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Journal Articles

Abstract PR008: Molecular determinants of prostate cancer lineage plasticity

Kristine Wadosky, Sheng-Yu Ku, Yanqing Wang, Xiaojing Zhang, Jie Wang, Jianmin Wang, Himisha Beltran, David W. Goodrich
Journal: Cancer Research
Cancer Res (2023) 83 (11_Supplement): PR008.
https://doi.org/10.1158/1538-7445.PRCA2023-PR008
Published: 02 June 2023
View article titled, Abstract PR008: Molecular determinants of prostate cancer lineage plasticity
Journal Articles

Abstract B017: Lineage-specific PRC2 targets and response to EZH2 inhibition in neuroendocrine prostate cancer

Varadha Balaji Venkadakrishnan, Richa Singh, Yasutaka Yamada, Kei Mizuno, Adam G. Presser, Sheng-Yu Ku, Henry Long, David Rickman, Himisha Beltran
Journal: Cancer Research
Cancer Res (2023) 83 (11_Supplement): B017.
https://doi.org/10.1158/1538-7445.PRCA2023-B017
Published: 02 June 2023
View article titled, Abstract B017: Lineage-specific PRC2 targets and response to EZH2 inhibition in neuroendocrine prostate cancer
Journal Articles

Abstract IA016: Epigenetic crosstalk associated with prostate cancer lineage plasticity

David Rickman, Richa Singh, Varadha Balaji Venkadakrishnan, Yasutaka Yamada, Himisha Beltran
Journal: Cancer Research
Cancer Res (2023) 83 (11_Supplement): IA016.
https://doi.org/10.1158/1538-7445.PRCA2023-IA016
Published: 02 June 2023
View article titled, Abstract IA016: Epigenetic crosstalk associated with prostate cancer lineage plasticity
Journal Articles

Abstract NG10: Chromatin profiles classify castration-resistant prostate cancers suggesting therapeutic targets

Fanying Tang, Duo Xu, Shangqian Wang, Chen Khuan Wong, Alexander Martinez-Fundichely, Cindy J. Lee, Sandra Cohen, Jane Park, Corinne E. Hill, Kenneth Eng, Rohan Bareja, Teng Han, Eric Minwei Liu, Ann Palladino, Wei Di, Dong Gao, Wassim Abida, Shaham Beg, Loredana Puca, Maximiliano Meneses, Elisa de Stanchina, Michael F. Berger, Anuradha Gopalan, Lukas E. Dow, Juan Miguel Mosquera, Himisha Beltran, Cora N. Sternberg, Ping Chi, Howard I. Scher, Andrea Sboner, Yu Chen, Ekta Khurana
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): NG10.
https://doi.org/10.1158/1538-7445.AM2023-NG10
Published: 04 April 2023
View article titled, Abstract NG10: Chromatin profiles classify castration-resistant prostate cancers suggesting therapeutic targets
Journal Articles

Abstract B026: Chromatin profiles classify castration-resistant prostate cancers suggesting therapeutic targets

Fanying Tang, Duo Xu, Shangqian Wang, Chen Khuan Wong, Alexander Martinez-Fundichely, Cindy Lee, Sandra Cohen, Jane Park, Corinne Hill, Kenneth Eng, Rohan Bareja, Teng Han, Eric Minwei Liu, Ann Palladino, Wei Di, Dong Gao, Wassim Abida, Shaham Beg, Loredana Puca, Maximiliano Meneses, Elisa De Stanchina, Michael Berger, Anuradha Gopalan, Lukas Dow, Juan Miguel Mosquera, Himisha Beltran, Cora Sternberg, Ping Chi, Howard Scher, Andrea Sboner, Yu Chen, Ekta Khurana
Journal: Cancer Research
Cancer Res (2022) 82 (23_Supplement_2): B026.
https://doi.org/10.1158/1538-7445.CancEpi22-B026
Published: 01 December 2022
View article titled, Abstract B026: Chromatin profiles classify castration-resistant prostate cancers suggesting therapeutic targets
Journal Articles

Abstract B022: CHD1 promotes sensitivity to aurora kinase inhibitors by modulating the interaction of AURKA with TPX2

Haoyan Li, Yin Wang, Kevin Lin, Varadha Balaji Venkadakrishnan, Martin Bakht, Kaitlyn Tremble, Yue Lu, Himisha Beltran, Di Zhao
Journal: Cancer Research
Cancer Res (2022) 82 (23_Supplement_2): B022.
https://doi.org/10.1158/1538-7445.CancEpi22-B022
Published: 01 December 2022
View article titled, Abstract B022: CHD1 promotes sensitivity to aurora kinase inhibitors by modulating the interaction of AURKA with TPX2
Journal Articles

CHD1 Promotes Sensitivity to Aurora Kinase Inhibitors by Suppressing Interaction of AURKA with Its Coactivator TPX2

