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Journal Articles

Abstract 5980: Cancer therapeutic and prevention strategy targeting mutated mitochondria DNA

Hiroki Nagase

Cancer Res (2024) 84 (6_Supplement): 5980.

https://doi.org/10.1158/1538-7445.AM2024-5980

Published: 22 March 2024

View article titled, Abstract 5980: Cancer therapeutic and prevention strategy targeting mutated mitochondria DNA

Journal Articles

Direct Targeting of MYCN Gene Amplification by Site-Specific DNA Alkylation in Neuroblastoma

Hiroyuki Yoda, Takahiro Inoue, Yoshinao Shinozaki, Jason Lin, Takayoshi Watanabe, Nobuko Koshikawa, Atsushi Takatori, Hiroki Nagase

Cancer Res (2019) 79 (4): 830–840.

https://doi.org/10.1158/0008-5472.CAN-18-1198

Published: 15 February 2019

View article titled, Direct Targeting of MYCN Gene Amplification by Site-Specific DNA Alkylation in Neuroblastoma

Includes: Supplementary data

Journal Articles

Abstract 2711: Development of a new innovative multifunctional immune checkpoint inhibitor

Hiroki Nagase, Keiko Fukushima, Asuka Hattori, Mayu Shinohara, Atsushi Takatori, Takayoshi Watanabe, Nobuko Koshikawa, Takahiro Inoue, Jason Lin, Yoshinao Shinozaki

Cancer Res (2018) 78 (13_Supplement): 2711.

https://doi.org/10.1158/1538-7445.AM2018-2711

Published: 01 July 2018

View article titled, Abstract 2711: Development of a new innovative multifunctional immune checkpoint inhibitor

Journal Articles

Abstract 4879: Genomic and epigenomic profiling of high-stage neuroblastoma

Miki Ohira, Yasutoshi Tatsumi, Yohko Nakamura, Kenji Tatsuno, Shuichi Tsutsumi, Shogo Yamamoto, Genta Nagae, Claire Renard-Guillet, Ryuichi Sugino, Hiroki Nagase, Takehiko Kamijo, Hiroyuki Aburatani, Akira Nakagawara

Cancer Res (2017) 77 (13_Supplement): 4879.

https://doi.org/10.1158/1538-7445.AM2017-4879

Published: 01 July 2017

View article titled, Abstract 4879: Genomic and epigenomic profiling of high-stage neuroblastoma

Journal Articles

Abstract 5164: A pyrrole-Imidazole polyamide conjugate targeting KRAS oncogenic mutations is a promising approach against KRAS mutated colorectal and pancreatic cancers

Hiroki Nagase, Atsushi Takatori, Takayoshi Watanabe, Nobuko Koshikawa, Jason Lin

Cancer Res (2017) 77 (13_Supplement): 5164.

https://doi.org/10.1158/1538-7445.AM2017-5164

Published: 01 July 2017

View article titled, Abstract 5164: A pyrrole-Imidazole polyamide conjugate targeting KRAS oncogenic mutations is a promising approach against KRAS mutated colorectal and pancreatic cancers

Journal Articles

Abstract 2426: Detection of somatic mutations associated with pulmonary metastasis of osteosarcoma by whole exome sequencing

Shintaro Iwata, Yasutoshi Tatsumi, Tsukasa Yonemoto, Hiroto Kamoda, Takeshi Ishii, Hiroki Nagase, Miki Ohira

Cancer Res (2016) 76 (14_Supplement): 2426.

https://doi.org/10.1158/1538-7445.AM2016-2426

Published: 15 July 2016

View article titled, Abstract 2426: Detection of somatic mutations associated with pulmonary metastasis of osteosarcoma by whole exome sequencing

Journal Articles

Abstract 3775: Mutated cancer cell-specific cell death activity of alkylating Pyrrole-Imidazole polyamide conjugates targeting a variety of oncogenic driver gene mutations

Hiroki Nagase, Kiriko Hiraoka, Takahiro Inoue, Hiroyuki Yoda, Krishnamurthy Sakthisri, Jason Lin, Takayoshi Watanabe, Nobuko Koshikawa, Atsushi Takatori

Cancer Res (2016) 76 (14_Supplement): 3775.

https://doi.org/10.1158/1538-7445.AM2016-3775

Published: 15 July 2016

View article titled, Abstract 3775: Mutated cancer cell-specific cell death activity of alkylating Pyrrole-Imidazole polyamide conjugates targeting a variety of oncogenic driver gene mutations

Journal Articles

Abstract 4691: KRAS mutation specific alkylating pyrrole-imidazole polyamide (KR12) suppresses mutant KRAS expression and inhibits tumor growth by showing accumulation in KRAS mutant xenografts

Takahiro Inoue, Kiriko Hiraoka, Yusei Suzuki, Hiroyuki Yoda, Takayoshi Watanabe, Atsushi Takatori, Nobuko Koshikawa, Toshinori Ozaki, Hiroki Nagase

Cancer Res (2015) 75 (15_Supplement): 4691.

