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Hiroshi Maeda
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Journal Articles

Challenges and Key Considerations of the Enhanced Permeability and Retention Effect for Nanomedicine Drug Delivery in Oncology

Free
Uma Prabhakar, Hiroshi Maeda, Rakesh K. Jain, Eva M. Sevick-Muraca, William Zamboni, Omid C. Farokhzad, Simon T. Barry, Alberto Gabizon, Piotr Grodzinski, David C. Blakey
Journal: Cancer Research
Cancer Res (2013) 73 (8): 2412–2417.
https://doi.org/10.1158/0008-5472.CAN-12-4561
Published: 15 April 2013
View article titled, Challenges and Key Considerations of the Enhanced Permeability and Retention Effect for Nanomedicine Drug Delivery in Oncology
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Includes: Supplementary data
Journal Articles

Identification of Hsp32 as a novel survival factor in solid tumors and hematologic malignancies: Targeting of Hsp32 by styrene maleic acid zinc protoporphyrin     (SMA-ZnPP) counteracts proliferation and viability of neoplastic cells.

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Karoline Gleixner, Matthias Mayerhofer, Anja Vales, Alexander Gruze, Michael Kneidinger, Gregor Hormann, Maria-Theresa Krauth, Rudin Kondo, Karoline Sonneck, Puchit Samorapoompichit, Eva Lackner, Khaled Greish, Winfried Pickl, Christian Sillaber, Christoph Zielinski, Hiroshi Maeda, Peter Valent
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 1526.
Published: 01 May 2007
View article titled, Identification of Hsp32 as a novel survival factor in solid tumors and hematologic malignancies: Targeting of Hsp32 by styrene maleic acid zinc protoporphyrin     (SMA-ZnPP) counteracts proliferation and viability of neoplastic cells.
Journal Articles

SMA-pirarubicin inhibits growth of colorectal cancer liver metastases in an animal model

Free
Jurstine Daruwalla, Khaled Greish, Mehrdad Nikfarjam, Cathy Malcontenti-Wilson, Hiroshi Maeda, Chris Christophi
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 721.
Published: 15 April 2006
View article titled, SMA-pirarubicin inhibits growth of colorectal cancer liver metastases in an animal model
Journal Articles

NGEP, a new gene encoding a membrane protein detected only in prostate and prostate cancer.

Free
Sudipto Das, Tapan Bera, Hiroshi Maeda, Richard Beers, Vasantha Kumar, Byungkook Lee, Ira Pastan
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 797.
Published: 01 April 2004
View article titled, NGEP, a new gene encoding a membrane protein detected only in prostate and prostate cancer.
Journal Articles

TARP, a prostate-specific protein localizing in mitochondria

Free
Hiroshi Maeda, Satoshi Nagata, Curt D. Wolfgang, Tapan K. Bera, Ira Pastan
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 445.
Published: 01 April 2004
View article titled, TARP, a prostate-specific protein localizing in mitochondria
Journal Articles

In Vivo Antitumor Activity of Pegylated Zinc Protoporphyrin: Targeted Inhibition of Heme Oxygenase in Solid Tumor

Free
Jun Fang, Tomohiro Sawa, Takaaki Akaike, Teruo Akuta, Sanjeeb K. Sahoo, Greish Khaled, Akinobu Hamada, Hiroshi Maeda
Journal: Cancer Research
Cancer Res (2003) 63 (13): 3567–3574.
Published: 01 July 2003
View article titled, In Vivo Antitumor Activity of Pegylated Zinc Protoporphyrin: Targeted Inhibition of Heme Oxygenase in Solid Tumor
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Journal Articles

Tumor-targeted Delivery of Polyethylene Glycol-conjugated d-Amino Acid Oxidase for Antitumor Therapy via Enzymatic Generation of Hydrogen Peroxide1

Free
Jun Fang, Tomohiro Sawa, Takaaki Akaike, Hiroshi Maeda
Journal: Cancer Research
Cancer Res (2002) 62 (11): 3138–3143.
Published: 01 June 2002
View article titled, Tumor-targeted Delivery of Polyethylene Glycol-conjugated d-Amino Acid Oxidase for Antitumor Therapy via Enzymatic Generation of Hydrogen Peroxide1
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Journal Articles

Tumor Growth Inhibition by Arsenic Trioxide (As2O3) in the Orthotopic Metastasis Model of Androgen-independent Prostate Cancer

Free
Hiroshi Maeda, Seiji Hori, Hideki Nishitoh, Hidenori Ichijo, Osamu Ogawa, Yoshiyuki Kakehi, Akira Kakizuka
Journal: Cancer Research
Cancer Res (2001) 61 (14): 5432–5440.
Published: 01 July 2001
View article titled, Tumor Growth Inhibition by Arsenic Trioxide (As2O3) in the Orthotopic Metastasis Model of Androgen-independent Prostate Cancer
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Journal Articles

Tumor-targeting Chemotherapy by a Xanthine Oxidase-Polymer Conjugate That Generates Oxygen-free Radicals in Tumor Tissue

Free
Tomohiro Sawa, Jun Wu, Takaaki Akaike, Hiroshi Maeda
Journal: Cancer Research
Cancer Res (2000) 60 (3): 666–671.
Published: 01 February 2000
View article titled, Tumor-targeting Chemotherapy by a Xanthine Oxidase-Polymer Conjugate That Generates Oxygen-free Radicals in Tumor Tissue
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Journal Articles

Modulation of Enhanced Vascular Permeability in Tumors by a Bradykinin Antagonist, a Cyclooxygenase Inhibitor, and a Nitric Oxide Scavenger

