10.1158/0008-5472.CAN-21-3230
Published: 15 June 2022
View article titled, Mitochondrial Calcium Uniporter Drives Metastasis and Confers a Targetable Cystine Dependency in Pancreatic Cancer
Open the PDF for Mitochondrial Calcium Uniporter Drives Metastasis and Confers a Targetable Cystine Dependency in Pancreatic Cancer in another window
Includes: Multimedia, Supplementary data
Journal Articles

Abstract 1337: The distribution of the phosphorylated Parkin in lung carcinoma

Hongwei Wang, Songlin Zhang, Catherine Ma, Yuan Zhou
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1337.
https://doi.org/10.1158/1538-7445.AM2017-1337
Published: 01 July 2017
View article titled, Abstract 1337: The distribution of the phosphorylated Parkin in lung carcinoma
Journal Articles

Abstract 4654: The primary study of the correlation between mRNA expression and protein phosphorylation of epidermal growth factor receptor EGFR in colorectal and breast cancer cell lines

Hongwei Wang, Catherine Ma, Yuan Zhou
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4654.
https://doi.org/10.1158/1538-7445.AM2017-4654
Published: 01 July 2017
View article titled, Abstract 4654: The primary study of the correlation between mRNA expression and protein phosphorylation of epidermal growth factor receptor EGFR in colorectal and breast cancer cell lines
Journal Articles

ESE3 Inhibits Pancreatic Cancer Metastasis by Upregulating E-Cadherin

Tiansuo Zhao, Wenna Jiang, Xiuchao Wang, Hongwei Wang, Chen Zheng, Yang Li, Yan Sun, Chongbiao Huang, Zhi-bo Han, Shengyu Yang, Zhiliang Jia, Keping Xie, He Ren, Jihui Hao
Journal: Cancer Research
Cancer Res (2017) 77 (4): 874–885.
https://doi.org/10.1158/0008-5472.CAN-16-2170
Published: 14 February 2017
View article titled, ESE3 Inhibits Pancreatic Cancer Metastasis by Upregulating E-Cadherin
Open the PDF for ESE3 Inhibits Pancreatic Cancer Metastasis by Upregulating E-Cadherin in another window
Includes: Supplementary data
Journal Articles

Abstract PR10: Significant improvements in therapeutic index for conjugated payloads using a nanoparticle-drug conjugate (NDC) platform to provide sustained drug release and potentially improved anticancer effects

Chester Metcalf, III, Derek van der Poll, Liang Zhao, Tiffany Halo, Doug Lazarus, Adam Stockmann, Christian Peters, Donna Brown, Roy Case, Ellen Rohde, Lata Jayaraman, Hongwei Wang, Tiffany Crowell, Adrian Senderowicz, Scott Eliasof
Journal: Cancer Research
Cancer Res (2017) 77 (2_Supplement): PR10.
https://doi.org/10.1158/1538-7445.EPSO16-PR10
Published: 16 January 2017
View article titled, Abstract PR10: Significant improvements in therapeutic index for conjugated payloads using a nanoparticle-drug conjugate (NDC) platform to provide sustained drug release and potentially improved anticancer effects
Journal Articles

Activation of Wnt/β-Catenin in Ewing Sarcoma Cells Antagonizes EWS/ETS Function and Promotes Phenotypic Transition to More Metastatic Cell States

Elisabeth A. Pedersen, Rajasree Menon, Kelly M. Bailey, Dafydd G. Thomas, Raelene A. Van Noord, Jenny Tran, Hongwei Wang, Ping Ping Qu, Antje Hoering, Eric R. Fearon, Rashmi Chugh, Elizabeth R. Lawlor
Journal: Cancer Research
Cancer Res (2016) 76 (17): 5040–5053.
https://doi.org/10.1158/0008-5472.CAN-15-3422
Published: 31 August 2016
View article titled, Activation of Wnt/β-Catenin in Ewing Sarcoma Cells Antagonizes EWS/ETS Function and Promotes Phenotypic Transition to More Metastatic Cell States
Open the PDF for Activation of Wnt/β-Catenin in Ewing Sarcoma Cells Antagonizes EWS/ETS Function and Promotes Phenotypic Transition to More Metastatic Cell States in another window
Includes: Supplementary data
Journal Articles

Abstract 2047: Pharmacokinetics (PK) of CRLX301, a novel nanoparticle-drug conjugate (NDC) containing the payload docetaxel, in patients with refractory solid tumors

William C. Zamboni, Ben Markman, Paul de Souza, E. Claire Dees, Tara Gangadhar, Scott Eliasof, Curran Murphy, Adrian Senderowicz, Hongwei Wang
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2047.
https://doi.org/10.1158/1538-7445.AM2016-2047
Published: 15 July 2016
View article titled, Abstract 2047: Pharmacokinetics (PK) of CRLX301, a novel nanoparticle-drug conjugate (NDC) containing the payload docetaxel, in patients with refractory solid tumors
Journal Articles

