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Journal Articles

Abstract 901: Elimination of senescent tumor cells by ABT263 interferes with proliferative recovery and provides a two-hit therapeutic approach

Tareq Saleh, Liliya Tyutyunyk-Massey, Graeme F. Murray, Moureq R. Alotaibi, Ajinkya S. Kawale, Zeinab Elsayed, Scott C. Henderson, Vasily Yakovlev, Lynne W. Elmore, Amir Toor, Hisashi Harada, Jason Reed, Joseph W. Landry, David A. Gewirtz

Cancer Res (2019) 79 (13_Supplement): 901.

DOI: https://doi.org/10.1158/1538-7445.AM2019-901

Published: 01 July 2019

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Journal Articles

Abstract 3082: Deficient NOXA in HER2-amplified breast cancer drives kinase inhibitor resistance

Konstantinos V. Floros, Kyung-A Song, Timothy L. Lochmann, Mark T. Hughes, Daniel A. Heisey, Hisashi Harada, Bin Hu, Jennifer Koblinski, Andrew J. Souers, Joel D. Leverson, Anthony C. Faber

Cancer Res (2017) 77 (13_Supplement): 3082.

DOI: https://doi.org/10.1158/1538-7445.AM2017-3082

Published: 01 July 2017

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Journal Articles

Abstract 2127: p53-independent Noxa induction by cisplatin is regulated by ATF3/ATF4 in HNSCC cells

Kanika Sharma, Thien-Trang Vu, Mitra Naseri, Wataru Nakajima, Kevin Zhan, Hisashi Harada

Cancer Res (2017) 77 (13_Supplement): 2127.

DOI: https://doi.org/10.1158/1538-7445.AM2017-2127

Published: 01 July 2017

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Journal Articles

Abstract 2981: DNA damaging agent-induced apoptosis is controled by MCL-1 phosphorylation and degradation mediated by the Noxa/MCL-1/CDK2 complex

Wataru Nakajima, June Y. Lee, Nicolas Maxim, Kanika Sharma, Mark A. Hicks, Thien-Trang Vu, Angela Luu, William Andrew Yeudall, Nobuyuki Tanaka, Hisashi Harada

Cancer Res (2016) 76 (14_Supplement): 2981.

DOI: https://doi.org/10.1158/1538-7445.AM2016-2981

Published: 15 July 2016

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Journal Articles

Abstract 2524: Combination with vorinostat overcomes ABT-263 resistance of small cell lung cancer

Wataru Nakajima, Mark A. Hicks, Kanika Sharma, Ngoc Le, Geoffrey W. Krystal, Hisashi Harada

Cancer Res (2015) 75 (15_Supplement): 2524.

DOI: https://doi.org/10.1158/1538-7445.AM2015-2524

Published: 01 August 2015

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Journal Articles

Abstract 1013: Understanding the molecular pathways underlying radio-sensitization of non-small cell lung cancer (NSCLC) by vitamin D (EB1089)

Khushboo Sharma, Theresa Thekkudan, David Gewirtz, Hisashi Harada, Frank Torti, Suzy Torti

Cancer Res (2015) 75 (15_Supplement): 1013.

DOI: https://doi.org/10.1158/1538-7445.AM2015-1013

Published: 01 August 2015

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Journal Articles

Abstract 998: Induction of non-protective autophagy by radiation in tumor cells: Implications for autophagy inhibition as a therapeutic strategy

Shweta Chakradeo, Khushboo Sharma, Aisha Alhaddad, Duaa Bakhshwin, Ngoc Le, Hisashi Harada, W. Andrew Yeudall, Suzy Torti, Frank Torti, David Gewirtz

Cancer Res (2015) 75 (15_Supplement): 998.

DOI: https://doi.org/10.1158/1538-7445.AM2015-998

Published: 01 August 2015

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Journal Articles

Abstract 1657: The role of Noxa/MCL-1 axis in solid tumors treated with DNA damaging agents

Wataru Nakajima, Kanika Sharma, Mark A. Hicks, June Y. Lee, Nobuyuki Tanaka, Hisashi Harada

Cancer Res (2015) 75 (15_Supplement): 1657.

DOI: https://doi.org/10.1158/1538-7445.AM2015-1657

Published: 01 August 2015

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Journal Articles

Abstract 5579: Paclitaxel-induced apoptosis is BAK-dependent, but BAX and BIM-independent in breast tumor.

Anna V. Miller, Mark A. Hicks, Amanda C. Richardson, Jolene J. Windle, Hisashi Harada

Cancer Res (2013) 73 (8_Supplement): 5579.

DOI: https://doi.org/10.1158/1538-7445.AM2013-5579

Published: 15 April 2013

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Journal Articles

Abstract 665: Targeting the pro-apoptotic protein BIM by dexamethasone combined with a MEK inhibitor PD184352 enhances the lethality in acute lymphoblastic leukemia

Nastaran Heidari, Amanda Richardson, Mark Hicks, Keneshia Turner, Hisashi Harada

Cancer Res (2010) 70 (8_Supplement): 665.