Free
Jun Wu, Takaaki Akaike, Hiroshi Maeda
Journal: Cancer Research
Cancer Res (1998) 58 (1): 159–165.
Published: 01 January 1998
View article titled, Modulation of Enhanced Vascular Permeability in Tumors by a Bradykinin Antagonist, a Cyclooxygenase Inhibitor, and a Nitric Oxide Scavenger
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Journal Articles

Changes in Cellular Components of Spleen and Lymph Node Cells and the Effector Cells Responsible for Meth A Tumor Eradication Induced by Zinostatin Stimalamer

Free
Etsuko Masuda, Hiroshi Maeda
Journal: Cancer Research
Cancer Res (1996) 56 (8): 1868–1873.
Published: 01 April 1996
View article titled, Changes in Cellular Components of Spleen and Lymph Node Cells and the Effector Cells Responsible for Meth A Tumor Eradication Induced by Zinostatin Stimalamer
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Journal Articles

Antitumor Effects of SMANCS on Rat Mammary Tumor Induced by 7,12-Dimethylbenz[a]anthracene

Free
Akihiro Kimoto, Toshimitsu Konno, Takanori Kawaguchi, Yoshimasa Miyauchi, Hiroshi Maeda
Journal: Cancer Research
Cancer Res (1992) 52 (4): 1013–1017.
Published: 01 February 1992
View article titled, Antitumor Effects of SMANCS on Rat Mammary Tumor Induced by 7,12-Dimethylbenz[a]anthracene
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Journal Articles

Role of Natural Killer Cells and Macrophages in the Nonspecific Resistance to Tumors in Mice Stimulated with SMANCS, a Polymer-conjugated Derivative of Neocarzinostatin

Free
Fujio Suzuki, Richard B. Pollard, Satomi Uchimura, Tetsuo Munakata, Hiroshi Maeda
Journal: Cancer Research
Cancer Res (1990) 50 (13): 3897–3904.
Published: 01 July 1990
View article titled, Role of Natural Killer Cells and Macrophages in the Nonspecific Resistance to Tumors in Mice Stimulated with SMANCS, a Polymer-conjugated Derivative of Neocarzinostatin
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Journal Articles

Comparison of the Cytotoxic Effects of the High- and Low-Molecular-Weight Anticancer Agents on Multidrug-resistant Chinese Hamster Ovary Cells in Vitro

Free
Yoichi Miyamoto, Tatsuya Oda, Hiroshi Maeda
Journal: Cancer Research
Cancer Res (1990) 50 (5): 1571–1575.
Published: 01 March 1990
View article titled, Comparison of the Cytotoxic Effects of the High- and Low-Molecular-Weight Anticancer Agents on Multidrug-resistant Chinese Hamster Ovary Cells in Vitro
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Journal Articles

Cytotoxicity of Bacterial Proteases in Various Tumor Cells Mediated through α2-Macroglobulin Receptor

Free
Hiroshi Maeda, Akhteruzzaman Molla, Kiyoshi Sakamoto, Akitoshi Murakami, Yasuhiro Matsumura
Journal: Cancer Research
Cancer Res (1989) 49 (3): 660–664.
Published: 01 February 1989
View article titled, Cytotoxicity of Bacterial Proteases in Various Tumor Cells Mediated through α2-Macroglobulin Receptor
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Journal Articles

Binding to and Internalization by Cultured Cells of Neocarzinostatin and Enhancement of Its Actions by Conjugation with Lipophilic Styrene-Maleic Acid Copolymer

Free
Tatsuya Oda, Hiroshi Maeda
Journal: Cancer Research
Cancer Res (1987) 47 (12): 3206–3211.
Published: 01 June 1987
View article titled, Binding to and Internalization by Cultured Cells of Neocarzinostatin and Enhancement of Its Actions by Conjugation with Lipophilic Styrene-Maleic Acid Copolymer
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Journal Articles

Reduction of Hepatic Metastases in Rabbits by Administration of an Oily Anticancer Agent into the Portal Vein

Free
Kenji Yamasaki, Toshimitsu Konno, Yoshimasa Miyauchi, Hiroshi Maeda
Journal: Cancer Research
Cancer Res (1987) 47 (3): 852–855.
Published: 01 February 1987
View article titled, Reduction of Hepatic Metastases in Rabbits by Administration of an Oily Anticancer Agent into the Portal Vein
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Journal Articles

Antitumor Activity of Some Bacterial Proteases: Eradication of Solid Tumors in Mice by Intratumor Injection

Free
Hiroshi Maeda, Yasuhiro Matsumura, Akhteruzzaman Molla
Journal: Cancer Research
Cancer Res (1987) 47 (2): 563–566.
Published: 01 January 1987
View article titled, Antitumor Activity of Some Bacterial Proteases: Eradication of Solid Tumors in Mice by Intratumor Injection
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Journal Articles

A New Concept for Macromolecular Therapeutics in Cancer Chemotherapy: Mechanism of Tumoritropic Accumulation of Proteins and the Antitumor Agent Smancs

Free
Yasuhiro Matsumura, Hiroshi Maeda
Journal: Cancer Research
Cancer Res (1986) 46 (12_Part_1): 6387–6392.
Published: 01 December 1986
View article titled, A New Concept for Macromolecular Therapeutics in Cancer Chemotherapy: Mechanism of Tumoritropic Accumulation of Proteins and the Antitumor Agent Smancs
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Journal Articles

Use of Oily Contrast Medium for Selective Drug Targeting to Tumor: Enhanced Therapeutic Effect and X-Ray Image

Free
Ken Iwai, Hiroshi Maeda, Toshimitsu Konno
Journal: Cancer Research
Cancer Res (1984) 44 (5): 2115–2121.
Published: 01 May 1984
View article titled, Use of Oily Contrast Medium for Selective Drug Targeting to Tumor: Enhanced Therapeutic Effect and X-Ray Image
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