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Journal Articles

Abstract 1046: Statin inhibits malignant mesothelioma cell growth by inactivating YAP1

Kosuke Tanaka, Taketo Kato, Akihiro Matsushita, Hiromi Furuta, Yuko Murakami, Hirotaka Osada, Yoshitaka Sekido
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 1046.
https://doi.org/10.1158/1538-7445.AM2016-1046
Published: 15 July 2016
View articletitled, Abstract 1046: Statin inhibits malignant mesothelioma cell growth by inactivating YAP1
Journal Articles

Abstract 441: Functional characterization of recurrent CD74‐NRG1 fusions in lung adenocarcinoma

Dennis Plenker, Lynnette Fernandez-Cuesta, Hirotaka Osada, Ruping Sun, Marc Bos, Juliane Daßler, Gavin Wright, Elisabeth Brambilla, Reinhard Büttner, Sascha Ansen, Stefan Haas, Yasushi Yatabe, Roman K. Thomas
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 441.
https://doi.org/10.1158/1538-7445.AM2014-441
Published: 01 October 2014
View articletitled, Abstract 441: Functional characterization of recurrent CD74‐NRG1 fusions in lung adenocarcinoma
Journal Articles

Abstract 4313: A LIM protein ajuba suppresses malignant mesothelioma cell proliferation via Hippo signaling cascade.

Ichidai Tanaka, Hirotaka Osada, Makiko Fujii, Yoshitaka Sekido
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4313.
https://doi.org/10.1158/1538-7445.AM2013-4313
Published: 15 April 2013
View articletitled, Abstract 4313: A LIM protein ajuba suppresses malignant mesothelioma cell proliferation via Hippo signaling cascade.
Journal Articles

Abstract 3082: TGF-β synergistically stimulates malignant mesothelioma growth with defects in the Hippo pathway by inducing CTGF expression

Makiko Fujii, Takeshi Toyoda, Hayao Nakanishi, Yasushi Yatabe, Ayuko Sato, Yasue Matsudaira, Hidemi Ito, Hideki Murakami, Yutaka Kondo, Eisaku Kondo, Tohru Tsujimura, Toyoaki Hida, Hirotaka Osada, Yoshitaka Sekido
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 3082.
https://doi.org/10.1158/1538-7445.AM2012-3082
Published: 15 April 2012
View articletitled, Abstract 3082: TGF-β synergistically stimulates malignant mesothelioma growth with defects in the Hippo pathway by inducing CTGF expression
Journal Articles

Abstract LB-17: NKX2-1/TITF1/TTF-1-induced ROR1 is required to sustain EGFR survival signaling in lung adenocarcinoma

Tomoya Yamaguchi, Kiyoshi Yanagisawa, Ryoji Sugiyama, Yasuyuki Hosono, Yukako Shimada, Chinatsu Arima, Seiichi Kato, Shuta Tomida, Motoshi Suzuki, Hirotaka Osada, Takashi Takahashi
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): LB-17.
https://doi.org/10.1158/1538-7445.AM2012-LB-17
Published: 15 April 2012
View articletitled, Abstract LB-17: NKX2-1/TITF1/TTF-1-induced ROR1 is required to sustain EGFR survival signaling in lung adenocarcinoma
Journal Articles

Abstract 3135: Epigenetic regulation of miR-1275 through histone H3 lysine 27 trimethylation during human glioma stem-like cell differentiation

Keisuke Katsushima, Keiko Shinjo, Fumiharu Ohka, Makiko Fujii, Hirotaka Osada, Yoshitaka Sekido, Atsushi Natsume, Yutaka Kondo
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 3135.
https://doi.org/10.1158/1538-7445.AM2012-3135
Published: 15 April 2012
View articletitled, Abstract 3135: Epigenetic regulation of miR-1275 through histone H3 lysine 27 trimethylation during human glioma stem-like cell differentiation
Journal Articles

Abstract 5003: Integrated analysis of genetic and epigenetic alterations reveals CpG island methylator phenotype associated with distinct clinical characters of lung adenocarcinoma

Keiko Shinjo, Yasuyuki Okamoto, Ichiro Takeuchi, Makiko Fujii, Hirotaka Osada, Noriyasu Usami, Hidemi Ito, Toyoaki Hida, Yoshitaka Sekido, Yutaka Kondo
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 5003.
https://doi.org/10.1158/1538-7445.AM2012-5003
Published: 15 April 2012
View articletitled, Abstract 5003: Integrated analysis of genetic and epigenetic alterations reveals CpG island methylator phenotype associated with distinct clinical characters of lung adenocarcinoma
Journal Articles

miR-375 Is Activated by ASH1 and Inhibits YAP1 in a Lineage-Dependent Manner in Lung Cancer