Abstract 4904: Developing a universal target retrieval solution and protocol for RNA in situ hybridization based on RNAscope technology

Li-chong Wang, Liuliu Pan, Kuang-Jung Chang, Daniel Kim, Xingyong Wu, Hongwei Wang, Casey Kernag, Bingqing Zhang, Mingxiao He, Nan Su, Xiao-Jun Ma, Yuling Luo
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4904.
https://doi.org/10.1158/1538-7445.AM2015-4904
Published: 01 August 2015
View article titled, Abstract 4904: Developing a universal target retrieval solution and protocol for RNA <em>in situ</em> hybridization based on RNAscope technology
Journal Articles

Abstract 2564: Histone deacetylase 6 is a novel target for enhancing T-cell function during anti-tumor response and tumor-peptide vaccination

Andressa S. Laino, David M. Woods, Fengdong Cheng, HongWei Wang, Eduardo M. Sotomayor
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2564.
https://doi.org/10.1158/1538-7445.AM2014-2564
Published: 01 October 2014
View article titled, Abstract 2564: Histone deacetylase 6 is a novel target for enhancing T-cell function during anti-tumor response and tumor-peptide vaccination
Journal Articles

Abstract 4086: Histone deacetylase 6 (HDAC6) as a new target modulating the proliferation and immune-related pathways in melanoma

Patricio Perez-Villarroel, Maritza Lienlaf, Calvin Lee, Fengdong Cheng, David Woods, Kelly Barrios, Karrune Woan, Jorge Canales, Tessa Knox, Danay Marante, Hongwei Wang, Pedro Horna, Keiran Smalley, Esteban Celis, Ed Seto, Jeffrey S. Weber, Eduardo M. Sotomayor, Alejandro Villagra
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4086.
https://doi.org/10.1158/1538-7445.AM2014-4086
Published: 01 October 2014
View article titled, Abstract 4086: Histone deacetylase 6 (HDAC6) as a new target modulating the proliferation and immune-related pathways in melanoma
Journal Articles

Abstract 4665: Quantitative in situ biomarker analysis via ultrasensitive RNA in situ hybridization and automated image analysis

Hongwei Wang, Laurent Lessard, Nan Su, Yuling Luo, Dave Hoon, Xiao-Jun Ma
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4665.
https://doi.org/10.1158/1538-7445.AM2014-4665
Published: 01 October 2014
View article titled, Abstract 4665: Quantitative in situ biomarker analysis via ultrasensitive RNA in situ hybridization and automated image analysis
Journal Articles

Abstract 5246: Histone deacetylase 6 (HDAC6) as a new modulator of the JAK/STAT pathway in melanoma.

Maritza Lienlaf, Patricio Perez-Villarroel, Jorge Canales, Tessa Knox, Fengdong Cheng, Danay Marante, David Woods, Karrune Woan, HongWei Wang, Ed Seto, Jeffrey S. Weber, Eduardo M. Sotomayor, Alejandro Villagra
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 5246.
https://doi.org/10.1158/1538-7445.AM2013-5246
Published: 15 April 2013
View article titled, Abstract 5246: Histone deacetylase 6 (HDAC6) as a new modulator of the JAK/STAT pathway in melanoma.
Journal Articles

Stat3 Inhibition Augments the Immunogenicity of B-cell Lymphoma Cells, Leading to Effective Antitumor Immunity

Fengdong Cheng, Hongwei Wang, Pedro Horna, Zi Wang, Bijal Shah, Eva Sahakian, Karrune V. Woan, Alejandro Villagra, Javier Pinilla-Ibarz, Said Sebti, Mitchell Smith, Jianguo Tao, Eduardo M. Sotomayor
Journal: Cancer Research
Cancer Res (2012) 72 (17): 4440–4448.
https://doi.org/10.1158/0008-5472.CAN-11-3619
Published: 30 August 2012
View article titled, Stat3 Inhibition Augments the Immunogenicity of B-cell Lymphoma Cells, Leading to Effective Antitumor Immunity
Open the PDF for Stat3 Inhibition Augments the Immunogenicity of B-cell Lymphoma Cells, Leading to Effective Antitumor Immunity in another window
Includes: Supplementary data
Journal Articles

Abstract 2259: Oncolytic attenuated measles virus exploits autophagy for its replication and spreads by suppressing Rig-1 like receptors (RLRs) in non-small cell lung cancer cells

Mao Xia, Patrick Gonzalez, Chunyan Li, Gang Meng, Hongwei Wang, Nike Luehl, Christian Beltinger, Jiwu Wei
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 2259.
https://doi.org/10.1158/1538-7445.AM2012-2259
Published: 15 April 2012
View article titled, Abstract 2259: Oncolytic attenuated measles virus exploits autophagy for its replication and spreads by suppressing Rig-1 like receptors (RLRs) in non-small cell lung cancer cells