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Hiroaki Nagano
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Journal Articles

Abstract 1872: A DLL3/CD3/CD137 trispecific T cell engager shows potent antitumor activity in small cell lung cancer models

Hirofumi Mikami, Shu Feng, Sotaro Naoi, Yumiko Azuma, Yoko Kayukawa, Toshiaki Tsunenari, Kentaro Asanuma, Ryutaro Iwabuchi, Hiroaki Nagano, Junko Shinozuka, Masaki Yamazaki, Haruka Kuroi, Siok Wan Gan, Priyanka Chichili, Shun Shimizu, Yutaka Matsuda, Shinya Ishii, Shogo Kamikawaji, Yasuko Kinoshita, Yuichiro Shimizu, Akihisa Sakamoto, Masaru Muraoka, Noriyuki Takahashi, Tatsuya Kawa, Hirotake Shiraiwa, Kenji Kashima, Futa Mimoto, Mika Kamata-Sakurai, Takehisa Kitazawa, Tomoyuki Igawa
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1872.
https://doi.org/10.1158/1538-7445.AM2023-1872
Published: 04 April 2023
View article titled, Abstract 1872: A DLL3/CD3/CD137 trispecific T cell engager shows potent antitumor activity in small cell lung cancer models
Journal Articles

Abstract CT251: Immunological and histopathological tumor responses to a novel neoadjuvant peptide vaccine targeting HSP70 and GPC3 antigens in patients with resectable HCC

Masao Nakajima, Shoichi Hazama, Koji Tamada, Keiko Udaka, Shun Doi, Michiie Sakamoto, Akira Saito, Shiro Akinaga, Hiroto Matsui, Yoshitaro Shindo, Satoshi Matsukuma, Yukio Tokumitsu, Shinobu Tomochika, Michihisa Iida, Shin Yoshida, Ryouichi Tsunedomi, Yuki Nakagami, Nobuaki Suzuki, Shigeru Takeda, Hiroaki Nagano
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): CT251.
https://doi.org/10.1158/1538-7445.AM2020-CT251
Published: 15 August 2020
View article titled, Abstract CT251: Immunological and histopathological tumor responses to a novel neoadjuvant peptide vaccine targeting HSP70 and GPC3 antigens in patients with resectable HCC
Journal Articles

Abstract 1091: Comparison of TCR repertoires between cancer tissues and lymph nodes in colorectal cancer patients

Kazuma Kiyotani, Tatsuo Matsuda, Eisaku Miyauchi, Yu-Wen Hsu, Satoshi Nagayama, Makda Zewde, Jae-Hyun Park, Taigo Kato, Makiko Harada, Nobuaki Suzuki, Hiroaki Nagano, Shoichi Hazama, Yusuke Nakamura
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1091.
https://doi.org/10.1158/1538-7445.AM2019-1091
Published: 01 July 2019
View article titled, Abstract 1091: Comparison of TCR repertoires between cancer tissues and lymph nodes in colorectal cancer patients
Journal Articles

Abstract 732: A practical strategy to pancreatic cancer immunotherapy using resected human tumor lysate vaccines remodeled to express α-gal epitopes

Masahiro Tanemura, Kenta Furukawa, Eiji Miyoshi, Hidetoshi Eguchi, Hiroaki Nagano, Katsuyoshi Matsunami, Satoshi Nagaoka, Manabu Mikamori, Kentaro Kishi, Hiroki Akamatsu, Masaki Mori, Yuichiro Doki
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 732.
https://doi.org/10.1158/1538-7445.AM2018-732
Published: 01 July 2018
View article titled, Abstract 732: A practical strategy to pancreatic cancer immunotherapy using resected human tumor lysate vaccines remodeled to express α-gal epitopes
Journal Articles

Abstract 1927: The significance of calreticulin in pancreatic cancer: a molecule highly expressed in pancreatic cancer stem-like cells

