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Hiroyuki Mano
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Journal Articles

Abstract 2325: Anatomical genomic and transcriptomic analyses of Helicobacter pylori-driven gastric transformation

Free
Yosuke Tanaka, Fumishi Kishigami, Toshihide Ueno, Shinya Kojima, Taiki Hashimoto, Yukinori Yamagata, Takaki Yoshikawa, Shigeki Sekine, Hiroyuki Mano
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 2325.
https://doi.org/10.1158/1538-7445.AM2025-2325
Published: 21 April 2025
View articletitled, Abstract 2325: Anatomical genomic and transcriptomic analyses of Helicobacter pylori-driven gastric transformation
Journal Articles

Abstract 5355: Whole genome landscape of small cell lung carcinoma and large cell neuroendocrine carcinoma of the lung

Free
Hisashi Hashimoto, Yosuke Tanaka, Jun Takahashi, Toshihide Ueno, Shinya Kojima, Kouya Shiraishi, Takashi Kohno, Yuichi Shiraishi, Yasushi Yatabe, Takeshi Kaneko, Hiroyuki Mano
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 5355.
https://doi.org/10.1158/1538-7445.AM2025-5355
Published: 21 April 2025
View articletitled, Abstract 5355: Whole genome landscape of small cell lung carcinoma and large cell neuroendocrine carcinoma of the lung
Journal Articles

Abstract 6629: Spatial immunogenomic analysis of the transformation process in acquired cystic disease of the kidney

Free
Jun TAKAHASHI, Yosuke Tanaka, Yusuke Sato, Tetsuo Ushiku, Hiroyoshi Nishikawa, Haruki Kume, Hiroyuki Mano
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 6629.
https://doi.org/10.1158/1538-7445.AM2025-6629
Published: 21 April 2025
View articletitled, Abstract 6629: Spatial immunogenomic analysis of the transformation process in acquired cystic disease of the kidney
Journal Articles

Abstract 6247: Comprehensive characterization of cancers with epithelial mesenchymal transition phenotype through long-read sequencing

Free
Yosuke Tanaka, Hiroyuki Mano
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6247.
https://doi.org/10.1158/1538-7445.AM2024-6247
Published: 22 March 2024
View articletitled, Abstract 6247: Comprehensive characterization of cancers with epithelial mesenchymal transition phenotype through long-read sequencing
Journal Articles

Abstract 256: Detection of METexon 14 skipping and fusions in non-small cell lung cancer by comprehensive genomic profiling using a dual targeted DNA/RNA panel

Free
Hidenori Kage, Shinji Kohsaka, Kenji Tatsuno, Aya Shinozaki-Ushiku, Hideaki Isago, Kousuke Watanabe, Motohiro Kato, Tetsuo Ushiku, Kiyoshi Miyagawa, Takahide Nagase, Jun Nakajima, Hiroyuki Aburatani, Hiroyuki Mano, Katsutoshi Oda
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 256.
https://doi.org/10.1158/1538-7445.AM2023-256
Published: 04 April 2023
View articletitled, Abstract 256: Detection of METexon 14 skipping and fusions in non-small cell lung cancer by comprehensive genomic profiling using a dual targeted DNA/RNA panel
Journal Articles

Novel Calcium-Binding Ablating Mutations Induce Constitutive RET Activity and Drive Tumorigenesis

Open Access
Junya Tabata, Takashi Nakaoku, Mitsugu Araki, Ryunosuke Yoshino, Shinji Kohsaka, Ayaka Otsuka, Masachika Ikegami, Ayako Ui, Shin-ichiro Kanno, Keiko Miyoshi, Shigeyuki Matsumoto, Yukari Sagae, Akira Yasui, Masakazu Sekijima, Hiroyuki Mano, Yasushi Okuno, Aikou Okamoto, Takashi Kohno
Journal: Cancer Research
Cancer Res (2022) 82 (20): 3751–3762.
https://doi.org/10.1158/0008-5472.CAN-22-0834
Published: 17 October 2022
View articletitled, Novel Calcium-Binding Ablating Mutations Induce Constitutive RET Activity and Drive Tumorigenesis
Open the PDF for Novel Calcium-Binding Ablating Mutations Induce Constitutive RET Activity and Drive Tumorigenesis in another window
Includes: Multimedia, Supplementary data
Journal Articles