Haoyan Li, Yin Wang, Kevin Lin, Varadha Balaji Venkadakrishnan, Martin Bakht, Wei Shi, Chenling Meng, Jie Zhang, Kaitlyn Tremble, Xin Liang, Jian H. Song, Xu Feng, Vivien Van, Pingna Deng, Jared K. Burks, Ana Aparicio, Khandan Keyomarsi, Junjie Chen, Yue Lu, Himisha Beltran, Di Zhao
Journal: Cancer Research
Cancer Res (2022) 82 (17): 3088–3101.
https://doi.org/10.1158/0008-5472.CAN-22-0631
Published: 02 September 2022
View article titled, CHD1 Promotes Sensitivity to Aurora Kinase Inhibitors by Suppressing Interaction of AURKA with Its Coactivator TPX2
Open the PDF for CHD1 Promotes Sensitivity to Aurora Kinase Inhibitors by Suppressing Interaction of AURKA with Its Coactivator TPX2 in another window
Includes: Supplementary data
Journal Articles

Abstract 2896: DLL3-targeted T cell engager therapy (HPN328) for neuroendocrine prostate cancer

Sheng-Yu Ku, Yasutaka Yamada, Patrick Ng, Laura Sun, Himisha Beltran
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2896.
https://doi.org/10.1158/1538-7445.AM2022-2896
Published: 15 June 2022
View article titled, Abstract 2896: DLL3-targeted T cell engager therapy (HPN328) for neuroendocrine prostate cancer
Journal Articles

Activated ALK Cooperates with N-Myc via Wnt/β-Catenin Signaling to Induce Neuroendocrine Prostate Cancer

Kenji Unno, Zachary R. Chalmers, Sahithi Pamarthy, Rajita Vatapalli, Yara Rodriguez, Barbara Lysy, Hanlin Mok, Vinay Sagar, Huiying Han, Young A. Yoo, Sheng-Yu Ku, Himisha Beltran, Yue Zhao, Sarki A. Abdulkadir
Journal: Cancer Research
Cancer Res (2021) 81 (8): 2157–2170.
https://doi.org/10.1158/0008-5472.CAN-20-3351
Published: 15 April 2021
View article titled, Activated ALK Cooperates with N-Myc via Wnt/β-Catenin Signaling to Induce Neuroendocrine Prostate Cancer
Open the PDF for Activated ALK Cooperates with N-Myc via Wnt/β-Catenin Signaling to Induce Neuroendocrine Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 3083: Selective inhibition of transcription factor BRN2 as a treatment strategy for Small Cell Prostate Cancer

Daksh Thaper, Ravi Munuganti, Adeleke Aguda, Soojin Kim, Shungyu Ku, Sahil Kumar, Sepideh Vahid, Shaghayegh Nouruzi, Olena Sivak, Dwaiyapan Ganguli, Colm Morrissey, Eva Corey, Himisha Beltran, Amina Zoubeidi
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3083.
https://doi.org/10.1158/1538-7445.AM2020-3083
Published: 15 August 2020
View article titled, Abstract 3083: Selective inhibition of transcription factor BRN2 as a treatment strategy for Small Cell Prostate Cancer
Journal Articles

Abstract 5310: Chromatin accessibility landscape and transcriptome of castration resistant prostate cancers reveals novel subtypes and diverse master regulators

Fanying Tang, Chen Khuan Wong, Sandra Cohen, Cindy Lee, Minwei Liu, Rohan Bareja, Kenneth Eng, Shaham Beg, Loredana Puca, Cora Sternberg, Juan Miguel Mosquera, Himisha Beltran, Andrea Sboner, Yu Chen, Ekta Khurana
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5310.
https://doi.org/10.1158/1538-7445.AM2020-5310
Published: 15 August 2020
View article titled, Abstract 5310: Chromatin accessibility landscape and transcriptome of castration resistant prostate cancers reveals novel subtypes and diverse master regulators
Journal Articles

Abstract 134: Immunogenomic landscape of neuroendocrine prostate cancer (NEPC)

Alison M. Ferguson, Bhavneet Bhinder, Vincenza Conteduca, Michael Sigouros, Andrea Sboner, David Nanus, Scott Tagawa, David Rickman, Olivier Elemento, Himisha Beltran
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 134.
https://doi.org/10.1158/1538-7445.AM2019-134
Published: 01 July 2019
View article titled, Abstract 134: Immunogenomic landscape of neuroendocrine prostate cancer (NEPC)
Journal Articles

Abstract 1295: First-in-field small molecule inhibitors targeting BRN2 as a therapeutic strategy for small cell prostate cancer

Daksh Thaper, Ravi Munuganti, Shaghayegh Nouruzi, Sahil Kumar, Soojin Kim, Olena Sivak, Adeleke Aguda, Dwaipayan Ganguli, Sepideh Vahid, Loredana Puca, Himisha Beltran, Amina Zoubeidi
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1295.
https://doi.org/10.1158/1538-7445.AM2019-1295
Published: 01 July 2019
View article titled, Abstract 1295: First-in-field small molecule inhibitors targeting BRN2 as a therapeutic strategy for small cell prostate cancer
Journal Articles

Abstract 2099: N-Myc-mediated epigenetic reprogramming drives lineage plasticity in advanced prostate cancer

