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Hiroto Izumi
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Journal Articles

Bidirectional Regulation between NDRG1 and GSK3β Controls Tumor Growth and Is Targeted by Differentiation Inducing Factor-1 in Glioblastoma

Hiroshi Ito, Kosuke Watari, Tomohiro Shibata, Tomofumi Miyamoto, Yuichi Murakami, Yukiko Nakahara, Hiroto Izumi, Hiroaki Wakimoto, Michihiko Kuwano, Tatsuya Abe, Mayumi Ono
Journal: Cancer Research
Cancer Res (2020) 80 (2): 234–248.
https://doi.org/10.1158/0008-5472.CAN-19-0438
Published: 15 January 2020
View article titled, Bidirectional Regulation between NDRG1 and GSK3β Controls Tumor Growth and Is Targeted by Differentiation Inducing Factor-1 in Glioblastoma
Open the PDF for Bidirectional Regulation between NDRG1 and GSK3β Controls Tumor Growth and Is Targeted by Differentiation Inducing Factor-1 in Glioblastoma in another window
Includes: Supplementary data
Journal Articles

Abstract 2924: Preclinical analysis of synergistic antitumor effect of eribulin and HDAC inhibitor for triple-negative breast cancer cells

Takaaki Oba, Hiroto Izumi, Ken-ichi Ito
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2924.
https://doi.org/10.1158/1538-7445.AM2018-2924
Published: 01 July 2018
View article titled, Abstract 2924: Preclinical analysis of synergistic antitumor effect of eribulin and HDAC inhibitor for triple-negative breast cancer cells
Journal Articles

Abstract 906: PATZ1 promotes migration and invasion of thyroid cancer cells through upregulation of the activity of plasminogen activator and matrix metalloproteinases

Asumi Iesato, Teruo Nakamura, Tsuyoshi Uehara, Hiroto Izumi, Ken-ichi Ito
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 906.
https://doi.org/10.1158/1538-7445.AM2017-906
Published: 01 July 2017
View article titled, Abstract 906: PATZ1 promotes migration and invasion of thyroid cancer cells through upregulation of the activity of plasminogen activator and matrix metalloproteinases
Journal Articles

Breast Cancer Resistance to Antiestrogens Is Enhanced by Increased ER Degradation and ERBB2 Expression

Tomohiro Shibata, Kosuke Watari, Hiroto Izumi, Akihiko Kawahara, Satoshi Hattori, Chihiro Fukumitsu, Yuichi Murakami, Ryuji Takahashi, Uhi Toh, Ken-ichi Ito, Shigehiro Ohdo, Maki Tanaka, Masayoshi Kage, Michihiko Kuwano, Mayumi Ono
Journal: Cancer Research
Cancer Res (2017) 77 (2): 545–556.
https://doi.org/10.1158/0008-5472.CAN-16-1593
Published: 16 January 2017
View article titled, Breast Cancer Resistance to Antiestrogens Is Enhanced by Increased ER Degradation and ERBB2 Expression
Open the PDF for Breast Cancer Resistance to Antiestrogens Is Enhanced by Increased ER Degradation and ERBB2 Expression in another window
Includes: Supplementary data
Journal Articles

Abstract LB-183: Y-box binding protein-1 YB-1 negatively regulates ERα expression accompanying by enhanced HER2/ErbB2 expression in breast cancer

Tomohiro Shibata, Hiroto Izumi, Akihiko Kawahara, Satoshi Hattori, Chihiro Fukumitsu, Ryuji Takahashi, Kosuke Watari, Yuichi Murakami, Kimitoshi Kohno, Ken-ichi Ito, Masayoshi Kage, Michihiko Kuwano, Mayumi Ono
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): LB-183.
https://doi.org/10.1158/1538-7445.AM2014-LB-183
Published: 01 October 2014
View article titled, Abstract LB-183: Y-box binding protein-1 YB-1 negatively regulates ERα expression accompanying by enhanced HER2/ErbB2 expression in breast cancer
Journal Articles

Abstract 3662: Tumor-derived interleukin-1 promotes lymphangiogenesis and lymph node metastasis through activation of M2-type macrophages by lung cancer cells

Kosuke Watari, Tomohiro Shibata, Akihiko Kawahara, Yuichi Murakami, Hiroshi Nabeshima, Ai Shinoda, Koichi Azuma, Hiroto Izumi, Masayoshi Kage, Michihiko Kuwano, Mayumi Ono
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3662.
https://doi.org/10.1158/1538-7445.AM2014-3662
Published: 01 October 2014
View article titled, Abstract 3662: Tumor-derived interleukin-1 promotes lymphangiogenesis and lymph node metastasis through activation of M2-type macrophages by lung cancer cells
Journal Articles

Loss of PTEN Expression by Blocking Nuclear Translocation of EGR1 in Gefitinib-Resistant Lung Cancer Cells Harboring Epidermal Growth Factor Receptor–Activating Mutations

