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Abstract 6328: Preclinical development of CAR T cells with antigen-inducible IL-18 enforcement to treat G_D2-positive solid cancers

Cancer Res (2024) 84 (6_Supplement): 6328.

https://doi.org/10.1158/1538-7445.AM2024-6328

Published: 22 March 2024

View article titled, Abstract 6328: Preclinical development of CAR T cells with antigen-inducible IL-18 enforcement to treat GD2-positive solid cancers

Journal Articles

Abstract 3182: CAR T cells as micropharmacies to induce locoregional tumor vascular infarction by antigen-specific delivery of tissue factor to the tumor microenvironment

Bianca Altvater, Sareetha Kailayangiri, Christian Spurny, Maike Flügge, Jutta Meltzer, Lea Greune, Christian Schwöppe, Caroline Brand, Christoph Schliemann, Wolfgang Hartmann, Hinrich Abken, Axel Schambach, Nicole Farwick, Wolfgang E. Berdel, Claudia Rossig

Cancer Res (2023) 83 (7_Supplement): 3182.

https://doi.org/10.1158/1538-7445.AM2023-3182

Published: 04 April 2023

View article titled, Abstract 3182: CAR T cells as micropharmacies to induce locoregional tumor vascular infarction by antigen-specific delivery of tissue factor to the tumor microenvironment

Journal Articles

Abstract A09: GPR64-specific CAR-transgenic T cells selectively kill Ewing sarcoma in vivo

David Schirmer, Isabel Storz, Karin Wisskirchen, Regina Feederle, Oxana Schmidt, Hinrich Abken, Ulrike Protzer, Stefan Burdach, Guenther H.S. Richter

Cancer Res (2018) 78 (19_Supplement): A09.

https://doi.org/10.1158/1538-7445.PEDCA17-A09

Published: 01 October 2018

View article titled, Abstract A09: GPR64-specific CAR-transgenic T cells selectively kill Ewing sarcoma in vivo

Journal Articles

Abstract 370: T-PLL cells resemble memory-type T-cells with aberrant effector functions implicating a leukemogenic cooperation of TCL1A and TCR signaling

Cancer Res (2017) 77 (13_Supplement): 370.

https://doi.org/10.1158/1538-7445.AM2017-370

Published: 01 July 2017

View article titled, Abstract 370: T-PLL cells resemble memory-type T-cells with aberrant effector functions implicating a leukemogenic cooperation of TCL1A and TCR signaling

Journal Articles

Abstract 3764: Targeting GPR64 in pediatric sarcomas with CAR transgenic T cells

David Schirmer, Isabel Storz, Karin Wisskirchen, Regina Feederle, Oxana Schmidt, Hinrich Abken, Crystall Mackall, Ulrike Protzer, Stefan Burdach, Günther H. Richter

Cancer Res (2017) 77 (13_Supplement): 3764.

https://doi.org/10.1158/1538-7445.AM2017-3764

Published: 01 July 2017

View article titled, Abstract 3764: Targeting GPR64 in pediatric sarcomas with CAR transgenic T cells

Journal Articles

Efficacy of CAR T-cell Therapy in Large Tumors Relies upon Stromal Targeting by IFNγ

Ana Textor, Joanna J. Listopad, Lara Le Wührmann, Cynthia Perez, Anna Kruschinski, Markus Chmielewski, Hinrich Abken, Thomas Blankenstein, Jehad Charo

Cancer Res (2014) 74 (23): 6796–6805.

https://doi.org/10.1158/0008-5472.CAN-14-0079

Published: 30 November 2014

View article titled, Efficacy of CAR T-cell Therapy in Large Tumors Relies upon Stromal Targeting by IFNγ

Includes: Supplementary data

Journal Articles

IL-12 Release by Engineered T Cells Expressing Chimeric Antigen Receptors Can Effectively Muster an Antigen-Independent Macrophage Response on Tumor Cells That Have Shut Down Tumor Antigen Expression