Satoshi Matsukuma, Kiyoshi Yoshimura, Atsunori Oga, Moeko Inoue, Takuya Fujimtoto, Atsuo Kuramasu, Masanori Fuse, Ryouichi Tsunedomi, Hidetoshi Eguchi, Hiroto Matsui, Shinsuke Kanekiyo, Yukio Tokumitsu, Shinobu Tomochika, Michihisa Iida, Yoshihiro Tokuhisa, Kazuhiko Sakamoto, Nobuaki Suzuki, Tomoko Furuya-Kondo, Hiroshi Itoh, Shigeru Takeda, Shigeru Yamamoto, Shigefumi Yoshino, Shoichi Hazama, Tomio Ueno, Hiroaki Nagano
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1927.
https://doi.org/10.1158/1538-7445.AM2017-1927
Published: 01 July 2017
View article titled, Abstract 1927: The significance of calreticulin in pancreatic cancer: a molecule highly expressed in pancreatic cancer stem-like cells
Journal Articles

Abstract 2512: Novel immunotherapy using a tumor lysate vaccine with α-gal epitopes against pancreatic cancer

Kenta Furukawa, Masahiro Tanemura, Eiji Miyoshi, Hiroaki Nagano, Masaki Wakasugi, Toru Masuzawa, Mitsuyoshi Tei, Kentaro Kishi, Hiroki Akamatsu, Hidetoshi Eguchi, Katsuyoshi Matsunami, Masaki Mori, Yuichiro Doki
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2512.
https://doi.org/10.1158/1538-7445.AM2015-2512
Published: 01 August 2015
View article titled, Abstract 2512: Novel immunotherapy using a tumor lysate vaccine with α-gal epitopes against pancreatic cancer
Journal Articles

Abstract 556: The detection of viable human circulating tumor cells (v-hCTCs) in resectable pancreatic cancer induced by neoadjuvant chemoradiotherapy (NACRT) using gemcitabine, S-1 and intensity-modulated radiotherapy (IMRT)

Masahiro Tanemura, Toshimitsu Irei, Masashi Inoue, Shinya Yamashita, Kenta Furukawa, Masaki Wakasugi, Kentaro Kishi, Hiroaki Nagano, Hiroki Akamatsu, Yasuo Urata, Nobuyoshi Hatanaka, Masaki Mori, Yuichiro Doki
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 556.
https://doi.org/10.1158/1538-7445.AM2015-556
Published: 01 August 2015
View article titled, Abstract 556: The detection of viable human circulating tumor cells (v-hCTCs) in resectable pancreatic cancer induced by neoadjuvant chemoradiotherapy (NACRT) using gemcitabine, S-1 and intensity-modulated radiotherapy (IMRT)
Journal Articles

Abstract CT218: Wilms′ tumor gene 1 (WT1) peptide-based cancer vaccine combined with gemcitabine for patients with advanced pancreatic cancer

Shigeo Koido, Sumiyuki Nishida, Sadamu Homma, Yutaka Takeda, Hideo Komita, Satoshi Morita, Toshinori Ito, Soyoko Morimoto, Yoshihiro Oka, Satoru Yanagisawa, Yoichi Toyama, Masahiro Ikegami, Hiroaki Nagano, Toshifumi Ohkusa, Hisao Tajiri, Haruo Sugiyama
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): CT218.
https://doi.org/10.1158/1538-7445.AM2014-CT218
Published: 01 October 2014
View article titled, Abstract CT218: Wilms′ tumor gene 1 (WT1) peptide-based cancer vaccine combined with gemcitabine for patients with advanced pancreatic cancer
Journal Articles

Abstract 2560: Strong cross-reactive responses to pancreatic cancer cells induced by α-gal epitopes-expressing tumor lysate and their implications for a universal cancer vaccine

Masahiro Tanemura, Eiji Miyoshi, Hiroaki Nagano, Masafumi Inoue, Toshimitsu Irei, Shinya Yamashita, Kenta Furukawa, Katsuyoshi Matsunami, Wataru Kamiike, Masaki Mori, Yuichiro Doki
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2560.
https://doi.org/10.1158/1538-7445.AM2014-2560
Published: 01 October 2014
View article titled, Abstract 2560: Strong cross-reactive responses to pancreatic cancer cells induced by α-gal epitopes-expressing tumor lysate and their implications for a universal cancer vaccine
Journal Articles

Abstract 2884: Immune-based therapy with human tumor lysate, expressing α-gal epitopes induce significant B cell response and in vivo tumor destruction against pancreatic cancer