Chizuko Yamamoto, Yuji Basaki, Akihiko Kawahara, Kazutaka Nakashima, Masayoshi Kage, Hiroto Izumi, Kimitoshi Kohno, Hidetaka Uramoto, Kosei Yasumoto, Michihiko Kuwano, Mayumi Ono
Journal: Cancer Research
Cancer Res (2010) 70 (21): 8715–8725.
https://doi.org/10.1158/0008-5472.CAN-10-0043
Published: 31 October 2010
View article titled, Loss of PTEN Expression by Blocking Nuclear Translocation of EGR1 in Gefitinib-Resistant Lung Cancer Cells Harboring Epidermal Growth Factor Receptor–Activating Mutations
Open the PDF for Loss of PTEN Expression by Blocking Nuclear Translocation of EGR1 in Gefitinib-Resistant Lung Cancer Cells Harboring Epidermal Growth Factor Receptor–Activating Mutations in another window
Includes: Supplementary data
Journal Articles

N-myc Downstream Regulated Gene 1/Cap43 Suppresses Tumor Growth and Angiogenesis of Pancreatic Cancer through Attenuation of Inhibitor of κB Kinase β Expression

Fumihito Hosoi, Hiroto Izumi, Akihiko Kawahara, Yuichi Murakami, Hisafumi Kinoshita, Masayoshi Kage, Kazuto Nishio, Kimitoshi Kohno, Michihiko Kuwano, Mayumi Ono
Journal: Cancer Research
Cancer Res (2009) 69 (12): 4983–4991.
https://doi.org/10.1158/0008-5472.CAN-08-4882
Published: 15 June 2009
View article titled, N-myc Downstream Regulated Gene 1/Cap43 Suppresses Tumor Growth and Angiogenesis of Pancreatic Cancer through Attenuation of Inhibitor of κB Kinase β Expression
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Includes: Supplementary data
Journal Articles

Abstract #3174: N-myc downstream regulated gene 1 (NDRG1)/Cap43 suppresses tumor growth and angiogenesis of pancreatic cancer through attenuation of NF-\#954;B signaling

Mayumi Ono, Fumihito Hosoi, Hiroto Izumi, Kazuto Nishio, Kimitoshi Kohno, Michihiko Kuwano
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 3174.
Published: 01 May 2009
View article titled, Abstract #3174: N-myc downstream regulated gene 1 (NDRG1)/Cap43 suppresses tumor growth and angiogenesis of pancreatic cancer through attenuation of NF-\#954;B signaling
Journal Articles

Programmed Cell Death Protein 4 Down-regulates Y-Box Binding Protein-1 Expression via a Direct Interaction with Twist1 to Suppress Cancer Cell Growth

Masaki Shiota, Hiroto Izumi, Akihide Tanimoto, Mayu Takahashi, Naoya Miyamoto, Eiji Kashiwagi, Akihiko Kidani, Gen Hirano, Daisuke Masubuchi, Yasushi Fukunaka, Yoshihiro Yasuniwa, Seiji Naito, Shigeru Nishizawa, Yasuyuki Sasaguri, Kimitoshi Kohno
Journal: Cancer Research
Cancer Res (2009) 69 (7): 3148–3156.
https://doi.org/10.1158/0008-5472.CAN-08-2334
Published: 01 April 2009
View article titled, Programmed Cell Death Protein 4 Down-regulates Y-Box Binding Protein-1 Expression via a Direct Interaction with Twist1 to Suppress Cancer Cell Growth
Open the PDF for Programmed Cell Death Protein 4 Down-regulates Y-Box Binding Protein-1 Expression via a Direct Interaction with Twist1 to Suppress Cancer Cell Growth in another window
Journal Articles

Twist Promotes Tumor Cell Growth through YB-1 Expression

Masaki Shiota, Hiroto Izumi, Takamitsu Onitsuka, Naoya Miyamoto, Eiji Kashiwagi, Akihiko Kidani, Akira Yokomizo, Seiji Naito, Kimitoshi Kohno
Journal: Cancer Research
Cancer Res (2008) 68 (1): 98–105.
https://doi.org/10.1158/0008-5472.CAN-07-2981
Published: 02 January 2008
View article titled, Twist Promotes Tumor Cell Growth through YB-1 Expression
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Journal Articles

The expression of polypeptide GalNAc N-acetylgalactosaminyl transferase-3 in thyroid carcinoma

Yasuhiro Mochizuki, Ken-Ichi Ito, Kazuma Maeno, Minoru Fujimori, Hiroto Izumi, Kimitoshi Kohno
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 436.
Published: 15 April 2006
View article titled, The expression of polypeptide GalNAc <em>N</em>-acetylgalactosaminyl transferase-3 in thyroid carcinoma
Journal Articles

ZNF143 activates gene expression in response to DNA damage, and binds to cisplatin-modified DNA

Tetsuro Wakasugi, Hiroto Izumi, Takeshi Yoshida, Tomonori Igarashi, Ichiro Niina, Takuya Imaizumi, Yasutomo Momii, Kimitoshi Kohno
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 349.
Published: 01 May 2005
View article titled, ZNF143 activates gene expression in response to DNA damage, and binds to cisplatin-modified DNA
Journal Articles

DNA topoisomerase II poison TAS-103 transactivates GC-box-dependent transcription via acetylation of Sp1

