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Journal Articles

Abstract 2749: Single-cell 3D genome structure analysis reveals clonal evolution and heterogeneity in acute myeloid leukemia

Free
Yu Luan, Ye Hou, Yutong Lei, Qiushi Jin, Jie Xu, Bei Jia, Siwei Xu, Ping Wang, Alok Swaroop, Yihao Fu, Juan Wang, Qixuan Wang, Hong Zheng, Jing Zhang, Feng Yue
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 2749.
https://doi.org/10.1158/1538-7445.AM2025-2749
Published: 21 April 2025
View article titled, Abstract 2749: Single-cell 3D genome structure analysis reveals clonal evolution and heterogeneity in acute myeloid leukemia
Journal Articles

Abstract 1018: Genetic landscape and functional exploration of kidney cancer predisposition in cross-ancestral populations

Free
Hongji Dai, Xinlei Chu, Han Du, Shutong Yang, Yanxin Yao, Xinru Yu, Yanrui Zhao, Zhangyan Lyu, Wei Wang, Chao Sheng, Hong Zheng, Fangfang Song, Fengju Song, Mulin Jun Li, Kexin Chen
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 1018.
https://doi.org/10.1158/1538-7445.AM2025-1018
Published: 21 April 2025
View article titled, Abstract 1018: Genetic landscape and functional exploration of kidney cancer predisposition in cross-ancestral populations
Journal Articles

Abstract 2226: Combined inhibition of MEK and HDACs improves the cytotoxicity of CD4 and CD8 T cells in NRAS;ASXL1-driven acute myeloid leukemia mice

Free
Meher Gayatri Bolisetti, Jing Li, Bei Jia, Esra’a Keewan, Erik A. Ranheim, Kalyan V.G Nadiminti, Hong Zheng, Xiaona You, Jing Zhang
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 2226.
https://doi.org/10.1158/1538-7445.AM2025-2226
Published: 21 April 2025
View article titled, Abstract 2226: Combined inhibition of MEK and HDACs improves the cytotoxicity of CD4 and CD8 T cells in NRAS;ASXL1-driven acute myeloid leukemia mice
Journal Articles

Abstract LB147: Fine-scale mapping of chromosome 9q22.33 identifies candidate causal variant in ovarian cancer

Free
an Li, Tongyu Xing, Yanrui Zhao, Kexin Chen, Hong Zheng
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): LB147.
https://doi.org/10.1158/1538-7445.AM2024-LB147
Published: 05 April 2024
View article titled, Abstract LB147: Fine-scale mapping of chromosome 9q22.33 identifies candidate causal variant in ovarian cancer
Journal Articles

Abstract 6655: Oncolytic adenovirus dually expressing interferon beta and membrane-stable CD40 ligand increases polyfunctional CD8+T cells associated with antitumor activity

Free
Mark J. Cantwell, Andreas N. Saltos, Hong Zheng, Dana Foresman, Amer A. Beg
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6655.
https://doi.org/10.1158/1538-7445.AM2024-6655
Published: 22 March 2024
View article titled, Abstract 6655: Oncolytic adenovirus dually expressing interferon beta and membrane-stable CD40 ligand increases polyfunctional CD8+T cells associated with antitumor activity
Journal Articles

Abstract CT228: Concordance between tissue and circulating tumor DNA (ctDNA) testing for neurotrophic tyrosine receptor kinase (NTRK) gene fusions in larotrectinib (laro) clinical trials

Free
Erin R. Rudzinski, Marc Ladanyi, Lauren L. Ritterhouse, Felix Sahm, Ricarda Norenberg, Hong Zheng, Chi Chen, Vadim Bernard-Gauthier, Nicoletta Brega, Cornelis M. van Tilburg, Jessica J. Lin, Marcia S. Brose, Ulrik N. Lassen, Ray McDermott, Theodore W. Laetsch, David S. Hong, Alexander Drilon, Sinchita Roy-Chowdhuri
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): CT228.
https://doi.org/10.1158/1538-7445.AM2023-CT228
Published: 14 April 2023
View article titled, Abstract CT228: Concordance between tissue and circulating tumor DNA (ctDNA) testing for neurotrophic tyrosine receptor kinase (NTRK) gene fusions in larotrectinib (laro) clinical trials
Journal Articles

Abstract 3264: Sotorasib, a selective G12C K-RAS inhibitor, modulates the tumor microenvironment to promote TNFα and IFNγ signaling and augment immunotherapy response

Free
Mohammed L. Ibrahim, Dana Foresman, Hong Zheng, Eric B. Haura, Daniel Abate-Daga, Xiaoqing Yu, Amer A. Beg
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3264.
https://doi.org/10.1158/1538-7445.AM2023-3264
Published: 04 April 2023
View article titled, Abstract 3264: Sotorasib, a selective G12C K-RAS inhibitor, modulates the tumor microenvironment to promote TNFα and IFNγ signaling and augment immunotherapy response
Journal Articles

Abstract A014: Cytokines surge in the blood years prior to a cancer diagnosis in elderly individuals

