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Hiroshi Sato
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Journal Articles

Suppressing TGFβ Signaling in Regenerating Epithelia in an Inflammatory Microenvironment Is Sufficient to Cause Invasive Intestinal Cancer

Hiroko Oshima, Mizuho Nakayama, Tae-Su Han, Kuniko Naoi, Xiaoli Ju, Yusuke Maeda, Sylvie Robine, Kiichiro Tsuchiya, Toshiro Sato, Hiroshi Sato, Makoto Mark Taketo, Masanobu Oshima
Journal: Cancer Research
Series: Author Choice
Cancer Res (2015) 75 (4): 766–776.
https://doi.org/10.1158/0008-5472.CAN-14-2036
Published: 15 February 2015
View article titled, Suppressing TGFβ Signaling in Regenerating Epithelia in an Inflammatory Microenvironment Is Sufficient to Cause Invasive Intestinal Cancer
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Includes: Supplementary data
Journal Articles

Activation of Matrix Metalloproteinase-2 (MMP-2) by Membrane Type 1 Matrix Metalloproteinase through an Artificial Receptor for ProMMP-2 Generates Active MMP-2

Yuki Nishida, Hisashi Miyamori, Erik W. Thompson, Takahisa Takino, Yoshio Endo, Hiroshi Sato
Journal: Cancer Research
Cancer Res (2008) 68 (21): 9096–9104.
https://doi.org/10.1158/0008-5472.CAN-08-2522
Published: 30 October 2008
View article titled, Activation of Matrix Metalloproteinase-2 (MMP-2) by Membrane Type 1 Matrix Metalloproteinase through an Artificial Receptor for ProMMP-2 Generates Active MMP-2
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Journal Articles

Inhibition of Membrane-Type 1 Matrix Metalloproteinase at Cell-Matrix Adhesions

Takahisa Takino, Hiromi Saeki, Hisashi Miyamori, Tomoya Kudo, Hiroshi Sato
Journal: Cancer Research
Cancer Res (2007) 67 (24): 11621–11629.
https://doi.org/10.1158/0008-5472.CAN-07-5251
Published: 18 December 2007
View article titled, Inhibition of Membrane-Type 1 Matrix Metalloproteinase at Cell-Matrix Adhesions
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Journal Articles

Cleavage of Lumican by Membrane-Type Matrix Metalloproteinase-1 Abrogates This Proteoglycan-Mediated Suppression of Tumor Cell Colony Formation in Soft Agar

Yingyi Li, Takanori Aoki, Yuya Mori, Munirah Ahmad, Hisashi Miyamori, Takahisa Takino, Hiroshi Sato
Journal: Cancer Research
Cancer Res (2004) 64 (19): 7058–7064.
https://doi.org/10.1158/0008-5472.CAN-04-1038
Published: 01 October 2004
View article titled, Cleavage of Lumican by Membrane-Type Matrix Metalloproteinase-1 Abrogates This Proteoglycan-Mediated Suppression of Tumor Cell Colony Formation in Soft Agar
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Journal Articles

The Phosphorylation of EphB2 Receptor Regulates Migration and Invasion of Human Glioma Cells

Mitsutoshi Nakada, Jared A. Niska, Hisashi Miyamori, Wendy S. McDonough, Jie Wu, Hiroshi Sato, Michael E. Berens
Journal: Cancer Research
Cancer Res (2004) 64 (9): 3179–3185.
https://doi.org/10.1158/0008-5472.CAN-03-3667
Published: 03 May 2004
View article titled, The Phosphorylation of EphB2 Receptor Regulates Migration and Invasion of Human Glioma Cells
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Journal Articles

Membrane Type 1 Matrix Metalloproteinase Regulates Collagen-Dependent Mitogen-Activated Protein/Extracellular Signal-Related Kinase Activation and Cell Migration

Takahisa Takino, Hisashi Miyamori, Yumi Watanabe, Katsuji Yoshioka, Motoharu Seiki, Hiroshi Sato
Journal: Cancer Research
Cancer Res (2004) 64 (3): 1044–1049.
https://doi.org/10.1158/0008-5472.CAN-03-1843
Published: 10 February 2004
View article titled, Membrane Type 1 Matrix Metalloproteinase Regulates Collagen-Dependent Mitogen-Activated Protein/Extracellular Signal-Related Kinase Activation and Cell Migration
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Journal Articles

Testican 2 Abrogates Inhibition of Membrane-type Matrix Metalloproteinases by Other Testican Family Proteins