Markus Chmielewski, Caroline Kopecky, Andreas A. Hombach, Hinrich Abken

Cancer Res (2011) 71 (17): 5697–5706.

https://doi.org/10.1158/0008-5472.CAN-11-0103

Published: 30 August 2011

View article titled, IL-12 Release by Engineered T Cells Expressing Chimeric Antigen Receptors Can Effectively Muster an Antigen-Independent Macrophage Response on Tumor Cells That Have Shut Down Tumor Antigen Expression

Includes: Supplementary data

Journal Articles

Abstract 1936: Anti CD30 chimeric immune receptor mRNA for therapy of CD30⁺ lymphomas

Pavel Karkanitsa, Sherman Weissman, Peter Rabinovich, Hinrich Abken, Andreas Hombach, Marina Komarovskaya, Francine M. Foss

Cancer Res (2010) 70 (8_Supplement): 1936.

https://doi.org/10.1158/1538-7445.AM10-1936

Published: 15 April 2010

View article titled, Abstract 1936: Anti CD30 chimeric immune receptor mRNA for therapy of CD30+ lymphomas

Journal Articles

The Proteasome Inhibitor Bortezomib Sensitizes Melanoma Cells toward Adoptive CTL Attack

Jens Michael Seeger, Patrick Schmidt, Kerstin Brinkmann, Andreas A. Hombach, Oliver Coutelle, Paola Zigrino, Diana Wagner-Stippich, Cornelia Mauch, Hinrich Abken, Martin Krönke, Hamid Kashkar

Cancer Res (2010) 70 (5): 1825–1834.

https://doi.org/10.1158/0008-5472.CAN-09-3175

Published: 28 February 2010

View article titled, The Proteasome Inhibitor Bortezomib Sensitizes Melanoma Cells toward Adoptive CTL Attack

Includes: Supplementary data

Journal Articles

CD28 Costimulation Overcomes Transforming Growth Factor-β–Mediated Repression of Proliferation of Redirected Human CD4⁺ and CD8⁺ T Cells in an Antitumor Cell Attack

Heike Koehler, David Kofler, Andreas Hombach, Hinrich Abken

Cancer Res (2007) 67 (5): 2265–2273.

https://doi.org/10.1158/0008-5472.CAN-06-2098

Published: 01 March 2007

View article titled, CD28 Costimulation Overcomes Transforming Growth Factor-β–Mediated Repression of Proliferation of Redirected Human CD4+ and CD8+ T Cells in an Antitumor Cell Attack

Journal Articles

Interleukin-6 Fused to an Anti-idiotype Antibody in a Vaccine Increases the Specific Humoral Immune Response against CA125⁺ (MUC-16) Ovarian Cancer

Silke Reinartz, Andreas Hombach, Siegmund Köhler, Harald Schlebusch, Diethelm Wallwiener, Hinrich Abken, Uwe Wagner

Cancer Res (2003) 63 (12): 3234–3240.

Published: 15 June 2003

View article titled, Interleukin-6 Fused to an Anti-idiotype Antibody in a Vaccine Increases the Specific Humoral Immune Response against CA125+ (MUC-16) Ovarian Cancer

Journal Articles

T-Cell Activation by Recombinant Receptors: CD28 Costimulation Is Required for Interleukin 2 Secretion and Receptor-mediated T-Cell Proliferation but Does Not Affect Receptor-mediated Target Cell Lysis

Andreas Hombach, Dagmar Sent, Claudia Schneider, Claudia Heuser, Dimitra Koch, Christoph Pohl, Barbara Seliger, Hinrich Abken

Cancer Res (2001) 61 (5): 1976–1982.