Eri Nishikawa, Hirotaka Osada, Yasumasa Okazaki, Chinatsu Arima, Shuta Tomida, Yoshio Tatematsu, Ayumu Taguchi, Yukako Shimada, Kiyoshi Yanagisawa, Yasushi Yatabe, Shinya Toyokuni, Yoshitaka Sekido, Takashi Takahashi
Journal: Cancer Research
Cancer Res (2011) 71 (19): 6165–6173.
https://doi.org/10.1158/0008-5472.CAN-11-1020
Published: 29 September 2011
View articletitled, miR-375 Is Activated by ASH1 and Inhibits YAP1 in a Lineage-Dependent Manner in Lung Cancer
Open the PDF for miR-375 Is Activated by ASH1 and Inhibits YAP1 in a Lineage-Dependent Manner in Lung Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 4811: Analysis of epigenetic alterations in mice with humanized liver after hepatitis virus infection

Yasuyuki Okamoto, Keiko Shinjo, Yasuhito Tanaka, Makiko Fujii, Hideki Murakami, Hirotaka Osada, Hiromi Kataoka, Takashi Joh, Yoshitaka Sekido, Yutaka Kondo
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 4811.
https://doi.org/10.1158/1538-7445.AM2011-4811
Published: 15 April 2011
View articletitled, Abstract 4811: Analysis of epigenetic alterations in mice with humanized liver after hepatitis virus infection
Journal Articles

Abstract 61: Integrated analysis of genetic and epigenetic alterations reveals CpG island methylator phenotype associated with clinical outcome of lung adenocarcinoma

Keiko Shinjo, Yutaka Kondo, Yasuyuki Okamoto, Toshihiko Yokoyama, Noriyasu Usami, Makiko Fujii, Hideki Murakami, Hirotaka Osada, Yoshitaka Sekido
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 61.
https://doi.org/10.1158/1538-7445.AM2011-61
Published: 15 April 2011
View articletitled, Abstract 61: Integrated analysis of genetic and epigenetic alterations reveals CpG island methylator phenotype associated with clinical outcome of lung adenocarcinoma
Journal Articles

Abstract 718: Acquired epithelial-mesenchymal transition like feature in an EGFR-mutant lung cancer cell line with acquired resistance to erlotinib

Kenichi Suda, Kenji Tomizawa, Hirotaka Osada, Yoshitaka Sekido, Yasushi Yatabe, Tetsuya Mitsudomi
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 718.
https://doi.org/10.1158/1538-7445.AM2011-718
Published: 15 April 2011
View articletitled, Abstract 718: Acquired epithelial-mesenchymal transition like feature in an EGFR-mutant lung cancer cell line with acquired resistance to erlotinib
Journal Articles

LATS2 Is a Tumor Suppressor Gene of Malignant Mesothelioma

Hideki Murakami, Tetsuya Mizuno, Tetsuo Taniguchi, Makiko Fujii, Futoshi Ishiguro, Takayuki Fukui, Shinya Akatsuka, Yoshitsugu Horio, Toyoaki Hida, Yutaka Kondo, Shinya Toyokuni, Hirotaka Osada, Yoshitaka Sekido
Journal: Cancer Research
Cancer Res (2011) 71 (3): 873–883.
https://doi.org/10.1158/0008-5472.CAN-10-2164
Published: 01 February 2011
View articletitled, LATS2 Is a Tumor Suppressor Gene of Malignant Mesothelioma
Open the PDF for LATS2 Is a Tumor Suppressor Gene of Malignant Mesothelioma in another window
Includes: Supplementary data
Journal Articles

Novel Metastasis-Related Gene CIM Functions in the Regulation of Multiple Cellular Stress–Response Pathways

Kiyoshi Yanagisawa, Hiroyuki Konishi, Chinatsu Arima, Shuta Tomida, Toshiyuki Takeuchi, Yukako Shimada, Yasushi Yatabe, Tetsuya Mitsudomi, Hirotaka Osada, Takashi Takahashi
Journal: Cancer Research
Cancer Res (2010) 70 (23): 9949–9958.
https://doi.org/10.1158/0008-5472.CAN-10-1055
Published: 06 December 2010
View articletitled, Novel Metastasis-Related Gene CIM Functions in the Regulation of Multiple Cellular Stress–Response Pathways
Open the PDF for Novel Metastasis-Related Gene CIM Functions in the Regulation of Multiple Cellular Stress–Response Pathways in another window
Includes: Supplementary data
Journal Articles

Regulation of DNA Polymerase POLD4 Influences Genomic Instability in Lung Cancer

Qin Miao Huang, Shuta Tomida, Yuji Masuda, Chinatsu Arima, Ke Cao, Taka-aki Kasahara, Hirotaka Osada, Yasushi Yatabe, Tomohiro Akashi, Kenji Kamiya, Takashi Takahashi, Motoshi Suzuki
Journal: Cancer Research
Cancer Res (2010) 70 (21): 8407–8416.
https://doi.org/10.1158/0008-5472.CAN-10-0784
Published: 31 October 2010
View articletitled, Regulation of DNA Polymerase POLD4 Influences Genomic Instability in Lung Cancer
Open the PDF for Regulation of DNA Polymerase POLD4 Influences Genomic Instability in Lung Cancer in another window
Includes: Supplementary data
Journal Articles