Mitsutoshi Nakada, Hisashi Miyamori, Junkoh Yamashita, Hiroshi Sato
Journal: Cancer Research
Cancer Res (2003) 63 (12): 3364–3369.
Published: 15 June 2003
View article titled, Testican 2 Abrogates Inhibition of Membrane-type Matrix Metalloproteinases by Other Testican Family Proteins
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Journal Articles

CrkI Adapter Protein Modulates Cell Migration and Invasion in Glioblastoma

Takahisa Takino, Mitsutoshi Nakada, Hisashi Miyamori, Junkoh Yamashita, Kenneth M. Yamada, Hiroshi Sato
Journal: Cancer Research
Cancer Res (2003) 63 (9): 2335–2337.
Published: 01 May 2003
View article titled, CrkI Adapter Protein Modulates Cell Migration and Invasion in Glioblastoma
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Journal Articles

Suppression of Membrane-type 1 Matrix Metalloproteinase (MMP)-mediated MMP-2 Activation and Tumor Invasion by Testican 3 and Its Splicing Variant Gene Product, N-Tes

Mitsutoshi Nakada, Akio Yamada, Takahisa Takino, Hisashi Miyamori, Tomoya Takahashi, Junkoh Yamashita, Hiroshi Sato
Journal: Cancer Research
Cancer Res (2001) 61 (24): 8896–8902.
Published: 01 December 2001
View article titled, Suppression of Membrane-type 1 Matrix Metalloproteinase (MMP)-mediated MMP-2 Activation and Tumor Invasion by Testican 3 and Its Splicing Variant Gene Product, N-Tes
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Journal Articles

Expression of Dominant-negative Form of Ets-1 Suppresses Fibronectin-stimulated Cell Adhesion and Migration Through Down-Regulation of Integrin α5 Expression in U251 Glioma Cell Line

Daisuke Kita, Takahisa Takino, Mitsutoshi Nakada, Tomoya Takahashi, Junkoh Yamashita, Hiroshi Sato
Journal: Cancer Research
Cancer Res (2001) 61 (21): 7985–7991.
Published: 01 November 2001
View article titled, Expression of Dominant-negative Form of Ets-1 Suppresses Fibronectin-stimulated Cell Adhesion and Migration Through Down-Regulation of Integrin α5 Expression in U251 Glioma Cell Line
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Journal Articles

Overexpression of Membrane-type Matrix Metalloproteinase-1 Gene Induces Mammary Gland Abnormalities and Adenocarcinoma in Transgenic Mice

Hye-Yeong Ha, Hyung-Bae Moon, Myoung-Soo Nam, Jeong-Woong Lee, Zae-Yoong Ryoo, Tae-Hoon Lee, Kyung-Kwang Lee, Byung-Jan So, Hiroshi Sato, Motoharu Seiki, Dae-Yeul Yu
Journal: Cancer Research
Cancer Res (2001) 61 (3): 984–990.
Published: 02 February 2001
View article titled, Overexpression of <em>Membrane-type</em> <em>Matrix Metalloproteinase-1</em> Gene Induces Mammary Gland Abnormalities and Adenocarcinoma in Transgenic Mice
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Journal Articles

Aspirin Inhibits Tumor Cell Invasiveness Induced by Epstein-Barr Virus Latent Membrane Protein 1 through Suppression of Matrix Metalloproteinase-9 Expression

Shigeyuki Murono, Tomokazu Yoshizaki, Hiroshi Sato, Hajime Takeshita, Mitsuru Furukawa, Joseph S. Pagano
Journal: Cancer Research
Cancer Res (2000) 60 (9): 2555–2561.
Published: 01 May 2000
View article titled, Aspirin Inhibits Tumor Cell Invasiveness Induced by Epstein-Barr Virus Latent Membrane Protein 1 through Suppression of Matrix Metalloproteinase-9 Expression
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Journal Articles

Enhanced Production and Activation of Progelatinase A Mediated by Membrane-Type 1 Matrix Metalloproteinase in Human Papillary Thyroid Carcinomas

Hiroyuki Nakamura, Hirohisa Ueno, Kaname Yamashita, Taketoshi Shimada, Etsuhide Yamamoto, Masakuni Noguchi, Noboru Fujimoto, Hiroshi Sato, Motoharu Seiki, Yasunori Okada
Journal: Cancer Research
Cancer Res (1999) 59 (2): 467–473.
Published: 15 January 1999
View article titled, Enhanced Production and Activation of Progelatinase A Mediated by Membrane-Type 1 Matrix Metalloproteinase in Human Papillary Thyroid Carcinomas
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Journal Articles

Transformation of Epithelial Madin-Darby Canine Kidney Cells with p60v-src Induces Expression of Membrane-Type 1 Matrix Metalloproteinase and Invasiveness

