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Hiroshi Nakagawa
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Journal Articles

Abstract 3082: Leveraging 3D organoids to identify molecular changes underlying HNSC initiation and development

Robert Agee, Samuel Flashner, Masataka Shimonosono, Andres Klein-Szanto, Hiroshi Nakagawa
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3082.
https://doi.org/10.1158/1538-7445.AM2022-3082
Published: 15 June 2022
View article titled, Abstract 3082: Leveraging 3D organoids to identify molecular changes underlying HNSC initiation and development
Journal Articles

Abstract 3077: Leveraging a 3D organoid library to identify novel therapeutic targets during ESCC initiation and progression

Samuel Flashner, Masataka Shimonosono, Satoshi Takada, Norihiro Matsuura, Yasuto Tomita, Xiao Chen, Alison Taylor, Andres Klein-Szanto, Fatameh Momen-Heravi, J. Alan Diehl, Chao Lu, Hiroshi Nakagawa
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3077.
https://doi.org/10.1158/1538-7445.AM2022-3077
Published: 15 June 2022
View article titled, Abstract 3077: Leveraging a 3D organoid library to identify novel therapeutic targets during ESCC initiation and progression
Journal Articles

Abstract 2329: Variable HPV E6 levels among oropharyngeal cancers govern therapy response via the PGC1/ERR axis

Malay K. Sannigrahi, Pavithra Rajagopalan, Ling Lai, Xinyi Liu, Varun Sahu, Hiroshi Nakagawa, Robert Brody, Iain M. Morgan, Bradford E. Windle, Xiaowei Wang, Phyllis A. Gimotty, Daniel P. Kelly, Elizabeth A. White, Devraj Basu
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2329.
https://doi.org/10.1158/1538-7445.AM2022-2329
Published: 15 June 2022
View article titled, Abstract 2329: Variable HPV E6 levels among oropharyngeal cancers govern therapy response via the PGC1/ERR axis
Journal Articles

Abstract 501: Aldh2 mutation promotes oral and esophageal cancer stem cells via autophagy-mediated redox homeostasis

Masataka Shimonosono, Takashi Kijima, Hisatsugu Maekawa, Satoshi Takada, Koji Tanaka, Varun Sahu, Manti Guha, Andres J. Klein-Szanto, J. Alan Diehl, Adam J. Bass, Anil K. Rustgi, Elizabeth Philipone, Angela J. Yoon, Hiroshi Nakagawa
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 501.
https://doi.org/10.1158/1538-7445.AM2020-501
Published: 15 August 2020
View article titled, Abstract 501: Aldh2 mutation promotes oral and esophageal cancer stem cells via autophagy-mediated redox homeostasis
Journal Articles

Abstract 5061: ALDH2 restricts esophageal stem/progenitor cell expansion via autophagy under alcohol-induced mitochondrial stress

Prasanna Modayur Chandramouleeswaran, Kelly A. Whelan, Noah Engel, Jason Correnti, Koji Tanaka, Satish Srinivasan, Manti Guha, Rotonya Carr, Andres J. Klein-Szanto, Balaraman Kalyanaraman, Che-hong Chen, Daria Mochly-Rosen, Narayan G. Avadhani, Hiroshi Nakagawa
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5061.
https://doi.org/10.1158/1538-7445.AM2018-5061
Published: 01 July 2018
View article titled, Abstract 5061: ALDH2 restricts esophageal stem/progenitor cell expansion via autophagy under alcohol-induced mitochondrial stress
Journal Articles

Abstract 5026: Alcohol enriches therapy-resistant cancer cells with high autophagy, CD44 expression and tumor initiating capability

Koji Tanaka, Takashi Kijima, Prasanna Modayur Chandramouleeswaran, Kelly A Whelan, Yuta Kasagi, Masataka Shimonosono, Haruna Furukawa, Takeo Hara, Tomoki Makino, Makoto Yamasaki, Andres J Klein-Szanto, Shoji Natsugoe, Masaki Mori, Yuichiro Doki, Hiroshi Nakagawa
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5026.
https://doi.org/10.1158/1538-7445.AM2018-5026
Published: 01 July 2018
View article titled, Abstract 5026: Alcohol enriches therapy-resistant cancer cells with high autophagy, CD44 expression and tumor initiating capability
Journal Articles

Abstract 1491: Mitochondrial dysfunction from defective Cytochrome oxidase complex induces tumorigenic phenotype

Satish Srinivasan, Manti Guha, Gordon Ruthel, Hiroshi Nakagawa, Narayan Avadhani
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1491.
https://doi.org/10.1158/1538-7445.AM2017-1491
Published: 01 July 2017
View article titled, Abstract 1491: Mitochondrial dysfunction from defective Cytochrome oxidase complex induces tumorigenic phenotype
Journal Articles

JARID1B Enables Transit between Distinct States of the Stem-like Cell Population in Oral Cancers