Adeline Berger, Nicholas Brady, Rohan Bareja, Brian Robinson, Vincenza Conteduca, Michael Augello, Loredana Puca, Adnan Ahmed, Xiaodong Lu, Inah Hwang, Alyssa Bagadion, Andrea Sboner, Olivier Elemento, Jihye Paik, Jindan Yu, Christopher Barbieri, Noah Dephoure, Himisha Beltran, David S. Rickman
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2099.
https://doi.org/10.1158/1538-7445.AM2019-2099
Published: 01 July 2019
View article titled, Abstract 2099: N-Myc-mediated epigenetic reprogramming drives lineage plasticity in advanced prostate cancer
Journal Articles

Abstract CT097: Phase I trial of apalutamide plus abiraterone acetate, docetaxel, and prednisone in patients with metastatic castration-resistant prostate cancer (mCRPC)

Ana Molina, Paul Christos, Amy Hackett, Luke Nordquist, Edward Gelmann, Mark Stein, Cora Sternberg, Himisha Beltran, Lauren Gracey, Giuseppe Galletti, Paraskevi Giannakakou, David M. Nanus, Scott T. Tagawa
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): CT097.
https://doi.org/10.1158/1538-7445.AM2019-CT097
Published: 01 July 2019
View article titled, Abstract CT097: Phase I trial of apalutamide plus abiraterone acetate, docetaxel, and prednisone in patients with metastatic castration-resistant prostate cancer (mCRPC)
Journal Articles

Abstract 451: Transferrin Receptor identifies a distinct pool of circulating tumor cells from metastatic prostate cancer patients with unique molecular profiles enriched in AR variants

Ada Gjyrezi, Giuseppe Galletti, Jiaren Zhang, Rohan Bareja, Ahmed Halima, Daniel Worroll, David Nanus, Scott Tagawa, Himisha Beltran, Paraskevi Giannakakou
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 451.
https://doi.org/10.1158/1538-7445.AM2019-451
Published: 01 July 2019
View article titled, Abstract 451: Transferrin Receptor identifies a distinct pool of circulating tumor cells from metastatic prostate cancer patients with unique molecular profiles enriched in AR variants
Journal Articles

Abstract 4865: Prognostic value of BRCA2 and AR gene alterations in advanced prostate cancer patients treated with PSMA-targeted radionuclide therapies

Panagiotis J. Vlachostergios, Vincenza Conteduca, Amy L. Hackett, Jyothi Manohar, Aileen Lee, Aidan Case, Michael Sun, Muhammad J. Niaz, Olivier Elemento, Ana M. Molina, David M. Nanus, Himisha Beltran, Neil H. Bander, Scott T. Tagawa
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4865.
https://doi.org/10.1158/1538-7445.AM2019-4865
Published: 01 July 2019
View article titled, Abstract 4865: Prognostic value of BRCA2 and AR gene alterations in advanced prostate cancer patients treated with PSMA-targeted radionuclide therapies
Journal Articles

Abstract IA19: Phenotype plasticity—a novel mechanism of targeted therapy resistance

Joanna Cyrta, David Wilkes, Sung Suk Chae, Matteo Benelli, Rohan Bareja, Davide Prandi, Paola Maria Giovanna Cavaliere, Himisha Beltran, Andrea Sboner, Francesca Demichelis, Mark A. Rubin
Journal: Cancer Research
Cancer Res (2018) 78 (16_Supplement): IA19.
https://doi.org/10.1158/1538-7445.PRCA2017-IA19
Published: 14 August 2018
View article titled, Abstract IA19: Phenotype plasticity—a novel mechanism of targeted therapy resistance
Journal Articles

Abstract IA05: Emerging therapeutic strategies for androgen indifferent prostate cancer

Himisha Beltran
Journal: Cancer Research
Cancer Res (2018) 78 (16_Supplement): IA05.
https://doi.org/10.1158/1538-7445.PRCA2017-IA05
Published: 14 August 2018
View article titled, Abstract IA05: Emerging therapeutic strategies for androgen indifferent prostate cancer
Journal Articles

Abstract A074: Aberrant activation of a gastrointestinal transcriptional circuit in prostate cancer mediates castration resistance

Shipra Shukla, Joanna Cyrta, Devan Murphy, Edward Walczak, Leili Ran, Praveen Agrawal, Yuanyuan Xie, Yuedan Chen, Shangqian Wang, Yu Zhan, Wai Pung E. Wong, Andrea Sboner, Himisha Beltran, Juan-Miguel Mosquera, Jessica Sher, Zhen Cao, John Wongvipat, Richard P. Koche, Anuradha Gopalan, Deyou Zheng, Mark Rubin, Howard I. Scher, Ping Chi, Yu Chen
Journal: Cancer Research
Cancer Res (2018) 78 (16_Supplement): A074.
https://doi.org/10.1158/1538-7445.PRCA2017-A074
Published: 14 August 2018
View article titled, Abstract A074: Aberrant activation of a gastrointestinal transcriptional circuit in prostate cancer mediates castration resistance