Yoshifumi Kadono, Yasunori Okada, Mikio Namiki, Motoharu Seiki, Hiroshi Sato
Journal: Cancer Research
Cancer Res (1998) 58 (10): 2240–2244.
Published: 01 May 1998
View article titled, Transformation of Epithelial Madin-Darby Canine Kidney Cells with p60<sup>v-<em>src</em></sup> Induces Expression of Membrane-Type 1 Matrix Metalloproteinase and Invasiveness
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Journal Articles

Tyrosine Phosphorylation Mediates ConA-induced Membrane Type 1-Matrix Metalloproteinase Expression and Matrix Metalloproteinase-2 Activation in MDA-MB-231 Human Breast Carcinoma Cells

Ming Yu, Emma T. Bowden, Jay Sitlani, Hiroshi Sato, Motoharu Seiki, Susette C. Mueller, Erik W. Thompson
Journal: Cancer Research
Cancer Res (1997) 57 (22): 5028–5032.
Published: 01 November 1997
View article titled, Tyrosine Phosphorylation Mediates ConA-induced Membrane Type 1-Matrix Metalloproteinase Expression and Matrix Metalloproteinase-2 Activation in MDA-MB-231 Human Breast Carcinoma Cells
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Journal Articles

Expression and Tissue Localization of Membrane-Types 1, 2, and 3 Matrix Metalloproteinases in Human Invasive Breast Carcinomas

Hirohisa Ueno, Hiroyuki Nakamura, Masaki Inoue, Kazushi Imai, Masakuni Noguchi, Hiroshi Sato, Motoharu Seiki, Yasunori Okada
Journal: Cancer Research
Cancer Res (1997) 57 (10): 2055–2060.
Published: 01 May 1997
View article titled, Expression and Tissue Localization of Membrane-Types 1, 2, and 3 Matrix Metalloproteinases in Human Invasive Breast Carcinomas
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Journal Articles

Expression of Membrane-type Matrix Metalloproteinase 1 (MT1-MMP) in Tumor Cells Enhances Pulmonary Metastasis in an Experimental Metastasis Assay

Yoshio Tsunezuka, Hiroaki Kinoh, Takahisa Takino, Yoh Watanabe, Yasunori Okada, Akira Shinagawa, Hiroshi Sato, Motoharu Seiki
Journal: Cancer Research
Cancer Res (1996) 56 (24): 5678–5683.
Published: 01 December 1996
View article titled, Expression of Membrane-type Matrix Metalloproteinase 1 (MT1-MMP) in Tumor Cells Enhances Pulmonary Metastasis in an Experimental Metastasis Assay
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Journal Articles

Processing of a Precursor of 72-Kilodalton Type IV Collagenase/Gelatinase A by a Recombinant Membrane-Type 1 Matrix Metalloproteinase

Takeshi Kinoshita, Hiroshi Sato, Takahisa Takino, Michiyasu Itoh, Toshifumi Akizawa, Motoharu Seiki
Journal: Cancer Research
Cancer Res (1996) 56 (11): 2535–2538.
Published: 01 June 1996
View article titled, Processing of a Precursor of 72-Kilodalton Type IV Collagenase/Gelatinase A by a Recombinant Membrane-Type 1 Matrix Metalloproteinase
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Journal Articles

Membrane-Type Matrix Metalloproteinase 1 Is a Gelatinolytic Enzyme and Is Secreted in a Complex with Tissue Inhibitor of Metalloproteinases 2

Kazushi Imai, Eiko Ohuchi, Takanori Aoki, Hidehiro Nomura, Yutaka Fujii, Hiroshi Sato, Motoharu Seiki, Yasunori Okada
Journal: Cancer Research
Cancer Res (1996) 56 (12): 2707–2710.
Published: 01 June 1996
View article titled, Membrane-Type Matrix Metalloproteinase 1 Is a Gelatinolytic Enzyme and Is Secreted in a Complex with Tissue Inhibitor of Metalloproteinases 2
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Journal Articles

Anti-Invasive Activity of Ursolic Acid Correlates with the Reduced Expression of Matrix Metalloproteinase-9 (MMP-9) in HT1080 Human Fibrosarcoma Cells

Hee-Jae Cha, Soo-Kyung Bae, Ho-Young Lee, Ok-Hee Lee, Hiroshi Sato, Motoharu Seiki, Byung Chae Park, Kyu-Won Kim
Journal: Cancer Research
Cancer Res (1996) 56 (10): 2281–2284.
Published: 01 May 1996
View article titled, Anti-Invasive Activity of Ursolic Acid Correlates with the Reduced Expression of Matrix Metalloproteinase-9 (MMP-9) in HT1080 Human Fibrosarcoma Cells
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