Nicole D. Facompre, Kayla M. Harmeyer, Xavier Sole, Sheheryar Kabraji, Zachary Belden, Varun Sahu, Kelly Whelan, Koji Tanaka, Gregory S. Weinstein, Kathleen T. Montone, Alexander Roesch, Phyllis A. Gimotty, Meenhard Herlyn, Anil K. Rustgi, Hiroshi Nakagawa, Sridhar Ramaswamy, Devraj Basu
Journal: Cancer Research
Cancer Res (2016) 76 (18): 5538–5549.
https://doi.org/10.1158/0008-5472.CAN-15-3377
Published: 15 September 2016
View article titled, JARID1B Enables Transit between Distinct States of the Stem-like Cell Population in Oral Cancers
Open the PDF for JARID1B Enables Transit between Distinct States of the Stem-like Cell Population in Oral Cancers in another window
Includes: Supplementary data
Journal Articles

Abstract 2678: Notch1 regulates epithelial-mesenchymal transition and tumor-initiating capability in esophageal squamous-cell carcinoma

Koji Tanaka, Kelly A. Whelan, Naryan L. Rustgi, Prasanna M. Chandramouleeswaran, Seiji Naganuma, Shingo Kagawa, Mitsuteru Natsuizaka, Yoshiaki Kita, Shoji Natsugoe, Que Jianwen, Devraj Basu, Andres J. Klein-Szanto, Adam Bass, J. Alan Diehl, Hiroshi Nakagawa
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2678.
https://doi.org/10.1158/1538-7445.AM2016-2678
Published: 15 July 2016
View article titled, Abstract 2678: Notch1 regulates epithelial-mesenchymal transition and tumor-initiating capability in esophageal squamous-cell carcinoma
Journal Articles

Abstract 1254: Mitochondrial SOD2 regulates EMT and cancer stem cell-like cell populations

Kelly A. Whelan, Hideaki Kinugasa, Koji Tanaka, Satish Srinivasan, Manti Guha, Daret St. Clair, Andres Klein-Szanto, Narayan Avadhani, Alan Diehl, Anil Rustgi, Hiroshi Nakagawa
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1254.
https://doi.org/10.1158/1538-7445.AM2015-1254
Published: 01 August 2015
View article titled, Abstract 1254: Mitochondrial SOD2 regulates EMT and cancer stem cell-like cell populations
Journal Articles

Abstract 5346: Notch3-mediated squamous cell differentiation shows anti-tumor effect on esophageal squamous cell carcinoma as well as reduces its resistance to 5-Fluorouracil

Osamu Kikuchi, Shinya Ohashi, Yukie Nakai, Yusuke Amanuma, Masahiro Yoshioka, Shin'ichi Miyamoto, Mitsuteru Natsuizaka, Hiroshi Nakagawa, Tsutomu Chiba, Manabu Muto
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 5346.
https://doi.org/10.1158/1538-7445.AM2015-5346
Published: 01 August 2015
View article titled, Abstract 5346: Notch3-mediated squamous cell differentiation shows anti-tumor effect on esophageal squamous cell carcinoma as well as reduces its resistance to 5-Fluorouracil
Journal Articles

Abstract 1517: G0-like cells support an oral cancer stem cell pool by transitioning to a JARID1B-high state

Nicole Facompre, Zachary Belden, Phyllis Gimotty, Anil Rustgi, Meenhard Herlyn, Hiroshi Nakagawa, Devraj Basu
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1517.
https://doi.org/10.1158/1538-7445.AM2015-1517
Published: 01 August 2015
View article titled, Abstract 1517: G0-like cells support an oral cancer stem cell pool by transitioning to a JARID1B-high state
Journal Articles

Abstract A74: TGF-β in tumor microenvironment changes a switch of Notch1-mediated signaling to maintain cancer stem-like cells in esophageal squamous cell carcinoma

Mitsuteru Natsuizaka, Shingo Kagawa, Kelly Whelan, Shinya Ohashi, Shunsuke Ohnishi, Goki Suda, Naoya Sakamoto, Anil K. Rustgi, Hiroshi Nakagawa
Journal: Cancer Research
Cancer Res (2015) 75 (1_Supplement): A74.
https://doi.org/10.1158/1538-7445.CHTME14-A74
Published: 12 January 2015
View article titled, Abstract A74: TGF-β in tumor microenvironment changes a switch of Notch1-mediated signaling to maintain cancer stem-like cells in esophageal squamous cell carcinoma
Journal Articles

Abstract A3: Facilitating epithelial to mesenchymal transition through inhibition of senescence checkpoint functions

Shinya Ohashi, Mitsuteru Natsuizaka, Gabrielle Wong, Katharine D. Grugan, Jiri Kalabis, Anil K. Rustgi, Hiroshi Nakagawa
Journal: Cancer Research
Cancer Res (2009) 69 (23_Supplement): A3.
https://doi.org/10.1158/0008-5472.FBCR09-A3
Published: 28 October 2014
View article titled, Abstract A3: Facilitating epithelial to mesenchymal transition through inhibition of senescence checkpoint functions
Journal Articles

