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Journal Articles

Abstract CT243: Clinical trial simulation to inform dose selection of zilurgisertib, an ALK2 inhibitor, in patients with anemia due to myelofibrosis (MF)

Yan-ou Yang, Hong Yang, Betty Lamothe, Matthew Stubbs, Amanda McBride, Francis Seguy, Kevin Rockich, Jay Getsy, Phillip Wang, Xiang Liu, Jeff Jackson, Ekaterine Asatiani, Xuejun Chen
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): CT243.
https://doi.org/10.1158/1538-7445.AM2023-CT243
Published: 14 April 2023
View article titled, Abstract CT243: Clinical trial simulation to inform dose selection of zilurgisertib, an ALK2 inhibitor, in patients with anemia due to myelofibrosis (MF)
Journal Articles

Abstract 1295: Small molecule reactivators of Y220C mutant p53 modulate tumor infiltrating leukocytes and synergize with immune checkpoint inhibitors

Anna M. Puzio-Kuter, Chris Mulligan, Brandon Russo, Amy Wiebesiek, Lizhong Xu, Hong Yang, Binh Vu, Melissa Dumble
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1295.
https://doi.org/10.1158/1538-7445.AM2022-1295
Published: 15 June 2022
View article titled, Abstract 1295: Small molecule reactivators of Y220C mutant p53 modulate tumor infiltrating leukocytes and synergize with immune checkpoint inhibitors
Journal Articles

Abstract 5402: Urothelial carcinomas in different anatomical positions exhibit distinct genomic and immunological characteristics

Ruiqian Li, Hushan Zhang, Qilin Wang, Hong Yang, Yu Bai, Chen Hu, Hongyi Wu, Chongjian Zhang, Ziyong Wang, Qiwei Wang, Pengjie Xu, Jun Li
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5402.
https://doi.org/10.1158/1538-7445.AM2022-5402
Published: 15 June 2022
View article titled, Abstract 5402: Urothelial carcinomas in different anatomical positions exhibit distinct genomic and immunological characteristics
Journal Articles

M6A Demethylase ALKBH5 Regulates PD-L1 Expression and Tumor Immunoenvironment in Intrahepatic Cholangiocarcinoma

Xinyao Qiu, Shuai Yang, Shan Wang, Jianmin Wu, Bo Zheng, Kaiting Wang, Siyun Shen, Seogsong Jeong, Zhixuan Li, Yanjing Zhu, Tong Wu, Xuan Wu, Rui Wu, Weiwei Liu, Hong-Yang Wang, Lei Chen
Journal: Cancer Research
Cancer Res (2021) 81 (18): 4778–4793.
https://doi.org/10.1158/0008-5472.CAN-21-0468
Published: 15 September 2021
View article titled, M<sup>6</sup>A Demethylase ALKBH5 Regulates PD-L1 Expression and Tumor Immunoenvironment in Intrahepatic Cholangiocarcinoma
Open the PDF for M<sup>6</sup>A Demethylase ALKBH5 Regulates PD-L1 Expression and Tumor Immunoenvironment in Intrahepatic Cholangiocarcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract LB006: PC14586: The first orally bioavailable small molecule reactivator of Y220C mutant p53 in clinical development

Melissa Dumble, Lizhong Xu, Romyr Dominique, Binbin Liu, Hong Yang, Mary-Kate McBrayer, Dafydd Thomas, Bruce Fahr, Hongju Li, Kuo-Sen Huang, Kimberly Robell, Chris Mulligan, Brandon Russo, Anna Puzio-Kuter, Thomas Davis, Binh Vu
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): LB006.
https://doi.org/10.1158/1538-7445.AM2021-LB006
Published: 01 July 2021
View article titled, Abstract LB006: PC14586: The first orally bioavailable small molecule reactivator of Y220C mutant p53 in clinical development
Journal Articles

Abstract 1601: Neoadjuvant programmed death-1 blockade plus chemotherapy in locally advanced esophageal squamous cell carcinoma