Kenta Furukawa, Masahiro Tanemura, Eiji Miyoshi, Hiroaki Nagano, Hidetoshi Eguchi, Toshimitsu Irei, Masashi Inoue, Shinya Yamashita, Yoshito Tomimaru, Naoki Hama, Hiroshi Wada, Koichi Kawamoto, Shogo Kobayashi, Katsuyoshi Matsunami, Kiyomi Taniyama, Wataru Kamiike, Masaki Mori, Yuichiro Doki
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2884.
https://doi.org/10.1158/1538-7445.AM2014-2884
Published: 01 October 2014
View article titled, Abstract 2884: Immune-based therapy with human tumor lysate, expressing α-gal epitopes induce significant B cell response and in vivo tumor destruction against pancreatic cancer
Journal Articles

Abstract 4650: Pharmacokinetic and pharmacodynamic study of adjuvant gemcitabine therapy of biliary tract cancer following major hepatectomy (KHBO1101)

Yutaka Fujiwara, Shogo Kobayashi, Hiroaki Nagano, Masashi Kanai, Etsuo Hatano, Masanori Toyoda, Tetsuo Ajiki, Yuki Takashima, Akinobu Hamada, Hironobu Minami, Tatsuya Ioka
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4650.
https://doi.org/10.1158/1538-7445.AM2014-4650
Published: 01 October 2014
View article titled, Abstract 4650: Pharmacokinetic and pharmacodynamic study of adjuvant gemcitabine therapy of biliary tract cancer following major hepatectomy (KHBO1101)
Journal Articles

Abstract 4385: Identification of the crucial microRNA, miR-1246 related to the chemoresistance and stemness in pancreatic cancer for new targeting therapy

Shinichiro Hasegawa, Ishii Hideshi, Hidetoshi Eguchi, Shogo Kobayashi, Hiroshi Wada, Naoki Hama, Yoshito Tomimaru, Kawamoto Koichi, Masamitsu Konno, Hisataka Ogawa, Shimpei Nishikawa, Yoshihiro Kano, Yoshihiro Kano, Takahito Fukusumi, Atsushi Hamabe, Takenori Nishimura, Kunihiko Hinohara, Taroh Satoh, Noriko Gotoh, Hiroaki Nagano, Yuichiro Doki, Masaki Mori
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4385.
https://doi.org/10.1158/1538-7445.AM2014-4385
Published: 01 October 2014
View article titled, Abstract 4385: Identification of the crucial microRNA, miR-1246 related to the chemoresistance and stemness in pancreatic cancer for new targeting therapy
Journal Articles

Abstract B29: High efficacy of α-gal epitopes immune-based therapy against pancreatic cancer using tumor cell lysates.

Eiji Miyoshi, Masahiro Tanemura, Tsukasa Tanida, Takahiro Deguchi, Yuji Nonaka, Hiroaki Nagano, Masaki Mori, Yuichiro Doki
Journal: Cancer Research
Cancer Res (2012) 72 (14_Supplement): B29.
https://doi.org/10.1158/1538-7445.PANCA2012-B29
Published: 03 April 2014
View article titled, Abstract B29: High efficacy of α-gal epitopes immune-based therapy against pancreatic cancer using tumor cell lysates.
Journal Articles

Abstract 5319: Cancer reprogramming.

Hisataka Ogawa, Hirofumi Yamamoto, Masamitsu Konno, Shin Kure, Susumu Miyazaki, Shinpei Nishikawa, Shinichiro Hasegawa, Katsuya Ohta, Yoshihiro Kano, Takahito Fukusumi, Atsushi Hamabe, Takeshi Yamamoto, Satoshi Obika, Taroh Satoh, Hidetoshi Eguchi, Hiroaki Nagano, Hidenori Inohara, Yuichirou Doki, Masaki Mori, Hideshi Ishii
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 5319.
https://doi.org/10.1158/1538-7445.AM2013-5319
Published: 15 April 2013
View article titled, Abstract 5319: Cancer reprogramming.
Journal Articles

Abstract 4897: Identification of microRNA networks in pancreatic cancer stem cells.

