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Journal Articles

Challenges and Key Considerations of the Enhanced Permeability and Retention Effect for Nanomedicine Drug Delivery in Oncology

Uma Prabhakar, Hiroshi Maeda, Rakesh K. Jain, Eva M. Sevick-Muraca, William Zamboni, Omid C. Farokhzad, Simon T. Barry, Alberto Gabizon, Piotr Grodzinski, David C. Blakey

Cancer Res (2013) 73 (8): 2412–2417.

DOI: https://doi.org/10.1158/0008-5472.CAN-12-4561

Published: 15 April 2013

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Includes: Supplementary data

Journal Articles

Identification of Hsp32 as a novel survival factor in solid tumors and hematologic malignancies: Targeting of Hsp32 by styrene maleic acid zinc protoporphyrin (SMA-ZnPP) counteracts proliferation and viability of neoplastic cells.

Karoline Gleixner, Matthias Mayerhofer, Anja Vales, Alexander Gruze, Michael Kneidinger, Gregor Hormann, Maria-Theresa Krauth, Rudin Kondo, Karoline Sonneck, Puchit Samorapoompichit, Eva Lackner, Khaled Greish, Winfried Pickl, Christian Sillaber, Christoph Zielinski, Hiroshi Maeda, Peter Valent

Cancer Res (2007) 67 (9_Supplement): 1526.

Published: 01 May 2007

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Journal Articles

SMA-pirarubicin inhibits growth of colorectal cancer liver metastases in an animal model

Jurstine Daruwalla, Khaled Greish, Mehrdad Nikfarjam, Cathy Malcontenti-Wilson, Hiroshi Maeda, Chris Christophi

Cancer Res (2006) 66 (8_Supplement): 721.

Published: 15 April 2006

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Journal Articles

TARP, a prostate-specific protein localizing in mitochondria

Hiroshi Maeda, Satoshi Nagata, Curt D. Wolfgang, Tapan K. Bera, Ira Pastan

Cancer Res (2004) 64 (7_Supplement): 445.

Published: 01 April 2004

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Journal Articles

NGEP, a new gene encoding a membrane protein detected only in prostate and prostate cancer.

Sudipto Das, Tapan Bera, Hiroshi Maeda, Richard Beers, Vasantha Kumar, Byungkook Lee, Ira Pastan

Cancer Res (2004) 64 (7_Supplement): 797.

Published: 01 April 2004

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Journal Articles

In Vivo Antitumor Activity of Pegylated Zinc Protoporphyrin: Targeted Inhibition of Heme Oxygenase in Solid Tumor

Jun Fang, Tomohiro Sawa, Takaaki Akaike, Teruo Akuta, Sanjeeb K. Sahoo, Greish Khaled, Akinobu Hamada, Hiroshi Maeda

Cancer Res (2003) 63 (13): 3567–3574.

Published: 01 July 2003

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Journal Articles

Tumor-targeted Delivery of Polyethylene Glycol-conjugated d-Amino Acid Oxidase for Antitumor Therapy via Enzymatic Generation of Hydrogen Peroxide1

Jun Fang, Tomohiro Sawa, Takaaki Akaike, Hiroshi Maeda

Cancer Res (2002) 62 (11): 3138–3143.

Published: 01 June 2002

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Journal Articles

Tumor Growth Inhibition by Arsenic Trioxide (As₂O₃) in the Orthotopic Metastasis Model of Androgen-independent Prostate Cancer

Hiroshi Maeda, Seiji Hori, Hideki Nishitoh, Hidenori Ichijo, Osamu Ogawa, Yoshiyuki Kakehi, Akira Kakizuka

Cancer Res (2001) 61 (14): 5432–5440.

Published: 01 July 2001

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Journal Articles

Tumor-targeting Chemotherapy by a Xanthine Oxidase-Polymer Conjugate That Generates Oxygen-free Radicals in Tumor Tissue

Tomohiro Sawa, Jun Wu, Takaaki Akaike, Hiroshi Maeda

Cancer Res (2000) 60 (3): 666–671.

Published: 01 February 2000

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Journal Articles

Modulation of Enhanced Vascular Permeability in Tumors by a Bradykinin Antagonist, a Cyclooxygenase Inhibitor, and a Nitric Oxide Scavenger

Jun Wu, Takaaki Akaike, Hiroshi Maeda

Cancer Res (1998) 58 (1): 159–165.

Published: 01 January 1998

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Journal Articles

Changes in Cellular Components of Spleen and Lymph Node Cells and the Effector Cells Responsible for Meth A Tumor Eradication Induced by Zinostatin Stimalamer

Etsuko Masuda, Hiroshi Maeda

Cancer Res (1996) 56 (8): 1868–1873.

Published: 01 April 1996

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Journal Articles

Antitumor Effects of SMANCS on Rat Mammary Tumor Induced by 7,12-Dimethylbenz[a]anthracene

Akihiro Kimoto, Toshimitsu Konno, Takanori Kawaguchi, Yoshimasa Miyauchi, Hiroshi Maeda

Cancer Res (1992) 52 (4): 1013–1017.

Published: 01 February 1992

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Journal Articles

Role of Natural Killer Cells and Macrophages in the Nonspecific Resistance to Tumors in Mice Stimulated with SMANCS, a Polymer-conjugated Derivative of Neocarzinostatin

Fujio Suzuki, Richard B. Pollard, Satomi Uchimura, Tetsuo Munakata, Hiroshi Maeda

Cancer Res (1990) 50 (13): 3897–3904.