DOI: https://doi.org/10.1158/1538-7445.AM10-665

Published: 15 April 2010

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Journal Articles

Abstract #2822: Evidence implicating Bim activation/induction in potentiation of PI3K/Akt inhibitor-mediated apoptosis in human leukemia cells

Mohamed Rahmani, Anh Anderson, Joseph Reza Habibi, Timothy Ryan Crabtree, Hisashi Harada, Paul Dent, Steven Grant

Cancer Res (2009) 69 (9_Supplement): 2822.

Published: 01 May 2009

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Journal Articles

Potentiation of UCN-01 lethality by MEK1/2 inhibitors in human multiple myeloma cells involves modulation of Bim phosphorylation and degradation

Xin-Yan Pei, Yun Dai, Sarah Tenorio, Hisashi Harada, Jianghua Lu, Paul Dent, Steven Grant

Cancer Res (2007) 67 (9_Supplement): 3210.

Published: 01 May 2007

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Journal Articles

MEK1/2 inhibitors sensitize BCR/ABL+ human leukemia cells to the dual ABL/SRC inhibitor BMS354825

Tri Nguyen, Mohamed Rahmani, Hisashi Harada, Paul Dent, Steven Grant

Cancer Res (2007) 67 (9_Supplement): 5745.

Published: 01 May 2007

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Journal Articles

Mcl-1 downregulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation

Shuang Chen, Yun Dai, Hisashi Harada, Paul Dent, Steven Grant

Cancer Res (2007) 67 (9_Supplement): 4952.

Published: 01 May 2007

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Journal Articles

Mcl-1 Down-regulation Potentiates ABT-737 Lethality by Cooperatively Inducing Bak Activation and Bax Translocation

Shuang Chen, Yun Dai, Hisashi Harada, Paul Dent, Steven Grant

Cancer Res (2007) 67 (2): 782–791.

DOI: https://doi.org/10.1158/0008-5472.CAN-06-3964

Published: 18 January 2007

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Journal Articles

BIM phosphorylation enhances its pro-apoptotic activity through down-regulation of the interaction with MCL-1

Jianghua Lu, Bonnie Quearry, Hisashi Harada

Cancer Res (2006) 66 (8_Supplement): 959.

Published: 15 April 2006

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Journal Articles

Identification of the Lysyl Oxidase Gene as a Target of the Antioncogenic Transcription Factor, IRF-1, and Its Possible Role in Tumor Suppression

Rosemary Sok-Pin Tan, Tadatsugu Taniguchi, Hisashi Harada

Cancer Res (1996) 56 (10): 2417–2421.

Published: 01 May 1996

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NARROW

Abstract 901: Elimination of senescent tumor cells by ABT263 interferes with proliferative recovery and provides a two-hit therapeutic approach

Abstract 3082: Deficient NOXA in HER2-amplified breast cancer drives kinase inhibitor resistance

Abstract 2127: p53-independent Noxa induction by cisplatin is regulated by ATF3/ATF4 in HNSCC cells

Abstract 2981: DNA damaging agent-induced apoptosis is controled by MCL-1 phosphorylation and degradation mediated by the Noxa/MCL-1/CDK2 complex

Abstract 2524: Combination with vorinostat overcomes ABT-263 resistance of small cell lung cancer

Abstract 1013: Understanding the molecular pathways underlying radio-sensitization of non-small cell lung cancer (NSCLC) by vitamin D (EB1089)

Abstract 998: Induction of non-protective autophagy by radiation in tumor cells: Implications for autophagy inhibition as a therapeutic strategy

Abstract 1657: The role of Noxa/MCL-1 axis in solid tumors treated with DNA damaging agents

Abstract 5579: Paclitaxel-induced apoptosis is BAK-dependent, but BAX and BIM-independent in breast tumor.

Abstract 665: Targeting the pro-apoptotic protein BIM by dexamethasone combined with a MEK inhibitor PD184352 enhances the lethality in acute lymphoblastic leukemia

Abstract #2822: Evidence implicating Bim activation/induction in potentiation of PI3K/Akt inhibitor-mediated apoptosis in human leukemia cells

Potentiation of UCN-01 lethality by MEK1/2 inhibitors in human multiple myeloma cells involves modulation of Bim phosphorylation and degradation

MEK1/2 inhibitors sensitize BCR/ABL+ human leukemia cells to the dual ABL/SRC inhibitor BMS354825

Mcl-1 downregulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation

Mcl-1 Down-regulation Potentiates ABT-737 Lethality by Cooperatively Inducing Bak Activation and Bax Translocation

BIM phosphorylation enhances its pro-apoptotic activity through down-regulation of the interaction with MCL-1

Identification of the Lysyl Oxidase Gene as a Target of the Antioncogenic Transcription Factor, IRF-1, and Its Possible Role in Tumor Suppression

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