https://doi.org/10.1158/1538-7445.AM2015-4691

Published: 01 August 2015

View article titled, Abstract 4691: KRAS mutation specific alkylating pyrrole-imidazole polyamide (KR12) suppresses mutant KRAS expression and inhibits tumor growth by showing accumulation in KRAS mutant xenografts

Journal Articles

Abstract 4687: A novel alkylating pyrrol-imidazole polyamide, KR12, specifically recognizes mutant KRAS genes and potently induces cell death

Kiriko Hiraoka, Takahiro Inoue, Hiroyuki Yoda, Atsushi Takatori, Takayoshi Watanabe, Nobuko Koshikawa, Toshinori Ozaki, Hiroki Nagase

Cancer Res (2015) 75 (15_Supplement): 4687.

https://doi.org/10.1158/1538-7445.AM2015-4687

Published: 01 August 2015

View article titled, Abstract 4687: A novel alkylating pyrrol-imidazole polyamide, KR12, specifically recognizes mutant KRAS genes and potently induces cell death

Journal Articles

Abstract 78: Targeted next-generation resequencing in pediatric osteosarcoma patients

Shintaro Iwata, Yasutoshi Tatsumi, Tsukasa Yonemoto, Hiroki Nagase, Hiroto Kamoda, Takeshi Ishii, Miki Ohira

Cancer Res (2015) 75 (15_Supplement): 78.

https://doi.org/10.1158/1538-7445.AM2015-78

Published: 01 August 2015

View article titled, Abstract 78: Targeted next-generation resequencing in pediatric osteosarcoma patients

Journal Articles

Abstract A49: Characterization of genomic alterations in pediatric osteosarcoma with differential chemosensitivities: Construction of genome-based prediction system using preoperative biopsy samples

Shintaro Iwata, Tsukasa Yonemoto, Hagime Kageyama, Sana Yokoi, Hiroki Nagase, Akira Nakagawara, Takeshi Ishii, Miki Ohira

Cancer Res (2014) 74 (20_Supplement): A49.

https://doi.org/10.1158/1538-7445.PEDCAN-A49

Published: 09 October 2014

View article titled, Abstract A49: Characterization of genomic alterations in pediatric osteosarcoma with differential chemosensitivities: Construction of genome-based prediction system using preoperative biopsy samples

Journal Articles

Abstract 3102: Genomic alterations in biopsy samples predict the chemosensitivity of pediatric osteosarcoma

Shintaro Iwata, Tsukasa Yonemoto, Hajime Kageyama, Hiroto Kamoda, Sana Yokoi, Hiroki Nagase, Akira Nakagawara, Takeshi Ishii, Miki Ohira

Cancer Res (2014) 74 (19_Supplement): 3102.

https://doi.org/10.1158/1538-7445.AM2014-3102

Published: 01 October 2014

View article titled, Abstract 3102: Genomic alterations in biopsy samples predict the chemosensitivity of pediatric osteosarcoma

Journal Articles

Abstract 2602: KRAS G12D and G12V specific alkylating agent (KR12) inhibits growth of colon cancer with those KRAS mutations in vitro as well as in vivo

Hiroki Nagase, Kiriko Hiraoka, Takahiro Inoue, Takayoshi Watanabe, Ken-Ichi Shinohara, Nobuko Koshikawa, Ozaki Toshinori

Cancer Res (2014) 74 (19_Supplement): 2602.

https://doi.org/10.1158/1538-7445.AM2014-2602

Published: 01 October 2014

View article titled, Abstract 2602: KRAS G12D and G12V specific alkylating agent (KR12) inhibits growth of colon cancer with those KRAS mutations in vitro as well as in vivo

Journal Articles

Abstract 5679: Automatic synthesis of efficient transcription inhibitors as anti-cancer agents designing sequence-specific DNA-binding molecules.

Hiroki Nagase, Nobuko Koshikawa, Takayoshi Watanabe

Cancer Res (2013) 73 (8_Supplement): 5679.

https://doi.org/10.1158/1538-7445.AM2013-5679

Published: 15 April 2013

View article titled, Abstract 5679: Automatic synthesis of efficient transcription inhibitors as anti-cancer agents designing sequence-specific DNA-binding molecules.

Journal Articles

Abstract 4712: Target epigenetic regulation at a specific genomic region by using DNA binding molecules and HDACi

Hiroki Nagase, Takayoshi Watanabe, Nobuko Koshikawa

Cancer Res (2012) 72 (8_Supplement): 4712.

https://doi.org/10.1158/1538-7445.AM2012-4712

Published: 15 April 2012

View article titled, Abstract 4712: Target epigenetic regulation at a specific genomic region by using DNA binding molecules and HDACi

Journal Articles

Abstract 3533: DNA binding molecules as a new tool to regulate cancer cell fate

Hiroki Nagase, Makoto T. Kimura, Xiaofei Wang, Takayoshi Watanabe, Kyoko Fujiwara, Rajeev Mishra, Hiroshi Sugiyama, Noboru Fukuda, Tadashi Terui

Cancer Res (2011) 71 (8_Supplement): 3533.