Epigenetic Profiles Distinguish Malignant Pleural Mesothelioma from Lung Adenocarcinoma

Yasuhiro Goto, Keiko Shinjo, Yutaka Kondo, Lanlan Shen, Minoru Toyota, Hiromu Suzuki, Wentao Gao, Byonggu An, Makiko Fujii, Hideki Murakami, Hirotaka Osada, Tetsuo Taniguchi, Noriyasu Usami, Masashi Kondo, Yoshinori Hasegawa, Kaoru Shimokata, Keitaro Matsuo, Toyoaki Hida, Nobukazu Fujimoto, Takumi Kishimoto, Jean-Pierre J. Issa, Yoshitaka Sekido
Journal: Cancer Research
Cancer Res (2009) 69 (23): 9073–9082.
https://doi.org/10.1158/0008-5472.CAN-09-1595
Published: 30 November 2009
View articletitled, Epigenetic Profiles Distinguish Malignant Pleural Mesothelioma from Lung Adenocarcinoma
Open the PDF for Epigenetic Profiles Distinguish Malignant Pleural Mesothelioma from Lung Adenocarcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract #5165: Comprehensive methylation analysis reveals characteristic methylation profiling of CpG island methylator phenotype-negative colorectal cancers in distal colon

Yutaka Kondo, Byonggu An, Keiko Shinjo, Yasuyuki Okamoto, Hidenori Yokoyama, Kenji Yamao, Takashi Hirai, Yasushi Yatabe, Makiko Fujii, Hideki Murakami, Hirotaka Osada, Lanlan Shen, Jean-Pierre Issa, Yoshitaka Sekido
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 5165.
Published: 01 May 2009
View articletitled, Abstract #5165: Comprehensive methylation analysis reveals characteristic methylation profiling of CpG island methylator phenotype-negative colorectal cancers in distal colon
Journal Articles

Abstract #5166: Silencing of tumor suppressor genes by DNA methylation affects the prognosis of gastrointestinal stromal tumor (GIST)

yasuyuki okamoto, Yutaka Kondo, Akira Sawaki, Keiko Shinjo, Byonggu An, Hidenori Yokoyama, Makiko Fujii, Hideki Murakami, Hirotaka Osada, Yoshitaka Sekido
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 5166.
Published: 01 May 2009
View articletitled, Abstract #5166: Silencing of tumor suppressor genes by DNA methylation affects the prognosis of gastrointestinal stromal tumor (GIST)
Journal Articles

Abstract #5194: Genomewide analysis of non-small cell lung cancer reveals high frequency of DNA methylation in adenocarcinoma without epidermal growth factor receptor mutation

Keiko Shinjo, Yutaka Kondo, Yasuhiro Goto, Toshihiko Yokoyama, Byonggu An, Yasuyuki Okamoto, Hidenori Yokoyama, Makiko Fujii, Hideki Murakami, Hirotaka Osada, Yoshitaka Sekido
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 5194.
Published: 01 May 2009
View articletitled, Abstract #5194: Genomewide analysis of non-small cell lung cancer reveals high frequency of DNA methylation in adenocarcinoma without epidermal growth factor receptor mutation
Journal Articles

Relationship of Deregulated Signaling Converging onto mTOR with Prognosis and Classification of Lung Adenocarcinoma Shown by Two Independent In silico Analyses

Hiromichi Ebi, Shuta Tomida, Toshiyuki Takeuchi, Chinatsu Arima, Takahiko Sato, Tetsuya Mitsudomi, Yasushi Yatabe, Hirotaka Osada, Takashi Takahashi
Journal: Cancer Research
Cancer Res (2009) 69 (9): 4027–4035.
https://doi.org/10.1158/0008-5472.CAN-08-3403
Published: 30 April 2009
View articletitled, Relationship of Deregulated Signaling Converging onto mTOR with Prognosis and Classification of Lung Adenocarcinoma Shown by Two Independent In silico Analyses
Open the PDF for Relationship of Deregulated Signaling Converging onto mTOR with Prognosis and Classification of Lung Adenocarcinoma Shown by Two Independent In silico Analyses in another window
Includes: Supplementary data
Journal Articles

Roles of ASH1 in DKK1 and E-cadherin repression and neuroendocrine differentiation in lung cancer

Hirotaka Osada, Shuta Tomida, Yasushi Yatabe, Yoshio Tatematsu, Toshiyuki Takeuchi, Hideki Murakami, Yutaka Kondo, Yoshitaka Sekido, Takashi Takahashi
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 3459.
Published: 01 May 2008
View articletitled, Roles of ASH1 in DKK1 and E-cadherin repression and neuroendocrine differentiation in lung cancer