Free
Guangbo Chen, Hong Zheng, Yael Rosenberg-Hasson, Saron Araya, Cindy Padilla, Kavita Sarin, Cornelia L. Dekker, Philip Grant, Holden T. Maecker, David Furman, Shai Shen-Orr, Purvesh Khatri, Mark M. Davis
Journal: Cancer Research
Cancer Res (2023) 83 (2_Supplement_1): A014.
https://doi.org/10.1158/1538-7445.AGCA22-A014
Published: 15 January 2023
View article titled, Abstract A014: Cytokines surge in the blood years prior to a cancer diagnosis in elderly individuals
Journal Articles

Abstract PR002: Cytokines surge in the blood years prior to a cancer diagnosis in elderly individuals

Free
Guangbo Chen, Hong Zheng, Yael Rosenberg-Hasson, Saron Araya, Cindy Padilla, Kavita Sarin, Cornelia L. Dekker, Philip Grant, Holden T. Maecker, David Furman, Shai Shen-Orr, Purvesh Khatri, Mark M. Davis
Journal: Cancer Research
Cancer Res (2023) 83 (2_Supplement_1): PR002.
https://doi.org/10.1158/1538-7445.AGCA22-PR002
Published: 15 January 2023
View article titled, Abstract PR002: Cytokines surge in the blood years prior to a cancer diagnosis in elderly individuals
Journal Articles

Abstract 3542: Oncolytic adenovirus encoding transgenes for IFN-beta and recombinant CD40 ligand promotes conventional dendritic cell activation and trafficking with enhanced tumor infiltrating lymphocytes for effective cancer immunotherapy

Free
Hong Zheng, Scott Antonia, Mark J. Cantwell, Xiaoqing Yu, Amer A. Beg
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3542.
https://doi.org/10.1158/1538-7445.AM2022-3542
Published: 15 June 2022
View article titled, Abstract 3542: Oncolytic adenovirus encoding transgenes for IFN-beta and recombinant CD40 ligand promotes conventional dendritic cell activation and trafficking with enhanced tumor infiltrating lymphocytes for effective cancer immunotherapy
Journal Articles

Abstract 2953: Subtype-specific and structure variation induced 3D genome alteration in acute myeloid leukemia

Free
Jie Xu, Fan Song, Baozhen Zhang, Huijue Lyu, Mikoto Kobayashi, Ziyu Zhao, Ye Hou, Xiaotao Wang, Yu Luan, Bei Jia, Lena Stasiak, Qixuan Wang, Qi Jin, Qiushi Jin, Yihao Fu, Ross C. Hardison, Sinisa Dovat, Leonidas C. Platanias, Yue Yang, Tomoko Yamada, Aaron D. Viny, Ross L. Levine, David F. Claxton, James R. Broach, Hong Zheng, Feng Yue
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2953.
https://doi.org/10.1158/1538-7445.AM2022-2953
Published: 15 June 2022
View article titled, Abstract 2953: Subtype-specific and structure variation induced 3D genome alteration in acute myeloid leukemia
Journal Articles

Abstract GS4-09: Quality of life results from OlympiA: A phase III, multicenter, randomized, placebo-controlled trial of adjuvant olaparib after (neo)-adjuvant chemotherapy in patients with germline BRCA1/2 mutations and high-risk HER-2 negative early breast cancer

Free
Patricia A Ganz, Hanna Bandos, Tanja Spanic, Sue Friedman, Volkmar Müller, Sherko Kümmel, Suzette Delaloge, Etienne Brain, Masakazu Toi, Hideko Yamauchi, Eduardo-Martínez de Dueñas, Anne Armstrong, Seock-Ah Im, Chuangui Song, Hong Zheng, Tomasz Sarosiek, Priyanka Sharma, Giovanna Rossi, Priya Rastogi, Anitra Fielding, Richard D Gelber, Christine Campbell, Judy E Garber, Charles E Geyer, Jr, Andrew NJ Tutt, On behalf of the OlympiA Trial Steering Committeeand Investigators
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): GS4-09.
https://doi.org/10.1158/1538-7445.SABCS21-GS4-09
Published: 15 February 2022
View article titled, Abstract GS4-09: Quality of life results from OlympiA: A phase III, multicenter, randomized, placebo-controlled trial of adjuvant olaparib after (neo)-adjuvant chemotherapy in patients with germline BRCA1/2 mutations and high-risk HER-2 negative early breast cancer
Journal Articles

Abstract 697: Defining anti-tumor immune stimulatory mechanisms of MEM-288, a CD40 ligand and IFN-beta dual-transgene armed oncolytic adenovirus

Free
Hong Zheng, Chase D. Powell, Scott Antonia, Mark J. Cantwell, Bradford A. Perez, Amer A. Beg
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 697.
https://doi.org/10.1158/1538-7445.AM2021-697
Published: 01 July 2021
View article titled, Abstract 697: Defining anti-tumor immune stimulatory mechanisms of MEM-288, a CD40 ligand and IFN-beta dual-transgene armed oncolytic adenovirus
Journal Articles