https://doi.org/10.1158/1538-7445.AM2011-3533

Published: 15 April 2011

View article titled, Abstract 3533: DNA binding molecules as a new tool to regulate cancer cell fate

Journal Articles

Abstract 527: Pyrrole-Imidazole polyamide inhibits MMP-9 transcription and induces suppression of tumor metastasis

Xiaofei Wang, Hiroki Nagase

Cancer Res (2010) 70 (8_Supplement): 527.

https://doi.org/10.1158/1538-7445.AM10-527

Published: 15 April 2010

View article titled, Abstract 527: Pyrrole-Imidazole polyamide inhibits MMP-9 transcription and induces suppression of tumor metastasis

Journal Articles

Abstract #497: Targeted chromatin modification mediated by pyrrole-imidazole polyamide to control gene expression for cancer therapy

Makoto Kimura, Maki Ikeda, Takayoshi Watanabe, Akimichi Ohtsuki, Tsukasa Suzuki, Hiroshi Sugiyama, Hiroki Nagase

Cancer Res (2009) 69 (9_Supplement): 497.

Published: 01 May 2009

View article titled, Abstract #497: Targeted chromatin modification mediated by pyrrole-imidazole polyamide to control gene expression for cancer therapy

Journal Articles

Tissue-specific differentially methylated regions (TDMs) in humans and aberrant DNA methylations in liver tumors.

Eiko Kitamura, Jun Igarashi, Aiko Morohashi, Naoko Hida, Toshinori Oinuma, Norimichi Nemoto, Naoki Sekine, Mitsuhiko Moriyama, Tadatoshi Takayama, Fei Song, Srimoyee Ghosh, William Held, Chikako Yoshida-Noro, Hiroki Nagase

Cancer Res (2007) 67 (9_Supplement): 2874.

Published: 01 May 2007

View article titled, Tissue-specific differentially methylated regions (TDMs) in humans and aberrant DNA methylations in liver tumors.

Journal Articles

Two Functional Coding Single Nucleotide Polymorphisms in STK15 (Aurora-A) Coordinately Increase Esophageal Cancer Risk

Makoto T. Kimura, Takahiro Mori, Jeffrey Conroy, Norma J. Nowak, Susumu Satomi, Katsuyuki Tamai, Hiroki Nagase

Cancer Res (2005) 65 (9): 3548–3554.

https://doi.org/10.1158/0008-5472.CAN-04-2149

Published: 02 May 2005

View article titled, Two Functional Coding Single Nucleotide Polymorphisms in STK15 (Aurora-A) Coordinately Increase Esophageal Cancer Risk

NARROW

Abstract 5980: Cancer therapeutic and prevention strategy targeting mutated mitochondria DNA

Direct Targeting of MYCN Gene Amplification by Site-Specific DNA Alkylation in Neuroblastoma

Abstract 2711: Development of a new innovative multifunctional immune checkpoint inhibitor

Abstract 4879: Genomic and epigenomic profiling of high-stage neuroblastoma

Abstract 5164: A pyrrole-Imidazole polyamide conjugate targeting KRAS oncogenic mutations is a promising approach against KRAS mutated colorectal and pancreatic cancers

Abstract 2426: Detection of somatic mutations associated with pulmonary metastasis of osteosarcoma by whole exome sequencing

Abstract 3775: Mutated cancer cell-specific cell death activity of alkylating Pyrrole-Imidazole polyamide conjugates targeting a variety of oncogenic driver gene mutations

Abstract 4691: KRAS mutation specific alkylating pyrrole-imidazole polyamide (KR12) suppresses mutant KRAS expression and inhibits tumor growth by showing accumulation in KRAS mutant xenografts

Abstract 4687: A novel alkylating pyrrol-imidazole polyamide, KR12, specifically recognizes mutant KRAS genes and potently induces cell death

Abstract 78: Targeted next-generation resequencing in pediatric osteosarcoma patients

Abstract A49: Characterization of genomic alterations in pediatric osteosarcoma with differential chemosensitivities: Construction of genome-based prediction system using preoperative biopsy samples

Abstract 3102: Genomic alterations in biopsy samples predict the chemosensitivity of pediatric osteosarcoma

Abstract 2602: KRAS G12D and G12V specific alkylating agent (KR12) inhibits growth of colon cancer with those KRAS mutations in vitro as well as in vivo

Abstract 5679: Automatic synthesis of efficient transcription inhibitors as anti-cancer agents designing sequence-specific DNA-binding molecules.

Abstract 4712: Target epigenetic regulation at a specific genomic region by using DNA binding molecules and HDACi

Abstract 3533: DNA binding molecules as a new tool to regulate cancer cell fate

Abstract 527: Pyrrole-Imidazole polyamide inhibits MMP-9 transcription and induces suppression of tumor metastasis

Abstract #497: Targeted chromatin modification mediated by pyrrole-imidazole polyamide to control gene expression for cancer therapy

Tissue-specific differentially methylated regions (TDMs) in humans and aberrant DNA methylations in liver tumors.

Two Functional Coding Single Nucleotide Polymorphisms in STK15 (Aurora-A) Coordinately Increase Esophageal Cancer Risk

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