Shinichiro Hasegawa, Hideshi Ishii, Shimpei Nishikawa, Hidetoshi Eguchi, Shogo Kobayashi, Hiroshi Wada, Naoki Hama, Hirofumi Akita, Koichi Kawamoto, Masamitsu Konno, Hisataka Ogawa, Katsuya Ohta, Yoshihiro Kano, Takahito Fukusumi, Atsushi Hamabe, Takenori Nishimura, Kunihiko Hinohara, Taroh Satoh, Noriko Gotoh, Yuichiro Doki, Masaki Mori, Hiroaki Nagano
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4897.
https://doi.org/10.1158/1538-7445.AM2013-4897
Published: 15 April 2013
View article titled, Abstract 4897: Identification of microRNA networks in pancreatic cancer stem cells.
Journal Articles

Abstract 2833: Significant protection against gemcitabine-resistant pancreatic cancer cells with tumor lysate vaccine, engineered to express α-gal epitopes.

Masahiro Tanemura, Eiji Miyoshi, Tsukasa Tanida, Hiroaki Nagano, Hidetoshi Eguchi, Kenta Furukawa, Yuji Nonaka, Hirofumi Akita, Naoki Hama, Hiroshi Wada, Koichi Kawamoto, Shyogo Kobayashi, Kiyomi Taniyama, Wataru Kamiike, Masaki Mori, Yuichiro Doki
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 2833.
https://doi.org/10.1158/1538-7445.AM2013-2833
Published: 15 April 2013
View article titled, Abstract 2833: Significant protection against gemcitabine-resistant pancreatic cancer cells with tumor lysate vaccine, engineered to express α-gal epitopes.
Journal Articles

Abstract 1559: A new immunotherapy for pancreatic cancer stem cells by tumor lysate vaccine, expressing α-gal epitopes

Masahiro Tanemura, Tsukasa Tanida, Eiji Miyoshi, Hiroaki Nagano, Hidetoshi Eguchi, Yoshifumi Iwagami, Koichi Kawamoto, Hiroshi Wada, Shyogo Kobayashi, Shigeru Marubashi, Kiyomi Taniyama, Wataru Kamiike, Masaki Mori, Yuichiro Doki
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 1559.
https://doi.org/10.1158/1538-7445.AM2012-1559
Published: 15 April 2012
View article titled, Abstract 1559: A new immunotherapy for pancreatic cancer stem cells by tumor lysate vaccine, expressing α-gal epitopes
Journal Articles

Abstract 1560: Immune-based therapy with tumor lysate remodeled to express α-gal epitopes induce significant B- and T-cell responses against pancreatic cancer

Tsukasa Tanida, Masahiro Tanemura, Eiji Miyoshi, Hiroaki Nagano, Hidetoshi Eguchi, Yoshifumi Iwagami, Yuji Nonaka, Hiroshi Wada, Koichi Kawamoto, Syogo Kobayashi, Shigeru Marubashi, Kiyomi Taniyama, Wataru Kamiike, Masaki Mori, Yuichiro Doki
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 1560.
https://doi.org/10.1158/1538-7445.AM2012-1560
Published: 15 April 2012
View article titled, Abstract 1560: Immune-based therapy with tumor lysate remodeled to express α-gal epitopes induce significant B- and T-cell responses against pancreatic cancer
Journal Articles

Abstract 5131: Identification of the genes that chemosensitize hepatocellular carcinoma cells to interferon-α and 5-fluorouracil therapy

Goshi Shiota, Tomohiko Sakabe, Hiroaki Nagano, Hiroyuki Tsuchiya
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 5131.
https://doi.org/10.1158/1538-7445.AM2012-5131
Published: 15 April 2012
View article titled, Abstract 5131: Identification of the genes that chemosensitize hepatocellular carcinoma cells to interferon-α and 5-fluorouracil therapy
Journal Articles

Abstract 774: Preliminary experiment of α-gal epitopes immune-based therapy against pancreatic cancer using tumor cell lysates

Tsukasa Tanida, Masahiro Tanemura, Eiji Miyoshi, Masahiro Inoue, Hiroaki Nagano, Yoshiaki Ohmura, Tomohiko Machida, Hiroshi Wada, Syogo Kobayashi, Shigeru Marubashi, Hidetoshi Eguchi, Toshinori Ito, Masaki Mori, Yuichiro Doki
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 774.
https://doi.org/10.1158/1538-7445.AM2011-774
Published: 15 April 2011
View article titled, Abstract 774: Preliminary experiment of α-gal epitopes immune-based therapy against pancreatic cancer using tumor cell lysates