Published: 01 March 2001

View article titled, T-Cell Activation by Recombinant Receptors: <subtitle>CD28 Costimulation Is Required for Interleukin 2 Secretion and Receptor-mediated T-Cell Proliferation but Does Not Affect Receptor-mediated Target Cell Lysis</subtitle>

Journal Articles

An Anti-CD30 Chimeric Receptor That Mediates CD3-ζ-independent T-Cell Activation against Hodgkin's Lymphoma Cells in the Presence of Soluble CD30

Andreas Hombach, Claudia Heuser, Ranjan Sircar, Thorsten Tillmann, Volker Diehl, Christoph Pohl, Hinrich Abken

Cancer Res (1998) 58 (6): 1116–1119.

Published: 01 March 1998

View article titled, An Anti-CD30 Chimeric Receptor That Mediates CD3-ζ-independent T-Cell Activation against Hodgkin's Lymphoma Cells in the Presence of Soluble CD30

Journal Articles

Prevention of Epstein-Barr Virus-induced Human B-Cell Lymphoma in Severe Combined Immunodeficient Mice Treated with CD3xCD19 Bispecific Antibodies, CD28 Monospecific Antibodies, and Autologous T Cells

Heribert Bohlen, Oliver Manzke, Sandra Titzer, Johann Lorenzen, Dieter Kube, Andreas Engert, Hinrich Abken, Jürgen Wolf, Volker Diehl, Hans Tesch

Cancer Res (1997) 57 (9): 1704–1709.

Published: 01 May 1997

View article titled, Prevention of Epstein-Barr Virus-induced Human B-Cell Lymphoma in Severe Combined Immunodeficient Mice Treated with CD3xCD19 Bispecific Antibodies, CD28 Monospecific Antibodies, and Autologous T Cells

NARROW

Abstract 6328: Preclinical development of CAR T cells with antigen-inducible IL-18 enforcement to treat G_D2-positive solid cancers

Abstract 3182: CAR T cells as micropharmacies to induce locoregional tumor vascular infarction by antigen-specific delivery of tissue factor to the tumor microenvironment

Abstract A09: GPR64-specific CAR-transgenic T cells selectively kill Ewing sarcoma in vivo

Abstract 370: T-PLL cells resemble memory-type T-cells with aberrant effector functions implicating a leukemogenic cooperation of TCL1A and TCR signaling

Abstract 3764: Targeting GPR64 in pediatric sarcomas with CAR transgenic T cells

Efficacy of CAR T-cell Therapy in Large Tumors Relies upon Stromal Targeting by IFNγ

IL-12 Release by Engineered T Cells Expressing Chimeric Antigen Receptors Can Effectively Muster an Antigen-Independent Macrophage Response on Tumor Cells That Have Shut Down Tumor Antigen Expression

Abstract 1936: Anti CD30 chimeric immune receptor mRNA for therapy of CD30⁺ lymphomas

The Proteasome Inhibitor Bortezomib Sensitizes Melanoma Cells toward Adoptive CTL Attack

CD28 Costimulation Overcomes Transforming Growth Factor-β–Mediated Repression of Proliferation of Redirected Human CD4⁺ and CD8⁺ T Cells in an Antitumor Cell Attack

Interleukin-6 Fused to an Anti-idiotype Antibody in a Vaccine Increases the Specific Humoral Immune Response against CA125⁺ (MUC-16) Ovarian Cancer

T-Cell Activation by Recombinant Receptors: CD28 Costimulation Is Required for Interleukin 2 Secretion and Receptor-mediated T-Cell Proliferation but Does Not Affect Receptor-mediated Target Cell Lysis

An Anti-CD30 Chimeric Receptor That Mediates CD3-ζ-independent T-Cell Activation against Hodgkin's Lymphoma Cells in the Presence of Soluble CD30

Prevention of Epstein-Barr Virus-induced Human B-Cell Lymphoma in Severe Combined Immunodeficient Mice Treated with CD3xCD19 Bispecific Antibodies, CD28 Monospecific Antibodies, and Autologous T Cells

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