Abstract 2185: MicroSEC: Sequence error filter for formalin-fixed and paraffin-embedded samples

Free
Masachika Ikegami, Shinji Kohsaka, Takeshi Hirose, Toshihide Ueno, Satoshi Inoue, Naoki Kanomata, Hideko Yamauchi, Taisuke Mori, Shigeki Sekine, Yoshihiro Inamoto, Yasushi Yatabe, Hiroshi Kobayashi, Sakae Tanaka, Toru Akiyama, Tomotake Okuma, Hiroyuki Mano
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2185.
https://doi.org/10.1158/1538-7445.AM2022-2185
Published: 15 June 2022
View articletitled, Abstract 2185: MicroSEC: Sequence error filter for formalin-fixed and paraffin-embedded samples
Journal Articles

A Hyperactive RelA/p65-Hexokinase 2 Signaling Axis Drives Primary Central Nervous System Lymphoma

Available to Purchase
Kensuke Tateishi, Yohei Miyake, Masahito Kawazu, Nobuyoshi Sasaki, Taishi Nakamura, Jo Sasame, Yukie Yoshii, Toshihide Ueno, Akio Miyake, Jun Watanabe, Yuko Matsushita, Norio Shiba, Naoko Udaka, Kentaro Ohki, Alexandria L. Fink, Shilpa S. Tummala, Manabu Natsumeda, Naoki Ikegaya, Mayuko Nishi, Makoto Ohtake, Ryohei Miyazaki, Jun Suenaga, Hidetoshi Murata, Ichio Aoki, Julie J. Miller, Yukihiko Fujii, Akihide Ryo, Shoji Yamanaka, Hiroyuki Mano, Daniel P. Cahill, Hiroaki Wakimoto, Andrew S. Chi, Tracy T. Batchelor, Motoo Nagane, Koichi Ichimura, Tetsuya Yamamoto
Journal: Cancer Research
Cancer Res (2020) 80 (23): 5330–5343.
https://doi.org/10.1158/0008-5472.CAN-20-2425
Published: 02 December 2020
View articletitled, A Hyperactive RelA/p65-Hexokinase 2 Signaling Axis Drives Primary Central Nervous System Lymphoma
Open the PDF for A Hyperactive RelA/p65-Hexokinase 2 Signaling Axis Drives Primary Central Nervous System Lymphoma in another window
Includes: Supplementary data
Journal Articles

Abstract 4900: An ALK fusion gene regulates different signaling pathways in mortal versus immortalized normal human cells for cellular senescence and transformation

Free
Masaru Matsumoto, Akihiko Miyanaga, Jessica Beck, Izumi Horikawa, Mohammed Khan, Delphine Lissa, Masahiro Seike, Akihiko Gemma, Hiroyuki Mano, Curtis Harris
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 4900.
https://doi.org/10.1158/1538-7445.AM2020-4900
Published: 15 August 2020
View articletitled, Abstract 4900: An ALK fusion gene regulates different signaling pathways in mortal versus immortalized normal human cells for cellular senescence and transformation
Journal Articles

Abstract 3683: Reciprocal expressions of TFF-1 and TTF-1 in lung adenocarcinomas

Free
Daisuke Matsubara, Manabu Soda, Taichiro Yoshimoto, Yusuke Amano, Atsushi Kihara, Yuji Sakuma, Shunsuke Endo, Koichi Hagiwara, Masashi Fukayama, Hiroyuki Mano, Toshiro Niki
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3683.
https://doi.org/10.1158/1538-7445.AM2018-3683
Published: 01 July 2018
View articletitled, Abstract 3683: Reciprocal expressions of TFF-1 and TTF-1 in lung adenocarcinomas
Journal Articles