Guozhen Yang, Xiaodong Su, Hong Yang, Guangyu Luo, Chan Gao, Yating Zheng, Wenzhuan Xie, Mengli Huang, Yuezong Bai, Zhiqiang Wang, Peiqiang Cai, Haoqiang He, Jin Xiang, Muyuan Cai, Yijun Zhang, Chunhua Qu, Jianhua Fu, Qianwen Liu, Yi Hu, Jiudi Zhong, Yuanheng Huang, Qiyu Guo, Xu Zhang
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1601.
https://doi.org/10.1158/1538-7445.AM2021-1601
Published: 01 July 2021
View article titled, Abstract 1601: Neoadjuvant programmed death-1 blockade plus chemotherapy in locally advanced esophageal squamous cell carcinoma
Journal Articles

PanIN Neuroendocrine Cells Promote Tumorigenesis via Neuronal Cross-talk

Smrita Sinha, Ya-Yuan Fu, Adrien Grimont, Maren Ketcham, Kelly Lafaro, Joseph A. Saglimbeni, Gokce Askan, Jennifer M. Bailey, Jerry P. Melchor, Yi Zhong, Min Geol Joo, Olivera Grbovic-Huezo, In-Hong Yang, Olca Basturk, Lindsey Baker, Young Park, Robert C. Kurtz, David Tuveson, Steven D. Leach, Pankaj J. Pasricha
Journal: Cancer Research
Cancer Res (2017) 77 (8): 1868–1879.
https://doi.org/10.1158/0008-5472.CAN-16-0899
Published: 13 April 2017
View article titled, PanIN Neuroendocrine Cells Promote Tumorigenesis via Neuronal Cross-talk
Open the PDF for PanIN Neuroendocrine Cells Promote Tumorigenesis via Neuronal Cross-talk in another window
Includes: Multimedia, Supplementary data
Journal Articles

Abstract 5371: PRMT5 inhibitors as novel treatment for cancers

Hendrik Falk, Richard C. Foitzik, Elizabeth Allan, Melanie deSilva, Hong Yang, Ylva E. Bozikis, Marica Nikac, Scott R. Walker, Michelle A. Camerino, Ben J. Morrow, Alexandra E. Stupple, Rachel Lagiakos, Jo-Anne Pinson, Romina Lessene, Wilhelmus JA Kersten, Danny G. Ganame, Ian P. Holmes, Gill E. Lunniss, Matthew Chung, Stefan J. Hermans, Michael W. Parker, Alison Thistlethwaite, Karen White, Susan A. Charman, Brendon J. Monahan, Patricia Pilling, Julian Grusovin, Thomas S. Peat, Stefan Sonderegger, Emma Toulmin, Stephen M. Jane, David J. Curtis, Paul A. Stupple, Ian P. Street
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 5371.
https://doi.org/10.1158/1538-7445.AM2015-5371
Published: 01 August 2015
View article titled, Abstract 5371: PRMT5 inhibitors as novel treatment for cancers
Journal Articles

CYP3A5 Functions as a Tumor Suppressor in Hepatocellular Carcinoma by Regulating mTORC2/Akt Signaling

Feng Jiang, Lei Chen, Ying-Cheng Yang, Xian-ming Wang, Ruo-Yu Wang, Liang Li, Wen Wen, Yan-Xin Chang, Cai-Yang Chen, Jing Tang, Gao-Mi-Yang Liu, Wen-Tao Huang, Lin Xu, Hong-Yang Wang
Journal: Cancer Research
Cancer Res (2015) 75 (7): 1470–1481.
https://doi.org/10.1158/0008-5472.CAN-14-1589
Published: 31 March 2015
View article titled, CYP3A5 Functions as a Tumor Suppressor in Hepatocellular Carcinoma by Regulating mTORC2/Akt Signaling
Open the PDF for CYP3A5 Functions as a Tumor Suppressor in Hepatocellular Carcinoma by Regulating mTORC2/Akt Signaling in another window
Includes: Supplementary data
Journal Articles

Separating Tumorigenicity from Bile Acid Regulatory Activity for Endocrine Hormone FGF19

Mei Zhou, Xueyan Wang, Van Phung, Darrin A. Lindhout, Kalyani Mondal, Jer-Yuan Hsu, Hong Yang, Mark Humphrey, Xunshan Ding, Taruna Arora, R. Marc Learned, Alex M. DePaoli, Hui Tian, Lei Ling
Journal: Cancer Research
Series: Author Choice
Cancer Res (2014) 74 (12): 3306–3316.
https://doi.org/10.1158/0008-5472.CAN-14-0208
Published: 12 June 2014
View article titled, Separating Tumorigenicity from Bile Acid Regulatory Activity for Endocrine Hormone FGF19
Open the PDF for Separating Tumorigenicity from Bile Acid Regulatory Activity for Endocrine Hormone FGF19 in another window
Includes: Supplementary data
Journal Articles

