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Journal Articles

Abstract 6322: The role of multidrug efflux transporters and CYP3A in the pharmacokinetics and tissue distribution of abemaciclib and its active metabolites

Alejandra Martinez Chavez, Matthijs M. Tibben, Maria C. Lebre, Hilde Rosing, Jos H. Beijnen, Alfred H. Schinkel
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 6322.
https://doi.org/10.1158/1538-7445.AM2020-6322
Published: 15 August 2020
View articletitled, Abstract 6322: The role of multidrug efflux transporters and CYP3A in the pharmacokinetics and tissue distribution of abemaciclib and its active metabolites
Journal Articles

Abstract 1268: The impact of P-glycoprotein, breast cancer resistance protein and CYP3A on pharmacokinetics and metabolism of galunisertib

Wenlong Li, Matthijs Tibben, Yaogeng Wang, Maria C. Lebre, Hilde Rosing, Jos H. Beijnen, Alfred H. Schinkel
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1268.
https://doi.org/10.1158/1538-7445.AM2019-1268
Published: 01 July 2019
View articletitled, Abstract 1268: The impact of P-glycoprotein, breast cancer resistance protein and CYP3A on pharmacokinetics and metabolism of galunisertib
Journal Articles

Abstract 3771: Splenic macrophages induce chemotherapy resistance via DNA damage repair

Julia M. Houthuijzen, Laura G.M. Daenen, Jeanine M.L. Roodhart, Klaas M. Govaert, Michelle E. Smith, Juergen Thomale, Sahar J. Sadatmand, Hilde Rosing, Fabian Kruse, Nico van Rooijen, Jos H. Beijnen, Piet Borst, Sven Rottenberg, Bodduluri Haribabu, Emile E. Voest
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3771.
https://doi.org/10.1158/1538-7445.AM2014-3771
Published: 01 October 2014
View articletitled, Abstract 3771: Splenic macrophages induce chemotherapy resistance via DNA damage repair
Journal Articles

Abstract 761: Phase I interaction study of docetaxel with supplementation of St. John's wort

Andrew K.L. Goey, Irma Meijerman, Hilde Rosing, Marianne Keessen, Jos H. Beijnen, Jan H.M. Schellens
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 761.
https://doi.org/10.1158/1538-7445.AM2012-761
Published: 15 April 2012
View articletitled, Abstract 761: Phase I interaction study of docetaxel with supplementation of St. John's wort
Journal Articles

Abstract 1294: Metabolism and excretion of eribulin in patients with advanced solid tumors

Anne-Charlotte Dubbelman, Marja Mergui-Roelvink, Barbara Koetz, Margarita Lymboura, Larisa Reyderman, Arturo Lopez-Anaya, Hilde Rosing, Serena Marchetti, Jos H. Beijnen, Jan HM Schellens
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 1294.
https://doi.org/10.1158/1538-7445.AM2011-1294
Published: 15 April 2011
View articletitled, Abstract 1294: Metabolism and excretion of eribulin in patients with advanced solid tumors
Journal Articles

Abstract 1518: P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) limit sunitinib brain accumulation which can be enhanced by oral elacridar treatment

Seng Chuan Tang, Jurjen S. Lagas, Nienke Lankheet, Hilde Rosing, Jos H. Beijnen, Alfred H. Schinkel
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 1518.
https://doi.org/10.1158/1538-7445.AM10-1518
Published: 15 April 2010
View articletitled, Abstract 1518: P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) limit sunitinib brain accumulation which can be enhanced by oral elacridar treatment
Journal Articles

Absence of Both Cytochrome P450 3A and P-glycoprotein Dramatically Increases Docetaxel Oral Bioavailability and Risk of Intestinal Toxicity

Robert A.B. van Waterschoot, Jurjen S. Lagas, Els Wagenaar, Cornelia M.M. van der Kruijssen, Antonius E. van Herwaarden, Ji-Ying Song, Rogier W. Rooswinkel, Olaf van Tellingen, Hilde Rosing, Jos H. Beijnen, Alfred H. Schinkel
Journal: Cancer Research
Cancer Res (2009) 69 (23): 8996–9002.
https://doi.org/10.1158/0008-5472.CAN-09-2915
Published: 30 November 2009
View articletitled, Absence of Both Cytochrome P450 3A and P-glycoprotein Dramatically Increases Docetaxel Oral Bioavailability and Risk of Intestinal Toxicity
Open the PDF for Absence of Both Cytochrome P450 3A and P-glycoprotein Dramatically Increases Docetaxel Oral Bioavailability and Risk of Intestinal Toxicity in another window
Includes: Supplementary data
Journal Articles

Abstract #5434: Co-administration of ritonavir strongly enhances the systemic exposure of oral docetaxel in patients with solid tumors

Jan Schellens, Roos Oostendorp, Stijn Koolen, Hilde Rosing, Robert Jansen, Rob ter Heine, Marianne Keessen, Alwin Huitema, Jos Beijnen
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 5434.
Published: 01 May 2009
View articletitled, Abstract #5434: Co-administration of ritonavir strongly enhances the systemic exposure of oral docetaxel in patients with solid tumors
Journal Articles

Use of novel pharmacodynamic end-points in early clinical trials: Development of a high performance liquid chromatography tandem mass spectrometry method for the quantitative analysis of prenylated proteins

Natalie M. Appels, Hilde Rosing, Jan H. Schellens, Jos H. Beijnen
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 1302.
Published: 01 April 2004
View articletitled, Use of novel pharmacodynamic end-points in early clinical trials: Development of a high performance liquid chromatography tandem mass spectrometry method for the quantitative analysis of prenylated proteins