Abstract 3394: Actionable fusion kinases in microsatellite instability-high colorectal cancers

Free
Kazuhito Sato, Masahito Kawazu, Yoko Yamamoto, Toshihide Ueno, Shinya Kojima, Genta Nagae, Manabu Soda, Takafumi Oga, Shinji Kohsaka, Eirin Sai, Yoshihiro Yamashita, Shoichi Hazama, Hisae Iinuma, Hiroyuki Aburatani, Hiroyuki Mano
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3394.
https://doi.org/10.1158/1538-7445.AM2018-3394
Published: 01 July 2018
View articletitled, Abstract 3394: Actionable fusion kinases in microsatellite instability-high colorectal cancers
Journal Articles

Abstract 921: High-throughput functional evaluation of variants of unknown significance in ERBB2

Free
Masaaki Nagano, Shinji Kohsaka, Toshihide Ueno, Shinya Kojima, Masachika Ikegami, Ikuko Takeda, Hiroyuki Mano
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 921.
https://doi.org/10.1158/1538-7445.AM2018-921
Published: 01 July 2018
View articletitled, Abstract 921: High-throughput functional evaluation of variants of unknown significance in ERBB2
Journal Articles

Abstract 516: High-throughput functional evaluation of variants of unknown significance in EGFR

Free
Shinji Kohsaka, Masaaki Nagano, Toshihide Ueno, Yoshiyuki Suehara, Takuo Hayashi, Naoko Shimada, Kazuhisa Takahashi, Kenji Suzuki, Kazuya Takamochi, Fumiyuki Takahashi, Hiroyuki Mano
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 516.
https://doi.org/10.1158/1538-7445.AM2017-516
Published: 01 July 2017
View articletitled, Abstract 516: High-throughput functional evaluation of variants of unknown significance in EGFR
Journal Articles

Mutational Landscape and Antiproliferative Functions of ELF Transcription Factors in Human Cancer

Free
Mizuo Ando, Masahito Kawazu, Toshihide Ueno, Daizo Koinuma, Koji Ando, Junji Koya, Keisuke Kataoka, Takahiko Yasuda, Hiroyuki Yamaguchi, Kazutaka Fukumura, Azusa Yamato, Manabu Soda, Eirin Sai, Yoshihiro Yamashita, Takahiro Asakage, Yasushi Miyazaki, Mineo Kurokawa, Kohei Miyazono, Stephen D. Nimer, Tatsuya Yamasoba, Hiroyuki Mano
Journal: Cancer Research
Cancer Res (2016) 76 (7): 1814–1824.
https://doi.org/10.1158/0008-5472.CAN-14-3816
Published: 31 March 2016
View articletitled, Mutational Landscape and Antiproliferative Functions of ELF Transcription Factors in Human Cancer
Open the PDF for Mutational Landscape and Antiproliferative Functions of ELF Transcription Factors in Human Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 3893: Whole-exome sequencing analysis of primary central nervous system lymphoma reveals recurrent MYD88 and PIM1 mutations

Free
Motoo Nagane, Kazutaka Fukumura, Toshihide Ueno, Jeunghun Lee, Yukiko Shishido-Hara, Mitsuaki Shirahata, Kazuhiko Mishima, Koichi Ichimura, Akitake Mukasa, Yoshitaka Narita, Ryo Nishikawa, Hiroyuki Mano
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 3893.
https://doi.org/10.1158/1538-7445.AM2015-3893
Published: 01 August 2015
View articletitled, Abstract 3893: Whole-exome sequencing analysis of primary central nervous system lymphoma reveals recurrent MYD88 and PIM1 mutations
Journal Articles