Takeshi Yoshida, Hiroto Izumi, Takayuki Torigoe, Tetsuro Wakasugi, Ichiro Niina, Tomonori Igarashi, Takuya Imaizumi, Yasutomo Momii, Kimitoshi Kohno
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 1174.
Published: 01 May 2005
View article titled, DNA topoisomerase II poison TAS-103 transactivates GC-box-dependent transcription via acetylation of Sp1
Journal Articles

Increased nuclear localization of transcription factor YB-1 accompanied by upregulation of P-glycoprotein in breast cancer pretreated with paclitaxel

Tomoyuki Fujita, Ken-Ichi Ito, Hiroto Izumi, Kazuma Maeno, Yoshihisa Hama, Kiyoshi Shingu, Morihiko Kimura, Muneaki Sano, Hiroshi Nakagomi, Shin-Ichi Tsuchiya, Minoru Fujimori, Kimitoshi Kohno, Jun Amano
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 124.
Published: 01 May 2005
View article titled, Increased nuclear localization of transcription factor YB-1 accompanied by upregulation of P-glycoprotein in breast cancer pretreated with paclitaxel
Journal Articles

Activating Transcription Factor 4 Increases the Cisplatin Resistance of Human Cancer Cell Lines

Mizuho Tanabe, Hiroto Izumi, Tomoko Ise, Shun Higuchi, Takao Yamori, Kosei Yasumoto, Kimitoshi Kohno
Journal: Cancer Research
Cancer Res (2003) 63 (24): 8592–8595.
Published: 24 December 2003
View article titled, Activating Transcription Factor 4 Increases the Cisplatin Resistance of Human Cancer Cell Lines
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Journal Articles

p53 Physically Interacts with Mitochondrial Transcription Factor A and Differentially Regulates Binding to Damaged DNA

Yoichiro Yoshida, Hiroto Izumi, Takayuki Torigoe, Hiroshi Ishiguchi, Hideaki Itoh, Dongchon Kang, Kimitoshi Kohno
Journal: Cancer Research
Cancer Res (2003) 63 (13): 3729–3734.
Published: 01 July 2003
View article titled, p53 Physically Interacts with Mitochondrial Transcription Factor A and Differentially Regulates Binding to Damaged DNA
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Journal Articles

Transcriptional Activation of the Human HMG1 Gene in Cisplatin-resistant Human Cancer Cells

Gunji Nagatani, Minoru Nomoto, Hiroshi Takano, Tomoko Ise, Ken Kato, Toshihiro Imamura, Hiroto Izumi, Kazumi Makishima, Kimitoshi Kohno
Journal: Cancer Research
Cancer Res (2001) 61 (4): 1592–1597.
Published: 02 February 2001
View article titled, Transcriptional Activation of the Human HMG1 Gene in Cisplatin-resistant Human Cancer Cells
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Journal Articles

Structural Basis for the Regulation of UDP-N-Acetyl-α-d-galactosamine: Polypeptide N-Acetylgalactosaminyl Transferase-3 Gene Expression in Adenocarcinoma Cells1

Minoru Nomoto, Hiroto Izumi, Tomoko Ise, Ken Kato, Hiroshi Takano, Gunji Nagatani, Kazunori Shibao, Ryo Ohta, Toshihiro Imamura, Michihiko Kuwano, Ken-ichi Matsuo, Yuji Yamada, Hideaki Itoh, Kimitoshi Kohno
Journal: Cancer Research
Cancer Res (1999) 59 (24): 6214–6222.
Published: 15 December 1999
View article titled, Structural Basis for the Regulation of UDP-<em>N</em>-Acetyl-α-<sc>d</sc>-galactosamine: Polypeptide <em>N</em>-Acetylgalactosaminyl Transferase-3 Gene Expression in Adenocarcinoma Cells1
Open the PDF for Structural Basis for the Regulation of UDP-<em>N</em>-Acetyl-α-<sc>d</sc>-galactosamine: Polypeptide <em>N</em>-Acetylgalactosaminyl Transferase-3 Gene Expression in Adenocarcinoma Cells1 in another window
Journal Articles

Transcription Factor Y-Box Binding Protein 1 Binds Preferentially to Cisplatin-modified DNA and Interacts with Proliferating Cell Nuclear Antigen

Tomoko Ise, Gunji Nagatani, Toshihiro Imamura, Ken Kato, Hiroshi Takano, Minoru Nomoto, Hiroto Izumi, Haruki Ohmori, Tatsuro Okamoto, Takefumi Ohga, Takeshi Uchiumi, Michihiko Kuwano, Kimitoshi Kohno
Journal: Cancer Research
Cancer Res (1999) 59 (2): 342–346.
Published: 15 January 1999
View article titled, Transcription Factor Y-Box Binding Protein 1 Binds Preferentially to Cisplatin-modified DNA and Interacts with Proliferating Cell Nuclear Antigen
Open the PDF for Transcription Factor Y-Box Binding Protein 1 Binds Preferentially to Cisplatin-modified DNA and Interacts with Proliferating Cell Nuclear Antigen in another window