Abstract 874: Adoptive transfer of cytotoxic lymphocytes generated by engineered human dendritic cells for AML treatment

Free
Chenchen Zhao, Bei Jia, Yixing Jiang, Hiroko Shike, David F. Claxton, W Christopher Ehmann, Todd D. Schell, Hua Cheng, Bei Liu, Hong Zheng
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 874.
https://doi.org/10.1158/1538-7445.AM2020-874
Published: 15 August 2020
View article titled, Abstract 874: Adoptive transfer of cytotoxic lymphocytes generated by engineered human dendritic cells for AML treatment
Journal Articles

Abstract 4578: Development of MEM-288, a dual-transgene armed and conditionally replication-enhanced oncolytic adenovirus with potent systemic antitumor immunity

Free
Hong Zheng, Wenjie Dai, Scott Antonia, Mark J. Cantwell, Amer A. Beg
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 4578.
https://doi.org/10.1158/1538-7445.AM2020-4578
Published: 15 August 2020
View article titled, Abstract 4578: Development of MEM-288, a dual-transgene armed and conditionally replication-enhanced oncolytic adenovirus with potent systemic antitumor immunity
Journal Articles

MEK Inhibition Modulates Cytokine Response to Mediate Therapeutic Efficacy in Lung Cancer

Free
Mengyu Xie, Hong Zheng, Ranjna Madan-Lala, Wenjie Dai, Nicholas T. Gimbrone, Zhihua Chen, Fumi Kinose, Sarah A. Blackstone, Keiran S.M. Smalley, W. Douglas Cress, Eric B. Haura, Uwe Rix, Amer A. Beg
Journal: Cancer Research
Cancer Res (2019) 79 (22): 5812–5825.
https://doi.org/10.1158/0008-5472.CAN-19-0698
Published: 15 November 2019
View article titled, MEK Inhibition Modulates Cytokine Response to Mediate Therapeutic Efficacy in Lung Cancer
Open the PDF for MEK Inhibition Modulates Cytokine Response to Mediate Therapeutic Efficacy in Lung Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 3558: Interrogation of onco-microRNA 125b reveals androgen receptor as a key upstream transcriptional factor that is targetable in female gastric cancer

Free
Ben Liu, Meng Zhou, Da Yang, Qinghua Wang, Qiang Zhang, Xiangchun Li, Meng Yang, Qiong Wang, Lian Li, Luyang Liu, Hongji Dai, Fengju Song, Hong Zheng, Wei Zhang, Kexin Chen
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3558.
https://doi.org/10.1158/1538-7445.AM2019-3558
Published: 01 July 2019
View article titled, Abstract 3558: Interrogation of onco-microRNA 125b reveals androgen receptor as a key upstream transcriptional factor that is targetable in female gastric cancer
Journal Articles

Eomes+T-betlow CD8+ T Cells Are Functionally Impaired and Are Associated with Poor Clinical Outcome in Patients with Acute Myeloid Leukemia

Free
Bei Jia, Chenchen Zhao, Kevin L. Rakszawski, David F. Claxton, W. Christopher Ehmann, Witold B. Rybka, Shin Mineishi, Ming Wang, Hiroko Shike, Michael G. Bayerl, Jeffrey M. Sivik, Todd D. Schell, Joseph J. Drabick, Raymond J. Hohl, Hong Zheng
Journal: Cancer Research
Cancer Res (2019) 79 (7): 1635–1645.
https://doi.org/10.1158/0008-5472.CAN-18-3107
Published: 01 April 2019
View article titled, Eomes+T-betlow CD8+ T Cells Are Functionally Impaired and Are Associated with Poor Clinical Outcome in Patients with Acute Myeloid Leukemia
Open the PDF for Eomes+T-betlow CD8+ T Cells Are Functionally Impaired and Are Associated with Poor Clinical Outcome in Patients with Acute Myeloid Leukemia in another window
Includes: Supplementary data
Journal Articles

Abstract 3405: A mutational signature associated with alcohol consumption and prognostically mutated driver genes in esophageal squamous cell carcinoma

Free
Xiangchun Li, Mengyao Wang, Meng Yang, Hongji Dai, Baifeng Zhang, Wei Wang, Xinlei Chu, Xin Wang, Hong Zheng, Ruifang Niu, Wei Zhang, Kexin Chen
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3405.
https://doi.org/10.1158/1538-7445.AM2018-3405
Published: 01 July 2018
View article titled, Abstract 3405: A mutational signature associated with alcohol consumption and prognostically mutated driver genes in esophageal squamous cell carcinoma
Journal Articles

Abstract 2472: Benchmark of lncRNA quantification in RNA-Seq of cancer samples

Free
Hong Zheng, Mikel Hernaez, Kevin Brennan, Olivier Gevaert
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2472.
https://doi.org/10.1158/1538-7445.AM2018-2472
Published: 01 July 2018
View article titled, Abstract 2472: Benchmark of lncRNA quantification in RNA-Seq of cancer samples