A Novel EGFR Isoform Confers Increased Invasiveness to Cancer Cells

Min Zhou, Hai Wang, Keke Zhou, Xiaoying Luo, Xiaorong Pan, Bizhi Shi, Hua Jiang, Jiqin Zhang, Kesang Li, Hua-Mao Wang, Huiping Gao, Shun Lu, Ming Yao, Ying Mao, Hong-Yang Wang, Shengli Yang, Jianren Gu, Chuanyuan Li, Zonghai Li
Journal: Cancer Research
Cancer Res (2013) 73 (23): 7056–7067.
https://doi.org/10.1158/0008-5472.CAN-13-0194
Published: 01 December 2013
View article titled, A Novel EGFR Isoform Confers Increased Invasiveness to Cancer Cells
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Includes: Supplementary data
Journal Articles

Abstract 999: Epidermal growth factor protects squamous cell carcinoma against cisplatin-induced cytotoxicity through increased interleukin-1β expression.

Chi-Ruei Huang, Jhen-Hong Yang, Wen-Chang Chang, Ben-Kuen Chen
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 999.
https://doi.org/10.1158/1538-7445.AM2013-999
Published: 15 April 2013
View article titled, Abstract 999: Epidermal growth factor protects squamous cell carcinoma against cisplatin-induced cytotoxicity through increased interleukin-1β expression.
Journal Articles

Abstract 2156: Preclinical combinations of vemurafenib, a selective BRAF inhibitor, with other targeted therapies in BRAFV600E colorectal cancer models

Hong Yang, Brian Higgins, Kenneth Kolinsky, Jiakui Li, Richard Margolis, Zenaida Go, Aruna Railkar, Kathryn Packman, Gideon Bollag, Fei Su
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 2156.
https://doi.org/10.1158/1538-7445.AM2012-2156
Published: 15 April 2012
View article titled, Abstract 2156: Preclinical combinations of vemurafenib, a selective BRAF inhibitor, with other targeted therapies in BRAF<sup>V600E</sup> colorectal cancer models
Journal Articles

Resistance to Selective BRAF Inhibition Can Be Mediated by Modest Upstream Pathway Activation

Fei Su, William D. Bradley, Qiongqing Wang, Hong Yang, Lizhong Xu, Brian Higgins, Kenneth Kolinsky, Kathryn Packman, Min Jung Kim, Kerstin Trunzer, Richard J. Lee, Kathleen Schostack, Jade Carter, Thomas Albert, Soren Germer, Jim Rosinski, Mitchell Martin, Mary Ellen Simcox, Brian Lestini, David Heimbrook, Gideon Bollag
Journal: Cancer Research
Cancer Res (2012) 72 (4): 969–978.
https://doi.org/10.1158/0008-5472.CAN-11-1875
Published: 14 February 2012
View article titled, Resistance to Selective BRAF Inhibition Can Be Mediated by Modest Upstream Pathway Activation
Open the PDF for Resistance to Selective BRAF Inhibition Can Be Mediated by Modest Upstream Pathway Activation in another window
Includes: Supplementary data
Journal Articles

Antitumor Activity of BRAF Inhibitor Vemurafenib in Preclinical Models of BRAF-Mutant Colorectal Cancer

Hong Yang, Brian Higgins, Kenneth Kolinsky, Kathryn Packman, William D. Bradley, Richard J. Lee, Kathleen Schostack, Mary Ellen Simcox, Scott Kopetz, David Heimbrook, Brian Lestini, Gideon Bollag, Fei Su
Journal: Cancer Research
Cancer Res (2012) 72 (3): 779–789.
https://doi.org/10.1158/0008-5472.CAN-11-2941
Published: 31 January 2012
View article titled, Antitumor Activity of BRAF Inhibitor Vemurafenib in Preclinical Models of BRAF-Mutant Colorectal Cancer
Open the PDF for Antitumor Activity of BRAF Inhibitor Vemurafenib in Preclinical Models of BRAF-Mutant Colorectal Cancer in another window
Includes: Supplementary data
Journal Articles