Abstract 3439: Recurrent CDC25C mutations drive malignant transformation in FPD/AML

Free
Akihide Yoshimi, Takashi Toya, Masahito Kawazu, Toshihide Ueno, Ayato Tsukamoto, Hiromitsu Iizuka, Masahiro Nakagawa, Yasuhito Nannya, Shunya Arai, Motoshi Ichikawa, Hironori Harada, Kensuke Usuki, Yasuhide Hayashi, Etsuro Ito, Keita Kirito, Hideaki Nakajima, Hiroyuki Mano, Mineo Kurokawa
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3439.
https://doi.org/10.1158/1538-7445.AM2014-3439
Published: 01 October 2014
View articletitled, Abstract 3439: Recurrent CDC25C mutations drive malignant transformation in FPD/AML
Journal Articles

Abstract 1911: A common BIM polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer

Free
S. Tiong Ong, King Pan Ng, Axel M. Hillmer, Charles T.H. Chuah, Wen Chun Juan, Tun-Kiat Ko, Audrey S.M. Teo, Pramila N. Ariyaratne, Naoto Takahashi, Kenichi Sawada, Yao Fei, Wah Heng Lee, John W.J. Huang, John C. Allen, Xing Yi Woo, Niranjan Nagarajan, Vikrant Kumar, Anbupalam Thalamuthu, Wan Ting Poh, Li Yi Yang, Liang Piu Koh, Veera S. Nadarajan, Wee Joo Chng, Hein Than, Lay Cheng Lim, Yeow Tee Goh, Sheila Soh, Shenli Zhang, Dianne Poh, Patrick Tan, Ju-Ee Seet, Mei-Kim Ang, Noan-Minh Chau, Quan-Sing Ng, Daniel S.W. Tan, Markus M. Nöthen, Tien Y. Wong, Atif Shahab, Xiaoan Ruan, Valère Cacheux-Rataboul, Wing-Kin Sung, Manabu Soda, Kazutoshi Isobe, Eng Huat Tan, Yasushi Yatabe, Hiroyuki Mano, Ross A. Soo, Tan Min Chin, Wan-Teck Lim, Yijun Ruan
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 1911.
https://doi.org/10.1158/1538-7445.AM2012-1911
Published: 15 April 2012
View articletitled, Abstract 1911: A common BIM polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer
Journal Articles

Abstract 2821: Anti-tumor activity of ASP3026, – A novel and selective ALK inhibitor -

Free
Sadao Kuromitsu, Masamichi Mori, Itsuro Shimada, Yutaka Kondoh, Nobuaki Shindoh, Takatoshi Soga, Takashi Furutani, Satoshi Konagai, Hideki Sakagami, Mari Nakata, Yoko Ueno, Rika Saito, Masao Sasamata, Hiroyuki Mano, Masafumi Kudou
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 2821.
https://doi.org/10.1158/1538-7445.AM2011-2821
Published: 15 April 2011
View articletitled, Abstract 2821: Anti-tumor activity of ASP3026, – A novel and selective ALK inhibitor -
Journal Articles

Abstract 4967: Array-based genomic resequencing of acute myeloid leukemia

Free
Yoshihiro Yamashita, Toshihide Ueno, Manabu Soda, Hiroyuki Mano
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 4967.
https://doi.org/10.1158/1538-7445.AM2011-4967
Published: 15 April 2011
View articletitled, Abstract 4967: Array-based genomic resequencing of acute myeloid leukemia
Journal Articles

Abstract LB-279: Cancer cDNA resequencing with an exon-capture system

Free
Toshihide Ueno, Yoshihiro Yamashita, Manabu Soda, Hiroyuki Mano
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): LB-279.
https://doi.org/10.1158/1538-7445.AM2011-LB-279
Published: 15 April 2011
View articletitled, Abstract LB-279: Cancer cDNA resequencing with an exon-capture system