Abstract C29: Periostin, a regulator of adhesion, is a novel effector of tumor invasion

Gabrielle Wong, Carmen Z. Michaylira, Charles G. Miller, Christie M. Gutierrez, Douglas B. Stairs, Jiri Kalabis, Hiroshi Nakagawa, Alan J. Diehl, Meenhard Herlyn, Anil K. Rustgi
Journal: Cancer Research
Cancer Res (2009) 69 (23_Supplement): C29.
https://doi.org/10.1158/0008-5472.FBCR09-C29
Published: 28 October 2014
View article titled, Abstract C29: Periostin, a regulator of adhesion, is a novel effector of tumor invasion
Journal Articles

Abstract 70: Loss of cellular senescence checkpoint functions reveals the oncogene characteristics of Notch1 in squamous cell carcinomas

Shingo Kagawa, Mitsuteru Natsuizaka, Seiji Naganuma, Yoshiaki Kita, Shoji Natsugoe, Sanders Chang, Harry Subramanian, Devraj Basu, Andres J. Klein-Szanto, Meenhard Herlyn, Hiroshi Nakagawa
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 70.
https://doi.org/10.1158/1538-7445.AM2012-70
Published: 15 April 2012
View article titled, Abstract 70: Loss of cellular senescence checkpoint functions reveals the oncogene characteristics of Notch1 in squamous cell carcinomas
Journal Articles

A NOTCH3-Mediated Squamous Cell Differentiation Program Limits Expansion of EMT-Competent Cells That Express the ZEB Transcription Factors

Shinya Ohashi, Mitsuteru Natsuizaka, Seiji Naganuma, Shingo Kagawa, Sotai Kimura, Hiroshi Itoh, Ross A. Kalman, Momo Nakagawa, Douglas S. Darling, Devraj Basu, Phyllis A. Gimotty, Andres J. Klein-Szanto, J. Alan Diehl, Meenhard Herlyn, Hiroshi Nakagawa
Journal: Cancer Research
Cancer Res (2011) 71 (21): 6836–6847.
https://doi.org/10.1158/0008-5472.CAN-11-0846
Published: 30 October 2011
View article titled, A NOTCH3-Mediated Squamous Cell Differentiation Program Limits Expansion of EMT-Competent Cells That Express the ZEB Transcription Factors
Open the PDF for A NOTCH3-Mediated Squamous Cell Differentiation Program Limits Expansion of EMT-Competent Cells That Express the ZEB Transcription Factors in another window
Includes: Supplementary data
Journal Articles

Loss of Transcription Factor KLF5 in the Context of p53 Ablation Drives Invasive Progression of Human Squamous Cell Cancer

Yizeng Yang, Hiroshi Nakagawa, Marie-Pier Tetreault, Janelle Billig, Noel Victor, Abha Goyal, Antonia R. Sepulveda, Jonathan P. Katz
Journal: Cancer Research
Cancer Res (2011) 71 (20): 6475–6484.
https://doi.org/10.1158/0008-5472.CAN-11-1702
Published: 12 October 2011
View article titled, Loss of Transcription Factor <em>KLF5</em> in the Context of p53 Ablation Drives Invasive Progression of Human Squamous Cell Cancer
Open the PDF for Loss of Transcription Factor <em>KLF5</em> in the Context of p53 Ablation Drives Invasive Progression of Human Squamous Cell Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 1059: Altered LKB1/CREB-regulated transcription co-activator (CRTC) signaling axis promotes esophageal cancer cell migration and invasion

Yumei Gu, Shuibin Lin, Jian-Liang Li, Hiroshi Nakagawa, Zirong Chen, Liang Tian, Deniz A. Ucar, Huangxuan Shen, Jianrong Lu, Steven N. Hochwald, Frederic J. Kaye, Lizi Wu
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 1059.
https://doi.org/10.1158/1538-7445.AM2011-1059
Published: 15 April 2011
View article titled, Abstract 1059: Altered LKB1/CREB-regulated transcription co-activator (CRTC) signaling axis promotes esophageal cancer cell migration and invasion
Journal Articles

Abstract 5194: Notch regulates squamous differentiation, cell plasticity and tumor heterogeneity in esophageal carcinoma

Mitsuteru Natsuizaka, Shinya Ohashi, Seiji Naganuma, Ross A. Kalman, Asami Ohyama, Ben Rhoades, Maria E. Vega, Douglas B. Stairs, Andres J. Klein-Szanto, J. Alan Diehl, Devraj Basu, Meenhard Herlyn, Warren S. Pear, Hiroshi Nakagawa
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 5194.
https://doi.org/10.1158/1538-7445.AM2011-5194
Published: 15 April 2011
View article titled, Abstract 5194: Notch regulates squamous differentiation, cell plasticity and tumor heterogeneity in esophageal carcinoma