Ex Vivo Graft Purging and Expansion of Autologous Blood Progenitor Cell Products from Patients with Multiple Myeloma

Hong Yang, Simon N. Robinson, Yago Nieto, Richard J. Jones, Christopher D. Gocke, Junjun Lu, Sergio A. Giralt, Roy B. Jones, William K. Decker, Dongxia Xing, David Steiner, Richard E. Champlin, John D. McMannis, Jingjing Ng, Michael W. Thomas, Nina Shah, Borje S. Andersson, Simrit Parmar, Elizabeth J. Shpall
Journal: Cancer Research
Cancer Res (2011) 71 (14): 5040–5049.
https://doi.org/10.1158/0008-5472.CAN-11-0842
Published: 14 July 2011
View article titled, <em>Ex Vivo</em> Graft Purging and Expansion of Autologous Blood Progenitor Cell Products from Patients with Multiple Myeloma
Open the PDF for <em>Ex Vivo</em> Graft Purging and Expansion of Autologous Blood Progenitor Cell Products from Patients with Multiple Myeloma in another window
Journal Articles

Hepatocyte Nuclear Factor 4α Suppresses the Development of Hepatocellular Carcinoma

Bei-Fang Ning, Jin Ding, Chuan Yin, Wei Zhong, Kun Wu, Xin Zeng, Wen Yang, Yue-Xiang Chen, Jun-Ping Zhang, Xin Zhang, Hong-Yang Wang, Wei-Fen Xie
Journal: Cancer Research
Cancer Res (2010) 70 (19): 7640–7651.
https://doi.org/10.1158/0008-5472.CAN-10-0824
Published: 29 September 2010
View article titled, Hepatocyte Nuclear Factor 4α Suppresses the Development of Hepatocellular Carcinoma
Open the PDF for Hepatocyte Nuclear Factor 4α Suppresses the Development of Hepatocellular Carcinoma in another window
Includes: Supplementary data
Journal Articles

RG7204 (PLX4032), a Selective BRAFV600E Inhibitor, Displays Potent Antitumor Activity in Preclinical Melanoma Models

Hong Yang, Brian Higgins, Kenneth Kolinsky, Kathryn Packman, Zenaida Go, Raman Iyer, Stanley Kolis, Sylvia Zhao, Richard Lee, Joseph F. Grippo, Kathleen Schostack, Mary Ellen Simcox, David Heimbrook, Gideon Bollag, Fei Su
Journal: Cancer Research
Cancer Res (2010) 70 (13): 5518–5527.
https://doi.org/10.1158/0008-5472.CAN-10-0646
Published: 30 June 2010
View article titled, RG7204 (PLX4032), a Selective BRAF<sup>V600E</sup> Inhibitor, Displays Potent Antitumor Activity in Preclinical Melanoma Models
Open the PDF for RG7204 (PLX4032), a Selective BRAF<sup>V600E</sup> Inhibitor, Displays Potent Antitumor Activity in Preclinical Melanoma Models in another window
Includes: Supplementary data
Journal Articles

Abstract #3496: FGFR2-positive fibroblasts provide a suitable microenvironment for tumor development and progression in esophageal carcinoma

Xin-Yuan Guan, Chunyu Zhang, Li Fu, Jianhua Fu, Liang Hu, Yan Li, Hong Yang, Haibo Liu
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 3496.
Published: 01 May 2009
View article titled, Abstract #3496: FGFR2-positive fibroblasts provide a suitable microenvironment for tumor development and progression in esophageal carcinoma
Journal Articles

Abstract #4420: PLX4032, a selective B-RafV600E inhibitor demonstrates potent antitumor activity in preclinical melanoma models

Fei Su, Hong Yang, Brian Higgins, Kenneth Kolinsky, Richard Lee, Kathryn Packman, Kathleen Schostack, David Heimbrook, Gideon Bollag
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 4420.
Published: 01 May 2009
View article titled, Abstract #4420: PLX4032, a selective B-Raf<sup>V600E</sup> inhibitor demonstrates potent antitumor activity in preclinical melanoma models