Published: 01 July 1990

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Journal Articles

Comparison of the Cytotoxic Effects of the High- and Low-Molecular-Weight Anticancer Agents on Multidrug-resistant Chinese Hamster Ovary Cells in Vitro

Yoichi Miyamoto, Tatsuya Oda, Hiroshi Maeda

Cancer Res (1990) 50 (5): 1571–1575.

Published: 01 March 1990

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Journal Articles

Cytotoxicity of Bacterial Proteases in Various Tumor Cells Mediated through α₂-Macroglobulin Receptor

Hiroshi Maeda, Akhteruzzaman Molla, Kiyoshi Sakamoto, Akitoshi Murakami, Yasuhiro Matsumura

Cancer Res (1989) 49 (3): 660–664.

Published: 01 February 1989

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Journal Articles

Binding to and Internalization by Cultured Cells of Neocarzinostatin and Enhancement of Its Actions by Conjugation with Lipophilic Styrene-Maleic Acid Copolymer

Tatsuya Oda, Hiroshi Maeda

Cancer Res (1987) 47 (12): 3206–3211.

Published: 01 June 1987

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Journal Articles

Reduction of Hepatic Metastases in Rabbits by Administration of an Oily Anticancer Agent into the Portal Vein

Kenji Yamasaki, Toshimitsu Konno, Yoshimasa Miyauchi, Hiroshi Maeda

Cancer Res (1987) 47 (3): 852–855.

Published: 01 February 1987

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Journal Articles

Antitumor Activity of Some Bacterial Proteases: Eradication of Solid Tumors in Mice by Intratumor Injection

Hiroshi Maeda, Yasuhiro Matsumura, Akhteruzzaman Molla

Cancer Res (1987) 47 (2): 563–566.

Published: 01 January 1987

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Journal Articles

A New Concept for Macromolecular Therapeutics in Cancer Chemotherapy: Mechanism of Tumoritropic Accumulation of Proteins and the Antitumor Agent Smancs

Yasuhiro Matsumura, Hiroshi Maeda

Cancer Res (1986) 46 (12_Part_1): 6387–6392.

Published: 01 December 1986

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Journal Articles

Use of Oily Contrast Medium for Selective Drug Targeting to Tumor: Enhanced Therapeutic Effect and X-Ray Image

Ken Iwai, Hiroshi Maeda, Toshimitsu Konno

Cancer Res (1984) 44 (5): 2115–2121.

Published: 01 May 1984

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NARROW

Challenges and Key Considerations of the Enhanced Permeability and Retention Effect for Nanomedicine Drug Delivery in Oncology

Identification of Hsp32 as a novel survival factor in solid tumors and hematologic malignancies: Targeting of Hsp32 by styrene maleic acid zinc protoporphyrin (SMA-ZnPP) counteracts proliferation and viability of neoplastic cells.

SMA-pirarubicin inhibits growth of colorectal cancer liver metastases in an animal model

TARP, a prostate-specific protein localizing in mitochondria

NGEP, a new gene encoding a membrane protein detected only in prostate and prostate cancer.

In Vivo Antitumor Activity of Pegylated Zinc Protoporphyrin: Targeted Inhibition of Heme Oxygenase in Solid Tumor

Tumor-targeted Delivery of Polyethylene Glycol-conjugated d-Amino Acid Oxidase for Antitumor Therapy via Enzymatic Generation of Hydrogen Peroxide1

Tumor Growth Inhibition by Arsenic Trioxide (As₂O₃) in the Orthotopic Metastasis Model of Androgen-independent Prostate Cancer

Tumor-targeting Chemotherapy by a Xanthine Oxidase-Polymer Conjugate That Generates Oxygen-free Radicals in Tumor Tissue

Modulation of Enhanced Vascular Permeability in Tumors by a Bradykinin Antagonist, a Cyclooxygenase Inhibitor, and a Nitric Oxide Scavenger

Changes in Cellular Components of Spleen and Lymph Node Cells and the Effector Cells Responsible for Meth A Tumor Eradication Induced by Zinostatin Stimalamer

Antitumor Effects of SMANCS on Rat Mammary Tumor Induced by 7,12-Dimethylbenz[a]anthracene

Role of Natural Killer Cells and Macrophages in the Nonspecific Resistance to Tumors in Mice Stimulated with SMANCS, a Polymer-conjugated Derivative of Neocarzinostatin

Comparison of the Cytotoxic Effects of the High- and Low-Molecular-Weight Anticancer Agents on Multidrug-resistant Chinese Hamster Ovary Cells in Vitro

Cytotoxicity of Bacterial Proteases in Various Tumor Cells Mediated through α₂-Macroglobulin Receptor

Binding to and Internalization by Cultured Cells of Neocarzinostatin and Enhancement of Its Actions by Conjugation with Lipophilic Styrene-Maleic Acid Copolymer

Reduction of Hepatic Metastases in Rabbits by Administration of an Oily Anticancer Agent into the Portal Vein

Antitumor Activity of Some Bacterial Proteases: Eradication of Solid Tumors in Mice by Intratumor Injection

A New Concept for Macromolecular Therapeutics in Cancer Chemotherapy: Mechanism of Tumoritropic Accumulation of Proteins and the Antitumor Agent Smancs

Use of Oily Contrast Medium for Selective Drug Targeting to Tumor: Enhanced Therapeutic Effect and X-Ray Image

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